SimProx: A Similarity-Based Aggregation in Federated Learning With Client Weight Optimization by Ayoub El-Niss, Ahmad Alzu'Bi, Abdelrahman Abuarqoub, Mohammad Hammoudeh, Ammar Muthanna

“…Traditional aggregation methods, such as Federated Averaging (FedAvg), often assume uniform client contributions, leading to suboptimal global models in heterogeneous data environments. …”
Get full text

Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring by Zhaoming Liu, Zhaoming Liu, Caixia Wu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li, Zhiyuan Li, Zhiyuan Li

“…Emerging evidence implicates the microbiota-gut-brain axis as a critical mediator of neuroinflammation and cognitive deficits, but causal pathways in VPA-induced ASD models require systematic exploration. This study investigates how prenatal VPA exposure reshapes gut microbiota composition, exacerbates neuroinflammatory responses, and drives cognitive dysfunction through the microbiota-gut-brain axis in C57BL/6 mouse offspring.MethodsPrenatal VPA-exposed and control offspring underwent behavioral assessments (open field, three-chamber social interaction, marble-burying, and Morris water maze tests). …”
Get full text

Curcumin supplementation accelerates high-altitude acclimatization, prevents polycythemia and modulates gut microbiota in male Han population: a randomized controlled trial by Jilei Hu, Hongmei Lang, Die Fan, Ting Wen, Jiaojiao Shi, Chunxiu Xiao, Yunming Li, Chao Kang, Peijie Shi, Peijie Shi, Lirong Shen, Ning Lin, Ning Lin, Ning Lin

“…BackgroundPrevious evidence showed that curcumin enhanced the oxygen supply efficiency of hemoglobin and alleviated acute plateau hypoxia injury in animal models. However, its efficacy on human beings is not yet verified. …”
Get full text

Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease by Zixuan Wang, Zixuan Wang, Ge Chen, Xutong Sun, Jia Xiao, Lingling Kong, Shunshun Jiang, Tingting Xu, Meijiao Wang, Meijiao Wang, Hong Zhao

“…Post-modeling, MASLD mice were randomized into three groups: HF (continued high-fat diet), HF-NC (switched to normal chow), and HF-MD (switched to MD). …”
Get full text

Intranasal Transplantation of Microbiota Derived from Parkinson’s Disease Mice Induced Astrocyte Activation and Neurodegenerative Pathology from Nose to Brain by Yi-Meng Xia, Mei-Xuan Zhang, Xiao-Yu Ma, Lu-Lu Tan, Ting Li, Jian Wu, Ming-An Li, Wei-Jiang Zhao, Chen-Meng Qiao, Xue-Bing Jia, Yan-Qin Shen, Chun Cui

“…However relative studies are rare. Methods: By consecutive 14-days intranasally transplanting bacteria, we established mice models exhibiting nasal microbiota dysbiosis (NMD), including animal group received intranasal drops of fecal bacterial suspension from normal mice (NB group) and animal group received intranasal drops of fecal bacterial suspension from PD mice (PB group), with animals that only received anesthesia used as the control group. …”
Get full text

Unlocking the therapeutic potential of Pelargonium sidoides natural extract: A scoping review by Bárbara Donadon Reina, Samuel Santana Malheiros, Sâmmea Martins Vieira, Paula Ferreira de Andrade, Lívia Nordi Dovigo

“…Nonetheless, the establishment of a concentration protocol to further studies is still challenging due to variations in extract origin, composition and extraction methods. In this sense, the use of a commercial extract such as EPs® 7630 is of great value to facilitate the standardization of the tested protocols. …”
Get full text

Obesity-fertility cohort study: protocol for the assessment of children aged 6–12 years and their mothers by Marie-Eve Mathieu, Jean-Patrice Baillargeon, Patrice Perron, Anne-Sophie Morisset, Farrah Jean-Denis, Frederic Dallaire, Alexandra Thibodeau, Soren Harnois-Leblanc, Martin Brochu

“…This manuscript details the study protocol.Methods and analysis This is an ancillary nested cohort study of the obesity-fertility RCT. …”
Get full text

Heat Adaptation Benefits for Vulnerable groups In Africa (HABVIA): a study protocol for a controlled clinical heat adaptation trial by Michaela Deglon, Chad Africa, Larske Marit Soepnel, Thandi Kapwata, Ama de-Graft Aikins, Kweku Bedu-Addo, Guy Howard, Estelle Victoria Lambert, Dale Elizabeth Rae, Martha Sibanda, Christopher Gordon, Mark New, Lara Ruth Dugas

“…Quantitative comparisons will be made between intervention and control conditions using generalised linear mixed models. Qualitative data from consultive workshops will be used to assess the acceptability and feasibility of the adaptations. …”
Get full text

Anti-Infection Efficacy, Osteogenesis Potential, and Biocompatibility of 3D Printed PLGA/Nano-Hydroxyapatite Porous Scaffolds Grafted with Vancomycin/DOPA/rhBMP-2 in Infected Rabbi... by Ke re mu ALM, Abulikemu M, Liang Z, Abulikemu A, Tuxun A

“…Through the three-dimensional (3D) printing technology, we fabricated a poly(lactic-co-glycolic acid)(PLGA)/nano-hydroxyapatite (n-HA) composite scaffold grafted with the antibiotic vancomycin and loaded with the osteoinductive agent recombinant human bone morphogenic protein-2 (rhBMP-2) via polydopamine (DOPA) chemistry, whose therapeutic effects on IBD were determined.Methods: After examining the hydrophilicity, surface chemical composition, mechanical properties, and drug release of the PLGA/n-HA, PLGA/n-HA/VAN, and PLGA/n-HA/VAN+DOPA/rhBMP-2 composite scaffolds, pre-osteoblast MC3T3-E1 cells were seeded onto the scaffold surface to assess the biocompatibility and osteoconductive properties of the scaffolds in vitro. …”
Get full text

Evaluation of the Efficiency of a Soft Dosage Form for the Treatment of Osteoarthritis: Influence on the Level of Pro-inflammatory Cytokines by U. V. Nogaeva, V. E. Kovanskov, D. Yu. Ivkin, E. V. Flisyuk, K. D. Yakimov, E. I. Yeletskaya, E. D. Semivelichenko, V. G. Antonov

“…Preclinical modeling of the pathology was carried out by combined injection of 0.1 ml of a mixture of complete Freund's adjuvant with a 10 % suspension of talc in isotonic sodium chloride solution in a ratio of 1 : 10 into the cavity of the hock (tarsal) joint of Brown Norvay Catholic Rats male rats. …”
Get full text

Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways by Chen Chen, Min Qi, Weilong Zhang, Fanxing Chen, Zhihong Sun, Weizhong Sun, Wenjie Tang, Zhenguo Yang, Xuan Zhao, Zhiru Tang

“…Partial least squares path modeling and molecular docking were used to explore the intrinsic relationship between PQ, Tau, and the gut-liver axis. …”
Get full text

Success Factors of Growth-Stage Digital Health Companies: Systematic Literature Review by Estelle Pfitzer, Laura Bitomsky, Marcia Nißen, Christoph Kausch, Tobias Kowatsch

“…We categorized them into internal factor categories (Product and Services, Operations, Business Models, and Team Composition) and external factor categories (Customers, Health Care System, Government and Regulators, Investors and Shareholders, Suppliers and Partners, and Competitors). …”
Get full text

Food additive mixtures and type 2 diabetes incidence: Results from the NutriNet-Santé prospective cohort. by Marie Payen de la Garanderie, Anaïs Hasenbohler, Nicolas Dechamp, Guillaume Javaux, Fabien Szabo de Edelenyi, Cédric Agaësse, Alexandre De Sa, Laurent Bourhis, Raphaël Porcher, Fabrice Pierre, Xavier Coumoul, Emmanuelle Kesse-Guyot, Benjamin Allès, Léopold K Fezeu, Emmanuel Cosson, Sopio Tatulashvili, Inge Huybrechts, Serge Hercberg, Mélanie Deschasaux-Tanguy, Benoit Chassaing, Héloïse Rytter, Bernard Srour, Mathilde Touvier

“…Exposure to food additives was evaluated through multiple food composition databases and laboratory assays. Mixtures were identified through nonnegative matrix factorization (NMF), and associations with type 2 diabetes incidence were assessed using Cox models adjusted for potential socio-demographic, anthropometric, lifestyle and dietary confounders. …”
Get full text

Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy by Li Zhang, Sergio Rutella, Jongbok Lee, Ismat Khatri, Yoosu Na, Enoch Tin, Karen Fang, Michele Nawata, Juan Arteaga, Mark D Minden

“…The anti-leukemic activity and in vivo persistence of DNTs and Vδ2 T-cells were explored using flow cytometry-based cytotoxicity assays, memory phenotyping, and xenograft models.Results Despite a shared Vδ2 expression between cellular products, we identified unique cellular compositions in DNTs that contribute to distinct transcriptional and cellular communication patterns relative to the donor-matched Vδ2 T cells, including higher expression of genes identified in chimeric antigen receptor T cells that persist in patients with durable cancer-remission. …”
Get full text

Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…Conclusions: We have developed convolutional neural network models that predict a wide range of echocardiographic findings, including left-sided cardiac abnormalities, valvular heart diseases, and right-sided cardiac abnormalities from ECGs and created a model to predict a composite findings label by logistic regression analysis. …”
Get full text

Similarity Principle for Ship Plate Structures by Haicheng Yu, Songhao Wu, Wenlong Liu, Haiyi Yang

“…We propose a design methodology to determine the appropriate scaled model for ship plate structures. To validate our proposed similarity principle and its associated design method, we present several numerical experiments. …”
Get full text

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism by Milić Rade, Džudović Boris, Subotić Bojana, Obradović Slobodan, Soldatović Ivan, Petrović Marina

“…Results from univariate logistic regression model showed that troponin was statistically significant predictor of 30-day mortality. …”
Get full text

基于APDL与高级语言的齿轮有限元建模方法 by 唐进元, 刘艳萍, 周长江, 吕文利

“…Based on the generating principle, conjugate curves of processed gear cut by the arc situated at pre-grinding hob are derived in term of coordinate conversion and separated. According to the method for plane curves synthesis, conjugate curves cut by the different parts of the hob are composed numerically, and the datum of complex tooth profile are calculated exactly.The datum are called by APDL in ANSYS, then FEM geometrical model of complex tooth profile machined by pre-grinding hob are established accurately.Combined by strong numeric analysis and treatment of MATLAB and the facility and openness of APDL, compositive programming with MATLAB and APDL is advanced based on full-text data files.…”
Get full text

Mapping subtidal seagrass in the turbid Baltic Sea: Rethinking satellite sensor selection using a sensor-agnostic pipeline by Eike M. Schütt, Florian Uhl, Philipp R. Schubert, Thorsten B.H. Reusch, Natascha Oppelt

“…Our results highlight the need for different preprocessing steps, such as water column correction, segmentation, compositing and de-striping, to maximize model performance based on sensor characteristics. …”
Get full text

Mechanical effects of foundation restoration on onlay preparations of mandibular first molars after endodontic treatment by Qiuyue Wang, Dongqi Shi, Xiangling Liu, Weijun Zhang, Zhaolun Sun, Yao Feng, Lingbo Zhang

“…The purpose was to analyze the stress distribution of onlays with composite resin foundation restorations and to investigate the potential benefits of preserving the remaining dental tissue.A three-dimensional finite element model of a mesial proximal defect of the mandibular first molar after endodontic treatment was established. …”
Get full text