Comparative study of specific activity of rectal suppositories with clopidogrel by I. L. Kechyn, V. V. Hladyshev, O. L. Drozdov, O. B. Kharaponova, S. A. Hladysheva

“…Using the biochemical model of pathology, it was established that the applicative semisolid medication of clopidogrel in the form of rectal suppository exhibited inductive anti-aggregation activity and its administration didn’t reveal any side effects and undesirable events. …”
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Asteroid Types, Albedos, and Diameters Catalog from Gaia DR3: Intelligent Inversion Results via Multisource Information Fusion by Jiayi Ge, Xiaoming Zhang, Juan Li, Huijuan Wang, Dawei Xu, Xiaojun Jiang

“…Applied to Gaia DR3, the proposed methods yield a catalog of taxonomic types, albedos, and diameters for 58,168 asteroids. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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New framework for the development of clinical guidelines in Russia by D. V. Blinov, E. S. Akarachkova, A. S. Orlova, E. V. Kryukov, D. I. Korabelnikov

“…Aim - based on the existing regulations and recent documents from the regulatory bodies, determine the methodology for the development of clinical guidelines (CG) that meet the requirements of the legislation in the Russian Federation.Materials and methods. We analyzed a number of regulatory and subordinate acts confirming the concept and status of the CG, in particular, the Federal Law № 323-ФЗ “On the principles of health care for citizens of the Russian Federation”, Federal Law № 489-ФЗ “On the amendments to article 40 of the Federal Law “On compulsory medical insurance in the Russian Federation” and the Federal Law “On the principles of health care for citizens of the Russian Federation” concerning clinical guidelines, Order № 102н of the Ministry of Health of the Russian Federation dated 28 Feb 2019 “Regulations on the scientific and practical council of the Ministry of Health of Russia” and Order № 103н of the Ministry of Health of the Russian Federation of 28 Feb 2019 “On Approval of the procedure and terms for the development of clinical guidelines and their revision, the model format of clinical guidelines and requirements to their structure, contents and scientific validity of the information included in the clinical guidelines”. …”
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Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer by Tetsuya Isaka, Takuya Nagashima, Kota Washimi, Haruhiro Saito, Hiroto Narimatsu, Shunsuke Shigefuku, Chiaki Kanno, Ryotaro Matsuyama, Naoko Shigeta, Yui Sueishi, Hiroyuki Ito

“…ABSTRACT Background The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early‐stage lung cancer remains unclear. …”
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The mechanism of SAP overexpression in alleviating periodontitis in mice by HUANG Yinyin, LIANG Dongliang, ZOU Yaokun, HAN Jingru, GE Qing, LIU Xueyan, GUO Yadong, HUANG Xinli, YANG Lan

“…Oral microorganism composition was analyzed using 16S ribosomal RNA (16S rRNA) gene sequencing. …”
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Urban landfill site selection with combined environmental and socio-economic criteria in Naein County and estimation of its possible emitted biogas by Mohammad Erfan Kaghazchi, Said Pourmanafi, Reza Peykanpour Fard

“…The aim of this study was to accurately locate the municipal landfill in Naein County by combining socio-economic and environmental parameters and also estimating the amount of emitted gas to evaluate the potential for energy recycling.Material and methods: In this study, the AHP model was used to weight the criteria and L Satty quantitative scale was used to grade the priorities. …”
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Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier by Yi Gao, Yi Gao, Lan Deng, Lan Deng, Yuanyuan Chen, Yuanyuan Chen, Peiyou Qin, Yuanyuan Zhao, Xiaoyan Zhao, Wei Liu, Dan Wang, Shuang Zhao

“…This study investigated the therapeutic potential of Pleurotus citrinopileatus polysaccharide (PCP-g), a novel galactoglucan, against sucralfate-induced constipation murine model, focusing on intestinal motility, fecal parameters, aquaporin signaling, and gut microbiota modulation.MethodsPCP-g was purified from P. citrinopileatus and its physicochemical properties were characterized. …”
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Chemical and isotopic signatures of hot springs from east-central Sonora State, Mexico: a new prospection survey of promissory low-to-medium temperature geothermal systems by Erika Almirudis, Edgar R. Santoyo-Gutiérrez, Mirna Guevara, Francisco Paz-Moreno, Enrique Portugal

“…The collected samples were analysed by chemical and isotopic methods for determining their chemical (major and trace elements) and isotopic (18O/16O and D/H) compositions. …”
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ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota by Yi-Hsuan Liu, Yueh-Lun Lee, Chia-Li Han, Yu-Chun Lo, Zih-An Liao, Yu-Syuan Shih, Yi-Wen Lin, Syue-Wei Peng, Kang-Yun Lee, Shu-Chuan Ho, Sheng-Ming Wu, Cheng-Wei Lin, Kian Fan Chung, Jer-Hwa Chang, Hsiao-Chi Chuang

“…This study investigated the effects of ITIH4 on the modulation of lung and gut microbiota, the attenuation of allergic inflammation, and the improvement of respiratory outcomes in an asthma mouse model. Methods Six-week-old male Balb/c mice were divided into five groups: control, ITIH4, ovalbumin (OVA), and two OVA + ITIH4 treatment groups at different doses. …”
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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation by Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

“…However, it remains unknown whether and how FPHA affects the immune microenvironment of the bone defects. Methods FPHA was synthesized and its composition and structural properties were confirmed. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Additionally, proteomic analysis was conducted to characterize the protein composition of HepLPC-secretomes. Results:. Transplantation of HepLPCs resulted in decreased active fibrogenesis and net fibrosis in cirrhosis models. …”
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The treatment of drug-induced rhinitis with an original intranasal combination: Efficacy and safety in experimental animals by E. A. Smolyarchuk, Xi Yang, V. M. Svistushkin, K. V. Eremeeva, Zh. M. Kozlova, D. A. Kudlay, A. S. Machikhin, A. V. Guryleva, D. A. Derevesnikova, A. A. Nedorubov

“…The model of induced RM was confirmed by histological examination of the nasal mucosa of 3 randomly selected out of 15 animals after necropsy. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Their structure and composition characterization were performed using TEM, NTA and UHPLC-QTOFMS. …”
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Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes by Luca Di Nunno, Luca Di Nunno, Veronica Pagani, Elena Canciani, Gerardina Ruocco, Gerardina Ruocco, Mattia Spedicati, Mattia Spedicati, Maria Talmon, Luca Fusaro, Dalila Di Francesco, Dalila Di Francesco, Simona Casarella, Manuela Rizzi, Francesca Boccafoschi, Francesca Boccafoschi

“…Scanning electron microscopy and energy-dispersive X‐ray spectroscopy were used in order to characterize the scaffold’s morphology and chemical composition. Mechanical properties were evaluated using a tensile stress test, while wettability was measured using contact angle analysis. …”
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Factors Affecting the Ideals of Childbearing among Young People within Iranian Ethnic Groups by Zahra Ghorbani, Mohamad Aghasi

“…Given Iran's diverse ethnic composition, it is crucial to explore the relationship between ethnicity and fertility. …”
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Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…This study aims to investigate the effect of PD-L1 knockout on gut microbiota in an experimental autoimmune uveitis (EAU) model.MethodsEAU was induced via immunization with interphotoreceptor retinoid-binding protein peptide 651-670 (IRBP651-670) in either wild type (WT) or PD-L1 knockout (KO) C57BL/6J female mice. …”
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Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia by Rongrong Zhou, Rongrong Zhou, Tingting Liu, You Qin, Jing Xie, Shuihan Zhang, Yi Xie, Jia Lao, Wei He, Hongliang Zeng, Xueyang Tang, Xuefei Tian, Xuefei Tian, Yuhui Qin, Yuhui Qin

“…This research endeavored to assess the medicinal efficacy of PCPs in alleviating muscle atrophy and fat lipolysis and explore the potential mechanisms.Methods: A cancer cachexia model was induced by male C57BL/6 mice bearing Lewis lung tumor cells and chemotherapy. …”
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Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden S... by Ekaterina Stepanova, Victoria Matyushenko, Daria Mezhenskaya, Ekaterina Bazhenova, Tatiana Kotomina, Alexandra Rak, Svetlana Donina, Anna Chistiakova, Arina Kostromitina, Vlada Novitskaya, Polina Prokopenko, Kristina Rodionova, Konstantin Sivak, Kirill Kryshen, Valery Makarov, Larisa Rudenko, Irina Isakova-Sivak

“…The trivalent LAIV/CoV-2 composition was compared to the classical 3×LAIV in the golden Syrian hamster model. …”
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Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing by Yueling Peng, Yaling Zhang, Yaling Zhang, Rui Wang, Xinyu Wang, Xingwei Liu, Hui Liao, Rongshan Li

“…Inonotus obliquus (Chaga), a traditional medicinal mushroom, has shown promising effects in chronic kidney disease (CKD), yet its cellular and molecular mechanisms remain largely unexplored.MethodsWe analysed the chemical composition of Chaga using UPLC-MS and predicted its biological targets using PubChem and Swiss Target Prediction. …”
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