Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis by Alexandros A. Polymeris, Masatoshi Koga, Daniel Strbian, Adhiyaman Vedamurthy, Manju Krishnan, Mattia Branca, Thomas Horvath, Martina Goeldlin, Gek Shim, Christoph Gumbinger, Liqun Zhang, Espen Saxhaug Kristoffersen, Philippe Desfontaines, Peter Vanacker, Angelika Alonso, Sven Poli, Ana Paiva Nunes, Nicoletta G. Caracciolo, Markus Kneihsl, Timo Kahles, Daria Giudici, Silja Räty, Marjaana Tiainen, Jesse Dawson, Urs Fischer, for the ELAN Investigators

“…Here, we explored the risks and benefits of this approach. Methods A post-hoc analysis of ELAN (Early versus Late Initiation of Direct Oral Anticoagulants in Post-ischemic Stroke Patients with Atrial Fibrillation) trial data (NCT03148457) was conducted to compare the risk of recurrent ischemic stroke, systemic embolism, major bleeding (extracranial or intracranial hemorrhage [ICH]), and vascular death within 30 days (as a composite and as individual outcomes) in participants treated with and without antiplatelets before DOAC initiation after an AF-associated ischemic stroke. …”
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Neurodevelopment at 10 months and 2–3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis by Laura Cornelissen, Siobhan Coffman, Isabelle Kim, Ellen Underwood, Alice Tao, Maria G. Maloney, Carolina Donado, Kimberly Lobo, Charles A. Nelson, Takao K. Hensch, Laurel J. Gabard-Durnam, Charles B. Berde

“…Analyses used adjusted Welch's t-tests, linear regression, and linear mixed effects models. Results: BSID composite scores for cognition were similar between general anaesthesia and unexposed cohorts at 10 months (Padj=0.566, standardised mean difference [SMD]=0.27) and at 2–3 yr (Padj=0.651, SMD=0.25). …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…We used linear regression to identify determinants of impaired RV myocardial strain and Cox proportional hazards models to evaluate their associations with clinical outcomes. …”
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Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability by Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin

“…Type 2 diabetes mellitus mouse models were established, and the mice were subsequently treated with Gps at doses of 200, 100, or 50 mg/kg for 4 weeks. …”
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Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…Results: In multivariable models, faster and more efficient HRF characteristic was found in non-smoker compared to smokers (AUHRF, p = 0.029). …”
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Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study by Na Liu, Xiong‐Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li

“…Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview‐Short Form at baseline. …”
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Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer by Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Arnethea Sutton, Priyanshu Nain, Nelson Hamerschlak, Neal L. Weintraub, Susan Dent, Meng‐Han Tsai, Amitava Banerjee, Arjun K Ghosh, Diego Sadler, Steven S. Coughlin, Ana Barac, John Shanahan, Alberto J. Montero, Avirup Guha

“…AL was modeled as an ordinal measure (0–11). Adjusted Fine–Gray competing risks regressions estimated the impact of AL precancer diagnosis on 2‐year MACE (a composite of heart failure, ischemic stroke, acute coronary syndrome, and atrial fibrillation). …”
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Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia by Sanaz Sedaghat, Saeun Park, Rob F. Walker, Shuo Wang, Jialing Liu, Timothy M. Hughes, Behnam Sabayan, Weihong Tang, Josef Coresh, James S. Pankow, Keenan A. Walker, Ramon Casanova, Ruth Dubin, Rajat Deo, Jerome I. Rotter, Alexis C. Wood, Peter Ganz, Pamela L. Lutsey, Weihua Guan, Anna Prizment

“…Abstract Background: Biological age can be quantified by composite proteomic scores, called proteomics-based aging clocks (PACs). …”
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Associations Between Gene Variants of Lipid‐Lowering Drug Targets and Adverse Outcomes After Ischemic Stroke by Lulu Sun, Qilu Zhang, Mengyao Shi, Yang Liu, Zhengbao Zhu, Jing Zhang, Hao Peng, Aili Wang, Jing Chen, Tan Xu, Yonghong Zhang, Jiang He

“…Genetic risk score was constructed from significant single‐nucleotide polymorphisms identified via additive models, which was calculated by multiplying the number of risk alleles at each locus by the corresponding beta coefficient and then summing the products. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
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Sources of risk communication, knowledge and preventive practices toward Lassa fever in Bauchi State, Nigeria by Benjamin Bukky Ilesanmi, Nathanael Afolabi, Olayinka Badmus, Munkail Titilola, Abdulmajid Ahmad, Usman Inuwa, Matthew Okoh, Hajara Aliyu, Shittu Abdu-Aguye, Foyeke Oyedokun-Adebagbo

“…Percentage and frequency were used to describe all the variables and binary logistic regression models were fitted to examine sources of risk communication and factors associated with KPLF at 95% confidence interval. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Following data cleaning, 1174 responses were included for analysis.Methods: Data were collected using online questionnaires. …”
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MORPHOLOGICAL CHANGES OF RAT PERIODONTIUM IN SUPRAOCCLUSAL RELATIONS OF INDIVIDUAL TEETH IN THE AGE ASPECT by S.M. Zviahin, Y.V. Lakhtin

“…In the experimental group, the state of supraocclusion was modeled by increasing the height of the lower right second molars by placing 1 mm high filling. …”
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The impact of deprivation and neighbourhood food environments on home food environments, parental feeding practices, child eating behaviours, food preferences and BMI: The Family F... by Andrea D Smith, Alice Kininmonth, Kristiane Tommerup, David Boniface, Chiara Gericke, Tiffany Denning, Carolyn Summerbell, Christina Vogel, Clare Llewellyn

“…Deprivation was characterised using a composite measure of family and neighbourhood indicators of socioeconomic position. …”
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Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study by Yuichiro Mori, Toshiaki Komura, Motohiko Adomi, Ryuichiro Yagi, Shingo Fukuma, Naoki Kondo, Motoko Yanagita, O. Kenrik Duru, Katherine R. Tuttle, Kosuke Inoue

“…The primary outcome was a composite of all-cause death, myocardial infarction, stroke, or heart failure. …”
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Prediabetes: prevalence, associations with cardiovascular risk factors and contribution to survival in the Russian population by Yu. A. Balanova, S. A. Shalnova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, S. E. Evstifeeva, G. A. Muromtseva, R. V. Ievlev, R. N. Shepel, O. M. Drapkina

“…To study the contribution of carbohydrate metabolism disorders to mortality and the occurrence of cardiovascular events.Material and methods. We included data from cross-sectional studies ESSE-RF and ESSE-RF2. …”
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Large-scale epidemiology of opisthorchiasis in 21 provinces in Thailand based on diagnosis by fecal egg examination and urine antigen assay and analysis of risk factors for infecti... by Kulthida Y Kopolrat, Chanika Worasith, Phattharaphon Wongphutorn, Anchalee Techasen, Chatanun Eamudomkarn, Jiraporn Sithithaworn, Watcharin Loilome, Nisana Namwat, Attapol Titapun, Chaiwat Tawarungruang, Bandit Thinkhamrop, Samarn Futrakul, Simon D Taylor-Robinson, Melissa R Haswell, Narong Khuntikeo, Thomas Crellen, Paiboon Sithithaworn

“…The data were analyzed with regression models which correlated individual-level explanatory variables against i) infection status with O. viverrini and ii) the intensity of infection, as measured by the antigen assay or FECT.…”
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Impact of coal mine dust exposure and cigarette smoking on lung disease in Appalachian coalminers by Rahul G. Sangani, Andrew J Ghio, Vishal Deepak, Javeria Anwar, Vinita Vaidya, Zalak Patel, Amirahwaty Abdullah

“…Ever-smokers (66% of miner cohort and 76% of non-miner cohort) smoked 35 and 28 composite pack years (CPY) respectively, where miners had greater intensity of smoking (22 vs 18 cigarettes/day) compared to non-miners. …”
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Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD by Bernard Chan, Amanda Varghese, Sunil V. Badve, Roberto Pecoits-Filho, Murilo Guedes, Clare Arnott, Rebecca Kozor, Emma O’Lone, Min Jun, Sradha Kotwal, Geoffrey A. Block, Glenn M. Chertow, Scott D. Solomon, Muthiah Vaduganathan, Vlado Perkovic, Brendon L. Neuen

“…The primary composite endpoint was hospitalization for heart failure or cardiovascular death. …”
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Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk by Maria Vassilaki, MD, PhD, Jeremiah A. Aakre, MPH, Timothy G. Lesnick, MS, Walter K. Kremers, PhD, Jonathan Graff-Radford, MD, David S. Knopman, MD, Thomas H. Mosley, PhD, B. Gwen Windham, MD, MHS, Michael E. Griswold, PhD, Yonas E. Geda, MD, MSc, Val J. Lowe, MD, Clifford R. Jack, Jr., MD, Ronald C. Petersen, MD, PhD, Prashanthi Vemuri, PhD

“…Using a cohort study design, the resulting composite scores were considered as covariates for incident mild cognitive impairment analysis using Cox proportional hazards models. …”
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