Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infecti... by Celina Jin, Malick M Gibani, Shaun H Pennington, Xinxue Liu, Alison Ardrey, Ghaith Aljayyoussi, Maria Moore, Brian Angus, Christopher M Parry, Giancarlo A Biagini, Nicholas A Feasey, Andrew J Pollard

“…A prolonged treatment response was observed significantly more frequently in the azithromycin group (28/52 [54.9%]) compared with the ciprofloxacin group (1/29 [3.5%]; p<0.001). …”
Get full text

Design of AgI/BiVO4 heterostructures for photocatalytic antibiotic removal and antimicrobial action by Hanh Thi Truong, Tho Truong Pham, Nhi Dinh Bui, Ha Tien Le, Thuan Chi Nguyen

“…This bandgap reduction supports more efficient separation of photogenerated electrons and holes, facilitating the production of reactive radicals such as ·O _2 ^− and ·OH. …”
Get full text

Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study by Eric Vicaut, Ramzi A Ajjan, J Seufert, Gérard de Pouvourville, Emmanuel Cosson, Laure Carcaillon-Bentata, Tadej Battelino, Patrick Blin, Fleur Levrat-Guillen, Michael Joubert

“…Continuous glucose monitoring (CGM)-derived glucose metrics provide a more comprehensive assessment of glycaemia, but their role in predicting future vascular complications remains unclear. …”
Get full text

Exploring Ethical, Cultural, and Transnational Competence Among International Healthcare Management Students: An Australian Perspective by Howard M, Tan KL, Jayasekara R

“…This exploratory study examined the challenges faced by these students to establish foundational understanding of the competencies needed for effective ethical decision-making, cultural integration, and transnational readiness in diverse healthcare environments.Methods: Using a composite theoretical framework incorporating Cultural Relativism, Ethical Climate Theory, Institutional Theory, and Transnationalism, a 35-item instrument was adapted from three validated sources. …”
Get full text

Increasing risk of postlung transplant hospitalizations for infection: An analysis of recent trends by Shi Nan Feng, BSPH, Armaan F. Akbar, BS, Alice L. Zhou, MS, Andrew Kalra, BS, Sean Agbor-Enoh, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…We examined trends in hospitalizations for infection in the first year after LT. Methods: We identified adult LT recipients in the United States (March 1, 2018-March 9, 2023) using the Organ Procurement and Transplantation Network database. …”
Get full text

Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study. by Kathryn E Fitzpatrick, Thomas van den Akker, Kitty W M Bloemenkamp, Catherine Deneux-Tharaux, Alexandra Kristufkova, Zhuoyang Li, Timme P Schaap, Elizabeth A Sullivan, Derek Tuffnell, Marian Knight

“…Factors associated with poor maternal outcomes (fatality and composite of fatality or permanent neurological injury) amongst women with AFE from each of the countries were investigated using logistic regression or Wilcoxon rank-sum test. …”
Get full text

Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhan... by Toshi A Furukawa, Pim Cuijpers, Tatsuo Akechi, Masaru Horikoshi, Yan Luo, Hisashi Noma, Takeo Nakayama, Helen Christensen, Naoki Kondo, Norito Kawakami, Aran Tajika, Ronald C Kessler, Shingo Fukuma, Masatsugu Sakata, Rie Toyomoto, James M S Wason

“…Guided internet cognitive–behavioural therapies (iCBT) appear promising but there is room for improvement because we do not yet know which of various iCBT skills are more efficacious than others, and for whom. In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysis Based on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. …”
Get full text

Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Adverse outcomes were more frequent, probably due to advanced disease at baseline.…”
Get full text

Implications of Tricuspid Regurgitation Severity in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair by Alon Shechter, Homa Taheri, Takashi Nagasaka, Aakriti Gupta, Danon Kaewkes, Vivek Patel, Kazuki Suruga, Manvir Dhillon, Keita Koseki, Ofir Koren, Moody Makar, Sabah Skaf, Dhairya Patel, Tarun Chakravarty, Robert J. Siegel, Raj R. Makkar

“…We aimed to explore the prevalence, correlates, and consequences of TR grades and postprocedural trends in this setting. Methods and Results A single‐center registry of isolated, first‐time interventions was retrospectively assessed for pre‐, intra‐, and postprocedural aspects up to 1 year, of them the primary composite outcome of all‐cause deaths or heart failure (HF) hospitalizations, all according to TR severity at baseline and at 1 month following mitral transcatheter edge‐to‐edge repair. …”
Get full text

Simulation of Low-Salinity Water-Alternating Impure CO₂ Process for Enhanced Oil Recovery and CO₂ Sequestration in Carbonate Reservoirs by Kwangduk Seo, Bomi Kim, Qingquan Liu, Kun Sang Lee

“…CO₂ injection and WAG methods can improve displacement efficiency and sweep efficiency. …”
Get full text

Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…However, whether these results can be applied to Asian patients with different ischemic stroke subtypes remains unclear. Methods Patients from 14 South Korean centers were analyzed separately. …”
Get full text

Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…This trend remained unaffected by adjustment for age, baseline eGFR, and 24 h-proteinuria.ConclusionIn individuals with non-advanced CKD, very low urinary excretion of MBG reflects a more sustained risk of CKD progression over time. …”
Get full text

Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…This study aimed to investigate the differences in RV function and clinical outcomes between these two groups. Methods The study included 246 T2DM patients {141 patients without OCAD [T2DM(OCAD−)] and 105 with [T2DM(OCAD+)]} and 85 control subjects. …”
Get full text

The relationship of sex and aortic diameter at the time of acute type A aortic dissectionCentral MessagePerspective by Lamia Harik, MD, Mario Gaudino, MD, PhD, Mohammed Rahouma, MD, Arnaldo Dimagli, MD, Roberto Perezgrovas-Olaria, MD, Kevin R. An, MD, Talal Alzghari, MD, Giovanni Soletti, Jr., MD, Jordan Leith, BS, Gianmarco Cancelli, MD, Charles Mack, MD, Leonard N. Girardi, MD, Christopher Lau, MD

“…Objective: Evaluate sex differences in patients undergoing repair of acute type A aortic dissection (ATAAD). Methods: Sex-stratified, single-center cohort study of patients undergoing ATAAD repair from 1997 to 2022. …”
Get full text

A Data‐Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types,... by Caroline Le, Maureen Lewis, Carolyn S. Harris, Liam Berger, Esther Chavez‐Iglesias, Lisa Morse, Anatol Sucher, Ritu Roy, Adam Olshen, Marilyn J. Hammer, Steve Paul, Margaret Wallhagen, Raymond Chan, Michael Sayer, Sue Yom, Nam‐Woo Cho, Alexandre Chan, Jon Levine, Anand Dhruva, Christine Miaskowski, Yvette P. Conley, Kord M. Kober

“…Patients of the “Fast ager” type were more likely to have high morning fatigue. Higher morning fatigue was associated with lower (CD4 memory, CD8 memory, and NK) and higher (neutrophil and T regulatory) estimated proportions of cell types. …”
Get full text

Interplay Between Residential Nature Exposure and Walkability and Their Association with Cardiovascular Health by Omar M. Makram, MD, MPH, Nwabunie Nwana, PhD, MPH, Alan Pan, MS, Juan C. Nicolas, BS, Rakesh Gullapelli, BS, MS, Budhaditya Bose, MS, Ashutosh Sabharwal, PhD, Jenny Chang, MD, Zulqarnain Javed, PhD, MBBS, MPH, Bita Kash, PhD, Jay E. Maddock, PhD, Khurram Nasir, MD, MPH, MSc, Sadeer Al-Kindi, MD

“…Methods: A cross-sectional study including one million adult patients from the Houston Methodist Learning Health System Outpatient Registry (2016-2022). …”
Get full text

Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hyperten... by Meiqian Chen, Meiqian Chen, Li Zhang, Qian Liu, Qingxin Gu, Shuhui Yu, Guanzhen Lu, Guanzhen Lu

“…The relationship between the novel composite lipid metric, NHHR, and all-cause and cardiovascular mortality in hypertensive patients remains unknown and warrants further investigation.MethodsWe analyzed data from 5,561 hypertensive participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. …”
Get full text

Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol... by Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang

“…No large, published, randomised controlled trials have compared these management options. Methods TIGER is a phase 3, pan-European, two-group, active-control, observer-masked, superiority, randomised controlled surgical trial. …”
Get full text

Right Ventricular–Pulmonary Artery Uncoupling and Strain in Acute Heart Failure by Alberto Palazzuoli, Frank Loyd Dini, Nicola Riccardo Pugliese, Gaetano Ruocco, Paolo Severino, Dario Vizza, Rosa Carbonara, Andrea Passantino, Erberto Carluccio

“…The end point was a composite of all‐cause death/HF‐related hospitalizations assessed at 180 days. …”
Get full text

The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study by Yifeng Wang, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Kerui Zhang

“…A two-piecewise linear regression model indicated that the risk of all-cause mortality increased more prominently when the hs-CRP/HDL-C ratio was less than 1.21. …”
Get full text