Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…Analyses will be performed via repeated measures linear mixed models and generalised linear mixed models of baseline, 6-month and 12-month time points, adjusted for baseline values and covariates selected a priori. …”
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BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease by Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real

“…Clustering analysis was applied to identify patient subgroups, and Cox proportional hazards models were used to assess associations with cerebrovascular events, coronary events, and composite MACE. …”
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Sleep disturbances in SCN8A‐related disorders by Francesca Furia, Katrine M. Johannesen, Claudia M. Bonardi, Roberto Previtali, Angel Aledo‐Serrano, Massimo Mastrangelo, Jacopo Favaro, Silvia Masnada, Valentina diMicco, Jacopo Proietti, Pierangelo Veggiotti, Guido Rubboli, Gaetano Cantalupo, Kern Olofsson, Rikke S. Møller, Elena Gardella

“…Animal studies showed sleep disturbances in SCN8A‐ and SCN1A‐Dravet Syndrome mice models, suggesting a role for voltage‐gated sodium channels in the regulation of sleep. …”
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Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden by Yueshan Zhao, Yueshan Zhao, Yueshan Zhao, Meixi Li, Meixi Li, Meixi Li, Meixi Li, Juan Zhang, Chao Wang, Mengyao Zhao, Qishuo Yang, Tianjun Wang, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv

“…Total CSVD burden was assessed using a composite score incorporating four MRI-based imaging markers. …”
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A 5-Year Follow-Up of Patient-Reported Outcome Measures Following External Beam Radiotherapy or Radical Prostatectomy in Localised Prostate Cancer by Rowan V. David, Peter L. Stapleton, Arman A. Kahokehr, Jason Lee, David I. Watson, John Leung, Michael E. O’Callaghan

“…Multivariable mixed-effects linear modelling was performed to compare differences between EPIC-26 domains over time between ERBT and RP patients. …”
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Associations of elevated levels of brain natriuretic peptide and heart failure and their contribution to survival in the Russian middle-aged population: data from the ESSE-RF study by S. A. Shalnova, V. A. Kutsenko, S. S. Yakushin, A. V. Kapustina, S. E. Evstifeeva, Yu. A. Balanova, A. E. Imaeva, G. A. Muromtseva, S. O. Kuzyakina, A. N. Redko, I. A. Viktorova, N. N. Prishchepa, O. M. Drapkina

“…The analysis used a composite endpoint (n=143) of CVD death plus non-fatal myocardial infarction or cerebrovascular accident. …”
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Food biodiversity and total and cause-specific mortality in 9 European countries: An analysis of a prospective cohort study. by Giles T Hanley-Cook, Inge Huybrechts, Carine Biessy, Roseline Remans, Gina Kennedy, Mélanie Deschasaux-Tanguy, Kris A Murray, Mathilde Touvier, Guri Skeie, Emmanuelle Kesse-Guyot, Alemayehu Argaw, Corinne Casagrande, Geneviève Nicolas, Paolo Vineis, Christopher J Millett, Elisabete Weiderpass, Pietro Ferrari, Christina C Dahm, H Bas Bueno-de-Mesquita, Torkjel M Sandanger, Daniel B Ibsen, Heinz Freisling, Stina Ramne, Franziska Jannasch, Yvonne T van der Schouw, Matthias B Schulze, Konstantinos K Tsilidis, Anne Tjønneland, Eva Ardanaz, Stina Bodén, Lluís Cirera, Giuliana Gargano, Jytte Halkjær, Paula Jakszyn, Ingegerd Johansson, Verena Katzke, Giovanna Masala, Salvatore Panico, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Bernard Srour, Rosario Tumino, Elio Riboli, Marc J Gunter, Andrew D Jones, Carl Lachat

“…DSR of an individual's yearly diet was calculated based on the absolute number of unique biological species in each (composite) food and drink. Associations were assessed by fitting multivariable-adjusted Cox proportional hazards regression models. …”
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A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging by Peggy Ler, Jonathan K. L. Mak, Chandra A. Reynolds, Alexander Ploner, Nancy L. Pedersen, Juulia Jylhävä, Anna K. Dahl Aslan, Deborah Finkel, Ida K. Karlsson

“…We analysed 6216–6512 evaluations from 1902 to 1976 Swedish twins. Dual change score models were applied to assess the bidirectional, longitudinal association between BMI and FI or FAI from ages 60.0–91.9. …”
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Matrix Metalloproteinases 7 and 10 Are Prognostic Biomarkers for Systemic Cardiovascular Risk in Individuals with Peripheral Artery Disease by Ben Li, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…The outcome of interest was a 2-year MACE, defined as a composite of myocardial infarction, stroke, or mortality. …”
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A life that’s worth living – measuring health-related quality of life among people treated for tuberculosis in Viet Nam: a longitudinal EQ-5D-5L survey by Luan Nguyen Quang Vo, Rachel Forse, Andrew James Codlin, Huy Ba Huynh, Anja Maria Christine Wiemers, Jacob Creswell, Tushar Garg, Thi Minh Ha Dang, Lan Huu Nguyen, Hoa Binh Nguyen, Luong Van Dinh, Nhung Viet Nguyen, Tom Wingfield, Kristi Sidney Annerstedt, Jad Shedrawy, Knut Lönnroth

“…We aimed to measure HRQoL among people with TB in Viet Nam at initiation and throughout treatment. Methods This study took place in four provinces from Oct-2020 to Sep-2022. …”
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Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial by Pablo Vidal-Calés, Kamil Bujak, Riccardo Rinaldi, Anthony Salazar-Rodríguez, Luis Ortega-Paz, Josep Gómez-Lara, Víctor Jiménez-Díaz, Marcelo Jiménez, Pilar Jiménez-Quevedo, Roberto Diletti, Pascual Bordes, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Antonio De Miguel-Castro, Andrés Íñiguez, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Nieves Gonzalo, Matteo Tebaldi, Simone Biscaglia, Rafael Romaguera, Joan Antoni Gómez-Hospital, Patrick W. Serruys, Manel Sabaté, Salvatore Brugaletta

“…All endpoints were adjusted with multivariable Cox regression models. Results: The LAD was the culprit vessel in 631 (42%) out of 1498 patients. …”
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The association between age and long-term quality of life after curative treatment for prostate cancer: a cross-sectional study by Reidun Sletten, Ola Berger Christiansen, Line Merethe Oldervoll, Lennart Åstrøm, Håvard Kjesbu Skjellegrind, Jūratė Šaltytė Benth, Øyvind Kirkevold, Sverre Bergh, Bjørn Henning Grønberg, Siri Rostoft, Asta Bye, Paul Jarle Mork, Marit Slaaen

“…Global QoL and PF were assessed by the European Organisation of Research and Treatment in Cancer Quality of life Questionnaire-C30 (QLQ-C30), side effects by the Expanded Prostate Cancer Index Composite (EPIC-26). Adjusted linear regression models were estimated to assess associations between age (continuous variable) at treatment and outcomes. …”
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Patient-reported Outcome Measures and Decision Regret After Prostate-specific Membrane Antigen–targeted Radioguided Surgery for Oligorecurrent Prostate Cancer by Fabian Falkenbach, Giovanni Mazzucato, Zhe Tian, Pierre I. Karakiewicz, Markus Graefen, Thomas Steuber, Derya Tilki, Daniel Koehler, Burkhard Beyer, Pierre Tennstedt, Sophie Knipper, Lars Budäus, Tobias Maurer

“…Data on patient-reported outcome measures (PROMs) are lacking. Methods: A retrospective assessment of validated PROMs (12-item Short Form Health Survey [SF-12], 26-item Expanded Prostate Index Composite, and Decision Regret Scale [DRS]) was performed before and after PSMA-RGS for oligorecurrent PCa. …”
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Timely post-discharge medication reviews to Improve Continuity—the Transitions Of Care stewardship (TIC TOC) study in rural and regional Australia: a parallel-group randomised cont... by Sepehr Shakib, Manya Angley, Jonathan Penm, Charley Budgeon, Kim Nguyen, Rebekah Jane Moles, Faye McMillan, Rohan A Elliott, Paul Yates, Katie Phillips, Jenny Chen, Stephen Ross Carter, Kingston Yeung, Deirdre Criddle, Deborah Rigby, Frank Mario Sanfilippo, Jerry Yik, Deborah Hawthorne, Cristen Fleming, Anna Packer, Linda Krogh, Simon K Poon, Brett Chambers, Shania Liu, Fatemeh Emadi, Klaudia Englezos, Ganga Ratnanayagam, Michelle Penm, Andrew Hawthorne, Alexander Khlentzos, Jilian Khlentzos

“…The primary outcome assessed is a composite of a first unplanned medication-related hospitalisation or ED presentation within 30 days of hospital discharge. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…This study used the TMB algorithm from the FDA-approved test supporting solid tumor CDx and composite mortality variable validated against the national death index: real-world overall survival (rwOS). …”
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CLINICAL EVALUATION OF RESTORATIONS OF ENDODONTICALLY TREATED TEETH by O.A. Udod, R.S. Kostenko

“…The restoration was fixed on a self-adhesive composite cement of double hardening. Clinical evaluation of restoration was performed in 18 and 24 months. …”
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Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction by Nousjka P. A. Vranken, Xinyu Li, Heleen Bouman, Sanne G. J. Mourmans, Anouk Achten, Arantxa Barandiarán Aizpurua, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P. M. van Empel, Jerremy Weerts

“…The primary outcome was a composite of HF hospitalizations (HFH) and all-cause mortality, and was analysed using multivariable-adjusted Cox-regression models. …”
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Serum Concentrations of Matrix Metalloproteinase‐1 and Procollagen Type I Carboxy Terminal Propeptide Discriminate Infarct‐Like Myocarditis and Non−ST‐Segment−Elevation Myocardial... by Lucas Bacmeister, Ersin Cavus, Sebastian Bohnen, Enver Tahir, Hanna Wolf, Annette Buellesbach, Adrian Heidenreich, Virginia K. Haacke, Susanne Weber, Ingo Hilgendorf, Tanja Zeller, Francisco Ojeda, Ulf K. Radunski, Gunnar K. Lund, Gerhard Adam, Stefan Blankenberg, Dirk Westermann, Kai Muellerleile, Diana Lindner

“…As assessed by likelihood ratio tests, incorporating MMP‐1 or PICP with age and C‐reactive protein into composite prediction models enhanced their diagnostic performance. …”
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Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid‐Lowering Therapy by Zhendong Mei, Lili Xu, Qingxia Huang, Chenhao Lin, Mengyao Yu, Shalaimaiti Shali, Hongyi Wu, Yijing Lu, Runda Wu, Zhen Wang, Lingfeng Luo, Zhonghan Sun, Liang Sun, Juying Qian, Guochong Chen, Huiru Tang, Kang Yao, Yan Zheng, Yuxiang Dai, Junbo Ge

“…The association of metabolites with CAD severity was examined using multivariate linear regression, and the underlying potential causality was explored using a 2‐sample Mendelian randomization approach. Two composite metabolomic indices were constructed to reflect CAD severity using least absolute shrinkage and selection operator linear regression, and their associations with risk of major adverse cardiac events during a median follow‐up of 3.8 years were evaluated using Cox models. …”
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Multilevel and multidimensional features of socioeconomic status and cognitive function in older adulthood: a cross-sectional analysis of the IGNITE studyResearch in context by Jermon A. Drake, Lu Wan, Chaeryon Kang, Peter J. Gianaros, Patricio Solis-Urra, Haiqing Huang, Rebecca Reed, Charles H. Hillman, Eric D. Vidoni, Jeffrey M. Burns, Arthur F. Kramer, Edward McAuley, George Grove, Kirk I. Erickson, Lauren E. Oberlin

“…A novel objective SES composite showed robust associations with cognition above and beyond traditional SES measures. …”
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