Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

“…Finally, combination MG1 and programmed cell death protein-1 antibody (αPD-1) therapy was investigated in advanced 4434 tumors.Results MG1 effectively supported priming of functional cytotoxic T cells (CTLs) against tumor-associated antigens as well as virus-derived peptides, as assessed using peptide recall and T2 killing assays, respectively. …”
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Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals by Ruili Wang, Baohui Hu, Ziyu Pan, Chongxia Mo, Xin Zhao, Guojia Liu, Ping Hou, Qi Cui, Zhao Xu, Wenjia Wang, Zhaojin Yu, Lin Zhao, Miao He, Yan Wang, Chen Fu, Minjie Wei, Lifeng Yu

“…This review provides a comprehensive overview of ADCs, summarizing the structural and functional characteristics of the three core components, antibody, linker, and payload. …”
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Environmental impact of rabbit production systems: a farm-based cradle-to-gate analysis by F. Bordignon, G. Xiccato, A. Trocino, A. Zuffellato, C. Castellini, S. Mattioli, M. Berton

“…The fattening phase contributed more (65%, on average) than the breeding phase (35%) to the environmental impact for all the impact categories. …”
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Investigation on the motion and fragmentation mechanism of rockfall based on PIV-seismic signal monitoring by Sui Zhende, Zhang Ke, Zhang Kai, Lin Qibin

“…Through EMD, the original seismic signal is decomposed into 9 Intrinsic Mode Function (IMF) components and 1 residual. FFT is applied to convert these modal components and the residual signal into frequency spectra. …”
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Short-term Wind Power Forecasting Based on BWO‒VMD and TCN‒BiGRU by LU Jing, ZHANG Yanru, WANG Rui

“…This combination model aims to use the advantages of TCN and BiGRU to process data and make more accurate predictions. Finally, the pre-dicted values of each subsequence are sequentially stacked to obtain the result, which is expected to provide reliable predictions for wind power generation.Results and DiscussionsThe RF algorithm is strategically employed to screen meteorological features and systematically rank their importance, enabling the accurate selection of features that significantly impact wind power forecasting. …”
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DCLTV: An Improved Dual-Condition Diffusion Model for Laser-Visible Image Translation by Xiaoyu Zhang, Laixian Zhang, Huichao Guo, Haijing Zheng, Houpeng Sun, Yingchun Li, Rong Li, Chenglong Luan, Xiaoyun Tong

“…In recent studies, diffusion models have demonstrated superior image generation and translation abilities and been shown to be capable of generating high-quality images. …”
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THE BIBLE IN THE WORLD OF JENA ROMANTICISM by Galina V. Sinilo

“…By “axial” archetext we mean the ancient “text-in-the-beginning”, which has increased axiological and aesthetic significance, a high degree of reinterpretability, which is the most important source of intertextual links, fulfills the meaning and text-generating function and is the general “text-code” (Yu.M. …”
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The Spodoptera frugiperda L-aminoacylase degrades fatty acid-amino acid conjugates and promotes larvae growth on Zea mays by Bin Li, Mei Luo, Xiaofeng Liu, Wangpeng Shi, Jinfeng Qi, Shaoqun Zhou, Guirong Wang

“…Abstract Oral secretions (OS) contain diverse functional molecules that play important roles in the molecular interactions between insect herbivores and their host plants. …”
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Trustworthy Analytics in ETSI ZSM: A 5G Security Case Study by Panagiotis Radoglou-Grammatikis, Efklidis Katsaros, Evangelos Syrmos, Georgios P. Katsikas, Dimitrios Klonidis, Vasileios Argyriou, Thomas Lagkas, Panagiotis Sarigiannidis

“…For this purpose, we take into account a particular case study which focuses on the orchestration of security services within the 5G core. More specifically, the deployment of a new User Plane Function (UPF) equipped with intrusion detection services that leverage Artificial Intelligence (AI) is investigated. …”
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Towards non-virtual inertia control of renewable energy for frequency regulation: Modeling, analysis and new control scheme by Haishu Gao, Feng Zhang, Lei Ding, Gang Zhang, Libin Yang, Athuman Salimu

“…Currently, when renewable generation participates in frequency regulation, the traditional control method is to emulate synchronous generators through virtual inertia control. …”
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Chromosome-scale genome assembly and annotation of two geographically distinct strains of malaria vector Anopheles albimanus by Dieunel Derilus, Gareth D. Weedall, Michael W. Vandewege, Dhwani Batra, Mili Sheth, Lori A. Rowe, Ananias A. Escalante, Audrey Lenhart, Lucy Mackenzie Impoinvil

“…TE analyses indicated more repetitive content was captured in the long read assemblies. …”
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Integrated Co-extraction Protocol for Transcriptomic and 1H NMR Metabolomic Analysis of Multi-species Biofilms by Anaïs Séguéla, Oriane Della-Negra, Roselyne Gautier, Jérôme Hamelin, Kim Milferstedt, Rémi Servien, Marie-Ange Teste, Cécile Canlet

“…Multi-omics approaches and, notably, the combination of metabolomics and transcriptomic analyses are required for understanding the functional changes and adaptation of microorganisms to different physico-chemical and environmental conditions. …”
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Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction by Siyuan Fu, Zhiyu Wang, Peihong Huang, Guanjun Li, Jian Niu, Zhiyang Li, Guangyue Zu, Pengcheng Zhou, Lianhui Wang, David Tai Leong, Xianguang Ding

“…The technology, termed electroactive patch for wirelessly and controllable EV generation (ePOWER), leverages wireless bioelectronic patch to stimulate embedded electrosensitive macrophages, actively modulating the biosynthesis of EVs and enabling EV production with high programmability to be delivered directly to the MI area. ~2400% more bioactive EVs were produced per cell under our ePOWER system. …”
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Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials by Antoni Ribas, Carl H June, Philip D Greenberg, Crystal L Mackall, Marcela V Maus, John E Connolly, Christopher R Cabanski, Ute Dugan, Mark D Stewart, Jeff D Allen, EnJun Yang, Alexander Marson

“…Recent advances in genome editing technologies have identified hundreds of gene edits that improve T-cell functionality in preclinical models. However, the limited direct translatability of these findings and the impracticality of testing each of the individual edits in a traditional clinical trial highlight the need for more efficient strategies.This article provides an overview of genome-wide screens that identify gene knockouts and knock-ins to enhance T-cell function and the limitations with translating these results to human trials. …”
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Mutant p53 induces SH3BGRL expression to promote cell engulfment by Lobsang Dolma, Mary I. Patterson, Antonia Banyard, Callum Hall, Steven Bell, Wolfgang Breitwieser, Sudhakar Sahoo, John Weightman, Maria Pazos Gil, Garry Ashton, Caron Behan, Nicola Fullard, Lewis D. Williams, Patricia AJ. Muller

“…TP53 can be found mutated at nearly every amino acid in cancers and mutant p53 expression is associated with various GOF (Gain-of-function) processes, including cancer cell invasion, metastasis, stemness and drug resistance. …”
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Fluid balance-adjusted creatinine at initiation of continuous venovenous hemofiltration and mortality. A post-hoc analysis of a multicenter randomized controlled trial. by Susanne Stads, Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Ilse M Purmer, Sylvia S den Boer, Cynthia G Kleppe, Marc G Vervloet, Albertus Beishuizen, Armand R J Girbes, Pieter M Ter Wee, Diederik Gommers, A B Johan Groeneveld, Heleen M Oudemans-van Straaten, CASH study group

“…However, creatinine is not only determined by renal function (excretion), but also by dilution (fluid balance) and creatinine generation (muscle mass). …”
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Assessment of Knowledge, Attitudes and Needs of Accredited Social Health Activist (ASHA) in Community based Cancer Awareness and Screening Programme: A Mixed Method Study from a Ru... by L Meenu, N Divyamol, K Anupriya, TK Abdu Saleem

“…Their needs as facilitators emerged under two global themes: functional and aspirational. The quantitative data showed a gap in specific knowledge areas, which was also echoed in FGDs, where ASHAs requested more training and supervision. …”
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Uncertainty management in multiobjective electric vehicle integrated optimal power flow based hydrothermal scheduling of renewable power system for environmental sustainability by Susanta Dutta, Siddhartha Ghosh, Tushnik Sarkar, Provas Kumar Roy, Chandan Paul, Ruba Abu Khurma, Mohd Asif Shah, Saurav Mallik

“…Moreover, an analysis of variance (ANOVA) test and box plot are used to thoroughly investigate this data to provide a more precise assessment of QOSCA’s robustness. After integrating wind-solar and EV, the numerical analysis for IEEE 57 bus and IEEE 118-bus utilizing QOSCA for single objective over generation cost is reduced by 21%, emission is reduced by 17.5%, APL is reduced by 0.17% and 2.59%. …”
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Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects by Joseph Mugaanyi, Jing Huang, Jiongze Fang, Arthur Musinguzi, Caide Lu, Zaozao Chen

“…While challenges remain, such as vascularization and long-term function, ongoing advancements are paving the way toward clinical and pharmaceutical integration. …”
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ASSISTITO, SUPPORTATO O GENERATO DALL’IA: UNA TASSONOMIA ISPIRATA DALLA CAPTOLOGIA PER L’USO DELL’INTELLIGENZA ARTIFICIALE NELLA DIDATTICA by Martin Ruskov

“…AI-assisted, AI-supported or AI-generated: A captology-inspired taxonomy for the use of artificial intelligence in education More than 25 years ago, B.J Fogg founded the research on persuasive technology, or captology for short. …”
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