Microneedle‐Delivered PDA@Exo for Multifaceted Osteoarthritis Treatment via PI3K‐Akt‐mTOR Pathway by Zihua Li, Hengli Lu, Limin Fan, Xiaoyi Ma, Zhengwei Duan, Yiwei Zhang, Yuesong Fu, Sen Wang, Yonghao Guan, Dong Yang, Qingjing Chen, Tianyang Xu, Yunfeng Yang

“…In vivo assessments robustly validate that PDA@Exo MN prevents cartilage degradation and OA progression, supported by histological assessments and micro‐CT analysis, highlighting its disease‐modifying impact. The excellent biocompatibility of PDA@Exo MN, verified through histological (H&E) and blood tests showing no organ damage, underscores its safety and efficacy for OA therapy, making it a novel and multifunctional nanomedical approach in orthopedics, characterized by organ‐friendliness and biosecurity.…”
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