Inpatient vaginal dinoprostone vs outpatient balloon catheters for cervical ripening in induction of labor: An individual participant data meta‐analysis of randomized controlled tr... by Fei Chan, Malitha Patabendige, Michelle R. Wise, John M. D. Thompson, Lynn Sadler, Michael Beckmann, Amanda Henry, Madeleine N. Jones, Ben W. Mol, Wentao Li

“…Women with live singleton pregnancies at 34 or more weeks of gestation were eligible. The authors of eligible trials were invited to share their de‐identified data. …”
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Untapped potential of wastewater for animal and potentially zoonotic virus surveillance: Pilot study to detect non-human animal viruses in urban settings by Mustafa Karatas, Mandy Bloemen, Jill Swinnen, Inge Roukaerts, Steven Van Gucht, Marc Van Ranst, Elke Wollants, Jelle Matthijnssens

“…Introduction: Wastewater surveillance has become an essential tool for monitoring viral outbreaks and surveillance of human viruses. While PCR-based methods are most frequently used, more advanced techniques, such as shotgun metagenomics in combination with viral capture methods, have been developed. …”
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Heartfelt Impact: A Descriptive Analysis of Ceftaroline-Containing Regimens in Endocarditis due to Methicillin-Resistant Staphylococcus aureus by Kaylee E. Caniff, Chloe Judd, Kristen Lucas, Sandra Goro, Caroline Orzol, Mirna Eshaya, Mohammed Al Musawa, Michael P. Veve, Michael J. Rybak

“…Comparative studies are needed to more clearly define its role in MRSA-IE.…”
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Clinical and demographic factors modify the association between plasma phosphorylated tau‐181 and cognition by Corey J. Bolton, Marilyn Steinbach, Omair A. Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L. Jefferson, Timothy J. Hohman, Henrik Zetterberg, Katherine A. Gifford, for the Alzheimer's Disease Neuroimaging Initiative

“…Level of p‐tau181 was more strongly associated with cognition in people with mild cognitive impairment (MCI) and apolipoprotein E (APOE) ε4.…”
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Diagnostic sensitivity of immune-inflammatory cell proportion in early diagnosis of endometrial cancer by Li Sun, Shujie Zhai, Guojia Wu, Jie Gu, Yiran Huang, Dandan Hong, Jianmei Wang, Yongmei Li

“…Furthermore, the combined predictive value of the immune-inflammatory cell ratio is more effective than using individual applications.…”
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RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure by Konstantinos Ioannidis, Paul Wilkinson, Paul Fletcher, Samantha N Sallie, Laura Moreno-López, Muzaffer Kaser, Katja Schueler, Adrian Dahl Askelund, Lorinda Turner, Anne-Laura van Harmelen, Alicia J Smith, Camilla Nord, Eugenia M Davidson, Nadia González-García, Oksana Berhe, Rosalie Shrofer, Sofia Orellana, Sophie L Bellow, Suzanne Schweizer

“…Introduction This paper describes the protocol for an ongoing project funded by the Royal Society, the Resilience After Individual Stress Exposure (RAISE) study; which aims to examine the factors and mechanisms that facilitate resilient functioning after childhood adversity (CA).Methods and analysis We aim to recruit up to 200 participants. …”
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial d... by Jing Wang, Jing Wang, James T. Peterson, Joaquim Diego D. Santos, Ada J. S. Chan, Maria Alejandra Diaz-Miranda, Imon Rahaman, Jean Flickinger, Amy Goldstein, Amy Goldstein, Emily Bogush, Elizabeth M. McCormick, Colleen C. Muraresku, Vernon E. Anderson, Matthew C. Dulik, Matthew C. Dulik, Douglas C. Wallace, Douglas C. Wallace, Rui Xiao, Marni J. Falk, Marni J. Falk, Angela N. Viaene, Angela N. Viaene, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham

“…We sought to evaluate clinical, biochemical, and histopathological phenotypes of a large clinical cohort harboring MLSMD in muscle to better understand their significance across a range of clinical phenotypes.MethodsA single-site retrospective study was performed of 212 diagnostic muscle biopsies obtained from patients referred for Primary Mitochondrial Disease (PMD) evaluation with muscle mitochondrial (mt)DNA sequencing performed at our institution, including electronic medical record (EMR) review of symptoms, biochemical results, and Mitochondrial Myopathy Composite Assessment Tool (MM-COAST) scores.ResultsMLSMD were identified in 50 of 212 (24%) diagnostic tissue biopsies, and were universally present. in subjects ≥50 years (n = 18/18). …”
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Inflammatory indices AISI and SIRI in atherosclerosis risk stratification: validation across community and intensive care populations by Jing Tang, Ting-xin Li, Ling Deng, Xin-cheng Huang, Pei-yuan He, Han Zhao

“…This study evaluated the predictive performance of two composite inflammatory indices—the Aggregate Index of Systemic Inflammation (AISI) and the Systemic Inflammation Response Index (SIRI)—across community and intensive care populations. …”
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Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study by Dongying Chen, Minxi Lao, Jianyu Zhang, Yanfeng Zhan, Weinian Li, Xiaoyan Cai, Zhongping Zhan

“…Multiple analysis showed that disease flares (OR, 8.1; CI, 3.8–17.2) and anticardiolipin antibody positivity (OR, 7.4; CI, 2.5–21.8) were associated with composite fetal APOs. Conclusion. Planned pregnancy improved fetal and maternal outcomes, presenting as a lower rate of fetal loss, more favorable outcomes for preterm infants, and less severe disease flares during pregnancy.…”
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Heat-Induced Preparation of Myofibrillar Protein Gels Reinforced Through Ferulic Acid, α-Cyclodextrin and Fe(III) by Ziyi You, Yushan Chen, Wendi Teng, Ying Wang, Yuemei Zhang, Jinxuan Cao, Jinpeng Wang

“…FA effectively promoted the conversion of some of the non-fluidizable water to the bound water morphology, and the addition of Fe(III) effectively enhanced this trend. In particular, the composite network structure formed by Fe@MP-FA/CD more significantly promoted the conversion to bound water and improved the water retention of the gel. …”
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Constricting Gaps: Protocol development, implementation challenges and lessons learned for the reality map of unmet needs for Palliative Care Interventions in advanced cancer patie... by Natalie Kalbermatten, Razvan Curca, Alexandru Grigorescu, Daniela Mosoiu, Florina Pop, Vladimir Poroch, Ariana Rosiu, Patriciu Achimas-Cadariu, Florian Strasser

“…A composite endpoint (QI, cofactors) was planned. Finally, local solutions responding to gaps were piloted. …”
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Neurological symptoms and comorbidity profile of hospitalized patients with COVID-19 by Renata Carvalho Cremaschi, Carla Alessandra Scorza Bahi, Angelo Amato Vincenzo de Paola, Jaquelina Sonoe Ota Arakaki, Paulo Roberto Abrão Ferreira, Nancy Cristina Junqueira Bellei, Vanderci Borges, Fernando Morgadinho Santos Coelho

“…The Composite Autonomic Symptom Score 31 (COMPASS-31) questionnaire was used. …”
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Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study by Olivier D. Steen, Martje Bos, Sonja L. van Ockenburg, Yiling Zhou, Ilja M. Nolte, Harold Snieder, Kenneth Kendler, Judith G. M. Rosmalen, Hanna M. van Loo

“…We investigated whether functional and internalizing disorders co-aggregate with these diseases in families to gain insight into the aetiology of functional and internalizing disorders.  Methods We included 166,774 subjects (aged 3–94), from the population-based Lifelines Cohort Study, a Dutch general population cohort. …”
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Ticagrelor Versus Prasugrel in Acute Coronary Syndrome: Real-World Treatment and Safety by Fadel Bahouth, Boris Chutko, Haitham Sholy, Sabreen Hassanain, Gassan Zaid, Evgeny Radzishevsky, Ibrahem Fahmwai, Mahmod Hamoud, Nemer Samnia, Johad Khoury, Idit Dobrecky-Mery

“…Primary endpoint: A composite endpoint of cardiovascular death, recurrent coronary syndrome, or ischemic stroke at one year. …”
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Determining optimal strategies for primary prevention of cardiovascular disease: a synopsis of an evidence synthesis study by Olalekan A Uthman, Lena Al-Khudairy, Chidozie Nduka, Rachel Court, Jodie Enderby, Seun Anjorin, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

“…This series of systematic reviews and meta-analyses synthesised evidence on the effectiveness, comparative effectiveness and cost-effectiveness of pharmacological and non-pharmacological interventions for primary cardiovascular disease prevention. Methods Five systematic reviews and meta-analyses were conducted using rigorous methods, including comprehensive searches, duplicate screening, risk-of-bias assessments and adherence to reporting guidelines. …”
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Severity of native pulmonary annular hypoplasia and late outcomes of tetralogy of Fallot: retrospective cohort study by Tugba Erdil, Klaus Steigmiller, John Ethan Rampa, Martin Christmann, Ulrike Held, Hitendu Dave

“…Large multicentre studies are needed to demonstrate more precisely the impact of pulmonary annulus Z scores on outcome. …”
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A Proposed Genetic Risk Score for Dilated Cardiomyopathy Susceptibility in the Chinese Han Population by Jianjun Lan, MD, Lin Wang, MD, Guoyuan Qiu, MD, Shihai Wang, MD, Chao Yang, MD, Mengnian Ran, MD, Hongyu Li, MD, Shiyang Li, MD

“…A score of at least 6.4 was more strongly associated with increased risk of DCM (odds ratio, 2.4; P < .001) than scores lower than 6.4. …”
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Meconium‐stained amniotic fluid and neonatal morbidity in nulliparous patients with prolonged pregnancy by Isabelle Attali, Diane Korb, Elie Azria, Jacques Lepercq, François Goffinet, Thomas Schmitz, for the Groupe de Recherche en Obstétrique et Gynécologie (GROG)

“…The principal end point was a composite criterion of severe neonatal morbidity (neonatal death, 5‐minute Apgar <7, convulsions in the first 24 h, meconium aspiration syndrome, mechanical ventilation ≥24 h, or neonatal intensive care unit admission for 5 days or more). …”
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Eco-friendly synthesis of ZnO, CuO, and ZnO/CuO nanoparticles using extract of spent Pleurotus ostreatus substrate, and their antioxidant and anticancer activities by Simangele Ngwenya, Nkanyiso J. Sithole, Khosi Ramachela, Doctor M. N. Mthiyane, Mulunda Mwanza, Moganavelli Singh, Damian C. Onwudiwe

“…The green synthesized metal oxides and their composite have the potential for biomedical applications.…”
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The Impact of Digital Inequities on Oropharyngeal Cancer Disparities in the United States by David J. Fei‐Zhang, Achilles A. Kanaris, Camaren M. Cuenca, Sydney A. Fleishman, Jill N. D'Souza, Anthony M. Sheyn, Daniel C. Chelius, Jeffrey C. Rastatter

“…Setting United States. Methods In total, 70,604 patients from 2008 to 2017 were assessed for regression trends in long‐term follow‐up period, survival, prognosis, and treatment across increasing overall digital inequity, as measured by the Digital Inequity Index (DII). …”
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