Anionic Lipid Catalyzes the Generation of Cytotoxic Insulin Oligomers by Jhinuk Saha, Audrey Wolszczak, Navneet Kaur, Malitha C. Dickwella Widanage, Samuel D. McCalpin, Riqiang Fu, Jamel Ali, Ayyalusamy Ramamoorthy

“…Furthermore, the soluble intermediates were found to be more cytotoxic than fibrils generated with or without lipids. …”
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More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology. by Wing-Cheong Wong, Sebastian Maurer-Stroh, Frank Eisenhaber

“…Large-scale genome sequencing gained general importance for life science because functional annotation of otherwise experimentally uncharacterized sequences is made possible by the theory of biomolecular sequence homology. …”
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Optimal setting automatic excitation controllers for synchronous generators by R. I. Kanafeev, A. D. Zhirnov, T. G. Klimova

“…Various optimization techniques required objective functions, developed on the basis of the root and frequency criteria for evaluation ofparameters of the regulatory process for the proper functioning of the automatic excitation controller for synchronous generator (AEC SG), working in different scheme-regime situations. …”
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Les fermes urbaines en Suisse : hybridations agri-urbaines ou simples redéfinitions des catégories usuelles  ? by Cyril Mumenthaler, Joëlle Salomon Cavin

“…Our hypothesis is that entry through hybridization and its limits is a relevant framework for observing, understanding and analysing the changes generated by urban farms and, more generally, urban agriculture.…”
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Development of a 1.0 KVA Fuelless Generator by Blessing Ngozi Goodluck Aliemeke, Munirat Abdullawal Momoh, Mercy Onoshioze Asekhome, Christian Azuka Anani, Afoke Chief Vincent

“…Comprehensive performance testing validated the functionality and reliability of the developed generator under various load conditions. …”
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Deep learning-aided segmentation combined with finite element analysis reveals a more natural biomechanic of dinosaur fossil by Lijia Zhang, Zixiong Cao, Qi Zhao

“…This novel methodology efficiently generates the FE model with stress distribution that closely reflects the trabecular architecture in fossils of extinct taxa, reflecting a more natural state of biomechanical performance with high biological reality. …”
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LIVER DISEASE & SICKLE CELL DISEASE: AUTOIMMUNE HEPATITIS MORE THAN A COINCIDENCE; A SYSTEMATIC LITERATURE REVIEW. by Kelvin Lynch, Andrea Mega, Andrea Piccin, Massimo Daves, Helen Fogarty

“…Symptoms such as jaundice, fatigue, and abdominal pain are common in SCD, as are abnormal liver function tests (LFTs). These abnormalities, attributed to the other more frequent liver involvements in SCD, can lead to delays in AIH diagnosis in this population…”
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Exploration of electrochemical energy storage potential of MWCNT scaffolds functionalized with Lu2FeMnO6 synthesized via a facile sol–gel Pechini chemical method by Vahid Rahimkhoei, Masoud Salavati-Niasari, Forat H. Alsultany, Aseel M. Aljeboree, Masood Hamadanian

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Penalized Intuitionistic Fuzzy Goal Programming Method for Solving Multi-Objective Decision-Making Problems by Demmelash Mollalign Moges, Berhanu Guta Wordofa, Allen Rangia Mushi

“…This research study focused on establishing a novel method by combining the penalty function method with an interactive goal programming methodology for addressing multi-objective decision-making problems in an intuitionistic fuzzy environment. …”
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Penalized Intuitionistic Fuzzy Goal Programming Method for Solving Multi-Objective Decision-Making Problems by Demmelash Mollalign Moges, Berhanu Guta Wordofa, Allen Rangia Mushi

“…This research study focused on establishing a novel method by combining the penalty function method with an interactive goal programming methodology for addressing multi-objective decision-making problems in an intuitionistic fuzzy environment. …”
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Investigation of Mutual Behavior of Stochastic Normally Distributed Processes with Additive Amplitude Randomization by S. A. Pyko, N. S. Pyko, O. A. Markelov, Yu. D. Uljanitski, M. I. Bogachev

“…The third approach uses the average value of the coherence function of the two processes - the coherence coefficient C. …”
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Brain-Shapelet: A Framework for Capturing Instantaneous Abnormalities in Brain Activity for Autism Spectrum Disorder Diagnosis by Yijie Ren, Zhengwang Xia, Yudong Zhang, Zhuqing Jiao

“…Some symptoms of Autism Spectrum Disorder (ASD), such as anxiety and depression, often manifest intermittently rather than continuously, complicating the identification of reliable pathophysiological biomarkers. Meanwhile, functional connectivity networks (FCNs) generate high-dimensional connectomes, making it difficult to accurately capture instantaneous abnormal biomarkers of neurological disorders. …”
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Collaborative filtering recommendation algorithm based on hybrid clustering and user preferences fusion by Ma Tian, Yu Benguo, Zhang Jing, Song Wenai, Jing Yu

“…Secondly, the weight classification method based on TF-IDF algorithm is used to calculate the weight of users on labels, and the exponential decay function incorporating time coefficient is used to capture the change of users′ interest preference with time. …”
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Multiobjective optimization of Murta (Ugni molinae Turcz) juice lactic acid fermentation with monocultures and cocultures of Lactobacillus acidophilus and Lactiplantibacillus plant... by C.J. Gomes-Lobo, R. Luna, A. Rodríguez-Machado, J.R. Pérez-Correa, W. Franco

“…While MOO and DF produced similar Pareto fronts, MOO required less computational time and generated more diverse solutions. These findings highlight the practical utility of MOO-MCDM for designing efficient multiobjective fermentation processes in functional food development.…”
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Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…This study aims to characterize adaptations occurring in human living myocardial slices (LMS) during ex vivo culture.During culture, LMS demonstrated progressive enhancements in contractile function including stronger force generation, reduced diastolic tension, and faster contraction-relaxation kinetics. …”
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Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enabl... by Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Justine Charon, Adrian Diaz, Kris De Jonghe, Sebastien Massart, Thierry Michon, Wim Vranken, Wim Vranken, Wim Vranken, Wim Vranken

“…The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. …”
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Evidence of Subsurface Control on the Coevolution of Hillslope Morphology and Runoff Generation by David G. Litwin, Ciaran J. Harman

“…We found that hillslopes were systematically shorter and saturated areas more dynamic at the lower transmissivity site. To test whether these features could be the result of coevolution between topography, hydrological function, and subsurface properties, we estimated all parameters of a coupled groundwater‐landscape evolution model for each site. …”
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Effectiveness and safety of new-generation antihistamines in allergenic rhinitis and urticaria by P.C. Potter

“…Histamine remains the most important mediator of clinical reactions in allergic diseases such as rhinitis, urticaria, and food and drug allergies. The need for more effective and safe antihistamines is critical and intensive drug development has become more demanding and competitive. …”
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Design of the Gear Generating Instrument on the type of Duplicate Planetary Transmission by Ye Youdong, Liu Lihong

“…The structure and function of the existing gear generating instrument are analyzed,its drawbacks and deficiencies of the structure and using are pointed out.The traditional structure mode of gear generating instrument is abandoned,and a new type of duplicate planetary transmission of involute gear generating instrument is designed,and then the structure,parameters,principle and characteristics are introduced.The duplicate planetary transmission of involute gear generating instrument is more convenient and quicker for operating by contrast of using the old and new gear generating instrument,and it can completely replace the existing gear generating instrument.…”
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The Generation and Regulation of Tissue-Resident Tregs and Their Role in Autoimmune Diseases by Shuang Wang, Xueyang Zou, Yi Zhang, Xiaoya Wang, Wei Yang, Yi Li

“…In recent years, studies have found that Tregs are divided into lymphatic and tissue-resident Tregs according to their location. Research on the generation and function of lymphoid Tregs has been more comprehensive and thorough, but the role of tissue Tregs is still in the exploratory stage, and it has become a research hot spot. …”
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