Long-term cancer risk in users of GLP-1 agonists in Denmark: a nationwide emulated trialResearch in context by Mads Gamborg, Mia Klinten Grand, Kathrine Grell, Susanne Rosthøj, Ulrik Pedersen-Bjergaard, Christian Torp-Pedersen, Lina Steinrud Mørch

“…We clarify the long-term cancer risk. Methods: This register-based nationwide emulated trial includes all Danes initiating treatment with GLP-1RA or dipeptidyl peptidase-4 inhibitors (DPP-4i) 2007–2019, propensity score matched 1:1 on baseline characteristics and followed 10 years. …”
Get full text

Preparation of Magnetic Photocatalyst Fe₃O₄@SiO₂@Fe-TiO₂ and Photocatalytic Degradation Performance of Methyl Orange in Na₂SO... by Li Sun, Zilong Li, Zhigang Yuan, Ying Liu, Shunqi Mei, Fanhe Meng, Xingyu Ouyang, Yi Xiong, Ke Zhang, Zhen Chen

“…In this study, Fe₃O₄@SiO₂@TiO₂ (FS-FT (0 g)) photocatalysts, featuring a magnetic core–shell structure, and Fe-doped Fe₃O₄@SiO₂@Fe-TiO₂ (FS-FT (x g)) photocatalysts, were fabricated via the sol–gel method. Structural and compositional analyses of the processed samples were systematically conducted through X-ray diffraction (XRD), transmission electron microscopy (TEM) with selected area electron diffraction (SAED), surface-sensitive X-ray photoelectron spectroscopy (XPS), and optical property assessment via UV-Vis diffuse reflectance spectroscopy (UV-DRS). …”
Get full text

Characteristics and control modes of geothermal fields in deep coal reservoirs in the Linxing-Shenfu block by Lifu XU, Yuhu BAI, Bingxiang XU, Weiqiang HU, Jianqi CHEN, Yong LI

“…Investigating geothermal fields facilitates the assessment and efficient development of deep CBM resources.MethodsThis study explored the Nos. 8 and 9 coal seams in the Linxing-Shenfu block using data from drilling, well logging, well tests, and experiments. …”
Get full text

P-91 NORMALIZATION OF ALKALINE PHOSPHATASE COMPARED TO CONVENTIONAL RESPONSE CRITERIA LEADS TO LOWER LIVER RELATED EVENTS AND MORTALITY IN PATIENTS LIVING WITH PRIMARY BILIARY CHOL... by LUIS ALEJANDRO ROSALES RENTERIA, José David Prieto Nava, Giovanni Francisco Pérez Roa, María Saraí González Huezo

“…Patients / Materials and Methods: This is a single center, retrospective, propensity score-matched cohort study, which included all patients with PBC and chronic liver disease, confirmed by liver biopsy that were followed by the hepatology clinic from January 1st, 2015 to March 1st 2024 under treatment with UDCA. …”
Get full text

AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecogniz... by Raquel M. Zimmerman, Edgar J. Hernandez, Mark Yandell, Martin Tristani-Firouzi, Robert M. Silver, William Grobman, David Haas, George Saade, Jonathan Steller, Nathan R. Blue

“…Our objective was to use data from a large, deeply phenotyped observational obstetric cohort to develop a probabilistic graphical model (PGM), a type of “explainable artificial intelligence (AI)”, as a potential framework to better understand how interrelated variables contribute to perinatal morbidity risk in FGR. Methods Using data from 9,558 pregnancies delivered at ≥ 20 weeks with available outcome data, we derived and validated a PGM using randomly selected sub-cohorts of 80% (n = 7645) and 20% (n = 1,912), respectively, to discriminate cases of FGR resulting in composite perinatal morbidity from those that did not. …”
Get full text

Exploring drought hazard, vulnerability, and related impacts on agriculture in Brandenburg by F. Brill, P. H. L. Alencar, H. Zhang, F. Boeing, F. Boeing, S. Hüttel, S. Hüttel, T. Lakes, T. Lakes

“…The aim of this study is to investigate to what extent hazard and vulnerability indicators can explain observed agricultural drought impacts via data-driven methods. We focus on the German federal state of Brandenburg, 2013–2022, including several consecutive drought years. …”
Get full text

Clinical characteristics and long‐term outcomes in patients with apical hypertrophic cardiomyopathy by Meng Guo, Chuanfen Liu, Jingjing Ye, Jian Liu

“…We aimed to describe the characteristics and outcomes of ApHCM and identify predictors of adverse outcomes. Methods In this single‐centre retrospective study, we included 479 patients with HCM and divided them into ApHCM and non‐ApHCM groups. …”
Get full text

Atrial fibrillation or flutter in patients undergoing stem cell transplantation, in-hospital and post-discharge outcomes in a large nationwide sample across the United States by Raja Zaghlol, Elena Deych, Nina Manian, Ahmed Altibi, Joshua D. Mitchell

“…There is a paucity of large-scale data on the prevalence of AF and their effect on outcomes following SCT. Methods The United States National Readmission Database (NRD) was used to identify hospitalized patients who underwent SCT. …”
Get full text

The predictive value of the serum creatinine-to-albumin ratio (sCAR) and lactate dehydrogenase-to-albumin ratio (LAR) in sepsis-related persistent severe acute kidney injury by Xiaoxiao Luo, Dongyang Liu, Cuicui Li, Jia Liao, Wuyang Lv, Yuchen Wang, Ruxue Diao, Yingyu Jin

“…The utility of the sCAR (secrum creatinine/albumin) and LAR (Lactate dehydrogenase/albumin) as diagnostic markers for persistent severe SA-AKI remains unclear. Methods We acquired training set data from the MIMIC-IV database and validation set data from the First Affiliated Hospital of Harbin Medical University. …”
Get full text

Infections and antibiotic resistance in Malawian children 6-59 months old hospitalized with severe acute malnutrition by Dr Bryan Vonasek, Ms. Mwawi Nyirongo, Mr. Alexander Kondwani, Dr. Anthony Garcia-Prats, Ms. Tiwonge Kamvaunamwali, Ms. Doris Ng'oma, Mr. James Kaphatika, Mr. Amazing-Grace Tepeka, Dr. Mercy Kumwenda, Dr. Emily Ciccone, Dr. Tisungane Mvalo

“…The aim of this study was to give a contemporary description of the prevalence of treatable infections and AMR in children hospitalized with SAM. Methods: This prospective cohort study enrolled children 6-59 months old hospitalized with SAM at a tertiary referral hospital in Malawi. …”
Get full text

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infecti... by Celina Jin, Malick M Gibani, Shaun H Pennington, Xinxue Liu, Alison Ardrey, Ghaith Aljayyoussi, Maria Moore, Brian Angus, Christopher M Parry, Giancarlo A Biagini, Nicholas A Feasey, Andrew J Pollard

“…Azithromycin is commonly used for first-line treatment of uncomplicated enteric fever, but the response to treatment may be sub-optimal in some patient groups when compared with fluoroquinolones.<h4>Methods</h4>We performed an analysis of responses to treatment with azithromycin (500mg once-daily, 14 days) or ciprofloxacin (500mg twice-daily, 14 days) in healthy UK volunteers (18-60 years) enrolled into two Salmonella controlled human infection studies. …”
Get full text

Design of AgI/BiVO4 heterostructures for photocatalytic antibiotic removal and antimicrobial action by Hanh Thi Truong, Tho Truong Pham, Nhi Dinh Bui, Ha Tien Le, Thuan Chi Nguyen

“…To examine their structural and optical properties, a suite of characterization methods, including energy-dispersive x-ray spectroscopy (EDX), Raman spectroscopy, transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), x-ray diffraction (XRD), and diffuse reflectance spectroscopy (DRS), was utilized. …”
Get full text

Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study by Eric Vicaut, Ramzi A Ajjan, J Seufert, Gérard de Pouvourville, Emmanuel Cosson, Laure Carcaillon-Bentata, Tadej Battelino, Patrick Blin, Fleur Levrat-Guillen, Michael Joubert

“…Continuous glucose monitoring (CGM)-derived glucose metrics provide a more comprehensive assessment of glycaemia, but their role in predicting future vascular complications remains unclear. …”
Get full text

Exploring Ethical, Cultural, and Transnational Competence Among International Healthcare Management Students: An Australian Perspective by Howard M, Tan KL, Jayasekara R

“…This exploratory study examined the challenges faced by these students to establish foundational understanding of the competencies needed for effective ethical decision-making, cultural integration, and transnational readiness in diverse healthcare environments.Methods: Using a composite theoretical framework incorporating Cultural Relativism, Ethical Climate Theory, Institutional Theory, and Transnationalism, a 35-item instrument was adapted from three validated sources. …”
Get full text

Increasing risk of postlung transplant hospitalizations for infection: An analysis of recent trends by Shi Nan Feng, BSPH, Armaan F. Akbar, BS, Alice L. Zhou, MS, Andrew Kalra, BS, Sean Agbor-Enoh, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…We examined trends in hospitalizations for infection in the first year after LT. Methods: We identified adult LT recipients in the United States (March 1, 2018-March 9, 2023) using the Organ Procurement and Transplantation Network database. …”
Get full text

Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study. by Kathryn E Fitzpatrick, Thomas van den Akker, Kitty W M Bloemenkamp, Catherine Deneux-Tharaux, Alexandra Kristufkova, Zhuoyang Li, Timme P Schaap, Elizabeth A Sullivan, Derek Tuffnell, Marian Knight

“…This study aimed to pool data from multiple countries in order to describe risk factors, management, and outcomes of AFE and to explore the impact on the findings of considering United Kingdom, international, and United States AFE case definitions.<h4>Methods and findings</h4>A population-based cohort and nested case-control study was conducted using the International Network of Obstetric Survey Systems (INOSS). …”
Get full text

Hypomethylating agents plus venetoclax for high-risk MDS and CMML as bridge therapy to transplant: a GESMD study by Ines Zugasti, Monica Lopez-Guerra, Sandra Castaño-Díez, Daniel Esteban, Alejandro Avendaño, Helena Pomares, Ana Perez, Sara García-Ávila, Irene Padilla Conejo, Cristina de la Fuente Montes, Alexandra Martínez-Roca, Beatriz Merchán, Carlos Jiménez-Vicente, Francesca Guijarro, Jose Ramón Álamo, Albert Cortes-Bullich, Victor Torrecillas, Lucia Mont, Esther Carcelero, Gisela Riu, Lurdes Zamora, Joan Bargay, Ana Triguero, Maria Suarez-Lledó, Maria Queralt Salas, Felix López-Cadenas, Fernando Ramos, Blanca Xicoy, David Valcárcel, Montserrat Arnan, Carmen Martínez, Montserrat Rovira, Francesc Fernández-Avilés, Maria Díez-Campelo, Jordi Esteve, Marina Díaz-Beyá

“…Recent evidence suggests that combining HMA with venetoclax (HMA/VEN) could increase HMA efficacy in HR-MDS but it remains unclear if this combination could bridge more patients to allo-SCT. Methods We retrospectively evaluated HMA/VEN as a bridge to allo-SCT in 30 patients with HR-MDS or CMML eligible for transplant. …”
Get full text

Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhan... by Toshi A Furukawa, Pim Cuijpers, Tatsuo Akechi, Masaru Horikoshi, Yan Luo, Hisashi Noma, Takeo Nakayama, Helen Christensen, Naoki Kondo, Norito Kawakami, Aran Tajika, Ronald C Kessler, Shingo Fukuma, Masatsugu Sakata, Rie Toyomoto, James M S Wason

“…Guided internet cognitive–behavioural therapies (iCBT) appear promising but there is room for improvement because we do not yet know which of various iCBT skills are more efficacious than others, and for whom. In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysis Based on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. …”
Get full text

Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Adverse outcomes were more frequent, probably due to advanced disease at baseline.…”
Get full text

Implications of Tricuspid Regurgitation Severity in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair by Alon Shechter, Homa Taheri, Takashi Nagasaka, Aakriti Gupta, Danon Kaewkes, Vivek Patel, Kazuki Suruga, Manvir Dhillon, Keita Koseki, Ofir Koren, Moody Makar, Sabah Skaf, Dhairya Patel, Tarun Chakravarty, Robert J. Siegel, Raj R. Makkar

“…We aimed to explore the prevalence, correlates, and consequences of TR grades and postprocedural trends in this setting. Methods and Results A single‐center registry of isolated, first‐time interventions was retrospectively assessed for pre‐, intra‐, and postprocedural aspects up to 1 year, of them the primary composite outcome of all‐cause deaths or heart failure (HF) hospitalizations, all according to TR severity at baseline and at 1 month following mitral transcatheter edge‐to‐edge repair. …”
Get full text