Prediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein design. by Elisabeth Humphris-Narayanan, Eyal Akiva, Rocco Varela, Shane Ó Conchúir, Tanja Kortemme

“…We find the model correctly captures a considerable fraction of protease and reverse-transcriptase mutational tolerance and shows comparable accuracy using either experimentally determined or computationally generated structural ensembles. Predictions of tolerated sequence space afforded by the model provide insights into stability-function tradeoffs in the emergence of resistance mutations and into strengths and limitations of the computational model.…”
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Proteasome caspase-like activity regulates stress granules and proteasome condensates by Shirel Steinberger, Julia Adler, Nadav Myers, Yosef Shaul

“…To investigate the functional implications of CL activity, we generated cell lines devoid of CL function by introducing the PSMB6 T35A mutation. …”
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Large language models for efficient whole-organ MRI score-based reports and categorization in knee osteoarthritis by Yuxue Xie, Zhonghua Hu, Hongyue Tao, Yiwen Hu, Haoyu Liang, Xinmin Lu, Lei Wang, Xiangwen Li, Shuang Chen

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Behavioral Analysis of EEG Signals in Loss-Gain Decision-Making Experiments by Jiaquan Shen, Ningzhong Liu, Deguang Li, Binbin Zhang

“…The experimental results show that the EEG generated after behavioral decision due to loss is more intense than that generated by gain in the medial frontal cortex (MFC). …”
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Stem Cells as a Tool to Improve Outcomes of Islet Transplantation by Emily Sims, Carmella Evans-Molina

“…Stem cells have been utilized not only as a functional replacement for β cells, but also as companion or supportive cells to address a variety of different obstacles that prevent ideal graft viability and function. …”
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Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura by Michael R. Snyder, Robert W. Maitta

“…In particular, specific amino acid sequences in ADAMTS13 may lead to conformational structures recognized by autoantibodies. Generation of these antibodies may occur more frequently among patients with a genetic predisposition. …”
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Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy by Alexander Zheleznyak, Joel R. Garbow, Michal Neeman, Suzanne E. Lapi

“…Herein we report first-in-mouse PET imaging of fetuses employing both tracers [ 18 F]FDG (metabolism) and 64 Cu-ATSM (hypoxia). [ 18 F]FDG PET/CT imaging allowed clear visualization of placental-fetal structures and supported quantification of tracer uptake, making this a sensitive tool for monitoring placental function in preclinical rodent models. These measurements illustrate the potentially irreversible damage generated by chronic exposure to hypoxia, which cannot be corrected by acute exposure to hyperoxia.…”
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Identification of Ecological Security Pattern and Ecological Restoration Zoning Strategy in the Shandong Section of the Beijing-Hangzhou Grand Canal by Chizhou Xu, Yande Jing, Yiwen Zhang, Yingchun Liu, Wenyang Yin, Shiping Zhao

“…Additionally, 40 ecological corridors, 48 ecological pinch points, and 75 ecological barrier points were generated, densely distributed in the east. The area was divided into five core functional zones. (4) Conclusions: Establishing ecological function zones and considering landscape changes from high-frequency human activities in spatial planning can lead to a more reasonable division of ecological restoration areas. …”
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Rice Leaf Disease Image Enhancement Based on Improved CycleGAN by YAN Congkuan, ZHU Dequan, MENG Fankai, YANG Yuqing, TANG Qixing, ZHANG Aifang, LIAO Juan

“…This addition enabled the deep learning model to more accurately measure perceptual differences between the generated images and real images, thereby guiding the network towards producing higher-quality samples. …”
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A Historical Approach to the Mirror Neuron System by Palacios-Sánchez, Leonardo, Botía, Inés, Palacios-Espinosa, Ximena

“…The initial enthusiasm manifested with the discovery of MN has been progressively nuanced, giving rise to a functional, neuroscientific perspective that requires more evidence on its therapeutic utility and applicability in areas of knowledge beyond health sciences.…”
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VISUALIZATION AND QUANTITATIVE CHARACTERIZATION OF SMALL OBJECTS IN A LENS ACOUSTIC MICROSCOPE WITH A TWO-DIMENSIONAL ARRAY by S. A. Titov, A. N. Bogachenkov

“…On the basis of the paraxial approximation it was found that the recorded spatio-temporal signal of the microscope ultrasonic array can be treated as an estimation of the scattering function of visualized objects. It was theoretically established that the scattering functions of the observed inhomogeneities can be used for the interpretation of the generated acoustic images. …”
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Modulation of network excitability by persistent activity: how working memory affects the response to incoming stimuli. by Elisa M Tartaglia, Nicolas Brunel, Gianluigi Mongillo

“…Neurons more active will be more excitable, and thus more responsive to external inputs. …”
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The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. by M Elise Bullock, Thea Hogan, Cayman Williams, Sinead Morris, Maria Nowicka, Minahil Sharjeel, Christiaan van Dorp, Andrew J Yates, Benedict Seddon

“…This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age.…”
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New Lifetime Distribution and its Application to Cancer Data by Samuel Adewale ADEROJU, Nihimat Iyebuhola Aleshinloye, Bako Lukmon Taiwo, Bello Ishola Sanni

“…Some of its mathematical properties such as the density function, cumulative distribution function, survival function, hazard rate function, moment generating function, Renyi entropy and order statistics are obtained. …”
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Constructing Real-Life Benchmarks for Community Detection by Rewiring Edges by Jing Xiao, Hong-Fei Ren, Xiao-Ke Xu

“…In order to make the performance evaluation of community detection algorithms more accurate and deepen our analysis of community structures and functional characteristics of real-life networks, a new benchmark constructing method is designed from the perspective of directly rewiring edges in a real-life network instead of building a model. …”
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A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast by Emma J Fenech, Nir Cohen, Meital Kupervaser, Zohar Gazi, Maya Schuldiner

“…Abstract Identification of both stable and transient interactions is essential for understanding protein function and regulation. While assessing stable interactions is more straightforward, capturing transient ones is challenging. …”
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Deriving Test Suites with the Guaranteed Fault Coverage for Extended Finite State Machines by A. D. Ermakov, N. V. Yevtushenko

“…However, the performed experiments clearly show that a test suite extended by such distinguishing sequences detects much more functional faults in software implementations of a system whose behaviour is described by the given EFSM.…”
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Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation by Jing Yang, Xuheng Sun, Hongjing Jiang, Jiandong Li, Jierong Liang, Zhanyi Lin

“…Methods This study systematically compared cell sheets generated under SFM and 10% FBS culture conditions in terms of structure, cellular phenotype, and functional properties. …”
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Recovery of Bioactive Peptides from Food Wastes and Their Bioavailability Properties by Ahmet Görgüç, Esra Gençdağ, Fatih Mehmet Yılmaz

“…Ensuring the correct and efficient use and recycling of wastes having high protein content and generated throughout the food production and supply chain is becoming more important both in our country and all over the world. …”
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No evidence for cardiac dysfunction in Kif6 mutant mice. by Abdul Hameed, Ellen Bennett, Barbara Ciani, Loes P C Hoebers, Roy Milner, Allan Lawrie, Sheila E Francis, Andrew J Grierson

“…We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. …”
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