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4141
Experimental studies of natural material-based coatings for thermal protection of metallic surfaces
Published 2025-03-01“…The thermodynamic characteristics of thermal tools have been established in the model and experimentally; the granulometric composition of materials has been obtained; the hydrodynamic operating modes of the burners have been selected (fuel combustion method, jet length, jet angle). …”
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4142
Distribution of vehicle speeds in traffic flow on multilane roads approaching major and metropolitan cities
Published 2025-06-01“…Specifically, the investigation focused on assessing the conformity of empirical data to the normal distribution model, establishing characteristic speed ranges by vehicle type, and evaluating the influence of traffic volume and traffic flow composition on speed parameters. …”
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4143
Research on Rotary Magnetorheological Finishing of the Inner Surface of Stainless Steel Slender Tubes
Published 2025-06-01“…This method does not require frequent replacement of the polishing medium during the processing, which helps to simplify the processing technology. …”
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4144
Closed-eye intraocular pressure and eye movement monitoring via a stretchable bimodal contact lens
Published 2025-05-01“…Ex vivo and in vivo MEM monitoring, based on composition-optimized magnetic interlayer film, demonstrated exceptional accuracy (≥97.25%) with eyes open and closed, surpassing existing methods. …”
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4145
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation
Published 2025-07-01“…This study aimed to examine the molecular mechanisms underlying the involvement of NSUN2 in immune evasion and metabolic reprogramming of HCC. Methods Single‐cell transcriptomic sequencing was applied to examine cellular composition changes, particularly immune cell dynamics, in HCC and adjacent normal tissues. …”
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4146
Gender and cultural aspects of brucellosis transmission and management in Nakasongola cattle corridor in Uganda.
Published 2025-01-01“…Data were collected using face -to -face interviews with an interview guide that was structured using the Socio Ecological Model of Human Behaviour framework (SEMHB) constructs. …”
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4147
Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer
Published 2024-12-01“…In this study, we investigated the impact of antiviral (AV) drug-induced gut virome dysbiosis on the efficacy of 5-FU in CRC treatment.MethodsUsing a subcutaneous CRC mouse model, we assessed tumor growth and immune responses following AV treatment, fecal microbiota transplantation (FMT), and 5-FU administration.ResultsAV therapy reduced the abundance of gut DNA and RNA viruses, leading to accelerated tumor growth, shortened survival, and diminished chemotherapy efficacy. …”
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4148
Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota
Published 2024-12-01“…A dextran sulfate sodium (DSS)-induced colitis mouse model was utilized to assess the therapeutic potential of HELNs in UC. …”
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4149
Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood
Published 2025-03-01“…Subsequently, an in vitro neuroinflammatory model was established via lipopolysaccharide (LPS)-stimulated BV-2 cells to evaluate the anti-neuroinflammatory activity of differential chromones. …”
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4150
Analysis of the spatiotemporal evolution and driving factors of land use change in Jinan springs area of the Northern Karst region, China from 1986 to 2022
Published 2025-04-01“…To explore the land-use change characteristics and their driving mechanisms, six periods of Landsat series land-use data were collected for the years 1986, 1995, 2000, 2009, 2016 and 2022. A Random Forest model was employed for classifying the remote sensing data, while the land use dynamic and land use transfer matrix were used to analyse the scale, composition, morphology, pattern and spatial and temporal characteristics of land use changes from 1986 to 2022. …”
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4151
Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress
Published 2025-02-01“…This study focused on the regulation of GTSs in intestinal homeostasis imbalance caused by microgravity.Methods: A hindlimb suspension (HLS) rat model was established to evaluate the intestinal protective effects of GTSs. …”
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4152
Adjuvanticity of Tannic Acid-Modified Nanoparticles Improves Effectiveness of the Antiviral Response
Published 2025-04-01“…HSV-1 also invades the nervous system where it establishes a lifelong latency-making infection poorly treatable We previously showed that both tannic acid-modified silver and gold nanoparticles (TA-Ag/AuNPs) inhibit HSV-1 infection in vitro.Methods: We used an in vitro and in vivo model of HSV-1 infection to study how metal type, size and tannic acid modification of nanoparticles can influence development of the early innate response and the mounting of specific anti-HSV-1 response upon treatment of the nasal mucosa.Results: We found that tannic acid is necessary for binding with HSV-1, with smaller sizes independent of the NPs composition, whereas for larger NPs, only TA-AgNPs can inhibit HSV-1 infection. …”
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4153
Small intestinal bacterial overgrowth and metabolic dysfunction-associated steatotic liver disease
Published 2024-12-01“…For heterogeneity >50%, a random effects model was used. There was a clear association between SIBO and MASLD (OR = 3.09; 95% CI 2.09–4.59, I2 = 66%, p < 0.0001). …”
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4154
Progression to fibrosis and hepatocellular carcinoma in DEN CCl4 liver mice, is associated with macrophage and striking regulatory T cells infiltration
Published 2025-07-01“…This study investigates immune dysregulation that occurs during the progression of CLD to HCC by delineating changes in immune cell composition and distribution within the liver microenvironment.MethodsMice were injected with Diethylnitrosamine (DEN) at 4 weeks of age, followed by continuous tri-weekly injections of carbon tetrachloride (CCl4) for 6 and 21 weeks to induce liver fibrosis and HCC. …”
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4155
Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis
Published 2025-08-01“…However, their potential associations and mechanisms remain unclear.MethodsThis study used antibiotics to construct a mouse model to analyze the performance of AD mice after gut microbiota destruction. 16S rRNA amplicon sequencing combined with HM700 high-throughput metabolomics was used to characterize differential microbial components and key metabolites in fecal specimens of AD murine models. …”
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4156
Protective Effects of Frankincense Oil on Wound Healing: Downregulating Caspase-3 Expression to Facilitate the Transition from the Inflammatory to Proliferative Phase
Published 2025-03-01“…<b>Methods:</b> The chemical composition of FEO was analyzed using gas chromatography-mass spectrometry (GC-MS). …”
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4157
Characteristics of the gut virome in patients with premalignant colorectal adenoma
Published 2025-05-01“…., bacteriome, mycobiome, and virome) characteristics of colorectal cancer have been extensively studied, yet there is still an insufficient description of the microbiota features in its early-stage, colorectal adenoma, particularly in the gut virome aspect. Methods Based on the Metagenomic Gut Virus catalogue (MGV) containing 54,118 non-redundant gut viral genomes, this study characterized the virome composition and diversity using publicly available metagenomic sequencing data from 419 individuals with premalignant colorectal adenoma and 552 healthy controls. …”
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4158
Impact of <i>Schistosoma mansoni</i> Infection on the Gut Microbiome and Hepatitis B Vaccine Immune Response in Fishing Communities of Lake Victoria, Uganda
Published 2025-03-01“…There was no significant difference in microbiome composition by location or infection status at baseline or discharge. …”
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4159
Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults
Published 2025-09-01“…Objectives: The authors aimed to study the effects of sex on body fat composition and aging-related diastolic function, as well as their longitudinal changes. …”
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4160
Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts
Published 2025-04-01“…The inadequacy of current screening methods has prompted investigations into stool-based assays and microbial classifiers as potential early detection markers. …”
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