Long-term effects of enhanced external counterpulsation in the management of patients with ischemic chronic heart failure by A. S. Lishuta, O. A. Slepova, N. A. Nikolaeva, M. F. Petruhnova, E. V. Privalova, Yu. N. Belenkov

“…To study the long-term effects of complex therapy with the addition of enhanced external counterpulsation (EECP) in patients with stable coronary artery disease (CAD) complicated by chronic heart failure (CHF).Material and methods. In the open randomized trial EXCEL (NCT05913778), 118 Patients with the verified ischemic CHF NYHA class II-III with reduced or intermediate left ventricular ejection fraction were included. …”
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The relationship between below average cognitive ability at age 5 years and the child’s experience of school at age 9 by Andrea K. Bowe, Mathias Urban, Anthony Staines, Deirdre M. Murray, Deirdre M. Murray

“…Principal components analysis was used to produce a composite general cognitive ability score for each child. …”
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Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines by Yu. V. Karpenko, O. I. Panasenko, A. P. Litun

“…Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. …”
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Exploration of mortality-associated creatinine thresholds for acute kidney injury in cardiac surgery patients with impaired kidney function: a single-center retrospective cohort st... by Wuhua Jiang, Jiarui Xu, Zhe Luo, Xialian Xu, Xiaoqiang Ding, Yi Fang

“…Previous studies have proposed alternative diagnostic thresholds that identify more AKI cases than KDIGO and are associated with adverse outcomes. …”
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Long-term trajectories of apolipoprotein A1 and major adverse cardiovascular events and mortality in a community cohort by Yang Chen, Yun-Yu Chen, Kuo-Liong Chien, Yenn-Jiang Lin, Fang-Yi Chen, Yu-Cheng Hsieh, Gregory Y. H. Lip, Shih-Ann Chen

“…This study aimed to evaluate the impact of ApoA1 trajectories over three early assessments. Methods Participants in the Chin-Shan Community Cardiovascular Cohort with dyslipidemia and receiving three early ApoA1 assessments were enrolled. …”
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Mental health care use in medically unexplained and explained physical symptoms: findings from a general population study by van Eck van der Sluijs J, ten Have M, Rijnders C, van Marwijk H, de Graaf R, van der Feltz-Cornelis C

“…Analyses were adjusted for sociodemographic characteristics and presence of any 12-month mental disorder assessed with the Composite International Diagnostic Interview 3.0. Results: At the primary care level, all three groups of subjects with physical symptoms showed entry into care for mental health problems significantly more often than controls. …”
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Associations of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with diabetes and prediabetes among adults with hypertension: a cross-section... by Qing Meng, Qing Meng, Shengqiang Fan, Shengqiang Fan, Li Zhang, Bin Shen, Chaoping Zou, Dezhou Sun, Xianghui Liu, Jian Zhang, Shugang Xu

“…BackgroundThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an emerging composite lipid marker. Prediabetes, characterized by an asymptomatic state with moderate hyperglycemia, is more prevalent than diabetes. …”
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Effect of radiation therapy on the dentin bond strength of a universal adhesive by Pipop Saikaew, P Hannongbua, P Jianratanajit, I Wongkertprayot, P Chaiklahan, N Srimaneekarn, A Prayongrat, P Eamsa-ard, AFMA Chowdhury, K Katekovit, S Hidehiko

“…Since radiotherapy may alter dental tissues and compromise bonding, this study evaluated how the timing of radiation exposure affects the microtensile bond strength (µTBS) of a universal adhesive to dentin with different application modes. Methods Forty-two human third molars were used in this study. …”
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Synthesis and evaluation of novel O-functionalized aminated chitosan derivatives as antibacterial, antioxidant and anticorrosion for 316L stainless steel in simulated body fluid by Nazly Hassan, Aisha Hendy, Asmaa Ebrahim, T.M. Tamer

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Blood pressure-lowering treatment for the prevention of cardiovascular events in patients with atrial fibrillation: An individual participant data meta-analysis. by Ana-Catarina Pinho-Gomes, Luis Azevedo, Emma Copland, Dexter Canoy, Milad Nazarzadeh, Rema Ramakrishnan, Eivind Berge, Johan Sundström, Dipak Kotecha, Mark Woodward, Koon Teo, Barry R Davis, John Chalmers, Carl J Pepine, Kazem Rahimi, Blood Pressure Lowering Treatment Trialists’ Collaboration

“…Therefore, this study aimed to compare the effects of BP-lowering drugs in patients with and without AF at baseline.<h4>Methods and findings</h4>The study was based on the resource provided by the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC), in which individual participant data (IPD) were extracted from trials with over 1,000 patient-years of follow-up in each arm, and that had randomly assigned patients to different classes of BP-lowering drugs, BP-lowering drugs versus placebo, or more versus less intensive BP-lowering regimens. …”
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First-in-human implementation of a bidirectional somatosensory neuroprosthetic system with wireless communication by Sedona R. Cady, Joris M. Lambrecht, Karina T. Dsouza, Jeremy L. Dunning, J. Robert Anderson, Kevin J. Malone, Kyle J. Chepla, Emily L. Graczyk, Dustin J. Tyler

“…Fully implanted sensorimotor systems without percutaneous leads are crucial for advancing implanted neuroprosthetic technologies to long-term community use and commercialization. Methods We present the first-in-human technical performance of the implanted Somatosensory Electrical Neurostimulation and Sensing (iSens®) system—an implanted, high-channel count myoelectric sensing and nerve stimulation system that uses wireless communication for advanced prosthetic systems. …”
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Educational Attainment Level and Risk of Mortality and Cardiopulmonary Outcomes in High‐Risk Patients With Cardiovascular Disease: The INVESTED Trial by Mats C. H. Lassen, Nicholas Howell, Brian L. Claggett, Tor Biering‐Sørensen, Orly Vardeny, Scott D. Solomon, Jacob Udell, Jacob Joseph, Sheila M. Hegde

“…However, the association between EAL and risk of clinical outcomes in high‐risk patients with cardiovascular disease has not been extensively investigated. Methods In the INVESTED (Influenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure) trial, patients with recent heart failure or myocardial infarction hospitalization were randomized 1:1 to high‐dose trivalent or standard‐dose quadrivalent influenza vaccine from September 2016 to January 2019. …”
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The osteoinductive and osseointegration properties of decellularized extracellular matrix bone derived from different sites by Weihua Huang, Lijing Hao, Xiayu Cai, Chujie Xiao, Huinan Yin, Weikang Xu

“…Aims: This study aimed to examine the differences in bone induction and osseointegration performance of acellular extracellular matrix bone at different sites. Methods: We decellularized bone from bovine epiphysis near the marrow cavity (NMC), the middle of the cancellous bone (MCB), and near the cartilage (NC). …”
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Nuclear factor κ-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension. by Laura C Price, Gaetano Caramori, Frederic Perros, Chao Meng, Natalia Gambaryan, Peter Dorfmuller, David Montani, Paolo Casolari, Jie Zhu, Konstantinos Dimopoulos, Dongmin Shao, Barbara Girerd, Sharon Mumby, Alastair Proudfoot, Mark Griffiths, Alberto Papi, Marc Humbert, Ian M Adcock, S John Wort

“…Increasing evidence indicates that inflammation is important in disease pathophysiology.<h4>Methods</h4>NF-κB-p65 and CD68, CD20 and CD45 were measured by immunohistochemistry and confocal microscopy on lung specimens from patients with idiopathic PAH (n = 12) and controls undergoing lung surgery (n = 14). …”
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Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond by Jiaxin Wen, Yanfeng Wang, Song Wang, Yuxin Liang, Xiaozhen Hu, Qiuxiang Ou, Hua Bao, Kuo Zhao, Youyu Wang

“…Abstract Background Integration of immune checkpoint inhibitors (ICIs) with non-immune therapies relies on identifying combinatorial biomarkers, which are essential for patient stratification and personalized treatment. Methods We analyzed genomic and transcriptomic data from pretreatment tumor samples of 342 melanoma patients treated with ICIs to identify mutations and expression signatures associated with ICI response and survival. …”
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Cognitive status and health-related quality of life for medical students by V. V. Kuznetsov, K. V. Kosilov, E. Yu. Kostina, E. V. Karashchuk, E. K. Fedorishcheva, O. A. Barabash

“…To study the comparative state and variability of cognitive capabilities, the degree of their correlation with the subjective and objective state of health among students of a medical university. Materials and methods. The study was carried out during the year from 01.12.2018 to 01.12.2019 at the Far Eastern Federal University and the Pacific State Medical University. …”
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Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population by Ying Li, Qianqian Zhang, Li Chen, Yue Wang, Qibao Ye, Wei Liu, Yan Liu, Guojuan Wang

“…Abstract Objective To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population. Methods Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). …”
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5-Item Modified Frailty Index Score is Associated with Increased Postoperative Complications Following Ankle Fracture ORIF by Ronit Kulkarni BS, Alexander S. Guareshi BS, Nikhil Vallabhaneni BA, Joshua L. Morningstar BS, Daniel J. Scott MBA, MD, Christopher E. Gross MD

“…(Table 1) Mortality was strongly predicted by mFI-5 with the risk more than tripling for each point increase in mFI-5 score (odds ratio (OR)=3.639, 95% CI= 3.038-4.360). …”
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Dynamic evolutionary pattern of fractures in tectonically deformed coal-bearing assemblages during loading by Pengxiang ZHAO, Yingying LIU, Shugang LI, Yanqun LIU, Yunchuan LIU, Laolao WANG, Weidong LU

“…However, the influence patterns remain unclear. MethodsUsing a NanoVoxel-3000 high-resolution inspection system for multiscale integrated geotechnical scanning and analysis, this study performed uniaxial compression and CT scanning experiments on TDC-bearing combination specimens. …”
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Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system by Harin Lee, Tarun Kadaru, Ruth Schneider, Taylor Triana, Carol Tujardon, Colby Ayers, Mujeeb Basit, Zahid Ahmad, Amit Khera

“…Of those contacted, 35 % had a follow-up visit with a PCP and/or a lipid specialist, and 22 % saw any composite change. Patients whose PCP was contacted were more likely to have adjustments made to their lipid lowering medication(s) (p = 0.016), be diagnosed with FH (p = 0.025), and have a follow-up visit (p = 0.033). …”
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