A novel gene signature for forecasting time to next relapse in multiple sclerosis using peripheral blood mononuclear cells by Huimin Zhang, Jiahui Yang, Xiaobo Zhang, Chaoyi Wu, Zhen Zhao, Ming Yang, Zhaoping Wu

“…Additionally, gene signatures were also validated for differential expression using an external independent dataset, GSE21942 (N = 29), along with experimental verification. Result Two key modules were identified with WGCNA. …”
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Optical Versus Electronic Implementation of Probabilistic Graphical Inference and Experimental Device Demonstration Using Nonlinear Photonics by Masoud Babaeian, Patrick Keiffer, Mark A. Neifeld, Ratchaneekorn Thamvichai, Robert A. Norwood, Pierre-A. Blanche, John Wissinger, N. Peyghambarian

“…The optical-based solution is tolerant to shot noise and imperfections of optical modules used in the architecture as well. We also performed an all-optical experimental verification of a graphical inference as the proof of concept and have demonstrated the essential mathematical operations, multiplication, and normalization (division), in photonics operations using nonlinear bulk materials. …”
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Comprehensive network pharmacology and experimentation to unveil the therapeutic efficacy and mechanisms of gypenoside LI in anaplastic thyroid cancer by Meiyu Liu, Haidong Liao, Qin Peng, Junwei Huang, Weixiang Liu, Mengqiao Dai, Zanbing Li, Yang Xie, Jiafeng Liu, Yong Ying, Xiangtai Zeng

“…Conclusions Gyp LI effectively inhibits ATC progression by modulating SRC/PI3K/AKT signaling, enhancing apoptosis, and promoting iodine uptake, offering potential therapeutic benefits for ATC treatment.…”
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Research on Delayed-feedback Compensation of Pneumatic Position Sensor in Hot Cell by ZHOU Keyuan1, DONG Jianpeng2, DONG Bibo1, YANG He1, XIANG Routong2

“…The compensation verification of pneumatic position sensors was carried out under two different working conditions. …”

Advancing mmWave Altimetry for Unmanned Aerial Systems: A Signal Processing Framework for Optimized Waveform Design by Maaz Ali Awan, Yaser Dalveren, Ali Kara, Mohammad Derawi

“…Leveraging the software-defined architecture, this study encompasses the intricacies of frequency modulated continuous waveform (FMCW) design for three distinct stages of UAS flight: cruise, landing approach, and touchdown within a signal processing framework. …”
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Genome‐wide analysis of HD‐Zip genes in Sophora alopecuroides and their role in salt stress response by Youcheng Zhu, Di Wang, Fan Yan, Le Wang, Ying Wang, Jingwen Li, Xuguang Yang, Ziwei Gao, Xu Liu, Yajing Liu, Qingyu Wang

“…Combined with cis‐acting element prediction and expression level analysis, HD‐Zip family transcription factors may be involved in regulating the balance between plant growth and stress resistance under salt stress by modulating the expression of auxin and abscisic acid signaling pathway genes. …”
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DermViT: Diagnosis-Guided Vision Transformer for Robust and Efficient Skin Lesion Classification by Xuejun Zhang, Yehui Liu, Ganxin Ouyang, Wenkang Chen, Aobo Xu, Takeshi Hara, Xiangrong Zhou, Dongbo Wu

“…Dermoscopic Feature Gate (DFG), which simulates the observation–verification operation of doctors through a convolutional gating mechanism and effectively suppresses semantic leakage of artifact regions. …”
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Prognostic model of total runoff and its components from a partially urbanized small lowland catchment by Tomasz Szymczak, Katarzyna Krężałek

“…The article presents the results of identifying the parameters for the model, and of its verification. For this purpose, 5 hydrographs of total runoff were used, between 192 and 432 hours long, including storm surges. …”
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Mechanism of Astragaloside-Brucea javanica oil nanoemulsion against oral squamous cell carcinoma through CDK1/MTFR2: Network pharmacology, bioinformatics, and experimental studies. by Yihan Lai, Runqiang Liu, Huajie Shao, Juan Zhan, Yujie Ma, Lanfei Zhou, Zhichao Wan, Sicheng Li, Wei Wang, Lin Jiang, Yisen Shao

“…<h4>Methods</h4>By integrating network pharmacology and weighted gene co-expression network analysis, critical gene modules linked to tumor phenotypes, EMT-related adverse prognosis, and elevated MTFR2 expression were identified, pinpointing the core target gene. …”
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Genomic identification, evolutionary analysis, and transcript profiling of protein phosphatase 2C in Solanum lycopersicum by Miah Mohammad Sakib, Md. Sifatul Islam, Asifur Rob Bhuya, Md. Rihan Kabir Shuvo, Mohammad Abdullah-Al-Shoeb, Muhammad Abul Kalam Azad, Ajit Ghosh

“…This dephosphorylation process is essential for controlling and modulating various cellular functions, including signal transduction, cell cycle progression, metabolic regulation, and stress responses. …”
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Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation by Li Liu, Qingqing Zhao, Daigang Xiong, Dan Li, Jie Du, Yunfei Huang, Yan Yang, Rui Chen

“…The analysis of The Cancer Genome Atlas (TCGA) database revealed that IMMT can serve as an independent prognostic factor for BC patients. Additionally, verification in clinical specimens of BC demonstrated a positive association between high IMMT expression and larger tumor size (> 2 cm), Ki-67 expression (> 15%), and HER-2 status. …”
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Dynamic Modeling and Simulation of Wind Turbine Unit Primary Frequency Regulation Considering Multi-domain Coupling Characteristics by Zhanyang JI, Yang HU, Lingxing KONG, Ziqiu SONG, Dan DENG, Jizhen LIU

“…Thirdly, based on balanced sampling of simulation operating data under discrete operating conditions, and guided by physical prior information, subspace identification and deep neural network algorithms are employed to conduct multi-input-multi-output modeling and simulation verification of the unit's primary frequency modulation dynamics across the full range of operating conditions. …”
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Off-targets effects of CNO on somatosensory and anxiety-related behaviors in rats by Xuan Li, Juan Yao, Lian-lin Zeng, Jia Huang, Xiao-qian Jiang, Jin-he Xu, Bing Wu, Hong-li Li, Ke-hui Hu

“…The underlying mechanisms may involve CNO-induced modulation of glutamatergic signaling in key limbic regions, potentially mediated by interactions between the ligand or its metabolites and endogenous brain receptors. …”
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Quantifying degradation in animal acoustic signals with the R package baRulho by Marcelo Araya‐Salas, Erin E. Grabarczyk, Marcos Quiroz‐Oliva, Adrián García‐Rodríguez, Alejandro Rico‐Guevara

“…Furthermore, frequency modulated sounds degraded to a greater extent than pure tones. …”
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A multi-dimensional validation strategy of pharmacological effects of Radix Isatidis Mixtures against the co-infection of Mycoplasma gallisepticum and Escherichia coli in poultry by Xiaodi Jin, Jinhai Huo, Yecheng Yao, Rui Li, Mengqing Sun, Jichang Li, Zhiyong Wu

“…Through a multi-omics joint analysis network, we identified key targets and metabolites associated with co-infection and conducted targeted verification experiments with RIM aqueous extracts. The experimental results indicated that, compared to the co-infection group, the RIM treatment group significantly modulated the expression of select genes and proteins, particularly MMP2 and TLR4, with a high level of statistical significance (p < 0.01). …”
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Evidence of focusing the MHC class I immunopeptidome by tapasin by Rachel Darley, Patricia T. Illing, Patrick Duriez, Alistair Bailey, Anthony W. Purcell, Andy van Hateren, Tim Elliott

“…We found that tapasin had a greater influence on tapasin dependent MHC-I molecules, and that tapasin modulated peptide selection according to peptide-MHC-I complex stability, disfavoring short-lived peptide-MHC-I complexes. …”
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Estimation of the drift velocity of Equatorial Plasma Bubbles using GNSS and digisonde data by Navas-Portella Víctor, Altadill David, Blanch Estefania, Altadill Mar, Segarra Antoni, de Paula Víctor, Timoté Cristhian Camilo, Juan José Miguel

“…Equatorial Plasma Bubbles (EPBs) play a crucial role in modulating plasma density and electron content within the equatorial ionosphere. …”
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Problems and Prospects for the Application of Neural Networks for the Sphere of Education by T. M. Shamsutdinova

“…To implement the neural network, the PyTorch deep learning library and Pandas library modules were used. SGD, Adam, Rprop were used as an optimizer to perform gradient descent steps. …”
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Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid by Chuan Wang, Chaode Cen, Huachuan Su, Yuhui Peng, Tao Wang, Jian Li, Fei Zhang, Wuxun Peng

“…The objective of this study was to identify potential biomarkers for ONFH through various analytical methods and experimental verification, thereby providing a robust reference for disease treatment. …”
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CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…Conclusion This study demonstrates a critical oncogenic role of PRC1 in NSCLC. CCNY, which modulates PRC1 phosphorylation, and the TET2-BACH1 cascade, which modulates demethylation and transcription of PRC1, may serve as promising targets for NSCLC management.…”
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