Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…A pain visual analogue scale (VAS) and Functional Assessment of Chronic Illness Therapy-Fatigue instrument (chosen from PROMS) were added as modifications to the Composite Psoriatic Disease Activity Index (CPDAI) and the GRAppa Composite Exercise (GRACE) composite measures. …”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…This study aimed to diagnose swallowing disorders and highlight the importance of swallowing therapy in older patients in intensive care units (ICUs).Materials and methodsTwenty-five older patients (12 men, 13 women, mean age 67.22 ± 24.03 years) hospitalized in the ICUs with complaints of dysphagia were analyzed prospectively. …”
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Candida and Bacterial Skin Colonisation of Critically-ill Patients in Two Tertiary Healthcare Facilities in Zambia by Prof Geoffrey Kwenda, Dr John Mwaba, Ms Chalwe Sokoni, Mr Christone Kaile, Ms Faith Kabansa, Mr Darlingtone Mwenya, Ms Tshiama Mirriam Mwamba, Ms Ruth Mpembe, Dr Sabelle Jallow, Ms Rudzani Mashau, Prof Nelesh Govender, Miss Chalwe Sokoni

“…This study aimed to investigate the prevalence of Candida and bacterial colonisation in critically ill patients in Zambia. Methods: In a Point-prevalence survey (PPS) for Candida and bacterial skin colonisation conducted on October 2 and 3, 2023, skin swab samples (composite axilla/groin) were collected from critically-ill patients who were admitted for at least 48 hours to two tertiary hospitals in Zambia. …”
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Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-... by Paris J Baptiste, Angel Y S Wong, Anna Schultze, Catherine M Clase, Clémence Leyrat, Elizabeth Williamson, Emma Powell, Johannes F E Mann, Marianne Cunnington, Koon Teo, Shrikant I Bangdiwala, Peggy Gao, Kevin Wing, Laurie Tomlinson

“…However, the effectiveness and risk of these drugs in Black populations in UK routine care is unknown.<h4>Methods and findings</h4>We applied a reference trial emulation approach to UK Clinical Practice Research Datalink Aurum data (linked with data from Hospital Episode Statistics and Office for National Statistics) to study the comparative effectiveness of ARB and ACEi in ethnic minority groups in England, after benchmarking results against the ONTARGET trial. …”
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Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry by M. M. Lukyanov, N. P. Kutishenko, S. Yu. Martsevich, A. A. Pulin, E. Yu. Andreenko, V. P. Voronina, V. A. Dindikova, N. A. Dmitrieva, O. V. Lerman, A. N. Makoveeva, E. Yu. Okshina, A. S. Sgibneva, A. A. Smirnov, E. N. Belova, V. G. Klyashtorny, E. V. Kudryashov, O. E. Karpov, O. M. Drapkina

“…To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). …”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…Participants in DSD models were more likely to have sustained viral suppression (weighted odds ratio 1.69, 95% CI 1.24–2.31), lower mortality (weighted hazard ratio 0.08, 95% CI 0.03–0.20) and lower LTFU rates (weighted hazard ratio 0.08, 95% CI 0.02–0.31). …”
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Feasibility and Surgical Effect of Annulus Sparing in Consecutive Patients with Tetralogy of Fallot: A Retrospective Cohort Study by Lizhi Lv, Jinyang Liu, Xianchao Jiang, Yang Liu, Yanjin Tian, Hong Cao, Zhimin Liu, Qiang Wang

“…The primary outcome was a composite of reintervention, significant pulmonary regurgitation, and significant annular peak gradient (APG). …”
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Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry by Elif Kaya, Jochen Senges, Matthias Hochadel, Lars Eckardt, Dietrich Andresen, Hüseyin Ince, Stefan G. Spitzer, Thomas Kleemann, Sebastian S.K. Maier, Werner Jung, Christoph Stellbrink, Tienush Rassaf, Reza Wakili

“…The aim of our study was to investigate the impact of DM on periprocedural complications and clinical outcome in HF patients undergoing ICD or CRT implantation. Methods and results Within the German Device Registry, data from 50 German centres were collected between January 2007 and February 2014. …”
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A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging by Peggy Ler, Jonathan K. L. Mak, Chandra A. Reynolds, Alexander Ploner, Nancy L. Pedersen, Juulia Jylhävä, Anna K. Dahl Aslan, Deborah Finkel, Ida K. Karlsson

“…FI measured physiological aging, while FAI assessed functional aging through a composite score of functional abilities. Results At first measurement, mean age was 74 ± 8, and 41% were males. …”
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A life that’s worth living – measuring health-related quality of life among people treated for tuberculosis in Viet Nam: a longitudinal EQ-5D-5L survey by Luan Nguyen Quang Vo, Rachel Forse, Andrew James Codlin, Huy Ba Huynh, Anja Maria Christine Wiemers, Jacob Creswell, Tushar Garg, Thi Minh Ha Dang, Lan Huu Nguyen, Hoa Binh Nguyen, Luong Van Dinh, Nhung Viet Nguyen, Tom Wingfield, Kristi Sidney Annerstedt, Jad Shedrawy, Knut Lönnroth

“…We aimed to measure HRQoL among people with TB in Viet Nam at initiation and throughout treatment. Methods This study took place in four provinces from Oct-2020 to Sep-2022. …”
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Correlation between coronary calcification and cardiac structure in non‐dialysis patients with chronic kidney disease by Siyi Rao, Mengjie Weng, Ruoshan Lian, Yongjie Zhuo, Jiaqun Lin, Danyu You, Jiong Cui, Yi Chen, Jianxin Wan

“…During a mean follow‐up time of 18.26 ± 10.17 months, 65 (36.52%) patients had a composite renal endpoint event, of which 36 (20.22%) were admitted to renal replacement therapy. …”
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One-step diagnosis of infection and lung cancer using metagenomic sequencing by Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye

“…Comparisons were made across different groups, subtypes, and stages of lung cancer regarding copy number variation (CNV) patterns, microbiome compositions, and clinical detection indices. Results Compared to conventional infection testing methods, Onco-mNGS demonstrates superior infection detection performance, boasting a sensitivity of 81.82%, specificity of 72.55%, and an overall accuracy of 77.58%. …”
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Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of... by Olalekan A Uthman, Rachel Court, Jodie Enderby, Chidozie Nduka, Lena Al-Khudairy, Seun Anjorin, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

“…This information could help doctors and policy-makers decide which prevention methods to recommend or support.…”
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Effects of missed anti-tuberculosis therapy doses on treatment outcome: a multi-center cohort studyResearch in context by Isabella B.B. Ferreira, Rodrigo C. Menezes, Mariana Araújo-Pereira, Valeria C. Rolla, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Timothy R. Sterling, Cody Staats, Gustavo Amorim, Anete Trajman, Bruno B. Andrade, A. Benjamin, Q. Medeiros, F. Ridolfi, A. Gomes-Silva, J. Oliveira, J. Marine, B. Durovni, S. Cavalcante, A. Rezende, A. Bezerra, A. Carvalho, A. Brito, A. Costa, R. Spener-Gomes, M. Rocha, V. Nascimento, B. Nogueira, A. Andrade, E. Silva

“…Overall, 23% of participants missed more than 10% of prescribed doses, and this group had an 81·2% likelihood of experiencing unfavorable outcomes, compared to only 21·6% among those with complete adherence. …”
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Tolerability for older, persistence for younger: a real-world evidence on sacubitril/valsartan in an Asian heart failure cohort across age by Po-Kai Chan, Po-Kai Chan, Chu-Yu Hsu, Chao-Chin Lee, Chao-Chin Lee, Fan-Han Yu, Fa-Po Chung, Fa-Po Chung, Chia-Te Liao, Chia-Te Liao, Jin-Long Huang, Jin-Long Huang, Huai-Wen Liang, Ying-Hsiang Lee, Ying-Hsiang Lee, Ying-Hsiang Lee, Po-Lin Lin, Po-Lin Lin, Po-Lin Lin, Wei-Ru Chiou, Wei-Ru Chiou, Wei-Ru Chiou, Chien-Yi Hsu, Chien-Yi Hsu, Hung-Yu Chang, Wen-Yu Lin, Wen-Yu Lin

“…Baseline characteristics, treatment doses, and clinical outcomes—including the composite of first unplanned heart failure hospitalization (HFH) or cardiovascular (CV) death, all-cause mortality, CV death, and HFH—were assessed over 5 years.ResultsAmong 1,987 patients, older adults had more comorbidities and received lower S/V doses. …”
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Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes by Xingxi Lin, Xingxi Lin, Luhan Zhou, Luhan Zhou, Shuting Si, Haoyue Cheng, Haoyue Cheng, Xialidan Alifu, Xialidan Alifu, Yiwen Qiu, Yiwen Qiu, Yan Zhuang, Yan Zhuang, Ye Huang, Ye Huang, Libi Zhang, Libi Zhang, Diliyaer Ainiwan, Diliyaer Ainiwan, Hui Liu, Yunxian Yu, Yunxian Yu

“…BackgroundsMany pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. …”
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Global assessment of swallow function (GASF) following VMAT radiotherapy for head and neck squamous cell carcinoma by Kate Toft, Kirsty McLachlan, Mark Winton, Karen Mactier, Nadine Hare, Claire Nugent, Lucie Wincott, Devraj Srinivasan, Joanna Mackenzie, Bill Nailon, David Noble

“…Results: One hundred and seventy-five patients were included. 55.2 % of patients experienced a fall in MDADI-Composite score greater than the published meaningful clinical important difference (MCID).A trend for a decrease in FOIS score reflects a decrease in range of diet textures and increase in reliance on enteral feeding at 6 months post-treatment.Mean PSS-NoD score decreased reflecting increased restriction in diet textures.20 patients’ WST capacity improved by the minimal clinically important difference of > 4mls whilst 37 % of patients experienced a decrease in WST capacity of 4mls or more. 12.6 % of patients developed trismus following radiotherapy. …”
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Patient-reported Outcome Measures and Decision Regret After Prostate-specific Membrane Antigen–targeted Radioguided Surgery for Oligorecurrent Prostate Cancer by Fabian Falkenbach, Giovanni Mazzucato, Zhe Tian, Pierre I. Karakiewicz, Markus Graefen, Thomas Steuber, Derya Tilki, Daniel Koehler, Burkhard Beyer, Pierre Tennstedt, Sophie Knipper, Lars Budäus, Tobias Maurer

“…Data on patient-reported outcome measures (PROMs) are lacking. Methods: A retrospective assessment of validated PROMs (12-item Short Form Health Survey [SF-12], 26-item Expanded Prostate Index Composite, and Decision Regret Scale [DRS]) was performed before and after PSMA-RGS for oligorecurrent PCa. …”
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Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients by Tara B. Gavcovich, Tara B. Gavcovich, Vaka K. Sigurjonsdottir, Vaka K. Sigurjonsdottir, Marissa J. DeFreitas, Marissa J. DeFreitas, Claudia Serrano, Claudia Serrano, Esther Rivas, Esther Rivas, Migdalia Jorge, Migdalia Jorge, Wacharee Seeherunvong, Wacharee Seeherunvong, Chryso Katsoufis, Chryso Katsoufis, Wendy Glaberson, Wendy Glaberson, Melisa Oliva, Adela D. Mattiazzi, Carolyn Abitbol, Carolyn Abitbol, Jayanthi Chandar, Jayanthi Chandar

“…A score of 1 or more was considered nonadherent. Tacrolimus 12 h trough levels, patient characteristics and clinical outcomes were collected. …”
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Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study. by Amol A Verma, Wayne Khuu, Mina Tadrous, Tara Gomes, Muhammad M Mamdani

“…<h4>Background</h4>The majority of people with hypertension require more than one medication to achieve blood pressure control. …”
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