Effects of combination antihypertensive therapy on intracardiac hemodynamics and blood vessels in patients with coronary heart disease, post-infarction cardiosclerosis and arterial... by M. M. Dolzhenko, S. A. Bondarchuk, L. Ye. Lobach

“…The aim of the work is to assess the effectiveness of prescribing a fixed-dose combination of amlodipine with the ACE inhibitor lisinopril or with the angiotensin 2 receptor blocker valsartan in patients with coronary artery disease, acute coronary syndrome with hypertensive disease regarding the impact on the structural and functional parameters of the heart and extracranial branches of the brachiocephalic arteries. Materials and methods. General clinical examination of 108 patients with postinfarction cardiosclerosis and hypertension was done within 12 months. …”
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A hybrid fuzzy logic–Random Forest model to predict psychiatric treatment order outcomes: an interpretable tool for legal decision support by Alexandre Hudon, Alexandre Hudon, Alexandre Hudon, Alexandre Hudon

“…This study aims to develop and evaluate a hybrid fuzzy logic–machine learning model to predict such outcomes and identify important influencing factors.MethodsA retrospective dataset of 176 Superior Court judgments rendered in Quebec in 2024 was curated from SOQUIJ, encompassing demographic, clinical, and legal variables. …”
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The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…In this study, we investigated the role of CD47 in tumor progression in colon adenocarcinoma (COAD) and evaluated its potential as a target for immunotherapy. Materials and Methods We analyzed surgical samples from 96 COAD patients. …”
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Health care professionals intention to use digital health data hub working in East Gojjam Hospitals, Northwest Ethiopia: Technology acceptance modeling. by Ayenew Sisay Gebeyew, Sefefe Birhanu Tizie, Bayou Tilahun Assaye, Afework Edmealem, Temesgen Feyu, Habtamu Mekonen, Tirsit Ketsela Zeleke, Melese Getachew, Andualem Fentahun

“…This study assessed health professionals' intention to use digital health data hubs in hospitals in East Gojjam, northwest Ethiopia, in 2024.<h4>Methods</h4>A cross-sectional study design was used to conduct the study. …”
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Safety and Efficacy of Mirogabalin in Lumbar Spinal Stenosis Patients with Peripheral Neuropathic Pain on NSAIDs: Post Hoc Analysis of the MiroTAS Study by Takuya Nikaido, Shunsuke Tabata, Kazuhito Shiosakai, Taichi Nakatani, Hiroshi Sakoda

“…Abstract Introduction The primary analysis of the MiroTAS study in patients with lumbar spinal stenosis (LSS) taking non-steroidal anti-inflammatory drugs showed that mirogabalin add-on therapy further improved pain and quality of life (QOL) without new safety concerns. Methods This post hoc analysis of the MiroTAS study examined the timing of onset of mirogabalin-related adverse drug reactions (mrADRs) (composite of somnolence, dizziness, edema, and peripheral edema), factors affecting safety and efficacy, and the relationships between baseline numbness severity (by spine painDETECT questionnaire [SPDQ] score), EQ-5D-5L scores, leg pain improvement (by visual analogue scale [VAS]), and patient satisfaction (by Patient Global Impression of Change [PGIC] scores). …”
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Socioeconomic and racial-ethnic disparities in flame retardant exposure and executive function skills in preschool children by Alexis Merculief, Megan McClelland, Stephanie Foster, John Geldhof, Shannon Lipscomb, Kim Anderson, Molly L. Kile

“…The present study examined independent and joint effects of income and race/ethnicity on flame retardant exposure in early childhood and investigated associations between flame retardant exposure and children’s EF. Methods This cross-sectional study used data from 349 preschool children recruited in Oregon. …”
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Evaluation of the marginal fit and fracture resistance of interim restorations fabricated using different techniques: an in vitro study by Mostafa Elashkar, Yehia Aboushady, Merna Ihab, Mohamed T. El Halawani

“…Aim The aim of this in vitro study was to investigate the marginal fit and fracture resistance of manually fabricated, computer-aided design and computer-aided manufacturing (CAD/CAM) milled, and CAD/CAM three-dimensionally (3D) printed 3-unit interim fixed dental prostheses (FDPs). Materials and methods Sixty-four 3-unit interim FDPs were fabricated on epoxy resin models using different fabrication techniques: manual fabrication with poly methyl methacrylate (PMMA) (n = 16), manual fabrication with Bis-acrylic composite resin (n = 16), CAD/CAM milling (n = 16), and CAD/CAM 3D-printing with a digital light processing (DLP) printer (n = 16). …”
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Trends in Complications Among Patients Undergoing Aortic Valve Replacement in the United States by James E. Harvey, Samir R. Kapadia, David J. Cohen, Ankur Kalra, William Irish, Candace Gunnarsson, Michael Ryan, Soumya G. Chikermane, Christin Thompson, Rishi Puri

“…These reductions were more pronounced for TAVR (41% to >19%, Δ=22%) than SAVR (51% to >47%, Δ=4%). …”
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Device measured physical activity before pregnancy and the risk of adverse pregnancy outcomes in the HUNT study: a population-based cohort study by Laura Vatn Slapgaard, Signe Nilssen Stafne, Vegar Rangul, Ingrid Aanesland Dahle, Julie Horn

“…We aimed to examine the association between objectively measured physical activity before pregnancy and risk of APOs. Methods The study population consisted of women with one or more singleton births registered in the Medical Birth Registry of Norway (MBRN) after participating in the fourth survey of the Trøndelag Health Study (HUNT4, 2017–2019). …”
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Sex Difference in Coronary Artery Spasm Tested by Intracoronary Acetylcholine Provocation Test in Patients with Nonobstructive Coronary Artery Disease by Ji Young Park, Se Yeon Choi, Seung-Woon Rha, Byoung Geol Choi, Yung-Kyun Noh, Yong Hoon Kim

“…The purpose of this study is to compare the sex difference in the characteristics of coronary artery spasm (CAS) in patients with nonobstructive cardiovascular disease (NOCVD) and the clinical outcomes in accordance with sex in CAS patients. Methods. The study analysed 5,491 patients with NOCVD who underwent an acetylcholine provocation test from November 2004 to May 2014 for evaluation of chest pain. …”
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A data science pipeline applied to Australia's 2022 COVID-19 Omicron waves by James M. Trauer, Angus E. Hughes, David S. Shipman, Michael T. Meehan, Alec S. Henderson, Emma S. McBryde, Romain Ragonnet

“…These packages can support infectious disease modelling to be more robust, efficient and transparent, which has been particularly important during the COVID-19 pandemic. …”
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Real-World Effectiveness of Bebtelovimab Versus Nirmatrelvir/Ritonavir in Outpatients with COVID-19 by Christopher G. Rowan, Russell M. Nichols, Neil Dhopeshwarkar, Jennifer M. Alyea, Baojin Zhu, Sengwee Toh, K. Arnold Chan, Elsie L. Grace

“…Abstract Introduction This real-world study assessed the effectiveness of bebtelovimab (BEB) versus nirmatrelvir/ritonavir (NR) among outpatients with COVID-19 during the Omicron variant era. Methods We conducted a cohort study evaluating patients treated with BEB or NR from February to August 2022 (study period). …”
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Rationale and design of randomized non-inferiority clinical trial to compare the safety and efficacy of ticagrelor monotherapy with dual antiplatelet therapy in chronic coronary sy... by Seyed Alireza Mirhosseini, Mohammadreza Akbari, Davar Aldavood, Hooyar Zarifkar, Armin Attar, Javad Kojuri

“…Despite promising data, the safety and efficacy of Ticagrelor monotherapy specifically in CCS patients have not been rigorously tested in randomized trials.<h4>Methods</h4>TICALONE is a non-inferiority, two-arm, double-blinded, randomized controlled clinical trial designed to evaluate the safety and efficacy of ticagrelor monotherapy compared to DAPT in CCS patients following PCI. …”
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Nanopore Characteristics of the Cambrian Niutitang Formation Organic-Rich Shales in the Middle Yangtze Region and Its Formation Controlling Factors by Jie Xu, Weihua Guo, Bin Yang, Dongxu Ma, Li Zhao, Haotian Liu, Hongjie Ji, Huifei Tao

“…The laser Raman, X-ray diffraction analysis, FE-SEM, and low-pressure N2 and CO2 adsorption methods are used to study the geochemical and mineral compositions of the shales, and the nanopore characteristics and its formation controlling factors of the shales are discussed. …”
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Study on the Cutter–Granite Interaction Mechanism in High-Temperature Geothermal Wells by Yan Yang, Dongdong Song, Kuilin Huang, Haitao Ren, Yingxin Yang, Shunzuo Qiu, Zequan Huang

“…Among them, the interaction between the cutter of the drill bit and the rock is the key factor determining the rock-breaking efficiency of PDC (Polycrystalline Diamond Composite) drill bits. To further explore the rock-breaking mechanism of cutters on granite, this study adopts a combination of experimental and simulation methods to conduct systematic research. …”
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Intrinsic capacity trajectories and cardiovascular disease incidence among Chinese older adults: a population-based prospective cohort study by Zhiting Guo, Yuling Chen, Binu Koirala, Jiaying Li, Yingying Jia, Cheryl R. Dennison Himmelfarb, Jingfen Jin

“…Abstract Background Intrinsic capacity (IC), a composite of physical and mental capacities, is a marker of healthy aging. …”
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Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…By monitoring these indexes, we can more accurately predict the occurrence of TIC and take effective treatment measures in time.…”
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Effects of CAD/CAM ceramics and thicknesses on translucency and color masking of substrates by Abdullah Saeed Alayad, Abdulaziz Alqhatani, Mohammed S. Alkatheeri, Mohammed Alshehri, Mohammed A. AlQahtani, Aljoharah Ebrahim Bin Osseil, Rawan Abdullah Almusallam

“…Objective: To compare the translucency and masking of zirconia-reinforced lithium silicate with lithium disilicate glass-ceramic and hybrid composite. Materials and methods: One hundred and twenty disc-shaped specimens were fabricated using Enamic, Celtra Duo, IPS E.max CAD, and Suprinity. …”
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Assessment of quality of maternal and newborn care and its determinants: a national study of primary health care facilities in Nigeria by Toluwani Oluwatola, Saheed Dipo Isiaka, Oluomachukwu Omeje, Folake Oni, Olugbemisola W. Samuel, Sidney Sampson, Hilda Ebinim, Oluwadamilare Olatunji, Oluwafisayo Ayodeji, Dolapo Ajibola, Stallone Ngobua, Oluwafunmilayo Dehinbo, Helen Ukoh, Leyira Ken-Aminikpo, Segun Adenipekun, Hilary I. Okagbue

“…This study aimed to assess the quality of MNCs among 25,840 public primary healthcare centers (PHCs) across Nigeria, analyze subnational variations, and determine the influence of contextual variables on the quality of care (QoC) by PHCs. Methods Data from a nationwide PHC assessment conducted in 2022 were utilized to create the composite index of care for PHC facilities in Nigeria. …”
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Adherence to oral anticoagulation in ischemic stroke patients with atrial fibrillation by Paula Tiili, Ioannis Leventis, Janne Kinnunen, Ida Svedjebäck, Mika Lehto, Efstathia Karagkiozi, Dimitrios Sagris, George Ntaios, Jukka Putaala

“…Background Non-vitamin K antagonist oral anticoagulants (NOAC) have superior safety and comparable efficacy profile compared to vitamin-K antagonists (VKAs), with more convenient dosing schemes. However, issues with adherence to the NOACs remain unsolved.Aims We sought to investigate the adherence to oral anticoagulation (OAC) and baseline factors associated with poor adherence after ischaemic stroke in patients with atrial fibrillation (AF).Methods We recruited hospitalised patients (2013–2019) from two prospective stroke registries in Larissa and Helsinki University Hospitals and invited survived patients to participate in a telephone interview. …”
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