Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…In general, photodegradation and biodegradation are more common than hydrolysis. In surface water, many PPCPs have avoided the strict biodegradation environment of wastewater treatment, and photochemistry may have a greater effect than the biodegradation under sunlight, in which antibiotics are mainly photodegraded in the water environment; ibuprofen, iopromide and caffeine are more prone to biodegradation; esters and amides are the most common functional groups that are easily hydrolyzed in PPCPs[63], and tetracycline can undergo hydrolysis reactions due to adsorption into sediments. …”
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The Effect of Delegation of Responsibilities on Teachers’ Performance in Selected Secondary Schools in Kabale Municipality, Kabale District. by Seth, Ahumuza

“…The study recommended that Head teachers should allocate more activities to teachers through ensuring that there is existence of functioning departments, consideration of expertise in assignment and allocation of activities, giving positions of responsibility to teachers and being flexible in the management of the schools through letting teachers be involved in handling different matters as situations arise. …”
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Space Imaging of Six-Wave Mixing in a Rydberg Dressing Atomic Ensemble by Junling Che, Jintao Bai, Yanpeng Zhang

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Improving transparency in malaria programme funds: A business case for connected diagnostics in Kenya by Charlotte M. Dieteren, Emmanuel Milimo, Angela Siteyi, Shannen van Duijn, Leon Stijvers, Lilyana Dayo, Gregory Ganda, Tobias F. Rinke de Wit

“…Conclusion: The concept of ConnDx can be used for any medical condition that can be diagnosed in a digital manner and linked to mobile payment systems. The generated data can contribute to better quality services for individual patients while at the same time support local health policy makers and managers for more targeted interventions. …”
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Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data by Vasiliki (Vicky) Bikia, Dionysios Adamopoulos, Dionysios Adamopoulos, Dionysios Adamopoulos, Marco Roffi, Marco Roffi, Georgios Rovas, Stéphane Noble, Stéphane Noble, François Mach, François Mach, Nikolaos Stergiopulos

“…Stroke volume (SV) is a major indicator of cardiovascular function, providing essential information about heart performance and blood flow adequacy. …”
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Generalized volume-complexity for Lovelock black holes by Monireh Emami, Shahrokh Parvizi

“…Abstract We study the time dependence of the generalized complexity of Lovelock black holes using the “complexity = anything” conjecture, which expands upon the notion of “complexity = volume” and generates a large class of observables. By applying a specific condition, a more limited class can be chosen, whose time growth is equivalent to a conserved momentum. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Abstract Plant growth behavior is a function of genetic network architecture. The importance of root microbiome variation driving plant functional traits is increasingly recognized, but the genetic mechanisms governing this variation are less studied. …”
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Development of a Force Feedback Controller with a Speed Feedforward Compensator for a Cable-Driven Actuator by Juan Fang, Michael Haldimann, Bardia Amiryavari, Robert Riener

“…The CDA consisted of a motor with a gearbox, a cable drum, and a force sensor. The transfer function between motor torque and cable force was estimated through an open-loop test. …”
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The Effect of Hydrogen Peroxide on Biogas and Methane Produced from Batch Mesophilic Anaerobic Digestion of Spent Coffee Grounds by Siham Sayoud, Kerroum Derbal, Antonio Panico, Ludovico Pontoni, Massimiliano Fabbricino, Francesco Pirozzi, Abderrezzaq Benalia

“…Further, while previous research has established oxidative pretreatment efficacy, this study uniquely combines the empirical analysis of H₂O₂ pretreatment with a detailed kinetic modeling approach using the modified Gompertz (MG) and logistic function (LF) models to estimate kinetic parameters and determine the accuracy of fit. …”
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Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer by Lu Zhang, Yan Wu, Suntao Li, Miao Guo, Jiaqi Zhao, Chengxi Cao, Yan Zhang, Hua Xiao

“…Compared to 95C EVs, 23 glycoproteins were significantly upregulated more than 20‐fold in 95D EVs, including CDCP1, TNC, NCAM2, and ITGA4. …”
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Quantifying the Impact of Comorbidities on Outcomes Following Surgery for Osteoporotic Vertebral Compression Fractures by Anmol Gupta, Thomas Cha, Joseph Schwab, Harold Fogel, Daniel Tobert, Afshin E. Razi, Carl Paulino, Christopher M. Bono, Stuart Hershman

“…Introduction Studies have shown that osteoporotic patients are more likely to have medical or surgical complications postoperatively. …”
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Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury by Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius

“…Abstract Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. …”
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Shotgun metagenomic sequencing reveals the influence of artisanal dairy environments on the microbiomes, quality, and safety of Idiazabal, a raw ewe milk PDO cheese by Gorka Santamarina-García, Min Yap, Fiona Crispie, Gustavo Amores, Cathy Lordan, Mailo Virto, Paul D. Cotter

“…Results The results revealed diverse microbial ecosystems across sample types, comprising more than 1300 bacterial genera and 3400 species. …”
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Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits by Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín

“…Milk oligosaccharide fermentation generated a more diverse metabolome compared to glucose. …”
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Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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The trials and errors of developing an experimental model to study the impact of maternal gut microbiome disruption on perinatal asphyxia by Mara Ioana Ionescu, Ana Maria Catrina, Ioana Alexandra Dogaru, Didina Catalina Barbalata, Cristian Ciotei, Cerasela Haidoiu, Vladimir Suhaianu, Gratiela Gradisteanu Pircalabioru, Siobhain M. O’Mahony, Ana-Maria Zagrean

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Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols by Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu

“…Interestingly, we found that while GPR161 signal almost completely disappeared from cilia upon Sonic hedgehog (SHH) stimulation in NSCs and immature neurons, this was not the case in more mature neurons, suggesting a possible developmental time window for cilia-dependent SHH signaling.ConclusionTaken together, our results provide a systematic description of cilia in hiPSC-derived neuronal cells generated with different protocols, underscoring the importance of selecting the optimal model system and controls for investigating primary cilia in hiPSC-derived neuronal cells.…”
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