Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy. by Xinyu Zhu, Zhaochen Luo, Rebecca A Leonard, Cait E Hamele, Rachel L Spreng, Nicholas S Heaton

“…Collectively, our results highlight a potentially generalizable method combining viral particles with differential antigenic compositions to elicit broader immune responses that may lead to more durable protection from influenza disease post-vaccination.…”
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Strain gauge evaluation of bone microstrain in full-arch implantsupported prostheses: cobalt-chromium and fiberglass materials by William Simões de Oliveira, Mariana Simões de Oliveira, Alinne Siqueira Carvalho, Guilherme de Siqueira Ferreira Anzaloni Saavedra, Marco Antonio Bottino, Lafayette Nogueira Júnior

“… Objective: This study addresses the strain gauge evaluation of bone microstrain in full-arch implant-supported prostheses using two distinct materials: Cobalt-Chromium (CoCr) and Fiber Reinforced with Composite (FRC). Material and methods: By employing strain gauge analysis, this study compares the mechanical properties of CoCr and FRC, noting that FRC bars exhibit significantly smaller microstrain under load, suggesting a more balanced strain distribution. …”
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Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening by Feng Guo, Xianglin Ji, Chuxiao Xiong, Hailiang Sun, Zhenghua Liang, Richard Yan-Do, Baowen Gai, Feng Gao, Linfeng Huang, Zhongping Li, Becki Yi Kuang, Peng Shi

“…This approach enables orders of magnitude reduction in time and cost associated with largescale siRNA screening, and resolves key insights to siRNA pharmacology that are not permissive to existing methods.…”
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Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin by Pranita Rananaware, Parimal Pandit, Varsha Brahmkhatri

“…The dual MOF composite exhibits a better affinity for loading C and 5-FU with 60% and 40% drug loading capacity, respectively. …”
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Problematic Digital Technology Use Measures in Children Aged 0 to 6 Years: Scoping Review by Špela Selak, Janja Horvat, Mark Žmavc

“…Existing composite measures conceptualize problematic use as either a group of risky behaviors or as a group of symptoms of a presumed underlying disorder, with the latter being more common. …”
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Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with kidney outcomes in patients with... by Shuo Yang, Wei He, Lu Zhao, Yaochuan Mi

“…<h4>Conclusions</h4>In this network meta-analysis, although none of the three new antidiabetic drug classes reduced the composite renal events in participants with type 2 diabetes, GLP-1 receptor agonists may be more effective. …”
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Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease by Abiy Agiro, Fan Mu, Erin Cook, Alexandra Greatsinger, Jingyi Chen, Angela Zhao, Elaine Louden, Ellen Colman, Pooja Desai, Glenn M. Chertow

“…The index date was the first CKD stage 3b/4 diagnosis with ≥1 hyperkalemia diagnosis and ≥1 serum potassium >5.0 mmol/L in the preceding 12 months (baseline) for patients with hyperkalemia and a randomly selected CKD stage 3b/4 diagnosis for controls. Cardiovascular composite end points included major adverse cardiovascular events plus (a composite end point of all‐cause mortality, myocardial infarction, stroke, or heart failure) and cardiac arrhythmias (a composite end point of new onset atrial fibrillation and other atrial and ventricular arrythmias), all in the hospital setting. …”
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Impact of Procedural Success Definitions on Long‐Term Outcomes in Patients With Rheumatic Mitral Stenosis Treated With Percutaneous Balloon Mitral Valvuloplasty: A Multicenter, Ret... by Premanan Manoret, Tasalak Thonghong, Krissada Meemook, Seththawut Kosallavat, Suchart Aroonsiriwattana, Thammarak Songsangjinda, Saranyou Suwanugsorn, Thanapon Nilmoje, Sirichai Cheewatanakornkul, Treechada Wisaratapong, Sunti Limumpornpetch, Watchara Lohawijarn, Metus Thungthienthong, Noppadol Chamnarnphol, Mann Chandavimol, Pannipa Suwannasom, Woravut Jintapakorn, Ply Chichareon

“…Three definitions were used as follows: (A) post‐PBMV mitral valve area (MVA) ≥1.5 cm2 or ≥50% increase in MVA with MR <3+; (B) post‐PBMV MVA ≥1.5 cm2 and MR ≤2+; and (C) post‐PBMV MVA ≥1.5 cm2 or ≥50% increase in MVA, with no more than 1‐grade increment in MR. Multivariable Cox regression analyses were performed to evaluate the associations between PBMV success and the composite of all‐cause mortality, mitral surgery, and repeat PBMV. …”
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Improved estimation of two-phase capillary pressure with nuclear magnetic resonance measurements via machine learning by Oriyomi Raheem, Misael M. Morales, Wen Pan, Carlos Torres-Verdín

“…One of the main challenges in characterizing pore structure is how to use data from core plugs to establish a relationship with microscopic pore and throat properties, enabling more accurate predictions of capillary pressure. …”
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Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability by Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard

“…Neutral media enabled a relatively good prediction of the extent of absorption observed in vivo, whereas the rate of absorption was more complicated to predict. <b>Conclusions:</b> FeSSIF media, and FaSSIF sink media to a lesser extent, were the only compositions enabling predictions of both extent and rate, indicating that emulsification is possibly a major contributor to the in vivo availability of the drug.…”
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A 48-month clinical performance of hybrid ceramic fragment restorations manufactured in CAD/CAM in non-carious cervical lesions: case report by Michael Willian Favoreto, Gabriel David Cochinski, Eveline Claudia Martini, Thalita de Paris Matos, Matheus Coelho Bandeca, Alessandro Dourado Loguercio

“…From the restorative perspective, various methods are available to prevent the progression of non-carious cervical lesions. …”
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Stackable 3D-printed core-shell nozzle system for multi-shell fiber and microdroplet generation by Jianfeng Li, Peer Fischer

“…Microfluidics is increasingly utilized in biofabrication to create more complex fiber and droplet structures, including those that involve multiple materials. …”
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Multi-Indicator Comprehensive Quality Evaluation of <i>Turpinia arguta</i> (Lindl.) Seem Herbs at Different Harvesting Periods by Jiangmei Hu, Junhuo Cai, Qiangqiang Cheng, Lijun Wang, Xinrui Hu, Wenzhao Wang, Zhifeng Liao, Xiuhua Tao

“…This study aimed to investigate differences in the leaf biomasses, chemical compositions, and pharmacological activities of <i>Turpinia arguta</i> histocultured seedlings and live seedlings at different harvesting periods (S1, S2, S3, and S4) in order to determine the optimal harvesting period. …”
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Optimization of Extraction Parameters for Phenolics Recovery from Avocado Peels Using Ultrasound and Microwave Technologies by Lorena Martínez-Zamora, María Carmen Bueso, Mathieu Kessler, Rosa Zapata, Perla A. Gómez, Francisco Artés-Hernández

“…This study optimized the extraction parameters of phenolics using ultrasound- (UAE) and microwave-assisted technologies (MAE) with a Central Composite Design (CCD). Methods: The extraction variables included EtOH concentration (0–100%), temperature (13–47 °C for UAE and 55–95 °C for MAE), and time (3–37 min for UAE and 3–27 min for MAE). …”
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Spatio-temporal Coupling of Ecological Service Value and Human Activity Intensity in the Central Urban Area of Lhasa City by Jiarui ZHANG, Wangdwei MIGMAR, Li CHENG, Liyuan QIAN

“…HAI is quantified through a composite index reflecting land-use change, population density, transportation infrastructure, and industrial development, with weights assigned based on ecological impacts. …”
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Unveiling psychobiological correlates in primary Sjögren’s syndrome: a machine learning approach to determinants of disease burden by László V. Módis, László V. Módis, András Matuz, András Matuz, Zsófia Aradi, Ildikó Fanny Horváth, Antónia Szántó, Antal Bugán

“…Importance of psychological factors in estimating disease burden may pave the way toward novel, more sensitive diagnostic tools and therapeutic methods and better understanding of pathomechanisms of pSS.…”
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The use of immobilized form of benzalkonium chloride and metronidazole in the treatment of purulent wounds by Anastasia S. Gorohova, Arsen Yu. Grigoryan, Alexander I. Bezhin, Tatyana A. Pankrusheva, Boris S. Sukovatykh, Ludmila V. Zhilyaeva, Ekaterina S. Mishina, Elena V. Kobzareva

“…The purpose of the study is to investigate the wound-healing effect of the immobilized form of benzalkonium chloride and metronidazole based on the sodium salt of carboxymethylcellulose (Na-CMC) or polyethylene oxide (PEO) in the treatment of an experimental purulent wound.Materials and methods. The following compositions were studied, %. …”
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Characterization of zeolitic imidazole framework (ZIF-8) catalyst for potential biodiesel production from waste cooking oil (WCO) by Chai Xin Hui, Ng Law Yong, Ng Ching Yin, Sim Jia Huey, Lim Ying Pei, Liew Josephine Ying Chyi

“…This study aims to develop magnetic vanadium-substituted HPAbased ZIF-8 composites to create a catalyst for biodiesel production from WCO that is more efficient and easier to separate. …”
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Structure and mineralization potential of the southwestern part of Sokoto Basin in Nigeria by U. Z. Magawata, U. Z. Magawata, N. K. Olasunkanmi, G. B. Egbeyale, A. Saleh

“…The integration of geophysical and remote sensing methods provides a more detailed and spatially extensive understanding of the subsurface geology compared to traditional field-based mapping, offering valuable insights for future mineral exploration and a refined geological interpretation of the Sokoto Basin.…”
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A Prospective double-blind, randomised controlled trial comparing angiotensin II to norepinephrine to reduce length of hospital stay in cardiac surgery patients (the PORTHOS study... by Rinaldo Bellomo, Eldho Paul, David Pilcher, Silvana F Marasco, Lachlan F Miles, Tim G Coulson, Daniel Frei

“…Furthermore, hyperreninaemic patients were more sensitive to angiotensin II. These findings support the need for a larger RCT to determine whether angiotensin II is superior to norepinephrine as a first-line treatment for low blood pressure after cardiac surgery.Methods and analysis We will conduct a double-blind RCT comparing an infusion of either angiotensin II or norepinephrine intraoperatively and for up to 48 hours after the start of surgery. …”
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