Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Siran Yue, Junyu Fan, Duoli Xie, Chunhao Cao, Zhuqian Wang, Jie Huang, Fang Qiu, Xu Yang, Dongyi He, Aiping Lu, Chao Liang

“…A deeper understanding of the molecular and functional heterogeneity of FLS may pave the way for more effective and precise therapeutic interventions in RA.…”
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Revolutionizing pharmacology: AI-powered approaches in molecular modeling and ADMET prediction by Irfan Pathan, Arif Raza, Adarsh Sahu, Mohit Joshi, Yamini Sahu, Yash Patil, Mohammad Adnan Raza, Ajazuddin

“…The convergence of AI with quantum chemistry and density functional theory (DFT) is illustrated through surrogate modeling and reaction mechanism prediction. …”
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Blockchain and NFT-Based Solution for Genomic Data Management, Sharing, and Monetization by Ahmad Musamih, Khaled Salah, Raja Jayaraman, Samer Ellaham, Mohammed Omar, Ibrar Yaqoob

“…We present various diagrams and algorithms to illustrate the functionality of our solution. Our testing and validation results demonstrate that smart contracts function as intended. …”
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Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy by Yutao Zou, Junjie Wu, Qiuyun Zhang, Jiayi Chen, Xuanxuan Luo, Yijie Qu, Rui Xia, Weiqi Wang, Xiaohua Zheng

“…Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). …”
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Gene expression profiling of extraocular muscles in primary inferior oblique overaction by Rui Hao, Yuchuan Wang, Wei Zhang

“…The results indicated that multiply innervated muscle fibers were more abundant in the primary IOOA group, likely enabling slow tension generation, whereas the secondary IOOA group exhibited higher collagen fibril levels that might improve muscle stiffness.…”
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The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications by Musaffe Tuna, Gordon B Mills, Christopher I. Amos

“…Among the various types of ncRNAs, long non‐coding RNAs (lncRNAs)—which have transcripts longer than 200 nucleotides—have emerged as key regulatory molecules in a myriad of cell functions by interacting with DNA, with other RNAs, including mRNA, miRNA and with proteins. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…These innovations enable early detection of adverse events such as bacterial infections and inflammation, facilitating more effective, on-demand treatment. This review highlights the current state of antibiotic-embedded wound dressings, discusses their limitations, and explores the potential of next-generation wound dressings incorporating microelectronic sensors for real-time monitoring and adaptive therapeutic responses to support healing and combat antimicrobial resistance.…”
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Agrobiological features of the new naked oat variety Baget by G. A. Batalova, O. A. Zhuikova, N. V. Krotova, E. N. Vologzhanina, M. V. Tulyakova

“…Naked oat variety Baget was created by method of individual selection from cross population ОА 503/1 (Canada) * Tumensky golozerny (Russia) with following control of trait in further generations. The variety is intended for production of food grain (children, diet, functional, and gluten-free nutrition) as well as for grain forage. …”
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Mental health disorders among children with special health needs: A population-based cohort study using linked administrative data from Manitoba, Canada. by Jennifer E Enns, Caroline Reid-Westoby, Gilles R Detillieux, Marni Brownell, Nathan C Nickel, Anne Gadermann, Astrid Guttmann, Teresa Bennett, Eric Duku, Barry Forer, Monique Gagné Petteni, Katholiki Georgiades, Martin Guhn, Ana Hanlon-Dearman, Brenda T Poon, Magdalena Janus

“…<h4>Objective</h4>An estimated 15-22% of Canadian kindergarten-age children have a special health need (SHN), defined as a clinical diagnosis, a functional need requiring special accommodation at school, or a health condition leading to increased needs. …”
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Research progress on high-entropy alloys for extreme loading environments by GAO Wei, ZHOU Xichen, ZHU Qianyong, PANG Shujie, ZHAO Shiteng

“…Additionally，tailored optimization approaches should be implemented for distinct advantageous systems and phase structures，particularly those capable of activating dislocation movements，twinning，phase transformations and incorporating novel processing methodologies such as additive manufacturing. Finally，conducting more realistic simulation experiments that closely replicate extreme environments along with generating relevant engineering data are vital steps toward accelerating the practical application of HEAs in challenging settings.…”
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Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation by Qiang Zhang, Zhe Wu, Boshuo An, Ruitian Sun, Yanping Cui

“…Taking the QPZZ-ii gearbox test bed as the physical entity, the research establishes a five-layer architecture: functional service layer, software support layer, model integration layer, data-driven layer, and digital twin layer, forming a closed-loop feedback mechanism. …”
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Benefits of Probiotics—Biodetoxification by Barbara Sionek, Aleksandra Szydłowska, Danuta Jaworska, Danuta Kołożyn-Krajewska

“…The rapid growth of the world’s population is generating escalating demands for food production. Global food demand is expected to increase by 35% to 56% between 2010 and 2050. …”
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Innovative gene delivery systems for retinal disease therapy by Hongguang Wu, Ling Dong, Shibo Jin, Yongwang Zhao, Lili Zhu

“…Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration, potentially restoring vision. …”
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Care-associated adverse events related to the use of laser in urological interventions: the French experience by Maher Abdessater, Maher Abdessater, Frédéric Panthier, Philippe Michel, Vanessa Avrillon, Bertrand Pogu, Bertrand Pogu, Stéphane Bart, Stéphane Bart

“…Training teams on the use of laser generators and providing feedback on functional results and related specific morbidity seem necessary to guarantee the proper use of these technologies and the safety of staff and patients.…”
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Agent-based modeling of macrophage-fibroblast interactions in the immune response to biomaterials. by Jennifer Riccio, Luca Presotto, Shir Bahiri, Liad Doniza, Donato Inverso, Laura Sironi, Uri Nevo, Giuseppe Chirico

“…They exhibit a variety of functional phenotypes (or states) induced by the stimulus they receive and the microenvironment. …”
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Antioxidant, bioactive, and nutritional potential of soybeans with brown and yellow seed coats by Victor Delino Barasuol Scarton, Ivan Ricardo Carvalho, Christiane de Fátima Colet, Jaqueline Piesanti Sangiovo, Willyan Júnior Adorian Bandeira, Murilo Vieira Loro, Ellen Cristina Perin, Solange Teresinha Carpes, Patricia Brugnerotto

“…Given the growing interest in biofortification to enhance the nutritional value of crops, this study aimed to assess the agronomic performance, nutritional, functional and physicochemical composition of soybean lines with both brown and yellow seed coats, with a particular focus on their biofortification potential. …”
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A data-mining analysis of host solute carrier family proteins in SARS-CoV-2 infection with reference to brain endothelial cells and the blood-brain barrier in COVID-19 by Talia Fradkin, Rainald Schmidt-Kastner

“…Literature searches for host SLCs revealed involvement of a subset of SLCs in infection mechanisms for SARS-CoV-2 and more broadly for other viruses. N = 17 host ABCs were found in brain endothelial cells where they may serve as efflux transporters.DiscussionThis hypothesis-generating work proposes a set of N = 80 host SLCs expressed in endothelial cells as contributors to BBB impairment after SARS-CoV-2 infection. …”
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Reconstruction of U.S. Regional-Scale Soybean SIF Based on MODIS Data and BP Neural Network by YAO Jianen, LIU Haiqiu, YANG Man, FENG Jinying, CHEN Xiu, ZHANG Peipei

“…Through the activation functions in the BP neural network, it enhanced the understanding of the complex nonlinear relationships between the original SIF data and these MODIS products. …”
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Characterization of FosA13, a novel fosfomycin glutathione transferase identified in a Morganella morganii isolate from poultry by Runzhi Zhang, Runzhi Zhang, Yan Yu, Yan Yu, Lulu Huang, Susu Chen, Ruxi Hu, Xiuxiu Wang, Dawei Huang, Chunhan Song, Junwan Lu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Qiyu Bao, Yunliang Hu, Pengfei Jiang, Wei Pan

“…This protein shares the highest aa identity of 55.6% with the functionally characterized protein FosA and has all the essential functional residues of FosA proteins. …”
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Assessment of The Potential Interference and Conflict of Artificial Intelligence With Human Rights and Citizenship: Challenges and Solutions by Hossein Khazaei, Mojtaba Hemmati

“…Determining legal responsibilities for the actions and functions of AI systems is complex. Traditional legal systems assign responsibility based on intention and action. …”
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