Syphilitic infection: a study on the factors of the innate humoral immune response by N. K. Levchik, N. V. Zilberberg, M. V. Ponomareva, O. A. Belykh

“…B1 cells are an innate subpopulation of B cells in the fetal hematopoiesis responsible for natural antibody production in the absence of exogenous stimulation. The protective function of B1 cells is to provide protection during the lag phase, the latent period necessary for the deployment of adaptive/acquired immunity mechanisms upon encountering an infectious agent, and in the regulation of subsequent immune responses. …”
Get full text

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. by Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

“…By further elucidating how Schistosoma molecular components cooperate to regulate parasite developmental processes, next generation targets will be identified. Here, we continue our studies on schistosome epigenetic participants and characterise the function of a DNA methylation reader, the Schistosoma mansoni methyl-CpG-binding domain protein (SmMBD2/3). …”
Get full text

Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones. by Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls

“…In summary, our results illuminate the pathophysiological basis of pancreatic β-cell hormone deficits in PWS, with evolutionary implications for the multigenic PWS-domain, and indicate that PWS-imprinted genes coordinate concerted regulation of ER chaperone biosynthesis and β-cell secretory pathway function.…”
Get full text

A Novel Time-Varying P-III Distribution Curve Fitting Model to Estimate Design Floods in Three Gorges Reservoir Operation Period by Yuzuo Xie, Shenglian Guo, Sirui Zhong, Xiaoya Wang, Jing Tian, Zhiming Liang

“…The results indicate that: (1) The modified reservoir index used as a covariate can effectively capture the non-stationary characteristics of the flood series; (2) The Tv-P3/CF model emphasizes the fitness of historical information, yielding superior results compared to time-varying P-III distribution estimated by the maximum likelihood method; (3) Compared to the original design values, the 1000-year design peak discharge <i>Q</i>_m and 3-day and 7-day flood volumes in the TGR operation period are reduced by approximately 20%, while the 15-day and 30-day flood volumes are reduced by about 16%; (4) The flood-limited water level of the TGR can be raised from 145 m to 154 m, which can annually generate 0.32 billion kW h more hydropower (or increase by 6.8%) during flood season without increasing flood prevention risks.…”
Get full text

ELTrack: Events-Language Description for Visual Object Tracking by Mohamad Alansari, Khaled Alnuaimi, Sara Alansari, Sajid Javed

“…ELTrack synthesizes event data, filters out noise, and applies imprinting and a step decay function to introduce a novel event image representation called Pseudo-Frames. …”
Get full text

Intertextuality of the Personosphere as a Factor of Meta-Genre (Clifford Simak “Shakespeare’s Planet”) by Dan Paranyuk, Alyona Tychinina

“…In this case, in Simak’s “Shakespeare’s Planet”, they perform the function of additional (implicit) narratives, and, consequently, as a particular (intertextual) link in the personosphere. …”
Get full text

Complex Synchronization Dynamics of Electronic Oscillators&#x2013;Part II: Simulations and Validation of Phase-Amplitude Reduced Models by Konstantinos Metaxas, Nikolaos P. Eleftheriou, Yannis Kominis, Paul P. Sotiriadis

“…The developed time-domain approach demonstrates that the same limit cycle oscillator can produce periodic output with tunable spectral characteristics, operating as a frequency divider, or function as a chaotic or quasiperiodic signal generator, depending on the driving signal. …”
Get full text

Optimal Planning of Wind-Based DG: A Two-Stage Approach Linking Penetration Factor, Turbine Type Selection, Capacity, and Power Factors to Minimize Line Losses by Sina Saboktakin, Tarek Medalel Masaud, Ehab F. El-Saadany

“…This is achieved through a novel correlation between DG size, loss reduction, and power factor improvement, ensuring a cost-effective and efficient solution using a single-objective function instead of more complex multi-objective approaches. …”
Get full text

Co-Simulation Model for Determination of Optimal Active Power Filters Settings in Low-Voltage Network by Mario Primorac, Zvonimir Klaić, Heidi Adrić, Matej Žnidarec

“…Applying optimization techniques enables the development of more realistic models for applying active power filters. …”
Get full text

Biomechanics and Performance of Single-Leg Vertical and Horizontal Hop in Adolescents Post-Anterior Cruciate Ligament Reconstruction by Eva M. Ciccodicola, Alison M. Hanson, Shawn E. Roberts, Mia J. Katzel, Tishya A. L. Wren

“…Biomechanics were compared between limbs and as a function of group using linear mixed models. <b>Results</b>: Among the 19 patients (15 female; age 16.3 years; 9.2 months post-surgery), approximately half were classified as asymmetric (10/19 = 53% for SLHH; 9/19 = 47% for SLVH). …”
Get full text

A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…In conventional ADCs, the drug molecules are chemically attached randomly to antibody surface residues (typically Lys or Cys), which can interfere with epitope binding and targeting, and lead to overall product heterogeneity, long-term colloidal instability and unfavorable pharmacokinetics. Here, we present a more controlled process for generating ADCs where drug is specifically conjugated to only Fab N-linked glycans in a narrow ratio range through functionalized sialic acids. …”
Get full text

New horizons in microbial fuel cell technology: applications, challenges, and prospects by Tikam Chand Dakal, Nitesh Singh, Amandeep Kaur, Prabhsangam Kaur Dhillon, Janvi Bhatankar, Ramovatar Meena, Rakesh Kumar Sharma, B. R. Gadi, Bikram Sen Sahu, Asmita Patel, Buddha Singh, Kajal Kumari

“…We conclude that nanotechnology-enabled MFCs, combined with engineered microbes and optimized system designs, hold immense potential for revolutionizing sustainable energy generation and biosensing applications, paving the way for a cleaner and more efficient future.…”
Get full text

Experimental Research on Environment Assistant Fatigue of Domestic SA-508-Ⅲ-1 Steel and Prediction Model Development for PWR Nuclear Power Plant by SHEN Rui, LIU Chang, TANG Lichen, WANG Bingxi

“…Comparing with ANL model, the fatigue prediction model of environmental assistant fatigue obtained by this paper is more suitable for fatigue life prediction of domestic SA-508-Ⅲ-1 steel, which can be used as a reference for the design of the primary loop equipment considering environmental assistant fatigue effect for the third generation nuclear power plant.…”

Sugarcane Straw Hemicellulose Extraction by Autohydrolysis for Cosmetic Applications by Maria João Pereira, Sílvia S. Pedrosa, Joana R. Costa, Maria João Carvalho, Tânia Neto, Ana L. Oliveira, Manuela Pintado, Ana Raquel Madureira

“…Sugarcane is a popular crop whose cultivation generates a wide range of by-products. The aim was to optimize the hydrothermal extraction of hemicellulose from sugarcane straw using response-surface methods with a two-factor composite design and to assess its functional qualities. …”
Get full text

Cultivars of the Itoh peony group in the collection of the M. M. Hryshko National Botanical Garden National Academy of Sciences of Ukraine by В. Ф. Горобець, Т. О. Щербакова

“…The Itoh group varieties of the collection can be material for developing technologies for their cultivation and propagation, can be a source of replenishment and expansion of regional botanical gardens collections, planting material for gardening and landscaping, and also perform an educational and cognitive function.…”
Get full text

Resectograms: Planning liver surgery with real-time occlusion-free visualization of virtual resections by Ruoyan Meng, Davit Aghayan, Egidijus Pelanis, Bjørn Edwin, Faouzi Alaya Cheikh, Rafael Palomar

“…To further improve functionality, we explored three flattening methods: fixed-shape, Least Squares Conformal Maps, and As-Rigid-As-Possible, to generate these 2D views. …”
Get full text

A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging by Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Youjun Yang

Get full text

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

“…Finally, combination MG1 and programmed cell death protein-1 antibody (αPD-1) therapy was investigated in advanced 4434 tumors.Results MG1 effectively supported priming of functional cytotoxic T cells (CTLs) against tumor-associated antigens as well as virus-derived peptides, as assessed using peptide recall and T2 killing assays, respectively. …”
Get full text

Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals by Ruili Wang, Baohui Hu, Ziyu Pan, Chongxia Mo, Xin Zhao, Guojia Liu, Ping Hou, Qi Cui, Zhao Xu, Wenjia Wang, Zhaojin Yu, Lin Zhao, Miao He, Yan Wang, Chen Fu, Minjie Wei, Lifeng Yu

“…This review provides a comprehensive overview of ADCs, summarizing the structural and functional characteristics of the three core components, antibody, linker, and payload. …”
Get full text

Performance Study on Zn-Doped α-FeOOH in Removing H2S from Blast Furnace Gas by Bin WANG, Xudong LIU, Yuran LI, Li LIU, Wenqing XU, Tingyu ZHU

“…In situ infrared spectroscopy analysis revealed that Zn functions as a catalyst component and also directly interacts with H2S to form ZnS. …”
Get full text