Educational Attainment Level and Risk of Mortality and Cardiopulmonary Outcomes in High‐Risk Patients With Cardiovascular Disease: The INVESTED Trial by Mats C. H. Lassen, Nicholas Howell, Brian L. Claggett, Tor Biering‐Sørensen, Orly Vardeny, Scott D. Solomon, Jacob Udell, Jacob Joseph, Sheila M. Hegde

“…During follow‐up (median: 9 months), 1706 (35%) participants experienced the composite of all‐cause death or cardiopulmonary hospitalization. …”
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The osteoinductive and osseointegration properties of decellularized extracellular matrix bone derived from different sites by Weihua Huang, Lijing Hao, Xiayu Cai, Chujie Xiao, Huinan Yin, Weikang Xu

“…This study provides a more complete basis for the selection of dECM scaffolds in bone defect repair. …”
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Nuclear factor κ-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension. by Laura C Price, Gaetano Caramori, Frederic Perros, Chao Meng, Natalia Gambaryan, Peter Dorfmuller, David Montani, Paolo Casolari, Jie Zhu, Konstantinos Dimopoulos, Dongmin Shao, Barbara Girerd, Sharon Mumby, Alastair Proudfoot, Mark Griffiths, Alberto Papi, Marc Humbert, Ian M Adcock, S John Wort

“…Increasing evidence indicates that inflammation is important in disease pathophysiology.<h4>Methods</h4>NF-κB-p65 and CD68, CD20 and CD45 were measured by immunohistochemistry and confocal microscopy on lung specimens from patients with idiopathic PAH (n = 12) and controls undergoing lung surgery (n = 14). …”
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Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond by Jiaxin Wen, Yanfeng Wang, Song Wang, Yuxin Liang, Xiaozhen Hu, Qiuxiang Ou, Hua Bao, Kuo Zhao, Youyu Wang

“…Results Responders were more likely to have received anti-PD-1 therapy rather than anti-CTLA-4 and exhibited a higher tumor mutation burden (both P < 0.001). …”
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Cognitive status and health-related quality of life for medical students by V. V. Kuznetsov, K. V. Kosilov, E. Yu. Kostina, E. V. Karashchuk, E. K. Fedorishcheva, O. A. Barabash

“…Senior students assess their psychological status more highly by optimizing the emotional component. …”
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Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population by Ying Li, Qianqian Zhang, Li Chen, Yue Wang, Qibao Ye, Wei Liu, Yan Liu, Guojuan Wang

“…Abstract Objective To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population. Methods Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). …”
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5-Item Modified Frailty Index Score is Associated with Increased Postoperative Complications Following Ankle Fracture ORIF by Ronit Kulkarni BS, Alexander S. Guareshi BS, Nikhil Vallabhaneni BA, Joshua L. Morningstar BS, Daniel J. Scott MBA, MD, Christopher E. Gross MD

“…(Table 1) Mortality was strongly predicted by mFI-5 with the risk more than tripling for each point increase in mFI-5 score (odds ratio (OR)=3.639, 95% CI= 3.038-4.360). …”
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Dynamic evolutionary pattern of fractures in tectonically deformed coal-bearing assemblages during loading by Pengxiang ZHAO, Yingying LIU, Shugang LI, Yanqun LIU, Yunchuan LIU, Laolao WANG, Weidong LU

“…Concurrently, fissures inside the specimen increased continuously, accompanied by more complex dip directions and angles of interfacial fractures. …”
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Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review) by N. B. Melnikova, I. A. Sheferov, A. A. Emasheva, A. A. Sheferova, D. A. Panteleev, A. I. Slivkin

“…Formally, this process, in accordance with pharmacopoeial methods, is assessed using various solubility tests. …”
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Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study by Nathaniel Moulson, Bradley J. Petek, Michael J. Ackerman, Timothy W. Churchill, Sharlene M. Day, Jonathan H. Kim, Stephanie A. Kliethermes, Rachel Lampert, Benjamin D. Levine, Matthew W. Martinez, Manesh R. Patel, Dermot Phelan, Kimberly G. Harmon, Aaron L. Baggish, Jonathan A. Drezner

“…Recent guidelines have taken a more permissive approach, using a shared decision‐making model. …”
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Dental Students’ Perception and Self-Perceived Confidence Level in Key Dental Procedures for General Practice and the Impact of Competency Implementation on Their Confidence Level,... by Wijdan R. Elmanaseer, Salah A. Al-Omoush, Rasha A. Alamoush, Rawan Abu Zaghlan, Firas Alsoleihat

“…The same applies to 6 out of 16 conservative dentistry procedures: placing anterior composite (4.41 vs. 4.12), placing posterior composite (4.43 vs. 3.88), placing posterior amalgam (4.29 vs. 4.02), placing matrix band for Class II restorations (4.24 vs. 3.71), placing a prefabricated post (3.34 vs. 2.88), and placing fiber post (3.45 vs. 3.34). …”
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Impact of antihypertensive drug classes on cardiovascular outcomes: insights from the STEP study by Xinyi Peng, Michael Hecht Olsen, Manan Pareek, Jingjing Bai, Yang Liu, Qirui Song, Jun Cai

“…Conclusions This post hoc analysis suggested that ARBs and CCBs might be more favourable for composite cardiovascular outcomes than diuretics and beta-blockers. …”
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Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis by Nur K. Abdul Jafar, Afra Al Balushi, Anuradhaa Subramanian, Siang Ing Lee, Christie J. Bennett, Lisa J. Moran, Aya Mousa, Chau Thien Tay, Helena J. Teede, Darren R. Mansfield

“…Compared with non-PCOS, those with PCOS showed higher risk for composite OSA (odds ratio (OR): 9.52; 95% CI: 3.90 to 23.26; I2 = 54.5%; 8 studies, n=942; P&lt;0.001) and more pronounced OSAS risk with increasing symptom severity in PCOS (AHI≥5 OR: 3.90; 95% CI: 1.63 to 9.34; AHI≥5 with symptoms OR: 17.95; 95% CI: 6.17 to 52.22; AHI≥10 with symptoms OR: 30.61; 95% CI: 7.99 to 117.25, all P ≤ 0.0023). …”
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Impact of Left Ventricular Diastolic Pressure Changes on Clinical Outcomes After Transcatheter Aortic Valve Replacement by Jiwon Seo, Ah‐Ram Kim, Iksung Cho, Chi Young Shim, Geu‐Ru Hong, Eui‐Young Choi, Se‐Joong Rim, Young‐Guk Ko, Myeong‐Ki Hong, Jae‐Kwan Song, Jong‐Won Ha

“…The primary outcome was a composite of all‐cause death and rehospitalization for heart failure. …”
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Coffee plant disease identification with an attentive multi-image segmentation framework (MISF) with CycleGAN by Savitri Kulkarni, P. Deepa Shenoy, K.R. Venugopal

“…It combines multiple classical methods—thresholding, K-means clustering, Watershed, GrabCut, and Mean Shift—to isolate disease-specific lesions while eliminating irrelevant background elements. …”
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Evaluation of real-time polymerase chain reaction for detection of Strongyloides stercoralis in immunocompromised patients in North India by Dr Abhishek Mewara, Ms. Nikita Sharma, Dr Gaurav Prakash, Dr Vignesh Pandiarajan, Dr Sahajal Dhooria, Dr Varun Dhir, Dr Surjit Singh, Dr Ritesh Agarwal

“…Discussion: A high prevalence of S. stercoralis infection was observed in immunosuppressed patients from different clinical specialties in North India using serological and molecular methods, while stool microscopy and helminth culture methods missed a large proportion of the infections. …”
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Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…Interventions Collection of prespecified standard clinicopathological variables and more novel imaging, genetic and immunohistochemical biomarkers, followed by 3-year follow-up to identify postoperative metastasis. …”
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Stabilization effect and mechanism of heavy metals by microbial consortium of phosphate-solubilizing bacteria and urease-producing bacteria by Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Zhenghao Yan, Yongfang Yan, Shuangquan Li, Shuangquan Li, Shuangquan Li, Shuangquan Li, Shuangquan Li, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Xiao Yan, Xiao Yan, Xiao Yan, Xiao Yan, Xiao Yan, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang

“…The microstructural and compositional changes during the biostabilization process were more deeply analyzed using XRD, FT-IR and SEM-EDS.Results and discussionThe precipitation of heavy metals could be promoted effectively when soluble starch (10.2 g/L) was used as carbon source and urea (7.8 g/L) as nitrogen source. …”
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Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in... by Neil Parry, Andrew Beckett, Jo Carroll, Homer Tien, Jeannie Callum, Andrew Petrosoniak, Damon Scales, Luis Teodoro da Luz, Keyvan Karkouti, Paul T Engels, Hans-Peter Hucke, Deep Grewal, Bruce Schwartz, Henry Peng

“…The primary outcome is a composite of the cumulative number of all units of red cells, plasma and platelets transfused within 24 hours following admission. …”
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Association of body mass index and outcomes in surgical and transcatheter aortic valve replacement by Bennet S. Cho, MD, Troy N. Coaston, BS, Amulya Vadlakonda, BS, Sara Sakowitz, MPH, MS, Syed Shaheer Ali, Esteban Aguayo, MD, Peyman Benharash, MD

“…TAVR patients were older (76 vs. 64 years; p < 0.001) and more frequently underweight (3.1 % vs. 1.5 %; p < 0.001) compared to SAVR patients. …”
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