TODAY'S CONSUMERS ON THE MARKET IN CSÍKSZEREDA (MIERCUREA CIUC) by Emőke Katalin Péter, László Illyés

“… Due to the geographical situation of Harghita County, farming mostly in small agricultural areas encourages farmers to engage in more integrated agricultural activities. As a result, more and more farmers who are open to development are starting to appear on local markets with processed products. …”
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Unlocking data: Decision-maker perspectives on cross-sectoral data sharing and linkage as part of a whole-systems approach to public health policy and practice by Emily Tweed, Kristina Cimova, Peter Craig, Mirjam Allik, Denise Brown, Mhairi Campbell, David Henderson, Charlie Mayor, Petra Meier, Nick Watson

“…This covered three key overarching themes: differing understandings of evidence; diverse functions of evidence; and factors affecting use (such as technical, political and institutional, workforce and governance). …”
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LcIMT1, a litchi inositol methyl transferase gene, is responsible for d-bornesitol biosynthesis and confers drought tolerance by Liang-Liang Huang, Xin-Ying Li, Fang-Fang Liu, Xu-Ming Huang, Ren-Fang Zeng, Farhat Abbas, Hui-Cong Wang

“…l-quebrachitol, also known as 2-O-methyl-l-chiro-inositol, is a common form of methylated cyclitol found in Litchi chinensis, accounting for more than half of the soluble sugars. Nonetheless, the biological function of l-quebrachitol is somewhat restricted. …”
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Análisis de imágenes mediante el método de los momentos usando funciones de base continuas a intervalos (PCBF) by Sergio Domínguez

“…Abstract: Invariants generated departing from moments, previously extracted from an image, appear frequently in the bibliography as one of the most powerful means of describing images, and more precisely shapes. …”
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Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Atte... by N. Ikani, A. Tyborowska, N. Kohn, N. Günther, G J. Siegle, A. H. Schene, J. A. S. Vorstman, C. J. Harmer, M. J. Kas, J. N. Vrijsen, H. G. Ruhé

“…Abstract Background Major Depressive Disorder (MDD) has a 50–80% recurrence rate highlighting the urgent need for more efficient recurrence prevention programs. Currently, recurrences are often identified too late, while existing preventive strategies may not sufficiently address ethio-patho-physiological mechanisms for recurrence. …”
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In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication by Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha

“…The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. …”
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Caged-hypocrellin mediated photodynamic therapy induces chromatin remodeling and disrupts mitochondrial energy metabolism in multidrug-resistant Candida auris by Xinyao Liu, Yiran Tao, Linwan Zhang, Yuzhou Liu, Dongmei Shi, Jiao Wang, Peng Xue, Bin Xu, Wenjie Fang, Yuping Ran

“…Confocal imaging confirmed that high-dose COP1T-HA-mediated PDT induces localized ROS accumulation near the nucleus and a temporally ordered cellular stress response. Furthermore, functional validation through QCR10, NDUFA5, and MP knockouts confirmed the essential roles of these genes in mitochondrial integrity, ATP synthesis, ROS homeostasis, and biofilm formation. …”
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Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility by Jing Shen, Zhen Li, Xiaoyu Liu, Mengqi Zheng, Peng Zhang, Yatai Chen, Qiuheng Tian, Wenyu Tian, Guanjun Kou, Yanyan Cui, Bowen Xu, Yunjiao Zhai, Weijia Li, Xiaohuan Guo, Ju Qiu, Chunyang Li, Ran He, Lixiang Li, Chunhong Ma, Yanqing Li, Xiuli Zuo, Detian Yuan, Shiyang Li

“…Mechanistically, the NAD+ salvage pathway regulates gut ILC2s in a cell‐intrinsic manner by supporting the generation of succinate, which fuels the electron transport chain to sustaining ILC2s function. …”
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Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants by Yan Cheng, Tianxi Zhang, Chao Yang, Kefyalew Gebeyew, Chengyu Ye, Xinxin Zhou, Tianqi Zhang, Ganyi Feng, Rui Li, Zhixiong He, Oren Parnas, Zhiliang Tan

“…A better understanding of the physiological mechanisms that regulate digestion patterns in ruminants could lead to an increased use of starch concentrates. Here we show more robust pancreatic exocrine function in adult goats (AG) than in neonatal goats (NG) by combining scRNA-seq and proteomic analysis. …”
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Anisotropic flexible stress sensors based on Loofah/CN/MWCNTs by 刘璐, 贾晓丽, 黄书童, 张景龙, 李守宝, 柯燎亮

“…Consequently, the loofah skeleton and conductive coating were compressed and released simultaneously, effectively functioning as a variable resistor. As applied stress increased, the loofah framework became more compact, gradually increasing the contact area between carbon-based materials of different sizes, thereby generating new current pathways. …”
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Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory dis... by Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Annina Lyly, Annina Lyly, Viljami Salmi, Viljami Salmi, Mikko Nuutinen, Mikko Nuutinen, Michael Kilpiö, Michael Kilpiö, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Mikko Niemi, Mikko Niemi, Mikko Niemi, Anu Laulajainen-Hongisto, Lena Hafrén, Mika Mäkelä, Paula Kauppi, Paula Virkkula, Alma Helevä, Alma Helevä

“…Secondary measures include variations in nasal polyp scores, CRS symptom control, general HRQoL, work productivity loss, peak nasal inspiratory flow (PNIF) with or without acoustic rhinometry (ARM), olfactory function assessed by the Sniffin' Sticks identification test, spirometry, peak expiratory flow (PEF), and histopathological findings at the 12-month follow-up.DiscussionThe AirGOs Medical trial is expected to generate data on the therapeutic value and safety profile of ATAD in patients with coexisting severe CRSwNP, N-ERD, and asthma, potentially informing future clinical practice. …”
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Leisure, work and simultaneous study in distance and virtual students (Ocio, trabajo y estudio simultáneo de estudiantes en modalidad a distancia y virtual) by Leonardo Andrés Aguirre-Cardona, Isabel Rubio-Florido, Edwin Alberto Puerto-Rodríguez

“…  The studies, analysis, reflections and positions regarding the leisure-work relationship is not new and is current, although sometimes it is not tangible and visible at first glance, even more so when the young population in Colombia takes advantage of distance and virtual education to be able to work and generate income and thus pay for a study; Thus, it was sought to analyze the incidence of working and studying simultaneously in the leisure time and spaces of students in distance and virtual mode of the Minuto de Dios-Uniminuto University Corporation in Bogotá-Colombia. …”
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Experimental Study on Hydraulic Characteristics of Fish-friendly Culverts with Baffles by MAO Jing-qiao, LU Peng, GONG Yi-qing, GAO Huan, DAI Jie

“…The transient vortices formed had planes parallel to the fish’s spine and body axis, reducing energy loss during upstream movement and improving swimming efficiency through vortex energy transfer. This provided a more favorable flow environment for weak-swimming fish species. …”
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Proses Kreatif Komposisi Karawitan “Gesang” Sebagai Wujud Representasi Sosial by Vivi Euis Susanti, Tri Suhatmini

“…The findings indicate that Gesang achieves an aesthetically rich musical form and exemplifies how karawitan can function as an expressive medium responsive to contemporary cultural developments. …”
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HEMOPHILIA: ADVANCES IN TREATMENTS by Nurgül Karakaya

“…Another method is PEGylation, where one or more PEG chains are covalently linked to rFVIII or rFIX. …”
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Optimization design of liquid crystal-based reconfigurable intelligent surface-assisted indoor visible light communication systems by Lisu YU, Xinxin LÜ, Run ZHONG, Mingli ZHANG, Zhenghai WANG, Yuhao WANG

“…Owing to the nonconvexity of the objective function, it is first transformed into a multinomial fractional planning problem using the Lagrangian dual transform, making it more tractable. …”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…As a result, few fully functional variable-rate spraying systems have been developed based on this parameter.MethodsThis study presents a variable-rate spraying method that integrates global navigation satellite system (GNSS) positioning with wind-excited audio-conducted estimation of canopy leaf area density. …”
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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…Methods We developed a new combination strategy for the synthesis of penetrating peptides functionalized with targeting of integrin α6. The linear peptide S5 was multimerized with 4 copies in linear sequential order spaced by GSG between each copy to yield the 4S5 peptide. …”
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Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…This TriKE is comprised of a camelid nanobody that binds to CD16 on NK cells, an interleukin (IL)-15 moiety, and another novel camelid nanobody that binds to the B7-H3 antigen, which is highly and specifically expressed on the tumor cell surface.Methods The B7H3 TriKE was generated using a mammalian expression system. Its functionality was evaluated using flow cytometry-based NK cell degranulation, cytokine production, proliferation and live cell imaging cytotoxicity assays. …”
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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

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