A Data‐Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types,... by Caroline Le, Maureen Lewis, Carolyn S. Harris, Liam Berger, Esther Chavez‐Iglesias, Lisa Morse, Anatol Sucher, Ritu Roy, Adam Olshen, Marilyn J. Hammer, Steve Paul, Margaret Wallhagen, Raymond Chan, Michael Sayer, Sue Yom, Nam‐Woo Cho, Alexandre Chan, Jon Levine, Anand Dhruva, Christine Miaskowski, Yvette P. Conley, Kord M. Kober

“…Given the numerous roles that epigenetic processes may play in the development and severity of fatigue, the purposes of this study were to (1) use a data‐driven discovery approach to evaluate for mechanisms underlying morning fatigue in a group of oncology patients receiving chemotherapy and (2) identify common biological mechanisms associated with morning fatigue severity across these independent epigenetic evaluations. Methods Patients completed questionnaires during the week prior to their chemotherapy treatment. …”
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Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…Patients with HFmrEF‐Decreasing were more likely to experience the composite outcome in unadjusted analyses (unadjusted HR 1.19, 95% CI 1.01–1.40, P = 0.040) but not adjusted analyses (adjusted HR 1.16, 95% CI 0.98–1.37, P = 0.092). …”
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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…The primary outcome was the composite of HF hospitalization or cardiovascular death. …”
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Impact on Outcome of Different Mechanisms, Baseline Degree and Changes of Mitral Regurgitation in Patients With Aortic Stenosis Who Underwent Transcatheter Aortic Valve Replacement by Francesco Melillo, Annamaria Tavernese, Vincenzo Rizza, Francesco Putortì, Alberto Preda, Francesco Ancona, Giacomo Ingallina, Stefano Stella, Antonio Colombo, Marco Ancona, Alaide Chieffo, Nicola Buzzatti, Alessandro Castiglioni, Michele De Bonis, Francesco Maisano, Matteo Montorfano, Eustachio Agricola

“…The aim of this study was to evaluate the impact of the MR mechanism in patients undergoing transcatheter aortic valve replacement (TAVR). Methods and Results This is a retrospective observational study of patients who underwent TAVR for severe aortic stenosis in a high‐volume tertiary care center. …”
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Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective... by Xuefei Mu, Miaohan Qiu, Shangxun Zhou, Shangxun Zhou, Yixuan Duan, Yixuan Duan, Daoshen Liu, Daoshen Liu, Kai Xu, Quanmin Jing, Yi Li, Yaling Han

“…The impact of hs-cTnT on mortality is more pronounced in diabetic patients.…”
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Predictive Value of Frailty, Comorbidity, and Patient-Reported Measures for Hospitalization or Death in Older Outpatients: Quality of Life and Depression as Prognostic Red Flags by Dimitrios Anagnostou, Nikolaos Theodorakis, Sofia Kalantzi, Aikaterini Spyridaki, Christos Chitas, Vassilis Milionis, Zoi Kollia, Michalitsa Christodoulou, Ioanna Nella, Aggeliki Spathara, Efi Gourzoulidou, Sofia Athinaiou, Gesthimani Triantafylli, Georgia Vamvakou, Maria Nikolaou

“…The primary outcome was a composite of hospitalization or all-cause mortality. …”
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Comparison of sedentary time, number of steps and sit-to-stand-transitions of desk-based workers in different office environments including working from home: analysis of quantitat... by Martha Sauter, Eva Backé, Carina Pfab, Michaela Prigge, Claudia Brendler, Falk Liebers, Peter von Löwis, Andrea Pfeiffer, Falko Papenfuss, Janice Hegewald

“…We also aimed to determine if the behaviors differ between both working environments (ie, working from home versus the office) and the office concepts (OPO versus AFO). METHODS: We conducted a cross-sectional study to measure sedentary time, sit-to-stand-transitions (STS), standing, and physical activity (time spent physically active and steps) in different working environments with activPAL3. …”
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HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol by Neil Ashman, Ben Caplin, David Wheeler, Tahseen Ahmad Chowdhury, Kieran Mccafferty, Sinead Knight, Paul Hockings, Stanley L Fan, Johannes Hulthe, Robert Kleta, Vasilios Papastefanou, Hemal Mehta, Alan Salama, Sinela Hadzovic, Lisa Jarl, Robert Unwin, Benjamin Challis, Anna K Sundgren, Muhammad Magdi Yaqoob

“…Measured glomerular filtration rate (GFR), echocardiography, retinal optical coherence tomography angiography and kidney and cardiac MRI will be performed at baseline and twice more during follow-up. The study is 90% powered to detect an association between key histological and imaging parameters and a composite of death, renal replacement therapy or a 30% decline in estimated GFR.Ethics and dissemination Ethical approval has been obtained from the Bloomsbury Research Ethics Committee (REC 18-LO-1921). …”
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Impact of diabetes on three-year outcome after coronary stenting in patients with polyvascular atherosclerotic disease – a secondary analysis of the randomized TWENTE trials by Daphne van Vliet, Tineke H. Pinxterhuis, Eline H. Ploumen, Marlies M. Kok, Rosaly A. Buiten, Paolo Zocca, Ariel Roguin, Carl E. Schotborgh, Rutger L. Anthonio, Peter W. Danse, Edouard Benit, Adel Aminian, Carine J.M. Doggen, Clemens von Birgelen

“…As the extent to which the presence of diabetes further increases this elevated risk is unclear, based on current literature, we sought to assess the long-term outcome after PCI in patients with polyvascular disease, comparing those with and without diabetes. Methods: The current study population consists of patients with known polyvascular disease, identified from a pooled patient-level database of 4 PCI trials in all-comers treated with new-generation drug-eluting stents; no exclusion criteria were set. …”
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Association of depression in multiple sclerosis with fatigue, sleep disturbances, disability, and health-related quality of life: Outcomes of a cross-sectional study by E. Aparicio-Castro, A. Candeliere-Merlicco, C.M. Santa, R. Villaverde-González

“…Introduction: Depression affect individuals with multiple sclerosis (MS) more frequently compared with the general population. …”
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Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…Although deep learning models can predict one or more echocardiographic findings from electrocardiograms (ECGs), such analyses are not comprehensive. …”
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Maternal Clostridium butyricum supplementation during late gestation and lactation enhances gut bacterial communities, milk quality, and reduces piglet diarrhea by Morakot Nuntapaitoon, Piraya Chatthanathon, Matanee Palasuk, Alisa Wilantho, Jakavat Ruampatana, Sissades Tongsima, Sarn Settachaimongkon, Naraporn Somboonna

“…This study thereby investigated the effects of probiotic supplementation on sow gut (feces) microbiota and their potential microbial metabolisms. Methods: Sow and litter performances, including milk compositions and incidences of piglet diarrhea, were recorded from farrowing to weaning of control- supplemented vs. probiotic-supplemented sows. …”
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A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population by Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide-van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Douwe J. Mulder, Jan-Luuk Hillebrands, Stephan J.L. Bakker, Robin P.F. Dullaart, Harry van Goor, Amaal E. Abdulle

“…In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. Methods: Individuals without CKD at baseline (n = 4662) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) prospective population-based cohort study in the Netherlands were included. …”
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BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease by Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real

“…This study aimed to identify distinct clusters of individuals with type 2 diabetes who have varying risks of MACE using a data-driven clustering approach. Methods This retrospective cohort study analyzed data from 49,506 individuals within a multicenter, population-based primary care registry in Catalonia, Spain. …”
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial d... by Jing Wang, Jing Wang, James T. Peterson, Joaquim Diego D. Santos, Ada J. S. Chan, Maria Alejandra Diaz-Miranda, Imon Rahaman, Jean Flickinger, Amy Goldstein, Amy Goldstein, Emily Bogush, Elizabeth M. McCormick, Colleen C. Muraresku, Vernon E. Anderson, Matthew C. Dulik, Matthew C. Dulik, Douglas C. Wallace, Douglas C. Wallace, Rui Xiao, Marni J. Falk, Marni J. Falk, Angela N. Viaene, Angela N. Viaene, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham

“…We sought to evaluate clinical, biochemical, and histopathological phenotypes of a large clinical cohort harboring MLSMD in muscle to better understand their significance across a range of clinical phenotypes.MethodsA single-site retrospective study was performed of 212 diagnostic muscle biopsies obtained from patients referred for Primary Mitochondrial Disease (PMD) evaluation with muscle mitochondrial (mt)DNA sequencing performed at our institution, including electronic medical record (EMR) review of symptoms, biochemical results, and Mitochondrial Myopathy Composite Assessment Tool (MM-COAST) scores.ResultsMLSMD were identified in 50 of 212 (24%) diagnostic tissue biopsies, and were universally present. in subjects ≥50 years (n = 18/18). …”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…This study aimed to diagnose swallowing disorders and highlight the importance of swallowing therapy in older patients in intensive care units (ICUs).Materials and methodsTwenty-five older patients (12 men, 13 women, mean age 67.22 ± 24.03 years) hospitalized in the ICUs with complaints of dysphagia were analyzed prospectively. …”
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Candida and Bacterial Skin Colonisation of Critically-ill Patients in Two Tertiary Healthcare Facilities in Zambia by Prof Geoffrey Kwenda, Dr John Mwaba, Ms Chalwe Sokoni, Mr Christone Kaile, Ms Faith Kabansa, Mr Darlingtone Mwenya, Ms Tshiama Mirriam Mwamba, Ms Ruth Mpembe, Dr Sabelle Jallow, Ms Rudzani Mashau, Prof Nelesh Govender, Miss Chalwe Sokoni

“…This study aimed to investigate the prevalence of Candida and bacterial colonisation in critically ill patients in Zambia. Methods: In a Point-prevalence survey (PPS) for Candida and bacterial skin colonisation conducted on October 2 and 3, 2023, skin swab samples (composite axilla/groin) were collected from critically-ill patients who were admitted for at least 48 hours to two tertiary hospitals in Zambia. …”
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Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-... by Paris J Baptiste, Angel Y S Wong, Anna Schultze, Catherine M Clase, Clémence Leyrat, Elizabeth Williamson, Emma Powell, Johannes F E Mann, Marianne Cunnington, Koon Teo, Shrikant I Bangdiwala, Peggy Gao, Kevin Wing, Laurie Tomlinson

“…However, the effectiveness and risk of these drugs in Black populations in UK routine care is unknown.<h4>Methods and findings</h4>We applied a reference trial emulation approach to UK Clinical Practice Research Datalink Aurum data (linked with data from Hospital Episode Statistics and Office for National Statistics) to study the comparative effectiveness of ARB and ACEi in ethnic minority groups in England, after benchmarking results against the ONTARGET trial. …”
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Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry by M. M. Lukyanov, N. P. Kutishenko, S. Yu. Martsevich, A. A. Pulin, E. Yu. Andreenko, V. P. Voronina, V. A. Dindikova, N. A. Dmitrieva, O. V. Lerman, A. N. Makoveeva, E. Yu. Okshina, A. S. Sgibneva, A. A. Smirnov, E. N. Belova, V. G. Klyashtorny, E. V. Kudryashov, O. E. Karpov, O. M. Drapkina

“…To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). …”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…This study assessed the impact of DSD models on Quality of life, loss to follow-up (LTFU), and mortality among persons living with HIV (PLHIV) on Antiretroviral therapy (ART) over time at a large urban HIV clinic in Uganda. Methods Records of 1,000 PLHIV enrolled in a 10-year cohort at the Infectious Diseases Institute (IDI) clinic in Kampala, Uganda were retrospectively analyzed. …”
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