Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading by Lan Cheng, Hui Chen, R. Nfornah Maboh, Huan Wang

“…Methods: We used the CRISPR/Cas9 technique to generate the Cacna1d D307G mutation rat model and investigated the effects of Cacna1d D307G mutation on blood pressure (BP) and renal function. …”
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Structure–function relationships in unspecific peroxygenases revealed by a comparative study of their action on the phenolic lignin monomer 4-propylguaiacol by Marta Barros-Reguera, Esteban Lopez-Tavera, Gabriela C. Schröder, Greta Nardini, Kenneth A. Kristoffersen, Iván Ayuso-Fernández, Vincent G. H. Eijsink, Morten Sørlie

“…Our study provides valuable insights into the structure–function relationships underpinning enhanced peroxygenase activity of UPOs and provides a functional mapping of a broad UPO-sequence space for 4-PG, highlighting these enzymes as promising catalysts for the selective oxyfunctionalization of a phenolic lignin monomer.…”
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PromarkerD Versus Standard of Care Biochemical Measures for Assessing Future Renal Function Decline in Type 2 Diabetes by Kirsten E. Peters, Isabella A. Joubert, Scott D. Bringans, Wendy A. Davis, Richard J. Lipscombe, Timothy M. E. Davis

“…<b>Conclusions:</b> PromarkerD more accurately identifies adults with T2D at risk of kidney function decline than current usual care biochemical tests.…”
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Development of channel transmission loss function for WRF_HYDRO modeling of semi-arid regions: The case of wadi Faria, Palestine by Abdelhaleem Khader, Anan Jayyousi, Sameer Shadeed, Joel Arnault, Harald Kunstmann, Christian Chwala, Benjamin Fersch

“…Faria (320 km2), located in the northeastern part of the West Bank, Palestine, is a gauged catchment where rainfall and streamflow data are available for more than ten years. This study aims to assess the functionality of the WRF-Hydro to predict reliable streamflow hydro-graphs at the upper part of the catchment. …”
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The financial basis for the functioning of Western Siberian departments of the Imperial Orthodox Palestine Society at the end of XIX - beginning of XX century by Tsys' Valerii, Tsys' Olga

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Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms by Aleksandr M. Reznik, Olga A. Karpenko, Elena A. Shumakova, Aleksandr V. Mudrak, Andrey V. Sokolov, Svetlana V. Nazimova, Alina M. Saifulina, Anton M. Eliseenko, Tatjana K. Matvievskaya, Angelina N. Khannanova, Vladimir I. Revenko, Dmitriy V. Scherbakov, Yuriy L. Martynyuk, Aleksandr L. Arbuzov, Oleg A. Yacenko, Polina N. Alekseeva, Aleksandr B. Berdalin, Larisa A. Burygina

“…Assessment of personal and social functioning was conducted five times: before the start of treatment, and 3, 6, 9, and 12 months later. …”
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Response of organic matter pore development to functional groups in overmature marine shale: Insights from AFM-IR spectroscopy by Jianhua ZHAO, Keyu LIU, Shenghui ZHAO, Qinhong HU, Wei WU, Yang CHEN, Guoheng LIU, Junqian LI, Lingjie YU, Zuhui YOU, Ye WANG

“…Pyrobitumen-clay mineral composites generally exhibit superior pore development, likely attributable to clay mineral dehydration participating in hydrocarbon generation reactions that promote the removal of more functional groups. …”
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Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression by Efrat Oron, Tamir Tuller, Ling Li, Nina Rozovsky, Daniel Yekutieli, Sigal Rencus‐Lazar, Daniel Segal, Benny Chor, Bruce A Edgar, Daniel A Chamovitz

“…We are using Drosophila as a model system to elucidate the function of this important complex. Transcriptome data were generated for four csn mutants, sampled at three developmental time points. …”
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Functional and Taxonomic Insights into Root Endophytic Bacterial Communities in Hybrid Tomato and Finger Millet: Implications for Crop Resilience and Growth by Surendirakumar Kannaiah, Ramganesh Selvarajan, Salam Nirmalashachi Chanu, Radha Raman Pandey, Akebe Luther King Abia

“…These sequences were processed to identify amplicon sequence variants (ASVs), which were then classified taxonomically to assess community composition and functional prediction. Across the two hybrid crops, 1400 ASVs were detected in tomato and 1838 in finger millet. …”
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Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation by Pedro Vicente, Lara R. Inocêncio, Asier Ullate‐Agote, Ana F. Louro, João Jacinto, Beatriz Gamelas, Olalla Iglesias‐García, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Gonzalo R. Ríos‐Muñoz, María Eugenia Fernández‐Santos, Alain vanMil, Joost P. G. Sluijter, Felipe Prósper, Manuel M Mazo Vega, Paula M. Alves, Margarida Serra

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Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression by E. R. Chernykh, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, Yu. D. Kurochkina, E. A. Oleynik, L. V. Sakhno, A. A. Ostanin

“…The presence of CD16+ cells in whole blood monocyte pool is associated with generation of DCs showed a more mature phenotype and higher allostimulatory activity. …”
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Adaptation of the REINVENT neural network architecture to generate potential HIV-1 entry inhibitors by D. A. Varabyeu, A. D. Karpenko, A. V. Tuzikov, A. M. Andrianov

“…To accelerate the learning of the neural network in the modified version of the REINVENT model, the AutoDock-Vina-GPU-2.1 docking program was used, and to clarify the results of its work, the procedure for revaluing the affinity of compounds to the target using the RFScore-4 evaluation function was used.Results. Using a modified version of the REINVENT model, more than 60,000 compounds were obtained, of which about 52,000 molecules have a binding energy value to the HIV-1 gp120 protein comparable to the value calculated for the HIV-1 inhibitor NBD-14204, used in calculations as a positive control. …”
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Deus ex nomine: Once more on the language myth and naïve religion by E. L. Berezovich, O. D. Surikova

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A Coupling Electromechanical Inhomogeneous Cell-Based Smoothed Finite Element Method for Dynamic Analysis of Functionally Graded Piezoelectric Beams by Bin Cai, Liming Zhou

“…ISFEM provides a close-to-exact stiffness of the continuous system, which could automatically and more easily generate for complicated domains and thus significantly decrease numerical errors. …”
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Investigation on Graphitization, Surface Functional Groups, and Oxidation Behavior of Soot Particulate Along Exhaust Pipe of Gasoline Direct Injection Engine by Zhiyuan Hu, Li Yin, Jiayi Shen, Zhangying Lu, Piqiang Tan, Diming Lou

“…Under a light load, as the engine speed increased, the disorder of the edge array of soot particles became higher, the content of oxygen-containing functional groups and oxidation activity became higher, and the soot particles were more easily oxidized. …”
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Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design by Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana, Qigai He

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Comparative analysis of AI-based search algorithms in solving 8 puzzle problems by Ghaniyyat Bolanle Balogun, Daniel Ibisagba, Amos Bajeh, Taofik Olawale Debo, Abdulraheem Muyideen, Olumuyiwa James Peter

“…DFS, while faster and more memory-efficient, is less consistent in producing optimal solutions. …”
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The Art of Generative Narrativity by Dejan Grba, Vladimir Todorović

“…It sometimes leads to generative experiments with non-verbal forms or events that have the potential to incite narratives through the audience’s experience of the works’ functionalities, backgrounds, and contexts. …”
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Research Progress of DNA Methylation in Fish by Hai HUANG, Yan LU, Liu CAO

“…Differential methylation—cytosine-phosphate-guanine sites—is involved in apoptosis, epigenetic regulation, autophagy, collagen metabolism, cell membrane function, and homeobox protein generation through gene expression regulation. …”
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Deep Reinforcement Learning-Based Routing Method for Low Earth Orbit Mega-Constellation Satellite Networks with Service Function Constraints by Yan Chen, Huan Cao, Longhe Wang, Daojin Chen, Zifan Liu, Yiqing Zhou, Jinglin Shi

“…Low-orbit satellite communication networks have gradually become the research focus of fifth-generation (5G) beyond and sixth generation (6G) networks due to their advantages of wide coverage, large communication capacity, and low terrain influence. …”
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