Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity. by Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Andrea Brancale, David A Fidock, Karl F Hoffmann, Marcus C S Lee

“…Finally, we examined whether the predicted hydrolase activity of PfQRP1 underlies its mechanism of resistance, showing that both mutation of the putative catalytic triad and a more severe loss of function mutation elicited resistance. …”
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IMPACTO EN LOS PROCESOS SOCIALES Y DE COMUNICACIONES EN UNA ENTIDAD ONCOLÓGICA COLOMBIANA by GELLY GERALDINE ÁLVAREZ SUÁREZ, EVER ÁNGEL FUENTES ROJAS, ANDERSON STIWAR MURCIA GARCÍA

“…Oncological entities aim at training, prevention and education programs on cancer-related issues; the Social andCommunications areas are fundamental to achieve this objective, since it exploits each function around society to thuspotentiate strategies that can be dissemination, approach with family and patients, in such a way that the exchange ofinformation on topics is promoted of health, paying greater attention to the care, protection and implementation ofhealthy lifestyles, given the above, the need to incorporate different methodologies that can standardize the processesthat are carried out has been generated, resulting in opportunities for improvement and effectiveness. …”
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UFO: A tool for unifying biomedical ontology-based semantic similarity calculation, enrichment analysis and visualization. by Duc-Hau Le

“…Also, more functions would facilitate their task with ontology.…”
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FEAR OF SOCIAL ALIENATION OF LOVE AS GENDER CHARACTERISTICS by V. V. Melnyk, L. І. Моzhovyi, I. A. Reshetova

“…The paper investigates the fear of alienation of love, not as an instinct or psychological experience, or as a social factor, but as a correlation between the functional types of fear and the peculiarities of social and cultural processes, and it acts as a dependence of the European societies on the various functional forms of fear of love that influence the processes of social transformations. …”
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Robust single modified divacancy color centers in 4H-SiC under resonant excitation by Zhen-Xuan He, Ji-Yang Zhou, Qiang Li, Wu-Xi Lin, Rui-Jian Liang, Jun-Feng Wang, Xiao-Lei Wen, Zhi-He Hao, Wei Liu, Shuo Ren, Hao Li, Li-Xing You, Rui-Jun Zhang, Feng Zhang, Jian-Shun Tang, Jin-Shi Xu, Chuan-Feng Li, Guang-Can Guo

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Age-related changes in diffuse optical tomography sensitivity profiles in infancy. by Xiaoxue Fu, John E Richards

“…The peak of the sensitivity function in the head was largest at the smallest separation distance and decreased as separation distance increased. …”
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Type 1 diabetes prevention clinical trial simulator: Case reports of model‐informed drug development tool by Juan Francisco Morales, Marian Klose, Yannick Hoffert, Jagdeep T. Podichetty, Jackson Burton, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim

“…We then applied trial‐specific inclusion/exclusion criteria, sample sizes in treatment and placebo arms, trial duration, assessment interval, and dropout rate. We implemented a function for presumed drug effects. To increase the size of the population pool, we generated virtual populations using multivariate normal distribution and ctree machine learning algorithms. …”
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Evaluation of inhibitory efficacy of plantaricin JK against NSP1 from SARS-CoV-2 by in silico methods by Manisha Mandal, Shyamapada Mandal

“…NSP1 (non-structural protein-1) of SARS-CoV-2 acts as a host translation inhibitor and reduces host immune function, thereby increasing viral pathogenicity and virulence. …”
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Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C by Vadym Sulimenko, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Omar Skalli, Pavel Dráber

“…Abstract Background G protein-coupled receptor kinase-interacting proteins (GITs) function as GTPase-activating proteins (GAPs) for small GTPases of the ADP-ribosylation factor (Arf) family. …”
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Ozone Aeration Enhance Flowability, Structure, and Antioxidant Activity in Blueberry Pulp Powder by Newton C. Santos, Raphael L. J. Almeida, Anna E. S. Tomé, Fábio G. Teles, Railene H. C. R. Araújo, Juanne Q. Farias, Maria T. S. d. Fonseca, Virgínia M. d. A. Silva, Victor H. d. A. Ribeiro, Márcia R. d. S. Pedrini, Josivanda P. Gomes, Ana P. T. Rocha

“…Morphological analysis revealed that BPP produced smaller, uniform particles (11.70 µm), whereas BPS generated larger (16.67 µm) and more agglomerated particles. …”
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Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform by Iisa Tujula, Tanja Hyvärinen, Johanna Lotila, Julia Rogal, Dimitrios Voulgaris, Lassi Sukki, Kaisa Tornberg, Katri Korpela, Henna Jäntti, Tarja Malm, Anna Herland, Pasi Kallio, Susanna Narkilahti, Sanna Hagman

“…Importantly, the microfluidic coculture platform established in this study provides a more functional and advanced setup for investigating inflammatory glial interactions in vitro.…”
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A Skillful Prediction of Monsoon Intraseasonal Oscillation Using Deep Learning by K. M. Anirudh, Prasang Raj, S. Sandeep, Hariprasad Kodamana, C. T. Sabeerali

“…These indices were obtained through an extended empirical orthogonal function analysis conducted on 25 years of daily rainfall anomalies over the Indian region. …”
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Wingless strain created using binary transgenic CRISPR/Cas9 alleviates concerns about mass rearing of Hermetia illucens by Zongqing Kou, Shaozhen Wang, Xingyu Luo, Jun Xu, Jeffery K. Tomberlin, Yongping Huang

“…Taken together, this study validates effective genetic tools that can be used for gene function studies and industrial applications in black soldier fly and provides an approach to alleviate the concern about massive rearing.…”
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Mobile Robot Path Planning Considering Obstacle Gap Features by Hongwei Wang, Li He, Shuai Zhang, Ruoyang Bai, Yunhang Wang

“…Specifically, this method addresses the issues of low search efficiency, excessive redundant points, and poor path quality in the traditional A* algorithm for global path planning by extracting gap grids in the global grid map and incorporating their influence into the heuristic function, thereby guiding the search more effectively. …”
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Computation strategies and clinical applications in neoantigen discovery towards precision cancer immunotherapy by Zhenchang Wang, Yu Gu, Xiao Sun, Hao Huang

“…Previous studies have demonstrated their capacity to mediate tumor-specific immune responses in targeting and eliminating tumor cells while preserving normal cellular function. Driven by advancements in high-throughput sequencing technologies, mass spectrometry, and artificial intelligence, researchers have developed a growing interest in establishing more accurate neoantigen prediction algorithms. …”
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Forward Computational Modeling of Respiratory Airflow by Emmanuel A. Akor, Bing Han, Mingchao Cai, Ching-Long Lin, David W. Kaczka

“…Such computational techniques are also useful for analyzing structure–function relationships in healthy and diseased lungs, assessing regional ventilation at various time points over the course of clinical treatment, or elucidating the changes in airflow patterns over the life span. …”
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Accurate and Robust Stellar Rotation Periods Catalog for 82771 Kepler Stars Using Deep Learning by Ilay Kamai, Hagai B. Perets

“…We train LightPred on self-supervised contrastive pretraining and simulated light curves generated using a realistic spot model. Our evaluation demonstrates that LightPred outperforms classical methods like the autocorrelation function in terms of accuracy and average error. …”
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Simulation of Solar Panel Maximum Power Point Tracking Using the Fuzzy Logic Control Method by Anna Mutia, Dahlan Abdullah, Kraugusteeliana Kraugusteeliana, Susatyo Adhi Pramono, Hendi Sama

“…In this study, MPPT consists of a Boost Converter whose function is to regulate the output voltage, while the algorithm used is the fuzzy logic which works based on Error (E) and Change Error (CE) from changes in the voltage and current of the photovoltaic module. …”
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Comparative Analysis of Electrostatic Charging Characteristics Considering the Flow Conditions of Nonconductive Flammable Liquids by Junghwan Byeon, Hyeongon Park, Woong Ko

“…By considering not only the decrease in liquid conductivity with temperature changes but also the variation in the work function of solid materials, the underlying causes of the observed results can be understood. …”
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Modeling and Optimal Control Analysis Applied to Real Cases of COVID-19 Pandemic with Double Dose Vaccination in Ethiopia by Fekadu Mosisa Legesse, Koya Purnachandra Rao, Temesgen Duressa Keno

“…Moreover, disease-free and endemic equilibria are determined, and their local and global stabilities are discussed using the Lyapunov function technique. These equilibria are found to be locally asymptotically stable if R0<1 and R0>1, respectively. …”
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