MiR-145 encapsulated small extracellular vesicles inhibit colorectal cancer progression by downregulating fascin actin-bundling protein 1 expression by Yanxia Chen, Meijuan He, Lei Cui, Jianguo Zhang, Hanpeng Huang, Zhimin Tao

“…Abstract Background Drug degradation poses a significant challenge in the pursuit of effective gene therapies for cancers. Methods Here we have developed a bioactive nanosized composite that utilizes human umbilical cord mesenchymal stem cells (hucMSCs) derived small extracellular vesicles (sEVs), to carry tumor suppressor miR-145 alongside erbium-doped rare earth nanoparticles (ErNPs). …”
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Correlation between hs-CRP-triglyceride glucose index and NAFLD and liver fibrosis by Yuhui Zhou, Hao Lin, Xiaochun Weng, Huifang Dai, Jing Xu

“…This study aims to examine the correlation between CTI and NAFLD/liver fibrosis in American adults. Methods This is a cross-sectional study utilizing data from NHANES during the period from 2017 to 2020. …”
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Physical fitness and incident mild cognitive impairment: a systematic review by Matteo Bergmann, Yonas Endale Geda, Klaus Boes, Alexander Woll, Janina Krell-Roesch

“…Our aim was to provide an overview of longitudinal research on the associations between physical fitness and the risk of incident MCI. Methods We conducted a systematic literature review that examined associations between different components of physical fitness such as strength or endurance with incident MCI in older adults. …”
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The influence of women's groups mobilisation on health emergency response: Evidence from the Ebola outbreak in Liberia. by Florence Wullo Anfaara, Erica S Lawson, Kilian Nasung Atuoye, Isaac Luginaah

“…We built a composite model from community response strategies that participants reported witnessing. …”
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Transplanting human umbilical cord mesenchymal stem cells and hyaluronate hydrogel repairs cartilage of osteoarthritis in the minipig model by Kun-Chi Wu, Yu-Hsun Chang, Hwan-Wun Liu, Dah-Ching Ding

“…We investigated the therapeutic potential of human umbilical cord-derived MSCs (HUCMSCs) with hyaluronic acid (HA) hydrogel transplanted into a porcine OA preclinical model. Materials and Methods: The HUCMSCs were characterized with respect to morphology, surface markers, and differentiation capabilities. …”
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The Effect of the Toothbrushing and Surface Treatments on the Surface Roughness of Interim Crown Materials Used for Conventional, Subtractive, and Additive Manufacturing Techniques... by Beşar İzzetağa, Onur Şahin, Ayşegül Köroğlu, Hatice Nalan Bozoğulları

“…Background: This study aimed to compare the effect of the surface treatment and toothbrushing abrasion on the surface roughness of interim crown material specimens manufactured using conventional, subtractive, and additive processing techniques. Material and methods: 80 disk-shaped specimens were prepared from 4 different interim crown materials; one auto-polymerized polymethyl methacrylate resin (PMMA);(IM) and one bis-acryl composite resin;(AC) for conventional technique, one computer-aided design/computer-aided manufacturing (CAD-CAM) PMMA block;(TC) for subtractive process, one 3-dimensionally (3D) printed resin;(CB) for additive process. …”
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Prophylactic Impella CP versus VA-ECMO in Patients Undergoing Complex High-Risk Indicated PCI by Deborah M.F. van den Buijs, Adriaan Wilgenhof, Paul Knaapen, Carlo Zivelonghi, Tom Meijers, Paul Vermeersch, Fatih Arslan, Niels Verouden, Alex Nap, Krischan Sjauw, Floris S. van den Brink

“…However, comparable data on different forms of MCS are not at hand. Methods. In this multicenter observational study, we retrospectively evaluated all CHIP procedures with the support of an Impella CP or VA-ECMO, who were declined surgery by the heart team. …”
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Prognostic significance of Ki-67 in assessing the risk of progression, relapse or metastasis in pheochromocytomas and paragangliomas by Zilan Luo, Xu Yan, Yang Liu, Fengrui Nan, Yuhong Lei, Yuan Ren, Lingyu Li

“…The prognostic value of Ki-67 in assessing the risk of progression, relapse, or metastasis in PPGLs remains debated.Methods This cohort study included 501 patients diagnosed with PPGLs at the First Hospital of Jilin University between 2000 and 2022, with clinical data, treatment details, pathological indicators, and germline gene test results collected. …”
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Planetary health in action: developing a heatwave vulnerability tool for primary care by Karolina Griffiths, Paul Basso-Bert, Mireille Abraham, Elise Chin, Layana Caroupaye-Caroupin, Manal Ahikki, Emilie Agrech, Camille Debrock, Rim Sabri, Grégoire Mercier, François Carbonnel

“…Background: Heatwaves are becoming longer and more frequent. Despite the availability of open environmental data, little is operable and formatted for primary care use. …”
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Vascularized skin tissue models featuring adipose cell spheroid-laden GelMA hydrogels by Dongjin Lee, Sangmin Lee, Jeongbok Lee, Dahong Kim, Hyunseok Kwon, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Heungsoo Shin, Su A Park

“…However, the technical challenges associated with the development of an in vitro model of such complex tissues include the difficulties of integrating tissues with diverse characteristics. Here, we present a method using a gelatin methacryloyl (GelMA) hydrogel to establish a microenvironment that hosts connected composite tissues: a vascularized skin layer and a subcutaneous adipose layer. …”
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Efficacy and safety of off-label direct oral anticoagulants vs. warfarin for left ventricular thrombus: an inverse probability of treatment weighting analysis by Taha Al-Maimoony, Khairallah Al-Matari, Abdulhafeedh Al-Habeet, Nouradden Noman Aljaber, Mohamad Al-Marwala, Salah Al-Hashmi

“…Alongside individual endpoints, a composite endpoint involving ischemic stroke or mortality was also examined.ResultsIPTW estimates suggested that DOACs were significantly more effective than warfarin in resolving LV thrombus within one month (RR: 1.38; 95% CI: 1.14–1.66; p-value: <0.001). …”
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Clinical characteristics, prognosis, and predictive modeling in class IV ± V lupus nephritis by Anjing Wang, Anjing Wang, Yunlong Qin, Yunlong Qin, Yan Xing, Zixian Yu, Liuyifei Huang, Jinguo Yuan, Yueqing Hui, Mei Han, Guoshuang Xu, Jin Zhao, Shiren Sun

“…The composite endpoint of the study was defined as a decline in the estimated glomerular filtration rate (eGFR) by more than 50%, progression to end stage renal disease, or death, whichever came first. …”
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Depression and Associated Factors Among Diabetic Patients Undergoing Diabetic Retinopathy Assessments at a Tertiary Care Center: A Cross-Sectional Study by Upaphong P, Choovuthayakorn J, Choovuthayakorn J, Phinyo P, Patikulsila D, Nanegrungsunk O, Chaikitmongkol V, Kunavisarut P, Apivatthakakul A, Wongpakaran N, Wongpakaran T

“…This study showed that people who felt their vision problems were interfering with daily life and had higher anxiety were more likely to be depressed, no matter how severe their actual eye condition was. …”
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Multi-Authored Articles and the Real Contribution of the Researcher in the Convergence of Writing with the Three-Dimensional Measurement CAWH: Aerospace Engineering Field by Somayeh Ghavidel, Nosrat Riahinia, Farshid Danesh, Abdolreza Noroozi Chakoli

“…Additionally, this method can improve transparency and build trust within research organizations. …”
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Clinically Important Improvements and Disease Stability with Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy in the ELLITHE Trial: A Post Hoc R... by Kai-Michael Beeh, Karl Scheithe, Heike Schmutzler, Saskia Krüger

“…We evaluated responders, clinically important improvement (CII), disease stability (DS), and the relation of short- to long-term responses in patients with chronic obstructive pulmonary disease (COPD) in ELLITHE. Methods ELLITHE was a multicenter, open-label, non-interventional effectiveness study between 2020 and 2022 evaluating the effects of treatment initiation with once-daily single-inhaler triple therapy (odSITT) FF/UMEC/VI (100/62.5/25 µg via ELLIPTA) on COPD Assessment Test (CAT), forced expiratory volume in 1 s (FEV1), and exacerbations over 12 months. …”
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Mapping subtidal seagrass in the turbid Baltic Sea: Rethinking satellite sensor selection using a sensor-agnostic pipeline by Eike M. Schütt, Florian Uhl, Philipp R. Schubert, Thorsten B.H. Reusch, Natascha Oppelt

“…Traditional monitoring methods for subtidal seagrass meadows are costly and labour-intensive for large-scale, repetitive mapping efforts. …”
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Mechanical effects of foundation restoration on onlay preparations of mandibular first molars after endodontic treatment by Qiuyue Wang, Dongqi Shi, Xiangling Liu, Weijun Zhang, Zhaolun Sun, Yao Feng, Lingbo Zhang

“…However, the stress distribution of teeth restored after foundation restoration placement is not fully understood. Methods Finite element analysis was used in this study. …”
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A retrospective study on predicting clinically significant prostate cancer via a bi-parametric ultrasound-based deep learning radiomics model by Xiang Liu, Zhong-Xin Zhang, Bing Zheng, Min Xu, Xin-Yu Cao, Hai-Ming Huang

“…PurposeThis study aimed to establish and evaluate a model utilizing bi-parametric ultrasound-based deep learning radiomics (DLR) in conjunction with clinical factors to anticipate clinically significant prostate cancer (csPCa).MethodsWe retrospectively analyzed 232 participants from our institution who underwent both B-mode ultrasound and shear wave elastography (SWE) prior to prostate biopsy between June 2022 and December 2023. …”
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Trait mindfulness in early pregnancy and adverse perinatal outcomes: a prospective cohort study by Audra C. Fain, Tess E. K. Cersonsky, Margaret H. Bublitz, Adam K. Lewkowitz, Erika F. Werner, Emily S. Miller, Nina K. Ayala

“…We aimed to evaluate the association between trait mindfulness and adverse pregnancy outcomes. Methods This is a planned secondary analysis of a prospective cohort study of nulliparous participants recruited between May 2019 and February 2022 from a single, high volume tertiary care center. …”
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Evaluation of a pharmacist-led actionable audit and feedback intervention for improving medication safety in UK primary care: An interrupted time series analysis. by Niels Peek, Wouter T Gude, Richard N Keers, Richard Williams, Evangelos Kontopantelis, Mark Jeffries, Denham L Phipps, Benjamin Brown, Anthony J Avery, Darren M Ashcroft

“…<h4>Background</h4>We evaluated the impact of the pharmacist-led Safety Medication dASHboard (SMASH) intervention on medication safety in primary care.<h4>Methods and findings</h4>SMASH comprised (1) training of clinical pharmacists to deliver the intervention; (2) a web-based dashboard providing actionable, patient-level feedback; and (3) pharmacists reviewing individual at-risk patients, and initiating remedial actions or advising general practitioners on doing so. …”
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