Protein Catalysis Through Structural Dynamics: A Comprehensive Analysis of Energy Conversion in Enzymatic Systems and Its Computational Limitations by Sarfaraz K. Niazi

“…Recent studies have suggested that proteins in solution undergo constant deformation due to collisions with water molecules, generating potential energy that can be harnessed for catalytic functions. …”
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Novel MAGT1 Mutation Found in the First Chinese XMEN in Hong Kong by Elaine Yuen Ling Au, Edmund Kwok Kwan Tung, Ricky Wai Ki Ip, Philip Hei Li

“…In recent years, with the advances of molecular diagnostics, more and more patients have been reclassified with more defined entities after their genetic causes were found. …”
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Product Line Diversification as a Growth Strategy in the E-Commerce Market: From a Startup to a Multi-Million Dollar Company by Vladimir Kochnev

“…With growth needs continuing to rise, more and more E-commerce businesses are becoming prone to adopt product line diversification as a strategic option to enhance their growth, expand their market reach and revenue generation. …”
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Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review by Xiaohua Hong, Lei Zeng, Qiong Li, Tiankai Yang, Jing Zhou, Huayou Li, Yunchao Mo, Shaoyi Zhuo, Jiudong Ma, Jingyue Cai, Caipeng Xie

“…Case Presentation: In this article, we reported a case of persistent chronic diarrhea and renal failure due to E.b infection after liver transplantation, which was definitively diagnosed using metagenomic next-generation sequencing (mNGS). Short course of albendazole was applied to the patient, resulting in rapid resolution of clinical symptoms and recovery of renal function. …”
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A novel divergence measure in Dempster–Shafer evidence theory based on pignistic probability transform and its application in multi-sensor data fusion by Shijun Xu, Yi Hou, Xinpu Deng, Peibo Chen, Kewei Ouyang, Ye Zhang

“…Dempster–Shafer (D–S) evidence theory is more and more extensively applied in multi-sensor data fusion. …”
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An Extensive Study Using the Beetle Swarm Method to Optimize Single and Multiple Objectives of Various Optimal Power Flow Problems by K. Sriram, S. P. Mangaiyarkarasi, S. Sakthivel, L. Jebaraj

“…An electric energy generation system, under the economic operation mode, is an imperative mission in the power system function. …”
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How Productivity, Capital Investment, Employment, Human Capital and Energy Are Affecting Economic Growth in Morocco? An ARDL, FMOLS, DOLS and CCR Approaches by El Asli Hamdi, Azeroual Mohamed, Mekkaoui Youssef, Jamil Youssef

“…This paper aims to scrutinize the effects of; productivity, capital investment, human capital, employment and energy intensity; on economic growth in Morocco under the Energy-augmented Cobb Douglas production function (CDPF) framework, using extended data from 1965 to 2022. …”
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Anomalous Behavior in Weather Forecast Uncertainty: Implications for Ship Weather Routing by Marijana Marjanović, Jasna Prpić-Oršić, Anton Turk, Marko Valčić

“…This allows uncertainty to be quantified not as a static estimate, but as a function sensitive to both variable type and prediction horizon. …”
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Solubility Characteristics and Microstructure of Bitumen: A Review by Han Liu, Haibo Ding, Yanjun Qiu, Hinrich Grothe

“…The paper also highlights the development of solubility theories and various characterization tests for bitumen, as well as the distribution of functional groups of solvents and their parameters. …”
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Pre Hoc and Co Hoc Explainability: Frameworks for Integrating Interpretability into Machine Learning Training for Enhanced Transparency and Performance by Cagla Acun, Olfa Nasraoui

“…Pre hoc uses the white-box model to regularize the black-box model, while co hoc jointly optimizes both models with a shared loss function. We extend these frameworks to generate instance-specific explanations using Jensen–Shannon divergence as a regularization term. …”
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Predicting the Behavior of Road Users in Rural Areas for Self-Driving Cars by S. A. Ivanov, B. Rasheed

“…Another proposed feature is to use an adapted loss function that penalizes the network for generating trajectories that go beyond the drivable area. …”
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CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
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Chromosome-level genome assembly of Parotis chlorochroalis (Lepidoptera: Crambidae: Spilomelinae) by Mei Xiong, Rui Cheng, Bo He, Chun-Sheng Wu, Chao-Dong Zhu, Arong Luo, Qing-Song Zhou

“…The genome assembly includes 16,299 protein-coding genes, of which 94.82% have been functionally annotated. This chromosome-level genome assembly not only advance understanding of P. chlorochroalis but also has the potential to facilitate genomic studies of other lepidopteran species.…”
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ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies by Jie Zhang, Jyothi Sethuraman, Marissa Herrman, Pranav Murthy, Ramandeep Kaur, Jonathan T S Wong, Kevin P Nishimoto, Smitha R Y Gundurao, Arun Bhat, Blake T Aftab, Shon Green, Aruna Azameera, Morgan Smith-Boeck, Michael Salum, Yvan Chanthery, Melinda Au, Amy Doan, Christopher J Rold, Swapna Panuganti, Helen Budworth, Gauri Lamture, Alexander G Teague, Yogendra Verma, Elizabeth B Speltz, Katherine M Wang, Dishant Bhatwala, Ana Giner-Rubio, Pavan Puligujja, Aya Jakobovits

“…Homing barriers, immunosuppressive factors, and target antigen heterogeneity can impair CAR-T cell functional activity within the TME. Alternative strategies have contemplated incorporating the use of gamma delta (γδ) T cells as a CAR-T cell approach to potentially overcome these limitations. γδ T cells possess both innate and adaptive immunity to facilitate broad tumor recognition, and their natural propensity for tissue tropism may allow for more effective tumor infiltration. …”
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A kinetic model for USP14 regulated substrate degradation in 26S proteasome. by Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao

“…The model elucidates that USP14 typically reduces the substrate degradation rate and reveals the functional dependence of this rate on the concentrations of substrate and adenosine triphosphate (ATP). …”
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Spatial Planning and Sustainable Development of Qiangang Village Based on Catalyst Theory by Lin Xiuhong, Wu Yilin

“…We need to explore new ways that are more in line with rural development. Catalyst Theory is the process of generating catalytic reactions through small-scale element modification or introduction, driving the activation rate of surrounding large-scale spaces, and striving to create a spatial development model of “small leads to large” with minimal cost investment and minimal spatial intervention. …”
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TCDE: Differential Evolution for Topographical Contour-Based Prediction to Solve Multimodal Optimization Problems by Zhen Cheng, Yun Zhang, Caifu Fan, Xingwei Gao, Haohan Jia, Lei Jiang

“…Experiments were conducted on a set of eight widely recognized benchmark functions with 15 excellent optimization algorithms, including both DE and non-DE multimodal optimization approaches. …”
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Evaluation of the effectiveness of a modified liposuction protective device: an experimental study in swine by Luiz Roberto Reis Araújo, Marcelo de Paula Loureiro; Bruno Hirt, Gabriela Sgrance Cruz, Luigia Maria Nardi Santos, Mateus Herculano Bonifácio Santos

“…This study aims to create a skin protective device prototype from an old model, which serves this purpose, and to observe its functionality and its effects on the pigskin. The tests were carried out on dead animals without suffering provided by the Veterinary Medicine sector at Universidade Positivo. …”
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Comparative Analysis of Pressure Platform and Insole Devices for Plantar Pressure Assessment by Catarina M. Amaro, Maria F. Paulino, Sara Valvez, Luis Roseiro, Maria António Castro, Ana M. Amaro

“…This parameter is essential in static and dynamic analyses to access accurate diagnoses, study the human body biomechanics, create functional footwear designs, aid in rehabilitation and physiotherapy, and prevent injuries in athletes during sports practice. …”
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A customized image editing framework for diverse prohibited and restricted products in illegal online transactions by Wenjin Liu, Jingyu Zou, Shudong Zhang, Ning Luo, Haoming Liu

“…This framework integrates three novel components: (1) a PR-adapter that optimizes image prompts through image augmentation and compression representation techniques; (2) a text description generator combining the CLIP model and a multimodal large language model (MobileVLM) to generate more precise textual descriptions of images; and (3) an image generator, including a new loss function designed to fine-tune the stable diffusion model, enabling a better understanding of text semantics and generating images that more closely align with the textual descriptions. …”
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