A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Methods Tumor, liver, and blood samples were obtained from patients undergoing resection for non-metastatic PDAC. …”
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Development and study of mucoadhesive microcapsules for the nasal levodopa delivery by D. S. Gordeeva, V. V. Khutoryanskiy, R. I. Moustafine

“…The amount of released drug was determined using an Evolution™ 220 UV spectrophotometer (Thermo Fisher Scientific, USA) at a wavelength of 202 nm.Results and discussion. A method for MC preparation was developed, the device parameters and the optimal composition of microparticles were selected. …”
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The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers by Anahita Fathi Kazerooni, Hamed Akbari, Xiaoju Hu, Vikas Bommineni, Dimitris Grigoriadis, Erik Toorens, Chiharu Sako, Elizabeth Mamourian, Dominique Ballinger, Robyn Sussman, Ashish Singh, Ioannis I. Verginadis, Nadia Dahmane, Constantinos Koumenis, Zev A. Binder, Stephen J. Bagley, Suyash Mohan, Artemis Hatzigeorgiou, Donald M. O’Rourke, Tapan Ganguly, Subhajyoti De, Spyridon Bakas, MacLean P. Nasrallah, Christos Davatzikos

“…Results Here, we show that glioblastoma mutations produce distinctive imaging signatures, which are more pronounced in tumors with less molecular heterogeneity. …”
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Comparative study of specific activity of rectal suppositories with clopidogrel by I. L. Kechyn, V. V. Hladyshev, O. L. Drozdov, O. B. Kharaponova, S. A. Hladysheva

“…The aim of the work is to investigate the specific activity of rectal suppositories with clopidogrel. Materials and methods. Experimental suppositories with clopidogrel 0,075 g for rectal administration were used as the objects in pre-line studies. …”
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Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells by Fatemeh Nosrati, Baratali Fakheri, Habib Ghaznavi, Nafiseh Mahdinezhad, Roghayeh Sheervalilou, Bahman Fazeli-Nasab

“…Abstract Astragalus fasciculifolius Bioss, commonly known as Anzaroot, is a medicinal plant from the Fabaceae family, recognized for its therapeutic properties due to its rich composition of saponins, flavonoids, and polysaccharides. …”
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Protective mechanism of weathering steel rust layers in atmospheric environments and their stabilization treatment technologies by Junyi GAO, Weichen XU, Binbin ZHANG, Canming LI, Guobao LI, Baorong HOU

“…This study discusses the protective properties of rust layers from multiple perspectives, including their internal and external structure, composition, formation mechanism, the influence of environmental factors and alloying elements on corrosion resistance, and current treatment technologies for rust stabilization. …”
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Synergizing population structure, habitat preferences, and ecological drivers for conservation of Cedrus deodara by Syed Waseem Gillani, Mushtaq Ahmad, Muhammad Manzoor, Muhammad Waheed, Andreas Tribsch, Hamayun Shaheen, Abdul Basit Mehmood, Beatrice Ambo Fonge, Abeer Al-Andal

“…The quadrat method was used to record the vegetation data across an elevational gradient ranging from 1300 to 2700 m. …”
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Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension by M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev

“…The compared groups did not differ in sex and age composition, prevalence of T2D and basic clinical data. …”
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Spatial distribution and determinants of children ever born among reproductive age women in Ethiopia: spatial and multilevel analysis of 2019 mini Ethiopian demographic health surv... by Ahmed Fentaw Ahmed, Bezawit Adane, Tilahun Degu Tsega, Mekides Nigusu, Kalaab Esubalew Sharew, Abebaw Molla, Mulugeta Tesfa

“…The primary outcome, CEB, was categorized as “low” if fewer than five children were born and “high” if five or more children were born. Global and local Moran's Index methods were used to assess the extent of clustering. …”
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Nutritional risk, functional decline, and symptom burden in lung cancer: a study based on PG-SGA scores and biochemical data by Shasha Shen, Shasha Shen, Shiyun Xing, Shiyun Xing, Tingting Shen, Li Niu, Xiaojing Tian, Xiaojing Tian, Hu Ma, Hu Ma, Xiaoxia Gou, Xiaoxia Gou

“…Patients with higher PG-SGA scores had significantly lower scores in physical functioning, role functioning, emotional functioning, and social functioning, alongside more severe symptoms such as fatigue, nausea, and pain. …”
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Bacterial diversity in longan orchard alluvial soil is influenced by cultivation time and soil properties by Nguyen Khoi Nghia, Kovacs Emoke Dalma, Kovacs Melinda Haydee, Le Thi Xa, Lois Wright Morton, Hüseyin Barış Tecimen, Javad Robatjazi, Jegan Sekar, Hendra Gonsalve W. Lasar, Trung Thanh Nguyen, Nguyen Minh Phuong, Chau Thi Anh Thy, Do Thanh Luan, Nguyen Thi Kieu Oanh

“…Longan orchard soils from all three time periods (N15, N20, N30) had more microbial species in common, than in unique ways. …”
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16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves by P. P. Cao, C. L. Hu, M. J. Li, Y. H. An, X. Feng, X. H. Ma, D. Z. Wang, Z. H. Song, G. S. Ji, D. Yang, Q. Ma, W. F. Yang, J. N. Dong, H. R. Zhang, Y. Ma, Y. F. Ma

“…These alterations in the fecal microbiota and metabolite composition were found to be the principal contributors to growth retardation in diarrheic calves.…”
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Fermented palm kernel waste with different sugars as substrate for black soldier fly larvae by R.A. Nugroho, R. Aryani, E.H. Hardi, H. Manurung, R. Rudianto, W.N. Jati

“…This study’s findings offer insights into managing the fermented palm kernel meal, which can be converted into valuable biomass with black soldier fly larvae, making the waste more sustainable and rich in nutrients. The addition of various sugars to fermented palm kernel meal improved the growth and nutritional value of the black soldier fly larvae. …”
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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review by Giulia Negro, Giulia Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti, Andrea Magi, Andrea Magi, Ildebrando Marco Appollonio, Ildebrando Marco Appollonio, Alfredo Costa, Alfredo Costa, Tino Emanuele Poloni, Tino Emanuele Poloni

“…No behavioral symptom is pathognomonic of a specific proteinopathy; rather, the topography and severity of lesions plays a more decisive role than their single molecular composition.Systematic review registrationINPLASY2024100082.…”
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Use and utility of endocrine multidisciplinary tumour board: an appraisal from a tertiary centre by Clotilde Sparano, Clotilde Sparano, Letizia Canu, Letizia Canu, Letizia Canu, Letizia Canu, Giuliano Perigli, Roberto Santoro, Silvia Pradella, Giulia Grazzini, Monica Mangoni, Gabriele Simontacchi, Benedetta Fibbi, Vania Vezzosi, Catia Olianti, Mario Maggi, Mario Maggi, Luisa Petrone

“…Although required by major guidelines, little is known about the current EMTB composition and working outcomes. The present study aims to analyse the use and support provided by an experienced EMTB, highlighting the skills of this board.MethodsThis monocentric and retrospective study considered all the cases discussed (N=1038, concerning 835 patients) within the ETMB of Careggi University Hospital of Florence from January 1st, 2021, to December 31st, 2023. …”
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Understanding the patterns and health impact of indoor air pollutant exposures in Bradford, UK: a study protocol by Elizabeth Bates, Rosemary McEachan, Lia Chatzidiakou, Roderic L Jones, Tiffany C Yang, Erika Ikeda, Dagmar Waiblinger, Jacqueline Hamilton, Chantelle Wood, Thomas Warburton, Athina Ruangkanit, Yunqi Shao, Denisa Genes, Chiara Giorio, Gordon McFiggans, Simon P O'Meara, Pete Edwards, David R Shaw, Nicola Carslaw

“…Introduction Relative to outdoor air pollution, there is little evidence examining the composition and concentrations of indoor air pollution and its associated health impacts. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Their structure and composition characterization were performed using TEM, NTA and UHPLC-QTOFMS. …”
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Effects of different vegetation restoration models on soil nutrients in the water level fluctuation zone of a large reservoir by Bai Qinfei, Bao Yuhai, Yu Yantong, Yang Jie, Wang Yanqi, Wei Jie

“…To evaluate the effects of different restoration approaches on soil nutrients in the WLFZ of Heilongtan Reservoir, the integrated levels of soil nutrients in similar topographical environments but with varying vegetation restoration strategies were quantitatively assessed using the entropy weight method. The results showed that reservoir water-level fluctuations significantly altered the distribution and composition of vegetation communities in the WLFZ. …”
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Computed tomography-based radiomics predicts prognostic and treatment-related levels of immune infiltration in the immune microenvironment of clear cell renal cell carcinoma by Shiyan Song, Wenfei Ge, Xiaochen Qi, Xiangyu Che, Qifei Wang, Guangzhen Wu

“…We also statistically analysed and compared the results of multiple typing models and explored an excellent non-invasive and convenient method for treatment of ccRCC patients and explored a better, non-invasive and convenient prediction method for ccRCC patients. …”
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Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement by Xiao-Yi Xiong, Xiao-Yi Xiong, Xiao-Yi Xiong, Haicheng Yuan, Ying Mu, Yi He, Fang Xie, Xiao-Shuang Feng, Jia-Xin Xie, Xin-Ru Pan, Yu-Fei Wang, Jian Gong, Xiaoming Zheng, Peng-Fei Wang

“…Aged microglial replacement is protective against brain injury in aged mice; however, whether/how the molecular changes in myeloid cells are affected by this replacement in injured brains remains unclear.MethodsAged microglia in mice were eliminated by PLX3397 for 21 consecutive days and repopulated following withdrawal for 21 days; then, intracerebral hemorrhage (ICH) models were constructed. …”
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