Epilepsy is associated with the accelerated aging of brain activity in sleep by Peter N. Hadar, Mike Westmeijer, Mike Westmeijer, Haoqi Sun, Erik-Jan Meulenbrugge, Jin Jing, Luis Paixao, Ryan A. Tesh, Madalena Da Silva Cardoso, Pierrick Arnal, Rhoda Au, Chol Shin, Chol Shin, Soriul Kim, Robert J. Thomas, Sydney S. Cash, M. Brandon Westover

“…The BAI is a machine learning-based biomarker that measures how much the brain activity of a person during overnight sleep deviates from chronological age-based norms.MethodsThis case–control study drew information of age-matched controls without epilepsy from home sleep monitoring volunteers and from non-epilepsy patients with Sleep Lab testing. …”
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…However, whether these results can be applied to Asian patients with different ischemic stroke subtypes remains unclear. Methods Patients from 14 South Korean centers were analyzed separately. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…In this prospective study, we investigated the prognostic significance of urinary Marinobufagenin (uMBG), a cardiotonic steroid with acknowledged pro-fibrotic activity, for stratifying the risk of CKD progression in individuals with non-advanced renal disease.MethodsAfter baseline uMBG measurements, 108 CKD patients (eGFR 40.54 ± 17 mL/min/1.73 m2) were prospectively followed up to 24 months. …”
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SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) by Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Giovanni Benfari, Claudio Montalto, Monika Shumkova, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Nurcan Baydaroglu, Andrea Raffaele Munafò, Daniele Oreste D’Atri, Matteo Casenghi, Lucia Scisciola, Michelangela Barbieri, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Martin Penicka, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio Bartorelli, Carmine Pizzi, Tullio Palmerini, Marc Vanderheyden, Francesco Saia, Flavio Ribichini, Emanuele Barbato

“…Patients not treated with SGLT2i were more likely to progress to a worse EVCD stage over time (p = 0.018). …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…This study aimed to investigate the differences in RV function and clinical outcomes between these two groups. Methods The study included 246 T2DM patients {141 patients without OCAD [T2DM(OCAD−)] and 105 with [T2DM(OCAD+)]} and 85 control subjects. …”
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The relationship of sex and aortic diameter at the time of acute type A aortic dissectionCentral MessagePerspective by Lamia Harik, MD, Mario Gaudino, MD, PhD, Mohammed Rahouma, MD, Arnaldo Dimagli, MD, Roberto Perezgrovas-Olaria, MD, Kevin R. An, MD, Talal Alzghari, MD, Giovanni Soletti, Jr., MD, Jordan Leith, BS, Gianmarco Cancelli, MD, Charles Mack, MD, Leonard N. Girardi, MD, Christopher Lau, MD

“…Objective: Evaluate sex differences in patients undergoing repair of acute type A aortic dissection (ATAAD). Methods: Sex-stratified, single-center cohort study of patients undergoing ATAAD repair from 1997 to 2022. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…The top candidate miRNAs were validated in an independent cohort of patients hospitalized for ACS using complementary methods for isolation of extracellular RNA carriers. …”
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Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hyperten... by Meiqian Chen, Meiqian Chen, Li Zhang, Qian Liu, Qingxin Gu, Shuhui Yu, Guanzhen Lu, Guanzhen Lu

“…The relationship between the novel composite lipid metric, NHHR, and all-cause and cardiovascular mortality in hypertensive patients remains unknown and warrants further investigation.MethodsWe analyzed data from 5,561 hypertensive participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. …”
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Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol... by Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang

“…No large, published, randomised controlled trials have compared these management options. Methods TIGER is a phase 3, pan-European, two-group, active-control, observer-masked, superiority, randomised controlled surgical trial. …”
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Right Ventricular–Pulmonary Artery Uncoupling and Strain in Acute Heart Failure by Alberto Palazzuoli, Frank Loyd Dini, Nicola Riccardo Pugliese, Gaetano Ruocco, Paolo Severino, Dario Vizza, Rosa Carbonara, Andrea Passantino, Erberto Carluccio

“…However, data in acute heart failure (AHF) are still lacking. Methods and Results This multicenter observational study includes 425 patients with AHF: 248 with reduced left ventricular ejection fraction (<50%) and 177 with preserved left ventricular ejection fraction (≥50%). …”
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The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study by Yifeng Wang, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Kerui Zhang

“…However, the predictive value of the hs-CRP/HDL-C ratio for long-term mortality in the general population remains unclear. Methods This retrospective cohort study included data from 9,492 adults obtained from the National Health and Nutrition Examination Survey (NHANES) (2015–2018) in the United States. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…This study investigated the interaction and effects of sEVs derived from low (LNCaP) and moderately metastatic (DU145) prostate cancer (PCa) cell lines with the human brain endothelial cell line hCMEC/D3. Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
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[18F]PSMA-1007 PET for biochemical recurrence of prostate cancer, a comparison with [18F]Fluciclovine by Cato C. Loeff, Willemijn van Gemert, Bastiaan M. Privé, Inge M. van Oort, Rick Hermsen, Diederik M. Somford, James Nagarajah, Linda Heijmen, Marcel J. R. Janssen

“…Abstract Aim The objective of this study was to compare the detection rates of [18F]PSMA-1007 and [18F]Fluciclovine in early biochemical recurrence (BCR) of prostate cancer, i.e. with low prostate-specific antigen (PSA) levels (0.2–5.0 µg/L). Methods This was a prospective, single-center (Radboudumc; Nijmegen, The Netherlands), comparative phase II diagnostic imaging study (NCT04239742). …”
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Sources of risk communication, knowledge and preventive practices toward Lassa fever in Bauchi State, Nigeria by Benjamin Bukky Ilesanmi, Nathanael Afolabi, Olayinka Badmus, Munkail Titilola, Abdulmajid Ahmad, Usman Inuwa, Matthew Okoh, Hajara Aliyu, Shittu Abdu-Aguye, Foyeke Oyedokun-Adebagbo

“…We examined the level and sources of risk communication influencing knowledge and preventive practices towards Lassa fever (KPLF) and determined its associated factors in Bauchi state. Methods A cross-sectional study was conducted. Multistage sampling technique was used to select the respondents. …”
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Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis by Gabriella Fredman, Kevin Jacobsen, Peter A Philipsen, Stine R Wiegell, Merete Haedersdal

“…This study explores the potential of a prebiotic and panthenol-containing Dermocosmetic Cream (DC) to enhance tolerance and mitigate post-dPDT induced LSR in the treatment of AKs. Materials &amp; Methods: This randomized controlled, intra-individual trial included 20 patients with ≥10 AKs in two symmetrical areas on their face or décolleté, treated with a single session of artificial dPDT. …”
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Exploration of the relationships between the information and communication technology (ICT) and the education system in Morocco by Abdelkarim Taam, Amine Amar, Brahim Hmedna, Khalid Benabbes, El Menzhi Kaoutar, Rachid Daoudi, Adil El Makrani

“…The second part of our methodology is based on the multiple correspondence analysis (MCA) to determine a composite indicator of ICT integration. Our key findings demonstrate that the “Online learning” is more associated with the “age”, the “education level”, the “cycle” and the “area”. …”
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Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study by Yuichiro Mori, Toshiaki Komura, Motohiko Adomi, Ryuichiro Yagi, Shingo Fukuma, Naoki Kondo, Motoko Yanagita, O. Kenrik Duru, Katherine R. Tuttle, Kosuke Inoue

“…The present study aims to investigate the effectiveness of SGLT2 inhibitors for cardiovascular outcomes among patients with type 2 diabetes and low-to-normal BMI, using finer stratification than previous trials. Methods This cohort study with a target trial emulation framework was conducted using insurance claims and health screening records of more than 30 million working-age citizens in Japan acquired from April 1, 2015 to March 31, 2022. 139,783 new users of SGLT2 inhibitors matched to 139,783 users of dipeptidyl protease (DPP) 4 inhibitors with stratification by BMI category (< 20.0, 20.0–22.4, 22.5–24.9, 25.0–29.9, 30.0–34.9, and 35.0 ≤ kg/m2). …”
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Preliminary evaluation of a mindfulness intervention program in women with long COVID dysautonomia symptoms by Elizabeth Vandenbogaart, Matthew Figueroa, Diana Winston, Steve Cole, Julienne Bower, Jeffrey J. Hsu

“…The study aim was to evaluate the effect of a six-week mindfulness program in women with Long COVID dysautonomia symptoms. Methods: Using a single arm, pre- and posttest design, women aged 18–54 years with Long COVID and orthostatic intolerance suggestive of dysautonomia were recruited from a single center. …”
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The Efficacy and Safety of Ferric Carboxymaltose in Heart Failure with Reduced Ejection Fraction and Iron Deficiency: An Updated Systematic Review and Meta-Analysis of Randomized C... by Inderbir Padda, Sneha Annie Sebastian, Daniel Fabian, Yashendra Sethi, Gurpreet Johal

“…However, while earlier studies showed favorable results, more recent studies have failed to demonstrate significant improvements in outcomes for patients with heart failure with reduced ejection fraction (HFrEF) and ID. …”
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Prevalence and correlates of anxiety disorders and depressive disorders among older adults with non-communicable diseases: results from China Mental Health Survey by Hongmin Ge, Zhaorui Liu, Yue Tong, Yueqin Huang, Xiaofei Hou, Minghui Li, Yongping Yan, Shuiyuan Xiao, Lingjiang Li, Tingting Zhang, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Xiangdong Xu, Limin Wang, Huifang Yin, Guangming Xu

“…This study, as a part of the 2013–2015 China Mental Health Survey (CMHS), aimed to assess the prevalence of ADs and DDs and identify associated factors among older adults with NCDs in China.MethodA total of 5,428 patients aged 60 years and above with reported NCDs were selected from the CMHS. …”
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