Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, p... by Caroline A Crowther, Pat Ashwood, Andrew J McPhee, Vicki Flenady, Thach Tran, Jodie M Dodd, Jeffrey S Robinson, PROGRESS Study Group

“…Our primary aim was to assess whether the use of vaginal progesterone pessaries in women with a history of previous spontaneous preterm birth reduced the risk and severity of respiratory distress syndrome in their infants, with secondary aims of examining the effects on other neonatal morbidities and maternal health and assessing the adverse effects of treatment.<h4>Methods</h4>Women with a live singleton or twin pregnancy between 18 to <24 weeks' gestation and a history of prior preterm birth at less than 37 weeks' gestation in the preceding pregnancy, where labour occurred spontaneously or in association with cervical incompetence or following preterm prelabour rupture of the membranes, were eligible. …”
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Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction by Nousjka P. A. Vranken, Xinyu Li, Heleen Bouman, Sanne G. J. Mourmans, Anouk Achten, Arantxa Barandiarán Aizpurua, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P. M. van Empel, Jerremy Weerts

“…We assessed the prevalence of impaired glucose metabolism and albuminuria in HFpEF over time, and evaluated its prognostic implications. Methods Consecutive patients referred to our outpatient clinic and diagnosed with HFpEF between March 2015–November 2023 were included in this study. …”
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Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study. by Amol A Verma, Wayne Khuu, Mina Tadrous, Tara Gomes, Muhammad M Mamdani

“…<h4>Background</h4>The majority of people with hypertension require more than one medication to achieve blood pressure control. …”
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Tolerability for older, persistence for younger: a real-world evidence on sacubitril/valsartan in an Asian heart failure cohort across age by Po-Kai Chan, Po-Kai Chan, Chu-Yu Hsu, Chao-Chin Lee, Chao-Chin Lee, Fan-Han Yu, Fa-Po Chung, Fa-Po Chung, Chia-Te Liao, Chia-Te Liao, Jin-Long Huang, Jin-Long Huang, Huai-Wen Liang, Ying-Hsiang Lee, Ying-Hsiang Lee, Ying-Hsiang Lee, Po-Lin Lin, Po-Lin Lin, Po-Lin Lin, Wei-Ru Chiou, Wei-Ru Chiou, Wei-Ru Chiou, Chien-Yi Hsu, Chien-Yi Hsu, Hung-Yu Chang, Wen-Yu Lin, Wen-Yu Lin

“…Baseline characteristics, treatment doses, and clinical outcomes—including the composite of first unplanned heart failure hospitalization (HFH) or cardiovascular (CV) death, all-cause mortality, CV death, and HFH—were assessed over 5 years.ResultsAmong 1,987 patients, older adults had more comorbidities and received lower S/V doses. …”
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Plasmidome analyses of Klebsiella pneumoniae co-producing blaKPC-2 and blaNDM-1 in Southern Brazil: characterisation of mobile genetic elements by Mayana Kieling Hernandez Berdichevski, Rafaela R. Guerra, Dariane C. Pereira, Camila M. Wilhelm, Patricia O. Barth, Melise C. Silveira, Fabiana C.Z. Volpato, Claudio Rocha-de-Souza, Richard M. Carrassai, Ana Paula Carvalho-Assef, Andreza F. Martins, Afonso Luís Barth

“…ABSTRACT: Objective: Infections due to carbapenemase-producing Enterobacterales harbouring more than one carbapenemase-encoding gene spread mainly by plasmid and transposon mobilisation. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…BN models may be a useful method to identify clusters of symptoms that predict PsA with reasonable accuracy. …”
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Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction by Giuseppina Basta, Serena Babboni, Daniele Pezzati, Serena Del Turco, Emanuele Balzano, Gabriele Catalano, Lara Russo, Giovanni Tincani, Paola Carrai, Stefania Petruccelli, Jessica Bronzoni, Caterina Martinelli, Simona Palladino, Arianna Trizzino, Lorenzo Petagna, Renato Romagnoli, Damiano Patrono, Giandomenico Biancofiore, Adriano Peris, Chiara Lazzeri, Davide Ghinolfi

“…Lipid peroxidation (TBARS) elevated at the start of NRP, declined over time, with higher levels in D-HOPE than in NMP, suggesting a more oxidative environment in D-HOPE. Metabolites like flavin mononucleotide (FMN) and NADH exhibited significant disparities between perfusion types, due to differences in perfusate compositions. …”
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Switching from intravenous to subcutaneous infliximab in patients with immune mediated diseases in clinical remission by Nikos Viazis, Anastasios Karamanakos, Konstantinos Mousourakis, Angeliki Christidou, Fotios Fousekis, Konstantinos Mpakogiannis, Anastasios Koukoudis, Konstantinos Katsanos, Dimitrios Christodoulou, Myrto Cheila, Maria Tzouvala, Eirini Zacharopoulou, Maria Palatianou, Olga Giouleme, Olga Giouleme, Anastasia Katsoula, Anastasia Katsoula, Christos Liatsos, Nikolaos Kyriakos, Evi Zampeli, Evgenia Papathanasiou, Angeliki Theodoropoulou, Konstantinos Karmiris, Ioannis Psaroudakis, George Tribonias, Souzanna Gazi, Evangelia Mole, Theodoros Dimitroulas, Christos Koutsianas, Dimitris Vassilopoulos, George E. Fragoulis, Nikos Michalakeas, Charalampos Papagoras, Pantelis Panagakis, Marina Papoutsaki, Vasiliki Chasapi, Alexandros Stratigos, George Katsikas

“…The primary endpoint was disease deterioration during a follow up period, of at least 6 months, according to disease specific composite measures.ResultsBetween April 2023 and April 2024, a total of 344 patients (CD = 136, UC = 62, SpA = 52, PsA = 38, RA = 7, PsO = 44, co-existence of more than one disease = 5) were switched from IFX-IV to IFX-SC. …”
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Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study by Albertino Damasceno, Hadiza Saidu, Gad Cotter, Beth Davison, Christopher Edwards, Jelena Celutkiene, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamilė Čerlinskaitė‐Bajorė, Ovidiu Chioncel, Alain Cohen‐Solal, Benjamin Deniau, Rafael Diaz, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S.P. Lam, Marco Metra, Maria Novosadova, Matteo Pagnesi, Peter S. Pang, Piotr Ponikowski, Jozine M. Ter Maaten, Daniela Tomasoni, Adriaan A. Voors, Koji Takagi, Alexandre Mebazaa, Karen Sliwa

“…Abstract Aims Acute heart failure (AHF) impacts millions globally, with outcomes varying based on socio‐economic status (SES). Methods SES measured by annual household income, years of education and medical insurance coverage. …”
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Exploring the Associations of Neck Circumference, Blood Pressure, CRP, and Insulin Resistance on the Visceral Adiposity Index: Insights from a Cross-Sectional Study by Lucas Fornari Laurindo, Francine Cruz Camargo, Alessandra Perfeito, Bruno Benedito Ciano, Clara Tainá Coelho, Gleice Assis Apolinário, Isabela do Nascimento Vicentin, Jéssica Cambui Andreasi, Beatriz Leme Boaro, Ricardo José Tofano, Cláudia Rucco Penteado Detregiachi, Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Lance Alan Sloan, Kátia Portero Sloan, Antonelly Cassio Alves de Carvalho, Marie Oshiiwa, Patrícia Cincotto dos Santos Bueno, Tereza Laís Menegucci Zutim, Rebeca Maria Siqueira da Silva, Eduardo Federighi Baisi Chagas, Marcelo Dib Bechara, Karina R. Quesada

“…Background: The visceral adiposity index (VAI) is a composite marker designed to quantify visceral adiposity and its metabolic implications. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. …”
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Reduced-dose chemotherapy followed by blinatumomab for newly diagnosed philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia: a propensity-matched comparis... by Jing Lu, Yu Zhu, Huiying Qiu, Ying Wang, Xin Zhou, Haiping Dai, Xuzhang Lu, Bin Gu, Ming Hong, Miao Miao, Ruinan Lu, Jun Wang, Qian Wu, Mengxing Xue, Yun Wang, Ailing Deng, Yaoyao Shen, Yin Liu, Xueqing Dou, Yutian Lei, Xiaofei Yang, Suning Chen

“…This regimen offers a safer and more effective induction therapy option, warranting further investigation in larger trials. …”
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The Role of Latvian Catholic Church Textiles in Perfecting People’s Aesthetic Values by Aija Jansone

“…At the same time, the pursuit of everything new, methodically led to a reduction in the specificity of traditional lifestyle. …”
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Tribological performances of alternating multilayer diamond films on Si3N4 ceramic substrates by He WANG, Haigen ZHAO, Guangyu YAN

“…When the number of alternations is more, the interlayer thickness is thin, the film does not have obvious layering, the surface roughness is large, and the film quality is poor. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…Background Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service. …”
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A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair by Tharusan Thevathasan, Sophie Berlinghof, Daniel Elschenbroich, Julia M. Wiedenhofer, Sêhnou Degbeon, Luise Holzhauser, Fabian Barbieri, Mario Kasner, Anna Brand, Henryk Dreger, Steffen Desch, Ulf Landmesser, Markus Reinthaler, Carsten Skurk

“…We analyzed peri-procedural healthcare resource utilization and safety of TEER with the MitraClip® system in the U.S. between 2016 and 2019. Methods: Primary outcomes (healthcare resource utilization) included hospital length of stay (LOS), adverse discharge to a short-term hospital or skilled nursing facility and hospital costs. …”
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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate by Chenquan Lin, Chenquan Lin, Chenquan Lin, Rui Ma, Rui Ma, Rui Ma, Xiao Zeng, Xiao Zeng, Xiao Zeng, Bikui Zhang, Bikui Zhang, Bikui Zhang, Ting Cao, Ting Cao, Ting Cao, Shimeng Jiao, Shimeng Jiao, Shimeng Jiao, Hui Chen, Hui Chen, Hui Chen, Yifang He, Yifang He, Yifang He, Mouze Liu, Mouze Liu, Mouze Liu, Hualin Cai, Hualin Cai, Hualin Cai

“…Additionally, individual variations including genetic underpinnings attributable to disparities in therapeutic effects and clinical toxicity remain to be elucidated.MethodsA total of 374 patients receiving initial HD-MTX treatment were selected for this study, which aimed to establish a predictive model using binary logistic regression and a visual nomogram for DILI risk assessment. …”
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Adherence to the ABC (atrial fibrillation better care) pathway and risk of adverse outcomes in patients with chronic kidney disease: a report from the prospective APHRS-AF registry... by Tommaso Bucci, Katarzyna Nabradalik, Krysztof Irlik, Alena Shantsila, Giulio Francesco Romiti, Marco Proietti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Tze-Fan Chao, Gregory Y.H. Lip, Hung-Fat Tse, Chun-Wah David Siu, Wataru Shimizu, Kenji Yodogawa, Hiroyuki Tsutsui, Yasushi Mukai, Hirofumi Tomita, Daisuke Horiuchi, Joji Hagii, Kazutaka Aonuma, Yasuo Okumura, Masahiko Goya, Kenzo Hirao, Ajioka Masayoshi, Nobuhisa Hagiwara, Atsushi Suzuki, Teiichi Yamane, Takanori Ikeda, Hitomi Yuzawa, Kazuhiro Satomi, Yoshinao Yazaki, Keiichi Fukuda, Yoshinori Kobayashi, Norishige Morita, Toyoaki Murohara, Eiichi Watanabe, Masahide Harada, Satoru Sakagami, Takahiro Saeki, Kengo Kusano, Koji Miyamoto, Shinsuke Miyazaki, Hiroshi Tada, Koichi Inoue, Nobuaki Tanaka, Yukihiro Koretsune, Haruhiko Abe, Yasuki Kihara, Yukiko Nakano, Akihiko Shimizu, Yasuhiro Yoshiga, Tomohiro Sakamoto, Ken Okumura, Naohiko Takahashi, Tetsuji Shinohara, Kyoko Soejima, Masahiko Takagi, Mitsuharu Kawamura, Yumi Munetsugu, Hyung-Wook Park, Jae-Min Shim, Jae Sun Uhm, Sung Il Im, Hyoung-Seob Par, Jun Hyung Kim, Young Keun On, Il-Young Oh, Seung Yong Shin, Jum Suk Ko, Jun Beom Park, Wee-Siong Teo, Kelvin Cheok-Keng Wong, Toon-Wei Lim, David Foo, Shih-Ann Chen, Tze-Fan Chao, YennJiang Lin, Fa-Po Chung, Yu-Feng Hu, Shil-Lin Chang, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-Hung Li, Jin-Long Huang, Yu-Cheng Hsieh, Tsu-Juey Wu, Ying-Chieh Liao, Cheng-Hung Chiang, Hsiang-Chiang Hsiao, Tung-Chen Yeh, Wei-Siang Lin, Wen-Yu Lin, Jen-Yuan Kuo, Chong-Lie Hong, Yih-Je Wu, Ying-Siang Li, Jui-Peng Tsai, Kuo-Tzu Sung, Sheng-Hsiung Chang

“…Summary: Background: Limited data exist on the effectiveness of the ABC (Atrial Fibrillation Better Care) pathway in reducing adverse events in Asian patients with atrial fibrillation (AF) and chronic kidney disease (CKD). Methods: A post-hoc analysis of the prospective APHRS AF Registry. …”
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Interferon Gamma and Tumor Necrosis Factor Alpha Are Inflammatory Biomarkers for Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease by Ben Li, Eva Lindner, Raghad Abuhalimeh, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…The objective of this study was to evaluate a broad panel of circulating inflammatory proteins to identify those independently associated with 2-year MACE in patients with PAD. <b>Methods:</b> We conducted a prospective cohort study involving 465 patients with PAD. …”
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Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…Finally, we assessed whether areas prone to changing aircraft noise patterns (i.e. with relief periods from aircraft noise) affected the increased risk of cardiovascular disease in areas with higher noise in the evenings and found the higher risks were only seen in areas with more constant noise levels. More research is needed to investigate potential health benefits of relief periods with lower noise. …”
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