Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling by Nikole J. Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner, Günter Roth, Michael M. Hoffmann, Katja E. Odening, Hauke Horstmann, Luke A. Potter, Christoph Bode, Dennis Wolf, Harald Sourij, Senka Ljubojevic-Holzer, Markus Wallner, Peter P. Rainer, Simon Sedej, Daniel Scherr, Dirk von Lewinski, Adam R. Wende, Andreas Zirlik, Heiko Bugger

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Graphdiyne biomaterials: from characterization to properties and applications by Ling-Xiao Zhao, Yong-Gang Fan, Xue Zhang, Chan Li, Xue-Yan Cheng, Feng Guo, Zhan-You Wang

“…Abstract Graphdiyne (GDY), the sole synthetic carbon allotrope with sp-hybridized carbon atoms, has been extensively researched that benefit from its pore structure, fully conjugated surfaces, wide band gaps, and more reactive C≡C bonds. In addition to the intrinsic features of GDY, engineering at the nanoscale, including metal/transition metal ion modification, chemical elemental doping, and other biomolecular modifications, endowed GDY with a broader functionality. …”
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Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota by Shulin Wei, Mingxing Li, Long Zhao, Tiangang Wang, Ke Wu, Jiayue Yang, Yubin Liu, Yueshui Zhao, Fukuan Du, Yu Chen, Shuai Deng, Jing Shen, Zhangang Xiao, Wanping Li, Xiaobing Li, Yuhong Sun, Li Gu, Mei Wei, Zhi Li, Xu Wu

“…Notably, LGS, LGSP, and LGSF mitigated intestinal damage and maintained barrier function in ALD mice. The intestinal barrier protection function of LGS, LGSP, and LGSF was generally more obvious than that of the positive drug meltadosine. …”
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“Cura te ipsum”: Healthy public safety leaders for healthy organizations by Rosemary Ricciardelli, Stan MacLellan, Alessandra Mazoza, Tom Stamatakis, Pierre Poirier, Taylor Sayers, Randy Mellow, Ken McMullen, Nadia Aleem, Leah Dunbar, Heidi Cramm

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Evaluating pain outcomes in Chinese ophthalmology patients using the APS-POQ-R-C: a Rasch analysis by Meina Huang, Meina Huang, Zheyi Chen, Zheyi Chen

“…The response category functioning results recommended merging categories 8, 9, and 10. …”
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A versatile framework for attitude tuning of beamlines at light source facilities by Peng-Cheng Li, Xiao-Xue Bi, Zhen Zhang, Xiao-Bao Deng, Chun Li, Li-Wen Wang, Gong-Fa Liu, Yi Zhang, Ai-Yu Zhou, Yu Liu

“…It supports flexible input/output ports, easy integration of diverse evaluation functions and free selection of optimization algorithms. …”
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Probe-screened carbon nanotube field-effect transistor biosensor to enhance breast cancer-related gene assay by Pei Liu, Yiwei Liu, Bingjie Cai, Jiahao Li, Guo-Jun Zhang

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Physical activity in kidney transplant recipients: benefits, barriers, interventions by Martyna Skweres, Mateusz Nieczyporuk, Szymon Pucyło, Gabriela Piotrowska, Katarzyna Ceglarz, Jan Pielaciński, Aleksander Rudnik, Kinga Sikora, Aleksandra Sikora

“…Exercise interventions, leading to improved physical functioning both pre- and post-transplant, have been demonstrated to lead to improved muscle strength, overall physical functioning, as well as cardiorespiratory performance. …”
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Clinical Presentation and Long‐Term Survival Outcomes of Patients With Monoclonal Gammopathy of Renal Significance (MGRS): A Multicenter Retrospective Study by K. Mancuso, R. Mina, S. Rocchi, E. Antonioli, M. T. Petrucci, F. Fazio, A. Gozzetti, M. Salvini, C. S. Cartia, G. Bertuglia, F. Patriarca, A. B. Dalla Palma, S. Barbato, G. De Cicco, F. Bigi, E. Favero, P. Tacchetti, L. Pantani, I. Rizzello, M. Puppi, M. Talarico, V. Solli, A. Kanapari, M. Cavo, E. Zamagni

“…Preserved renal function at diagnosis was predictive of improved PFS in the AL amyloidosis group (eGFR ≥ 60 mL/min: HR = 0.003; p = 0.018; eGFR 30–60 mL/min: HR = 0.04, p = 0.046). …”
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Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion by Inger Lauritzen, Anaïs Bini, Anaïs Bécot, Anne‐Sophie Gay, Céline Badot, Sophie Pagnotta, Mounia Chami, Frédéric Checler

“…Altogether, we here demonstrate that PSENs, and particularly PSEN1, act as hub proteins controlling the balance between endosomal/autophagic degradation and secretion. More generally, our findings strengthen the view of a strong interconnection between the endocytic and autophagic pathways and their complementary roles in sEV secretion.…”
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Hospitalizations in adolescents with anorexia nervosa in Spain over two decades by Vicente Soriano, José Manuel Ramos, Manuel Faraco, Lucía Gallego, María Inés López-Ibor, Carlos Chiclana-Actis, Eduardo González-Fraile, Gemma Mestre-Bach, Héctor Pinargote, Manuel Corpas, Octavio Corral, Hilario Blasco-Fontecilla

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Improved YOLOv8 Model for Multi-type Lung Nodule Detection by BAO Qiangqiang, TANG Siyuan, LI Qingqian, WANG Naiyu, YANG Min, GU Yu, ZHAO Jinliang, GAO Jingbo, WANG Jiaxin, QU Yuhan

“…The generalizability is tested on a mixed dataset of LUNA16 and local hospitals, and the improved model has strong generalization ability. The improvement of the model is more effective for the task of detecting multiple types of lung nodules and it can accurately detect different types of lung nodules.…”
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Recognition of Geometrical and Proportional Principles in Open and Semi-Open Spaces of Hot and Humid Climate (Case Study: Historical Houses of Bushehr) by Neda Naseri, Jamshid Davtalab, Faramarz Hassan Pour, Abolfazl Heidari, Zohreh Oveisi Keikha

“…In the theoretical basis part, the archival method was used to introduce and examine the history and the functions of these spaces. In the fieldwork part, the direct observation was the main method. …”
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SPECTRUM OF MOLECULAR GENETIC ALTERATIONS AND DIVERSITY OF CLINICAL FORMS OF STARGARDT DISEASE by N. L. Sheremet, I. G. Grushke, N. V. Zhorzholadze, I. A. Ronzina, A. A. Mikaelyan, S. A. Kurbatov, V. V. Kadyshev, K. I. Anoshkin, V. V. Strelnikov

“…Conclusions. The loss of visual functions in Stargardt disease depends on the severity of the genetic defect in each case and on the disease’s duration in general.…”
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An updated non-intrusive, multi-scale, and flexible coupling interface in WRF 4.6.0 by S. Masson, S. Jullien, E. Maisonnave, D. Gill, G. Samson, M. Le Corre, L. Renault

“…The present paper details the development and the functionalities of the coupling interface we implemented in WRF. …”
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Blood pressure change and hypertension incidence among Ghanaians living in rural Ghana, urban Ghana and The Netherlands: a prospective cohort studyResearch in context by Eva L. van der Linden, Marieke Hoevenaar-Blom, Erik Beune, Samuel Nkansah Darko, Sampson Twumasi Ankrah, Karlijn A.C. Meeks, Felix Chilunga, Charles Hayfron-Benjamin, Peter Henneman, Bert-Jan van den Born, Ellis Owusu Dabo, Charles Agyemang

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同向双螺杆挤出植物蛋白肉过程特性研究Characteristic of co-rotating twin-screw extrusion process for plant-based protein meat by 同向双螺杆挤出植物蛋白肉过程特性研究Characteristic of co-rotating twin-screw extrusion process for plant-based protein meat

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Clinico-pathological profile of patients with HIV and tuberculosis co-infection by Cheryl Sarah Philipose, Sinchana KM, Haritha Haridas, John Ramapuram, Sharada Rai

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Exploratory DNA methylation analysis in post-mortem heart tissue of sudden unexplained death by Charlotte Sutter, Cordula Haas, Peter K. Bode, Jacqueline Neubauer, Jeppe Dyrberg Andersen

“…Some were associated with heart morphology (e.g. heart outflow tract morphogenesis or trabecular morphogenesis), but the majority belonged to more general cellular regulatory pathways (e.g. transcription coactivator activity, long non-coding RNAs, etc.). …”
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HIGHER EDUCATION SERVICES: THE STRUCTURE OF THE PROPOSAL AND THE LEVEL OF COMPETITION by D.M. Zagirniak

“…The higher the establishment’s potential, the more likely it is to win the competition. This general condition is almost always elucidated by a very important circumstance, which makes it impossible to determine the direct relationship between the size of the establishment of higher education and the chance to realize it. …”
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