The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis by Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen

“…Here, we investigate the therapeutic potential of GSK-J4 to prevent diabetes development and examine the importance of H3K4 methylation for islet function. Materials and Methods. We used two mouse models of diabetes to investigate the therapeutic potential of GSK-J4. …”
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Long-term straw return with moderate nitrogen levels reshapes soil bacterial communities in a vertisol by Zichun Guo, Rui Qian, Rui Qian, Rui Qian, Wei Li, Tianyu Ding, Tianyu Ding, Lei Gao, Lei Gao, Xinhua Peng

“…The Mantel test showed a strong correlation between soil pH and bacterial diversity, while fungal composition was influenced by SOC, TN, and NO3−-N. Partial Least Squares Path Modeling (PLS-PM) demonstrated that N fertilization directly and indirectly increased wheat yield through improved soil properties, while straw return enhanced bacterial diversity, indirectly supported wheat yield. …”
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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…The WWI-VI correlation may eliminate the obesity paradox in the ophthalmic epidemiological area and indicate the detrimental impact of changes in body composition on VI.…”
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Application of Response Surface Methodology for the Optimization of Basic Red 46 Dye Degradation in an Electrocoagulation–Ozonation Hybrid System by Nguyen Trong Nghia, Vinh Dinh Nguyen

“…The quadratic model exhibited strong predictive power, with an adjusted R² of 0.9897 and a predicted R² of 0.9812. …”
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Ivan Nebesnyi’s Music for Plays: Syntactic Aspect by Олена Якимчук

“…The theme is the semantic and intonational code of the play, its sound model, and business card. The characteristic feature of I. …”
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Predictors of the Development of Major Adverse Cardiac Events following Percutaneous Coronary Intervention by Nouha Azaza, Fahad O. Baslaib, Akram Al Rishani, Mariam Ahmed, Jumana Al-Zainal, Mohamed Aboalela, Marian Gargousa, Geili Abdalla, Nadim Shah

“…In the multivariable regression model, only cardiogenic shock (odds ratio [OR] = 32.43) and the presence of diabetes mellitus (OR = 3.36) were predictors of MACE. …”
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Axial Compression Behavior of Circular Concrete-Filled High-Strength Thin-Walled Steel Tubular Columns with Out-of-Code D/t Ratios by Jun-Xin Li, Jian-Tao Wang, Qing Sun, Yan-Ru Wu, Shi-Ming Zhou, Fa-Cheng Wang

“…The axial compression test was first conducted to examine the failure mode, load-displacement curves, and composite mechanism effect. The finite element (FE) model was thereafter established to perform full-range analysis on the load versus displacement curve as well as the interaction behavior, where the parametric study was performed to investigate the influences of the material strengths and geometric sizes. …”
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Development, Validity, and Reliability of Adolescent Motivation Inventory-Cerebral Palsy by Moslem Dehghanizadeh, Malahat Akbarfahimi, Armin Zareiyan, Farzaneh Yazdani, Mitra Khalafbeigi

“…Results: Five factors with 22 items were extracted by EFA, accounting for 50.42% of the variance. The results of model fit indexes confirmed the goodness-of-fit of the final model with 20 items. …”
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Optimization of ultrasound-electrocatalytic process for improving the quality of biological treatment effluent by Parviz Abdi, Kobra Verdijkazemi, Arezoo Nejaei, Afshin Takdastan

“…The anode electrode analyses indicate that the synthesis is sufficient. The quadratic model is noteworthy because of the P-value (0.0001) and the F-value (600.39). …”
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Prognosis of acute ST-elevation myocardial infarction depending on the morphological features of intracoronary thrombi by D. I. Besh

“…The model is reliable (P < 0.0001) with a sensitivity of 83.33 % and a specificity of 88.24 %. …”
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Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Methods: MEDLINE, Embase and PubMed were searched from inception to 30 April 2025. …”
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The GD3 ganglioside promotes cell growth, plasticity and chemotherapy resistance of human glioblastoma cancer stem cells by Victoria Hein, Nathalie Baeza-Kallee, Raphaël Bergès, Nora Essakhi, Aurélie Soubéran, Carole Colin, Philippe Morando, Romain Appay, Thomas Graillon, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret

“…Here, we aimed to demonstrate that the GD3 ganglioside was a relevant marker and actionable target for glioblastoma cancer stem-like cells. Methods To this end, we used commercial glioblastoma cell lines, human glioblastoma samples, organotypic culture and xenografted mouse models to study GD3 antigen expression and consequences of its downregulation through a shRNA strategy targeting the ST8SIA1 mRNA which encodes the key enzyme for GD3 synthesis. …”
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Influence of cognitive, neuropsychiatric, and diagnostic factors on financial capacity: A longitudinal analysis of the ADNI cohort by Milap A. Nowrangi, Jeannie Marie Leoutsakos, Haijuan Yan, Arnold Bakker, Kevin J. Manning, George W. Rebok, Paul B. Rosenberg, Vidyulata Kamath

“…To investigate the relationship between FC, cognitive domains, neuropsychiatric symptoms, and transitions from normal cognition (cognitive normal [CN]) to mild cognitive impairment (MCI) or Alzheimer's disease (AD), we conducted a secondary analysis of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Financial Capacity Instrument short form (FCI‐SF). Methods To examine these longitudinal relationships, we fit two models, a random effects (random intercept) “time‐averaged” model and a “time since previous visit” model, where we regressed each of the five component financial scores on each of the cognitive composite scores. …”
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Potential activity of Ferula macrecolea essential oil for treating Giardia lamblia infection through modulating electrolytes and suppressing NF-κB p65 pathway by Iraj Salimikia, Seyed Ehsan Yaghoubi, Amal Khudair Khalaf, Leila Masoori, Javad Ghasemian Yadegari, Hossein Mahmoudvand, Hossein Mahmoudvand

“…In light of the previously discussed information and the recognized antimicrobial properties of Ferula macrecolea, this study aims to investigate both the in vitro and in vivo anti-giardial effects of F. macrecolea essential oil (FME) on G. lamblia infection.MethodsGas chromatography-mass spectrometry (GC-MS) was utilized to analyze the chemical composition of the prepared FME. …”
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Modulation of the Plasma Lipidomic Profile in Piglets Fed Polar Lipid-Rich Diets by Rayllana Larsen, Salma Chakroun, Marie-Pierre Létourneau-Montminy, Janie Levesque, Dimas Estrasulas de Oliveira, Jorge Eduardo Rico, Daniel E. Rico

“…Their health benefits need to be further characterized in other models of stress and inflammation.…”
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Abstract 229: Recanalization Rate in Mechanical Thrombectomy in Patients With Elevated LDL‐C Levels by Xiaoyi Gao, Kara Christopher, Wilson Rodriguez, Weston Gordon, Guillermo Linares

“…Multivariable logistic regression models were fitted to determine the odds of the outcomes while adjusting for age, race, and gender. …”
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Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude by Feng Zeng, Hanxue Li, Yan Ma, Yan Ma, Shuang Ma, Shuang Ma

“…This study investigated the contribution of gut microbiota to cognitive dysfunction induced by chronic hypoxia.MethodsC57BL/6 J mice were assigned to four groups: control group (NC), control pseudo-germ-free group (CA), hypoxic group (HC), and hypoxic pseudo-germ-free group (HA). …”
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Gut microbiota dysbiosis in patients with Alzheimer’s disease and correlation with multiple cognitive domains by Qionglei Chen, Jiayu Shi, Gaojie Yu, Huijia Xie, Shicheng Yu, Jin Xu, Jiaming Liu, Jing Sun

“…The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.MethodsA total of 64 subjects (18 mild AD, 23 severe AD and 23 healthy control) were recruited in the study. 16 s rDNA sequencing was performed for the gut bacteria composition, followed by liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) analysis of short-chain fatty acids (SCFAs). …”
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Cropland restricts occurrence and alters spatial ecology near the mule deer geographical range limit by Levi J. Heffelfinger, David G. Hewitt, Joshua P. Vasquez, Timothy E. Fulbright, Randy W. DeYoung, Louis A. Harveson, Warren C. Conway, Shawn S. Gray

“…Cropland can benefit wildlife nutritionally but may result in habitat loss because of changes in landscape composition and human disturbance. Methods We quantified the influence of cropland presence and coverage on mule deer spatial ecology in the southern Great Plains. …”
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The effect of prenatal balanced energy and protein supplementation on gestational weight gain: An individual participant data meta-analysis in low- and middle-income countries. by Dongqing Wang, Uttara Partap, Enju Liu, Janaína Calu Costa, Ilana R Cliffer, Molin Wang, Sudeer Kumar Nookala, Vishak Subramoney, Brittany Briggs, Imran Ahmed, Alemayehu Argaw, Shabina Ariff, Nita Bhandari, Ranadip Chowdhury, Daniel Erchick, Armando García-Guerra, Masoumah Ghaffarpour, Giles Hanley-Cook, Lieven Huybregts, Fyezah Jehan, Fatemeh Kaseb, Nancy F Krebs, Carl Lachat, Tsering Pema Lama, Dharma S Manandhar, Elizabeth M McClure, Sophie E Moore, Ameer Muhammad, Lynnette M Neufeld, Andrew M Prentice, Amado D Quezada-Sánchez, Dominique Roberfroid, Naomi M Saville, Yasir Shafiq, Bhim P Shrestha, Bakary Sonko, Sajid Soofi, Sunita Taneja, James M Tielsch, Laéticia Céline Toe, Naser Valaei, Wafaie W Fawzi

“…Linear and log-binomial models were used to estimate study-specific mean differences or risk ratios (RRs), respectively, with 95% confidence intervals (CIs) of the effects of prenatal BEP on the GWG outcomes. …”
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