Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients by Ahmed Essam Abou Warda, Rylie M. Flohr, Rania M. Sarhan, Rania M. Sarhan, Mohamed Nabil Salem, Heba F. Salem, Heba F. Salem, Ayman N. Moharram, Abdullah S. Alanazi, Christelle Lteif, Brian E. Gawronski, Leanne Dumeny, Tariq G. Alsahli, Khaled Elenizi, Bassem Zarif, Neven Sarhan, Julio D. Duarte

“…Adjusted Cox proportional-hazard regression models were used to assess the effect of SLC5A2 variation on a primary composite outcome of cardiovascular (CV) hospitalization or all-cause mortality in SGLT2i-naïve patients, and HF hospitalization or CV death in dapagliflozin-treated patients. …”
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Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Cox proportional hazard models were used to assess association of outcomes with baseline categories. …”
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Outpatient acute kidney disease detection by national and institutional health data by Hsiu-Yin Chiang, Hung-Chieh Yeh, Zi-Han Lin, Bradley Chen, David Ray Chang, I-Wen Ting, Jie-Sian Wang, Yun-Lun Chang, Hung-Lin Chen, Yu-Chih Liu, Mei-Chuan Hsieh, Tzu-Ling Karen Tzeng, Chin-Chi Kuo

“…In this retrospective cohort study, the associations between AKDOPT and composite kidney outcome (CKO; e.g., end-stage kidney disease, a >40% drop in estimated glomerular filtration rate, or a 2-fold or more increase in serum creatinine), all-cause mortality, and de novo non-dialysis chronic kidney disease (CKD-ND) were evaluated using multivariable Cox proportional hazards models. …”
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Efficacy and safety of direct oral anticoagulants compared with warfarin in antiphospholipid syndrome. Results of a multicenter retrospective cohort study by Maha A.T. Elsebaie, Zoe Wickham, Stephanie DeBragga, Stacey Fedewa, Mohamed Amgad, Jane Jungyoon Park, Allen Li, Ali Eshaghpour, Juan Li, Mark Crowther, Manila Gaddh

“…Cox proportional hazards models estimated hazard ratios (HRs) for the clinical endpoints and defined DOAC or warfarin exposure as time-varying to account for anticoagulant switching. …”
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Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project... by Eva Soler-Espejo, Yang Chen, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, Raquel López-Gálvez, Francisco Marín, Vanessa Roldán, Gregory Y.H. Lip

“…Associations between RC levels and clinical outcomes across LDL-C strata were assessed using multivariable Cox proportional hazards models and as a continuous variable using restricted cubic spline (RCS) analyses. …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…All models will be fitted via generalised estimating equations to account for multiple births and adjusted for the hospital sites.Ethics and dissemination This trial has Royal Children’s Hospital Human Research and Ethics Committee approval (HREC/67604/RCHM-2020) with specific site approval for all participating sites. …”
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Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials. by Kirk U Knowlton, Lianne K Siegel, Christina E Barkauskas, Sanjay Bhagani, Nila J Dharan, Edward M Gardner, Robert L Gottlieb, Marie Helleberg, Helene C Highbarger, Thomas L Holland, Christian Kjer Heerfordt, Susana Lazarte, Lindsey M Leither, Joseph Lutaakome, Magdalena Ardelt, Eleftherios Mylonakis, Sean W X Ong, Jeffrey Scott Overcash, Hassan Taha, Phyllis C Tien, Barbara W Trautner, David Vallee, Amy C Weintrob, Giota Touloumi, Abdel G Babiker, STRIVE ACTIV-3/TICO Study Group

“…Within each trial, three major outcomes (sustained recovery, mortality, and a composite safety outcome) were compared between treatment and placebo using Fine-Gray and Cox proportional hazards models. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“…Generalized linear regression models were used to examine the associations between HAC-OP-DPC and LOS, and logistic regression models were used to examine the associations between HAC-OP-DPC and discharge to other hospitals and long-term care facilities (LTCFs). …”
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The bidirectional relationship between severity of obsessive-compulsive symptoms and lifestyle factors in patients with obsessive-compulsive disorder: a contemporaneous and prospec... by Johanna A. M. du Mortier, Anton J. L. M. van Balkom, Anton J. L. M. van Balkom, Jos W. R. Twisk, Patricia van Oppen, Patricia van Oppen, Henny A. D. Visser, Henny A. D. Visser

“…In the present study, drug and alcohol use, higher BMI, and a composite score of unhealthy lifestyle factors were not associated with more severe OCD symptoms and did not predict greater symptom severity two years later. …”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Marginal structural models showed similar results (HR, 1.75; 95% CI, 1.32–2.31 and HR, 2.09; 95% CI, 1.23–3.55, respectively). …”
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Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events by Yun‐Jiu Cheng, Zi‐Li Liao, Li‐Juan Liu, Yue‐Dong Ma, Xu‐Miao Chen, Ze‐Xuan Wu, Hui‐Qiang Wei, Wei‐Dong Lin, Yi‐Jian Liao, Su‐Hua Wu, Yu‐Mei Xue, Li‐Chun Wang, Yang Wu

“…Cox proportional hazards models were applied to evaluate the association between LV size and composite cardiovascular outcomes. …”
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Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide. by Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, Megan Rice, Ana Pereira, Maria Luisa Garmendia, Rulla M Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Samera A Qureshi, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Farhana Fadzli, Beata Peplonska, Agnieszka Bukowska, Chisato Nagata, Jennifer Stone, John Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schüz, Carla H Van Gils, Johanna O P Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Caroline Dickens, Mikael Hartman, Kee-Seng Chia, Christopher Scott, Anna M Chiarelli, Linda Linton, Marina Pollan, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Norman Boyd, Isabel Dos-Santos-Silva, Valerie McCormack

“…MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. …”
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Impact of Medical Conditions and Area Deprivation on Fundraising Success in Online Crowdfunding: Cross-Sectional Study by Steven S Doerstling, Matthew M Engelhard, Dennis Akrobetu, Caroline E Sloan, Ada Campagna, Thuy-Vi Nguyen, Farrah Madanay, Felicia Chen, Peter A Ubel

“…Generalized linear models were constructed to estimate the impact of mentioning specific disease categories and the campaign’s area deprivation on the amount of money raised. …”
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Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome by Yongwei Huang, Xiaoshuang Yin, Zongping Li

“…Kaplan–Meier analysis and Cox proportional hazards and Fine-Gray competing risk regression models were utilized to evaluate the links between SII/SIRI and death outcomes in CKM individuals. …”
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Comparative cardiovascular outcomes of aripiprazole vs. risperidone in patients with type 2 diabetes and schizophrenia: a retrospective cohort study by Yi-Ting Yeh, Shih-Chang Lo, Chien-Ning Huang, Chien-Ning Huang, Chien-Ning Huang, Yi-Sun Yang, Yi-Sun Yang, Pei-Lun Liao, Edy Kornelius, Edy Kornelius

“…Kaplan-Meier estimation and Cox proportional hazards models were used to compare outcomes over up to 10 years of follow-up. …”
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4-D ERT monitoring of oil spill contamination dynamics and remediation planning in southern Nigeria by Stanley Uchechukwu Eze, Difference Odeyovwi Ogagarue, Juyeon Jeong, Myung Jin Nam, Omafume M. Orji, Williams N. Ofuyah

“…A time-dependent evaluation of 3-D ERT models showed a reduction in the apparent resistivity of the contaminant plume during the rainy season compared to the dry season. …”
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Remnant cholesterol inflammatory index, calculated from residual cholesterol to C-reactive protein ratio, and stroke outcomes: a retrospective study using the National institutes o... by Yanmei Yu, Yiming Zhang, Chunyan Zhu, Tingting Duan, Zichen Rao

“…Subpopulation analysis, inflection point analysis, generalized additive models (GAM), and receiver operating curve (ROC) analyses were utilized to evaluate the ability of these biomarkers to predict outcomes and to identify their optimal cutoff points. …”
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Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study by Han-Qing Zhao, Han-Qing Zhao, Jia-Le Lv, Jia-Le Lv, Yuan-Zhi Gao, Bo Hu, Zong-Da Du, Zong-Da Du, Zong-Da Du, Yan Wang, Mei-Lin Wang, Mei-Lin Wang, Meng-Di Hou, Fang Li, Xue Xing, Ming-Hui Sun

“…BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. …”
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Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity by Yuqin Ouyang, Yuqin Ouyang, Xinyue Xiang, Xinyue Xiang, Xinyun Hu, Xinyun Hu, Xuehui Chu, Wenjuan Tang, Wenjuan Tang, Wenhuan Feng, Wenhuan Feng, Wenhuan Feng

“…Participants were categorized based on therapeutic success: those achieving composite endpoints (≥5% total weight loss [TWL] and BMI normalization to <28 kg/m²) versus suboptimal responders. …”
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Associations between triglyceride glucose-body mass index and 30-day mortality in patients with hemorrhagic stroke: analysis of the MIMIC-IV database by Yuexin Lu, Yuexin Lu, Enjie Song, Enjie Song, Ruilin Chen, Ruilin Chen, Long Jing, Long Jing, Jiahao Tang, Jiahao Tang, Shunan Shi, Shunan Shi, Ming Wang, Ming Wang, Ming Wang, Ming Wang, Shu Wan, Shu Wan, Shu Wan, Shu Wan

“…Multivariable Cox regression, Kaplan–Meier analysis, and restricted cubic spline models assessed mortality risks at 30-day, 90-day, and 1-year intervals. …”
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