Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants by Yao Peng, Yao Peng, Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Hu-Dan Pan, Liang Liu, Liang Liu, Liang Liu, Jing-Rong Wang, Jing-Rong Wang

“…The Spike protein forms trimers that bind to the ACE2 receptor on host cells, with the S1 subunit being a primary target for vaccines and antiviral treatments.MethodsHerein, we performed an in-depth analysis of the N-glycosylation of the recombinant Spike S1 protein (S1 protein) across the wild-type (WT) virus and its 5 variants, including Alpha, Beta, Gamma, Delta, and Lambda, by integrating ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF MS) and unique TiO₂-PGC chip-based LC/MS techniques.ResultsA total of 332 glycan structures arising from 180 compositions on the S1 and RBD regions were identified, revealing remarkable glycosylation diversity of the S1 protein. …”
Get full text

Interferon Gamma and Tumor Necrosis Factor Alpha Are Inflammatory Biomarkers for Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease by Ben Li, Eva Lindner, Raghad Abuhalimeh, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…Incorporating these biomarkers into PAD management may improve systemic cardiovascular outcomes through more personalized and targeted treatment approaches.…”
Get full text

First-line vs Second-Line Catheter Ablation Therapy for Patients with Atrial Fibrillation—Data from a National Multicentre Registry by Ranin Hilu, MD, Mahmoud Suleiman, MD, Adi Elias, MD, MPH, Ibrahim Marai, MD, Roy Beinart, MD, Eyal Nof, MD, Yoav Michowitz, MD, Michael Glikson, MD, Yuval Konstantino, MD, Moti Haim, MD, David Luria, MD, David Pereg, MD, Avishag Laish-Farkash, MD, PhD, Alexander Omelchenko, MD

“…Patients in the first-line group were younger, had a shorter AF duration, and more frequently had a normal left atrial size prior to the procedure. …”
Get full text

The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…This strategy fails to adequately capture the full impact of treatment in heterogenous neurological conditions like SCI. A more patient-centric analysis requires assessment of neurological function, functional capacity, and quality of life, incorporating meaningful patient-reported outcomes. …”
Get full text

DOAC Score for Predicting Clinical Outcomes After Left Atrial Appendage Closure by Masahiko Asami, MD, Yu Horiuchi, MD, Jun Tanaka, MD, Daiki Yoshiura, MD, Masanori Taniwaki, MD, Kota Komiyama, MD, PhD, Hitomi Yuzawa, MD, PhD, Kengo Tanabe, MD, PhD, Mitsuru Sago, CE, Shuhei Tanaka, MD, PhD, Ryuki Chatani, MD, Toru Naganuma, MD, Yohei Ohno, MD, PhD, Tomoyuki Tani, MD, Hideharu Okamatsu, MD, Kazuki Mizutani, MD, PhD, Yusuke Watanabe, MD, PhD, Masaki Izumo, MD, PhD, Mike Saji, MD, PhD, Shingo Mizuno, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, PhD, Shunsuke Kubo, MD, Shinichi Shirai, MD, Masaki Nakashima, MD, Masanori Yamamoto, MD, PhD, Kentaro Hayashida, MD, PhD

“…Results: Among 1464 patients (mean age 77.1 years; 67.6% male), the HBR group (923 patients) had a lower body mass index, more frequent comorbidities, and higher risk profiles for bleeding and stroke. …”
Get full text

Genome-Wide Identification of the HSP Gene Family in Penaeus japonicus and Their Expression Characteristics During Development Stages by Xueqiong BIAN, Xianyun REN, Junxia WANG, Shaoting JIA, Jianjun GUO, Kuangcheng ZHAO, Ping LIU, Jian LI, Jitao LI

“…However, previous studies were based on single genes, and more systematic studies based on the role of the hsp gene family in the growth and development of P. japonicus have not been published. …”
Get full text

Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of... by Jasvinder A Singh, Vesna Zadnik, Mohammad Ali Mansournia, Alessandra Lugo, Silvano Gallus, Amir Almasi-Hashiani, Saeid Safiri, Mahdi Sepidarkish, Mohsen Naghavi, Fares Alahdab, Félix Carvalho, Lalit Dandona, Rakhi Dandona, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Samer Hamidi, Simon I Hay, Reza Malekzadeh, Tomislav Mestrovic, Shafiu Mohammed, Ali H Mokdad, Lorenzo Monasta, Huong Lan Thi Nguyen, Amir Radfar, Alireza Rafiei, Gholamreza Roshandel, Khanh Bao Tran, Ahmad Ghashghaee, Giuseppe Gorini, Mariam Molokhia, Ahad Ashrafi-Asgarabad, Salman Rawaf, Dejana Braithwaite, Nicholas L S Roberts, Vahid Alipour, Jalal Arabloo, Ali Bijani, Mowafa Househ, Olayinka Stephen Ilesanmi, Bartosz Miazgowski, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Cuong Tat Nguyen, Navid Rabiee, David Laith Rawaf, Abdallah M Samy, Sadaf G Sepanlou, Bach Xuan Tran, Zhi-Jiang Zhang, Giulia Carreras, Masood Ali Shaikh, Hai Quang Pham, Faris Hasan Lami, Stanislav S Otstavnov, Rajan Nikbakhsh, Roman Topor-Madry, G Anil Kumar, Tone Bjørge, Nima Hafezi-Nejad, Dinh-Toi Chu, Farahnaz Joukar, Mukhammad David Naimzada, Ali-Asghar Kolahi, Amir Abdoli, Atif Amin Baig, Mansour Ghafourifard, Soheil Hassanipour, Segun Emmanuel Ibitoye, Milena D Ilic, Carlo La Vecchia, Masoud Moghadaszadeh, Priya Rathi, Feng Sha, Maryam Zamanian, Mahaveer Golechha, Shailesh M Advani, Akshaya Srikanth Bhagavathula, Artem Alekseevich Fomenkov, Rahmatollah Moradzadeh, Mariya Vladimirovna Titova, Yohannes Tekalegn, Xiaochen Dai, Yonas Getaye Tefera, Bingyu Li, Iman El Sayed, Seyed Aria Nejadghaderi, Mark J M Sullman, Eman Abu-Gharbieh, Erfan Amini, Etsay Woldu Anbesu, Jason A Anderson, Atalel Fentahun Awedew, Antonio Biondi, Florentino Luciano Caetano dos Santos, Kelly Compton, Vera Marisa Costa, Meseret Derbew Molla, Abebaw Alemayehu Desta, Mostafa Dianatinasab, Hedyeh Ebrahimi, Sahar Eftekharzadeh, Babak Eshrati, Berhanu Elfu Feleke, Kebebe Bekele Gonfa, James D Harvey, Hannah Jacqueline Henrikson, Irena M Ilic, Seyedeh-Sanam Ladi-Seyedian, Iván Landires, Irmina Maria Michalek, Osama Mohamad, Behnam Nabavizadeh, Mohammad Reza Nowroozi, Virginia Nuñez-Samudio, Majid Pirestani, Faheem Hyder Pottoo, Nima Rezaei, Sara Sheikhbahaei, Sudeep K Siddappa Malleshappa, Emma Elizabeth Spurlock, Eyayou Girma Tadesse, Eugenio Traini, Ravensara S Travillian, Marco Vacante, Rixing Xu, Yordanos Gizachew Yeshitila

“…Introduction The current study determined the level and trends associated with the incidence, death and disability rates for bladder cancer and its attributable risk factors in 204 countries and territories, from 1990 to 2019, by age, sex and sociodemographic index (SDI; a composite measure of sociodemographic factors).Methods Various data sources from different countries, including vital registration and cancer registries were used to generate estimates. …”
Get full text

Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design... by Kengo Kusano, Ayako Okada, Koji Miyamoto, Eizo Tachibana, Wataru Shimizu, Masato Murakami, Tomoo Harada, Kojiro Tanimoto, Takeshi Kato, Satoru Sakagami, Katsuhito Fujiu, Tatsuya Hayashi, Yasuo Okumura, Kazuhiro Satomi, Tomoyuki Shiozawa, Hideki Kobayashi, Michifumi Tokuda, Teiichi Yamane, Ryohsuke Narui, Seigo Yamashita, Satoru Miyanaga, Ikutaro Nakajima, Hidehira Fukaya, Hajime Kihara, Shiro Nakahara, Koichi Nagashima, Kenta Murotani, Shinya Suzuki, Ryuta Watanabe, Katsuaki Yokoyama, Hidemori Hayashi, Yu-ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Masaomi Kimura, Masahide Harada, Junjiroh Koyama, Hideharu Okamatsu, Mitsuru Takami, Morio Shoda, Kenichi Hiroshima, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Yuji Watari, Mina Hatsuno, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Haruna Tabuchi, Kenjiro Miyamoto, Hiroshi Mase

“…Results of the study will be published in one or more peer-reviewed journals.Trial registration number UMIN000047023.…”
Get full text

Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions by Elizaveta S. Meteleva, Elizaveta A. Roenko, Nikolay E. Polyakov

“…It is shown that the solubility increases for all studied compositions. These phenomena are obliged by complexation with HP-β-CD, which was shown by 1H-NMR methods, and enhanced ionization in the cases of using calcium carbonate and MG. …”
Get full text