Intermediate Clinical and Radiographic Outcomes of the Inbone II: for Patients with Five Years Minimum Follow-up by Parin Kothari MD, Alexander Phillips, Ramsey Potter, Drew Albert MD, MBA, Michelle A. Padley PhD, CRTM, John G. Anderson MD, Donald R. Bohay MD, FACS, John D. Maskill MD, Marshall A. Boose DO, Lindsey A. Behrend BS

“…Category: Ankle Arthritis; Ankle Introduction/Purpose: The TAA was originally introduced in the 1970s and each subsequent generation of implant has been improved upon. Innovative solutions led to second and third generation arthroplasties, which addressed the initial failures and incorporated new designs to improve patients’ lives through significant improvements in pain and function. …”
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Integrated Bidding and Battery Scheduling in a Microgrid for Sealed-Bid Double Auction Power Trading With Peer Microgrids Under Uncertainty and Its Blockchain-Based Implementation by Zubin J. B., Sunitha R., Gopakumar Pathirikkat

“…We assume a normal distribution of prediction errors and introduce an uncertainty range and a bid buffer capacity to account for expected variations in forecasted generation and load, enabling more robust coordination between bidding and storage operations. …”
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Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…Despite rapid advances of next-generation sequencing, both the technology and the analysis of the data it produces are in its infancy. …”
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Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B. by Md Shadab, Baijayanti Jha, Mohammad Asad, Makaraju Deepthi, Mohd Kamran, Nahid Ali

“…<h4>Conclusions</h4>KalsomeTM10 induces apoptotic-like cell death in L. donovani parasites to exhibit its anti-leishmanial function.…”
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Sustainable Transmitters for High-Capacity Metro-Access Networks by Stefano Gaiani, Alberto Gatto, Paola Parolari, Pierpaolo Boffi

“…The simulations evaluate the performance of the various architectures in terms of capacity as a function of the propagation distance (up to 50 km), comparing also the associated signal to noise ratio curves. …”
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Rudraksh: A compact and lightweight post-quantum key-encapsulation mechanism by Suparna Kundu, Archisman Ghosh, Angshuman Karmakar, Shreyas Sen, Ingrid Verbauwhede

“…We have also shown how ASCON can be used for lightweight pseudo-random number generation and hash function in the lattice-based KEMs instead of the widely used Keccak for lightweight design. …”
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Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy by Veera Vijaya Basamshetty, Vijay Kumar Gangipangi, Uppulapu Shravan Kumar, Santhosh Shanthi Bhupathi, Sridhar Reddy Kaulagari, Prashant Giri, Swapnil Sinha, Utpal Mohan, Konstantinos Sdrimas

“…This study presents a proof of concept for a novel strategy to evolve functional DNAzymes against native mRNA sequences and highlights their potential as gene-silencing tools in cancer therapy. …”
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Molecular tools for genome editing in plants: a synthetic overview by Nicolau Brito da Cunha, Michel Lopes Leite, Júlio Carlyle Macedo Rodrigues, Jéssica Carrijo, Fabrício Falconi Costa, Simoni Campos Dias, Elíbio Leopoldo Rech, Giovanni Rodrigues Vianna

“…However, the stochastic nature of the DNA delivery systems, with little control over where the genome modification occurred, required regulatory measures to ensure environmental, human, and animal safety, which has hindered the ability and speed to generate new and more adapted varieties. New technological advances have made it possible to increase the precision of genome modifications leading to a third generation of agricultural products. …”
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Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities by Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy

“…Treatment efficacy was also measured.Results Our data show that VSV-interleukin-2 is superior as a vaccine boosting adjuvant compared with the parental virus as it induces more antigen-specific CD8 T cells with enhanced effector functions that persist over time. …”
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Structural Parameter Identification Using Multi-Objective Modified Directional Bat Algorithm by LIU Li-jun, LIN Ying-hai, SU Yong-hui, LEI Ying

“…However， traditional single-objective optimization methods， which aggregate multiple evaluation indices into a single weighted objective function， often face challenges. The manual determination of weight factors introduces subjectivity， which can significantly affect the accuracy of the results. …”
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Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis by Xi Chen, Xiaohong Kong, Jie Zhu, Tingting Zhang, Yanwei Li, Guifeng Ding, Huijuan Wang

“…Oligogenicity may explain the genetic basis of disease in many DH patients. Functional studies and further clinical studies with larger DH patient cohorts are needed to validate the roles of the mutations identified in this study.…”
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Competitive Roles of DNRA and Denitrification on Organic Nitrogen Dynamics in Partially Saturated Soil‐Water Systems by Lecheng Liu, Tianyuan Zheng, Yingying Qiu, Yujie Hao, Haoran Ma, Xilai Zheng, Alberto Guadagnini

“…Our analysis further suggests the relevance of hydrogeochemical factors (e.g., moisture variation, soil texture, and C/N ratio) on DON transformation through the influence of functional microorganisms. These insights advance our understanding of nitrogen dynamics in agroecosystems, which has significant implications for environmental management practices aimed at controlling NO3−‐N pollution in partially saturated soils.…”
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Using a Co-Designed Implementation Enhancement Plan to Increase the Adoption of a Digital Fall Prevention Platform: A Non-Randomized Pre-Post Interventional Study by Delaforce A, Li J, Niven P, Maddock E, Grujovski M, Fahy MJ, Good NM, Jayasena R

“…The findings have broader implications for the implementation of other fall prevention interventions.Evidence is generated in support of digital falls prevention systems in the context of providing more efficient and responsive care, as well as improved patient-staff communication and satisfaction.Keywords: implementation science, health information technology, nursing, co-design…”
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Prevalencia de neuromitos en estudiantes de Pedagogía en Educación Física de Chile (Prevalence of neuromyths in students of Physical Education Pedagogy of Chile) by Fernando Maureira, Elizabeth Flores Ferro, Franklin Castillo Retamal, Manuel Cortés Cortés, Sebastián Peña Troncoso, Valentina Bahamonde Acevedo, Sonia Cárdenas Begazo, Natalia Escobar Ruiz, Benjamín Cortes Escaffi

“…Introduction: the lack of a common language between neuroscience and education has generated erroneous interpretations about the functioning of the nervous system, giving rise to neuromyths. …”
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Explainable multi-modal radiomics for early prediction of liver metastasis in rectal cancer: a multicentric study by Yaru Feng, Jing Gong, Yanyan Wang, Yanfen Cui, Tong Tong

“…The SHAP method elucidated the model’s functionality by highlighting key feature contributions. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…These epigenetic modifications control gene expression by regulating chromatin accessibility, thereby modulating macrophage function and polarization. Histone acetylation generally promotes a more open chromatin structure conducive to gene activation, while histone methylation can either activate or repress gene expression depending on the specific residue and its methylation state. …”
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Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination by Victor A. Garcia, Paulina M. Eberts, Brenda M. Ogle, Casim A. Sarkar

“…To further map the BPI landscape, we measured particle binding to HEK293T cells transiently transfected with HER2-EGFP, leveraging the inherent transfection heterogeneity to generate continuous binding response curves as a function of HER2 expression. …”
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Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review by Seemarani M. Pawar, Trupti Chitre, Prasad Dandawate

“…Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier function. Sphingolipids are diverse and involved in regulating growth, the cell cycle, cell motility, adhesion, migration, and more by influencing cell signaling functions. …”
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Massively parallel sequencing and analysis of the Necator americanus transcriptome. by Cinzia Cantacessi, Makedonka Mitreva, Aaron R Jex, Neil D Young, Bronwyn E Campbell, Ross S Hall, Maria A Doyle, Stuart A Ralph, Elida M Rabelo, Shoba Ranganathan, Paul W Sternberg, Alex Loukas, Robin B Gasser

“…In N. americanus, essential molecules were predicted using a combination of orthology mapping and functional data available for C. elegans. Further analyses allowed the prioritization of 18 predicted drug targets which did not have homologues in the human host. …”
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A non-sub-sampled shearlet transform-based deep learning sub band enhancement and fusion method for multi-modal images by Sudhakar Sengan, Praveen Gugulothu, Roobaea Alroobaea, Julian L. Webber, Abolfazl Mehbodniya, Amr Yousef

“…Abstract Multi-Modal Medical Image Fusion (MMMIF) has become increasingly important in clinical applications, as it enables the integration of complementary information from different imaging modalities to support more accurate diagnosis and treatment planning. The primary objective of Medical Image Fusion (MIF) is to generate a fused image that retains the most informative features from the Source Images (SI), thereby enhancing the reliability of clinical decision-making systems. …”
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