Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer by Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

“…GO and KEGG analysis confirmed these genes were enriched in the generation of precursor metabolites and energy. It illustrated more lymphocyte infiltration in the high MS group than low MS group. …”
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Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 by Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages

“…The method generates a ranking of drug-target interactions, the most promising of which are channeled towards experimental validation. …”
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Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy by Keisuke Shirai, Tiffany Chen, Mary Jo Turk, Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Joseph D Phillips, Pamela C Rosato, Yina H Huang

“…However, the underlying basis for treatment efficacy, more specifically the implications of codepleting other CD4-expressing cell compartments in tumor-bearing hosts, is not well understood.Methods Tumor-bearing mice were treated with anti-CD4 versus other therapies that preserve helper T cell function, and the priming, tissue distribution, and maintenance of tumor antigen-specific CD8 T cells were assessed. …”
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Transcriptional profiles of Microcystis reveal gene expression shifts that promote bloom persistence in in situ mesocosms by Lauren E. Krausfeldt, Paisley S. Samuel, Robert P. Smith, Hidetoshi Urakawa, Barry H. Rosen, Rita R. Colwell, Jose V. Lopez

“…We added pulses of nutrients that are commonly associated with anthropogenic sources to the mesocosms for 72 hours and collected samples for metatranscriptomics to examine how the physiological function of Microcystis and bloom status changed. The addition of nitrogen (N) as urea, but not the addition of PO4, resulted in conspicuous bloom persistence for at least 9 days after the final introduction of nutrients. …”
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Sustainable and cost-efficient hydrogen production using platinum clusters at minimal loading by Hongliang Zeng, Zheng Chen, Qiu Jiang, Qingtian Zhong, Yuan Ji, Yizhen Chen, Jiawei Li, Chunxiao Liu, Runhao Zhang, Jialin Tang, Xiaoxia Xiong, Zhongyue Zhang, Zhaoyang Chen, Yizhou Dai, Chengbo Li, Yinfang Chen, Donghao Zhao, Xu Li, Tingting Zheng, Xin Xu, Chuan Xia

“…We herein present a Mo2TiC2 MXene-supported Pt nanocluster catalyst (Mo2TiC2-PtNC) that requires a minimal Pt content (36 μg cm−2) to function, yet remains highly active and stable. Operando spectroscopy and theoretical simulation provide evidence for anomalous charge transfer from the MXene substrate to PtNC, thus generating highly efficient electron-rich Pt sites for robust hydrogen evolution. …”
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Expectation Confirmation and Technology Acceptance: A Study of the Public's Attention to Accept the Government's Digital Human Avatar by Jinghao CHEN, Feng JIA, Qianxi LIU

“…Unlike previous studies that have focused primarily on technological and functional aspects, this research emphasizes users' perceptions and expectations, filling the gap in existing research on user experience. …”
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Paper and cardboard as sustainable materials by Jerzy F. Latka

“…Sustainable construction improves the life cycle of building by lengthening the lifespan of building components, increasing the flexibility of the functional and spatial layout of buildings and their potential changes, and promoting the recycling of materials and products after a building has been demolished. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Results: Transgenic mice showed more depressive-like behaviors in the forced swim test, but not in the tail suspension, anxiety, or memory tests. …”
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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

“…While the large and complex genome of pepper severely hampered the understanding of its functional genome, it also indicates a rich yet unexplored reservoir of regulatory elements (REs). …”
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Educational Technologies in Modern Higher Education Institutions (Analysis of Russian and Foreign Research and Practice) by N. V. Bordovskaia, E. A. Koshkina, N. A. Bochkina

“…Statistically significant differences were identified for all considered functional characteristics of educational technology in Russian and foreign publications, with the exception of “Student Attitude to Educational Technology”. …”
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Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean by Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao, Qingxin Song

“…To accelerate utilization of SoyGRN, we develop an interactive webserver ( www.soytfbase.cn ) for soybean community to explore functional TFs involved in trait regulation. Conclusions Overall, our study unravels intricate landscape of TF-target interactions in soybean and provides a valuable resource for dissecting key regulators for control of agronomic traits to accelerate soybean improvement.…”
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Solar Spectrum Simulation Algorithms Considering AM0G and AM1.5G by Junjie Yang, Guoyu Zhang, Bin Zhao, Dongpeng Yang, Ke Zhang, Yu Zhang, Jian Zhang, Zhengwei Ren, Jingrui Sun, Lu Wang, Xiaoxu Mo, Taiyang Ren, Dianwu Ren, Zeng Peng, Songzhou Yang, Jiabo Lv

“…An LSTM-based neural network for solar spectrum simulation was developed, with the RMSE serving as the evaluation function. The analysis and selection of 29 narrowband LEDs produced 5000 solar spectrum simulation training datasets. …”
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New insights of cerium oxide nanoparticles in head and neck cancer treatment by Elif Tarakci, Sahra Esmkhani, Jamila Bayramova, Feride Melisa Bilgin, Kubra Kidik, Sevin Adiguzel, Yigithan Tufan, Ahsen Morva Yilmaz, Hulya Yilmaz, Ozgur Duygulu, Serpil Harbeck, Batur Ercan, Filiz Kaya, Digdem Aktoprakligil Aksu, Hulya Yazici, Hilal Yazici

“…The effectivity of the SD1 and SD2 on the HNC cell lines (A253, SCC-25, FaDu) were investigated by analyzing their cytotoxicity, genotoxicity, reactive oxygen species (ROS) generation properties. Low IC50 value, high ROS generation and stability profiling of SD2 compared to SD1 indicates the distinct function of dextran type on Dex-CeNPs effectivity on HNC. …”
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A Reflection on the Visual Representation of Nationalism Discourse in Iran During the Qajar Period (A Case Study of Qajar Newspaper Images as Cultural Texts of the Modernization Pe... by Shadi Taki, Sedaghat Jabbari Kalkhoran, Yaghoub Azhand

“…In response to this question, the formation and function of modern nationalist thought and the process of its discursive development within the context of its related codes will first be explored. …”
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Contribution of entropy analysis on three-dimensional Prandtl model under Hall and ion slip effects with generalized mass and heat fluxes via OHAM by Sana Akbar, Muhammad Sohail, Syed Tehseen Abbas, Abha Singh

“…The influence of distinct parameters associated with this current study like Brownian and diffusion constraint, temperature and also concentration difference, Eckert number, Hall as well as ion slip parameters, Brinkman number, magnetic constraint, radiation and Prandtl fluid constraint are sketched for temperature, velocity field along xy-axes, concentration and entropy generation rate. It is noticed that velocity distribution along x-axes is an increasing function of magnetic constraint, Prandtl fluid and also elastic constraint whilst contrast impact is seen along y-axes. …”
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Sepsis beyond bundles: contextualising paediatric care in resource-limited settings through situational analysis by John Adabie Appiah, Leah Ratner, Sheila Agyeiwaa Owusu, Ahmet Uluer, Gustav Nettey, Allysa Warling, Charles Martyn-Dickens, Emma Otchere, R. Elaine Cagnina, Maame Fremah Kotoh- Mortty, Eugene Martey

“…Paediatric sepsis bundles, which include prompt administration of antibiotics, fluid resuscitation and continuous organ function monitoring, are crucial for improving outcomes, especially when initiated within the first ‘golden hour’ of sepsis recognition. …”
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RESEARCH OF EFFECT OF PLATELET RICH FIBRIN, PRF ON PARADONTOSIS TISSUES REGENERATION DURING THE EXPERIMENT by О. S. Barylo, Т. М. Kanishyna, А.V. Biloshytska

“…The main function of macrophages is absorption and resorption of foreign structures. …”
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Biomarkers for neurodegenerative diseases in regulatory decision‐making by the European Medicines Agency by Audrey M. M. Hermans, Elisabeth Bakker, Viktoriia Starokozhko, Loes den Otter, André J. A. Elferink, Angela Bradshaw, Lorenzo Guizzaro, Peter G. M. Mol, Anna M. G. Pasmooij

“…BMs were categorized based on both nature and function. RESULTS In total, 105 procedures that discussed BMs were analyzed, 57 SAs (January 2020 to December 2022), 19 QAs/QOs (January 2008 to December 2023), and 29 MAAs (January 1995 to December 2023). …”
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Prediction of dam deformation using adaptive noise CEEMDAN and BiGRU time series modeling by WANG Zixuan, OU Bin, CHEN Dehui, YANG Shiyong, ZHAO Dingzhu, FU Shuyan

“…【Method】The model uses sample entropy reconstruction and the K-means clustering algorithm to optimize the adaptive noise complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) process, generating multiple intrinsic mode functions (IMF). …”
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Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight by Sitara Ejaz, Hafiz Muhammad Haseeb Khaliq

“…Data indicates that individuals who spend more than three hours daily on social media face a 60% higher likelihood of developing anxiety or depressive symptoms 5. …”
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