Plasmidome analyses of Klebsiella pneumoniae co-producing blaKPC-2 and blaNDM-1 in Southern Brazil: characterisation of mobile genetic elements by Mayana Kieling Hernandez Berdichevski, Rafaela R. Guerra, Dariane C. Pereira, Camila M. Wilhelm, Patricia O. Barth, Melise C. Silveira, Fabiana C.Z. Volpato, Claudio Rocha-de-Souza, Richard M. Carrassai, Ana Paula Carvalho-Assef, Andreza F. Martins, Afonso Luís Barth

“…ABSTRACT: Objective: Infections due to carbapenemase-producing Enterobacterales harbouring more than one carbapenemase-encoding gene spread mainly by plasmid and transposon mobilisation. …”
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A retrospective assessment of COVID-19 vulnerability index indicators and mortality rates pre-COVID-19 (2018–2020) and during COVID-19 (2020–2022) in a health and demographic surve... by Takwanisa Machemedze, Chodziwadziwa Whiteson Kabudula, Jean Juste Harrisson Bashingwa, Beth A. Tippett Barr, Nellie Myburgh, Sana Mahtab, Cleopas Hwinya, Stephen Tollman, Ziyaad Dangor, Shabir A. Madhi

“…All cause-mortality across all tertiles more than doubled during the COVID-19 period compared to pre-COVID-19 (15.5 against 7.2). …”
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BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults by Claire J. Cadwallader, Anna M. VandeBunte, D. Luke Fischer, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario‐Lago, Julio C. Rojas, Eliana Marisa Ramos, Jessica E. Rexach, Jennifer S. Yokoyama, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto

“…The neuroprotective benefits of PA may be more pronounced in BDNF Val/Val carriers. There may be a sex‐specific PA pathway for neuroinflammation in Val/Val males.…”
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Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction by Giuseppina Basta, Serena Babboni, Daniele Pezzati, Serena Del Turco, Emanuele Balzano, Gabriele Catalano, Lara Russo, Giovanni Tincani, Paola Carrai, Stefania Petruccelli, Jessica Bronzoni, Caterina Martinelli, Simona Palladino, Arianna Trizzino, Lorenzo Petagna, Renato Romagnoli, Damiano Patrono, Giandomenico Biancofiore, Adriano Peris, Chiara Lazzeri, Davide Ghinolfi

“…Lipid peroxidation (TBARS) elevated at the start of NRP, declined over time, with higher levels in D-HOPE than in NMP, suggesting a more oxidative environment in D-HOPE. Metabolites like flavin mononucleotide (FMN) and NADH exhibited significant disparities between perfusion types, due to differences in perfusate compositions. …”
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Switching from intravenous to subcutaneous infliximab in patients with immune mediated diseases in clinical remission by Nikos Viazis, Anastasios Karamanakos, Konstantinos Mousourakis, Angeliki Christidou, Fotios Fousekis, Konstantinos Mpakogiannis, Anastasios Koukoudis, Konstantinos Katsanos, Dimitrios Christodoulou, Myrto Cheila, Maria Tzouvala, Eirini Zacharopoulou, Maria Palatianou, Olga Giouleme, Olga Giouleme, Anastasia Katsoula, Anastasia Katsoula, Christos Liatsos, Nikolaos Kyriakos, Evi Zampeli, Evgenia Papathanasiou, Angeliki Theodoropoulou, Konstantinos Karmiris, Ioannis Psaroudakis, George Tribonias, Souzanna Gazi, Evangelia Mole, Theodoros Dimitroulas, Christos Koutsianas, Dimitris Vassilopoulos, George E. Fragoulis, Nikos Michalakeas, Charalampos Papagoras, Pantelis Panagakis, Marina Papoutsaki, Vasiliki Chasapi, Alexandros Stratigos, George Katsikas

“…The primary endpoint was disease deterioration during a follow up period, of at least 6 months, according to disease specific composite measures.ResultsBetween April 2023 and April 2024, a total of 344 patients (CD = 136, UC = 62, SpA = 52, PsA = 38, RA = 7, PsO = 44, co-existence of more than one disease = 5) were switched from IFX-IV to IFX-SC. …”
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Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study by Albertino Damasceno, Hadiza Saidu, Gad Cotter, Beth Davison, Christopher Edwards, Jelena Celutkiene, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamilė Čerlinskaitė‐Bajorė, Ovidiu Chioncel, Alain Cohen‐Solal, Benjamin Deniau, Rafael Diaz, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S.P. Lam, Marco Metra, Maria Novosadova, Matteo Pagnesi, Peter S. Pang, Piotr Ponikowski, Jozine M. Ter Maaten, Daniela Tomasoni, Adriaan A. Voors, Koji Takagi, Alexandre Mebazaa, Karen Sliwa

“…Higher SES patients benefitted more from HIC.…”
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Exploring the Associations of Neck Circumference, Blood Pressure, CRP, and Insulin Resistance on the Visceral Adiposity Index: Insights from a Cross-Sectional Study by Lucas Fornari Laurindo, Francine Cruz Camargo, Alessandra Perfeito, Bruno Benedito Ciano, Clara Tainá Coelho, Gleice Assis Apolinário, Isabela do Nascimento Vicentin, Jéssica Cambui Andreasi, Beatriz Leme Boaro, Ricardo José Tofano, Cláudia Rucco Penteado Detregiachi, Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Lance Alan Sloan, Kátia Portero Sloan, Antonelly Cassio Alves de Carvalho, Marie Oshiiwa, Patrícia Cincotto dos Santos Bueno, Tereza Laís Menegucci Zutim, Rebeca Maria Siqueira da Silva, Eduardo Federighi Baisi Chagas, Marcelo Dib Bechara, Karina R. Quesada

“…Background: The visceral adiposity index (VAI) is a composite marker designed to quantify visceral adiposity and its metabolic implications. …”
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Studies on the effectiveness of artificial pollination and pollen xenia in macadamia nut Guire No.1 by PAN Haonan, PAN Zhenzhen, HUAN Xiuju, QIN Xiaomin, ZHENG Shufang, LU Yuming, KANG Zhuanmiao, TAO Liang, WANG Wenlin, QIN Zhenshi

“…Muell) independently selected and bred in Guangxi, Guire No.1 is the macadamia variety with the largest cultivation area in Guangxi at present, accounting for about more than 65% of the total planting area. It was a self-incompatible variety. …”
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CLINICAL EVALUATION OF RESTORATIONS OF ENDODONTICALLY TREATED TEETH by O.A. Udod, R.S. Kostenko

“… For endodontically treated lateral teeth, direct restoration made of photocomposites is most often used, and indirect ceramic restoration appears to be more promising, for which, however, additional retention is required. …”
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Predicting the Development of Thrombosis of the Femoral-Popliteal Bypass in the Long-Term Follow-Up Period by A. B. Zakeryaev, R. A. Vinogradov, P. V. Sukhoruchkin, S. R. Butayev, T. E. Bakhishev, A. I. Derbilov, E. R. Urakov, A. G. Baryshev, V. A. Porkhanov

“…The development of a program for predicting thrombosis with subsequent amputation of a limb in the long-term period after femoral-popliteal bypass (FPB).Material and methods. This is a retrospective open comparative study performed from January 10, 2016 to December 25, 2019 at Research Institute – Professor S.V. …”
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Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, p... by Caroline A Crowther, Pat Ashwood, Andrew J McPhee, Vicki Flenady, Thach Tran, Jodie M Dodd, Jeffrey S Robinson, PROGRESS Study Group

“…No differences were seen between study groups for other respiratory morbidities and adverse infant outcomes, including serious infant composite outcome (155/406 [38.2%] in the progesterone group and 152/393 [38.7%] in the placebo group, adjusted RR 0.98, 95% CI 0.82-1.17, p = 0.798). …”
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Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction by Nousjka P. A. Vranken, Xinyu Li, Heleen Bouman, Sanne G. J. Mourmans, Anouk Achten, Arantxa Barandiarán Aizpurua, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P. M. van Empel, Jerremy Weerts

“…Albuminuria is a prognostic marker in heart failure patients and more prevalent in patients with diabetes What is the key research question? …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…The primary outcome measured at baseline, 6 and 12 months is performance on a cognitive composite score measuring the executive domain calculated from a combination of computerised (NeuroTrax) and paper-and-pencil tests. …”
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Reduced-dose chemotherapy followed by blinatumomab for newly diagnosed philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia: a propensity-matched comparis... by Jing Lu, Yu Zhu, Huiying Qiu, Ying Wang, Xin Zhou, Haiping Dai, Xuzhang Lu, Bin Gu, Ming Hong, Miao Miao, Ruinan Lu, Jun Wang, Qian Wu, Mengxing Xue, Yun Wang, Ailing Deng, Yaoyao Shen, Yin Liu, Xueqing Dou, Yutian Lei, Xiaofei Yang, Suning Chen

“…This regimen offers a safer and more effective induction therapy option, warranting further investigation in larger trials. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…The elderly with genetically susceptible gut microbiota may experience distinct sleep improvement effects from green spaces compared to those with more stable gut microbiota compositions. Additionally, culturally-specific lifestyle patterns and attitudes toward nature may lead to variations in sleep improvement outcomes among the elderly from diverse cultural backgrounds when they use green spaces.ConclusionResearch on improving sleep health of the elderly must transcend single-discipline limitations, integrating theories and research methods from multiple fields including geriatrics and gerontology, neuroscience and neurology, psychiatry, psychology, behavioral science, sociology, rehabilitation medicine, exercise science, and environmental science and ecology. …”
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Adherence to the ABC (atrial fibrillation better care) pathway and risk of adverse outcomes in patients with chronic kidney disease: a report from the prospective APHRS-AF registry... by Tommaso Bucci, Katarzyna Nabradalik, Krysztof Irlik, Alena Shantsila, Giulio Francesco Romiti, Marco Proietti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Tze-Fan Chao, Gregory Y.H. Lip, Hung-Fat Tse, Chun-Wah David Siu, Wataru Shimizu, Kenji Yodogawa, Hiroyuki Tsutsui, Yasushi Mukai, Hirofumi Tomita, Daisuke Horiuchi, Joji Hagii, Kazutaka Aonuma, Yasuo Okumura, Masahiko Goya, Kenzo Hirao, Ajioka Masayoshi, Nobuhisa Hagiwara, Atsushi Suzuki, Teiichi Yamane, Takanori Ikeda, Hitomi Yuzawa, Kazuhiro Satomi, Yoshinao Yazaki, Keiichi Fukuda, Yoshinori Kobayashi, Norishige Morita, Toyoaki Murohara, Eiichi Watanabe, Masahide Harada, Satoru Sakagami, Takahiro Saeki, Kengo Kusano, Koji Miyamoto, Shinsuke Miyazaki, Hiroshi Tada, Koichi Inoue, Nobuaki Tanaka, Yukihiro Koretsune, Haruhiko Abe, Yasuki Kihara, Yukiko Nakano, Akihiko Shimizu, Yasuhiro Yoshiga, Tomohiro Sakamoto, Ken Okumura, Naohiko Takahashi, Tetsuji Shinohara, Kyoko Soejima, Masahiko Takagi, Mitsuharu Kawamura, Yumi Munetsugu, Hyung-Wook Park, Jae-Min Shim, Jae Sun Uhm, Sung Il Im, Hyoung-Seob Par, Jun Hyung Kim, Young Keun On, Il-Young Oh, Seung Yong Shin, Jum Suk Ko, Jun Beom Park, Wee-Siong Teo, Kelvin Cheok-Keng Wong, Toon-Wei Lim, David Foo, Shih-Ann Chen, Tze-Fan Chao, YennJiang Lin, Fa-Po Chung, Yu-Feng Hu, Shil-Lin Chang, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-Hung Li, Jin-Long Huang, Yu-Cheng Hsieh, Tsu-Juey Wu, Ying-Chieh Liao, Cheng-Hung Chiang, Hsiang-Chiang Hsiao, Tung-Chen Yeh, Wei-Siang Lin, Wen-Yu Lin, Jen-Yuan Kuo, Chong-Lie Hong, Yih-Je Wu, Ying-Siang Li, Jui-Peng Tsai, Kuo-Tzu Sung, Sheng-Hsiung Chang

“…Summary: Background: Limited data exist on the effectiveness of the ABC (Atrial Fibrillation Better Care) pathway in reducing adverse events in Asian patients with atrial fibrillation (AF) and chronic kidney disease (CKD). Methods: A post-hoc analysis of the prospective APHRS AF Registry. …”
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A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair by Tharusan Thevathasan, Sophie Berlinghof, Daniel Elschenbroich, Julia M. Wiedenhofer, Sêhnou Degbeon, Luise Holzhauser, Fabian Barbieri, Mario Kasner, Anna Brand, Henryk Dreger, Steffen Desch, Ulf Landmesser, Markus Reinthaler, Carsten Skurk

“…Conclusion: Mitral TEER has become safer and more efficient due to technological advances, operator experience and centralized care. …”
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Tribological performances of alternating multilayer diamond films on Si3N4 ceramic substrates by He WANG, Haigen ZHAO, Guangyu YAN

“…When the number of alternations is more, the interlayer thickness is thin, the film does not have obvious layering, the surface roughness is large, and the film quality is poor. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…Both miR-223-3p and 378c were more enriched in small EVs (sEVs) compared to NVEPs. …”
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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate by Chenquan Lin, Chenquan Lin, Chenquan Lin, Rui Ma, Rui Ma, Rui Ma, Xiao Zeng, Xiao Zeng, Xiao Zeng, Bikui Zhang, Bikui Zhang, Bikui Zhang, Ting Cao, Ting Cao, Ting Cao, Shimeng Jiao, Shimeng Jiao, Shimeng Jiao, Hui Chen, Hui Chen, Hui Chen, Yifang He, Yifang He, Yifang He, Mouze Liu, Mouze Liu, Mouze Liu, Hualin Cai, Hualin Cai, Hualin Cai

“…Besides, patient administrated with HD-MTX were more prevalent to have higher C/D levels when using intravenous plus triple intrathecal injection route than those who were using intravenous injection alone. …”
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