Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs by Joshua Kelley, Nathan Buchweitz, Avery Madden, Hongming Fan, Glenn Hepfer, Michael Kern, Danyelle M. Townsend, Tong Ye, Hai Yao, Yongren Wu

“…This study aimed to address this knowledge gap through a quantitative assessment of IVD structural composition and diffusion properties using a Sprague–Dawley rat model. …”
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Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis by Liuzhu Chen, Linpei Zhuo, Jie Zheng, Xiaoyun Sun, Jing Sun, Jiaming Liu

“…Thus, this study aimed to explore the relationship between atorvastatin, gut microbiota and IS through animal experiments, clinical trials and Mendelian randomization (MR) analysis. Methods Male mice were induced with bilateral common carotid artery occlusion (BCCAO) to establish an IS animal model, and then intragastrically treated with atorvastatin. …”
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Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder by Yuanyuan Yang, Jinglei Si, Jiayuan Mo, Jin Li, Bin Pan, Yi Pan, Lihe Jiang, Decai Wang, Xueping Feng

“…To investigate its anti-obesity mechanisms, we established a high-fat diet (HFD)-induced obesity model in mice. The obese mice subsequently received daily oral gavage of PS extract for 21 consecutive days. …”
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Tadalafil Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells-Derived Exosomes in Pulmonary Hypertension by Upregulating miR-29a-3p by Liu Y, He C, Zhong Q, Shi X, Li H, Fu G, Guo L, Zhao C, Tian L, Li X, Jiao X, Shan L

“…This study aimed to identify an intervention strategy to enhance the efficacy of mesenchymal stem cell exosomes in treating PH.Methods: Exosomes were isolated from control MSC and tadalafil-pretreated MSCs. …”
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UV-C and Nanomaterial-Based Approaches for Sulfite-Free Wine Preservation: Effects on Polyphenol Profile and Microbiological Quality by Kamila Pachnowska, Jolanta Kochel-Karakulska, Adrian Augustyniak, Valentina Obradović, Ireneusz Ochmian, Sabina Lachowicz-Wiśniewska, Ireneusz Kapusta, Klaudia Maślana, Ewa Mijowska, Krzysztof Cendrowski

“…Controlling the microorganisms employed in vinification is a critical factor for successful wine production. Novel methods aimed at lowering sulfites used for wine stabilization are sought. …”
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Willingness to use a drug checking service for cannabis and cannabis-based products: results from an online survey of people who regularly use cannabis in France by Martin Bastien, Salim Mezaache, Cécile Donadille, Laélia Briand Madrid, Maëla Lebrun, Victor Martin, Perrine Roux

“…Abstract Introduction As cannabis is illegal in France, there is no regulation of the quality or composition of cannabis products on the illicit market. …”
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Scheme design for neutron beam shaping assembly based on D-Be compact fast neutron source by WANG Jia, ZHANG Zixiong, LI Kaixuan, PAN Yangxuan, WEI Qianglin, LIU Yibao

“…Then, a scheme design for BSA was carried out using a 1.45 MeV, 30 mA deuterium beam to bombard a 9 μm thin beryllium target, and set a basis BSA model with a cylindrical structure as a whole.ResultsThe simulation results show that using a 20 cm thick BiF3 and 30 cm thick MgF2 combined slowing layer, a 30 cm thick Pb reflector layer, a 9 cm thick MgF2 supplementary slowing layer, and a 0.2 mm thick Cd thermal neutron absorption layer, the outlet is ensured to γ and fast neutron composition, Φepi/Φth, Φepi/Φfast meets the recommended values of the IAEA (International Atomic Energy Agency).ConclusionsThis study obtained the neutron spectra and BSA specific design scheme of low-energy deuterium beams and thin beryllium targets, providing data reference for the slowing shaping of neutrons in D-Be neutron sources and supporting subsequent research on D-Be sources.…”
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Restoration of antibiotic associated diarrhea induced gut microbiota disorder by using Dictyophora indusiata water-insoluble polysaccharides in C57BL/6J mice by Yong Lai, Yong Lai, Qifan Zhang, Maohan Xu, Xiurong Guo, Quan Zhou, Qiuyu Liu, Huiling Deng, Can Song

“…Subsequently, by comprehensively evaluating multiple parameters including the body weight, dietary patterns, cecal histomorphological characteristics, intestinal microbiota composition, concentrations of short-chain fatty acids (SCFAs), and the levels of inflammatory factors in the antibiotic-associated diarrhea (AAD) model animals, we delved into both the action mechanisms of these polysaccharides and their impacts on the intestinal flora and metabolites within C57BL/6J mice.ResultsOur results showed that DIPY effectively ameliorated AAD in mice by modulating the intestinal flora, increasing microbial diversity, the Shannon and Ace index was significantly higher in the DIPY group than in the NR group after the DIPY intervention (p < 0.001). …”
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Discussions on the Adsorption Behaviors Affected by the Differences Between Graphene Oxide and Graphene Grafted by Chitosan by Chin-Chun Chung, Hua-Wei Chen, Jin-Lin Han, Hung-Ta Wu

“…The Toth adsorption isotherm model was used to fit the adsorption uptake, and the average deviation was about 1.36%.…”
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Applicability of Machine Learning and Mathematical Equations to the Prediction of Total Organic Carbon in Cambrian Shale, Sichuan Basin, China by Majia Zheng, Meng Zhao, Ya Wu, Kangjun Chen, Jiwei Zheng, Xianglu Tang, Dadong Liu

“…This study introduces three key innovations to address these challenges: (1) A Dynamic Weighting–Calibrated Random Forest Regression (DW-RFR) model integrating high-resolution Gamma-Ray-guided dynamic time warping (±0.06 m depth alignment precision derived from 237 core-log calibration points using cross-validation), Principal Component Analysis-Deyang–Anyue Rift Trough Shapley Additive Explanations (PCA-SHAP) hybrid feature engineering (89.3% cumulative variance, VIF < 4), and Bayesian-optimized ensemble learning; (2) systematic benchmarking against conventional ΔlogR (R² = 0.700, RMSE = 0.264) and multi-attribute joint inversion (R² = 0.734, RMSE = 0.213) methods, demonstrating superior accuracy (R² = 0.917, RMSE = 0.171); (3) identification of Gamma Ray (r = 0.82) and bulk density (r = −0.76) as principal TOC predictors, contrasted with resistivity’s thermal maturity-dependent signal attenuation (r = 0.32 at Ro > 3.0%). …”
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Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis by Fan Yang, Beibei Ni, Xiaoqi Liang, Yizhan He, Chao Yuan, Jiajie Chu, Yiju Huang, Hongyu Zhong, Li Yang, Jianxi Lu, Yan Xu, Qi Zhang, Wenjie Chen

“…However, their effects on autoimmune hepatitis (AIH) are not yet well understood. Methods and results In this study, we utilized a well-established concanavalin A (Con A)-induced fulminant hepatitis mouse model to investigate the effects of MSC-EVs on AIH. …”
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The impact of the international rice genebank’s (IRG) on rice farming in Bangladesh by Donald Villanueva, Yuji Enriquez, Grace Lee Capilit

“…On average, 52% of the improved rice varieties’ genetic composition, cultivated by farmers in Bangladesh, definitely came from IRG accessions. …”
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Extractive distillation of tetrahydrofuran–ethyl acetate–water mixture in schemes including columns with side sections and side draws by D. G. Rudakov, S. M. Kharlamov, P. S. Klauzner, E. A. Anokhina, A. V. Timoshenko

“…The local composition UNIQUAC equation model was used for describing vapor–liquid equilibrium. …”
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Characteristics of adaptive immune effectors involved in the secondary xenogeneic immune response to human melanoma cells by N. A. Persiyantseva, A. A. Kalinina, M.  A. Zamkova, L. M. Khromykh, D. B. Kazansky

“…To assess the prospects for using xenogeneic immunizations to generate tumor-specific memory T cells and identify their TCRs suitable for adoptive immunotherapy, we studied the dynamics of the secondary xenogeneic response in a model of induction of an immune response in mice to human melanoma cells.Materials and methods. …”
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Effect of different dialysis duration on the prognosis of peritoneal dialysis-associated peritonitis: a single-center, retrospective study by Qichen Liang, Huiping Zhao, Bei Wu, Qingyu Niu, Lixia Lu, Jie Qiao, Chuncui Men, Yuting He, Xinxin Chu, Li Zuo, Mei Wang

“…The risk factors for treatment failure were analyzed using a logistic regression model.Results During 14 years, 156 patients had 267 peritonitis episodes. …”
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Research on Malodor Component Identification Based on Sensor Array by Jiaxing Xie, Wen Chen, Shiyun Chen, Peiwen Wu, Zhendong Lv, Jiatao Wu, Zihao Chen, Zonghong Li, Fan Luo, Xiaohong Liu

“…Experimental results demonstrate that the proposed IED-CNN-LSTM model outperforms conventional methods significantly in both prediction accuracy and long-term stability. …”
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NeXtMD: a new generation of machine learning and deep learning stacked hybrid framework for accurate identification of anti-inflammatory peptides by Chengzhi Xie, Yijie Wei, Xinwei Luo, Huan Yang, Hongyan Lai, Fuying Dao, Juan Feng, Hao Lv

“…While various machine learning and deep learning approaches have been explored, their limitations in feature representation and model integration hinder the effective discovery of novel AIPs. …”
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ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity by Domonkos Czárán, Péter Sasvári, Kende Lőrincz, Krisztina Ella, Virág Gellén, Roland Csépányi-Kömi

“…ARHGAP25 altered cytokine composition in the sensitization and elicitation phase of the disease. …”
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Patterns of student socio-emotional development and teacher-student-relationship-quality for high-school students with and without special educational needs: a multigroup latent tr... by Giuliana Pastore, Wassilis Kassis, André Kunz, Reto Luder

“…In addition, we tested whether having SEN or being in a high vs. low selective schools make a difference for the composition of each profile.MethodsTo this end, latent class (LCA) and latent transition analyses (LTA) were conducted with longitudinal data from a three-waves (2019, 2020, and 2021) questionnaire study with N = 807 junior high school students in Switzerland.ResultsFour similar patterns could be identified in both low and high selective schools: “happy” students, feeling generally well (emotionally, socially and cognitively) and well-supported by teachers; “unhappy” students, not feeling well and not supported, “teacher-oriented” students, not feeling well but well-supported by teachers, and finally “unstable” students, drastically changing their perceptions of wellbeing, inclusion and self-concept over time but consistently feeling less reliance on teachers. …”
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Comparative efficacy of transdermal forms for alopecia therapy by U. V. Nogaeva, D. Yu. Ivkin, G. A. Plisko, E. V. Flisyuk, V. E. Kovanskov, Yu. G. Shtyrlin, K. O. Sidorov

“…Investigate the possibility of applying the original substance Y in several dosage forms for the treatment of alopecia in comparison with reference drugs: minoxidil and burdock oil.Materials and methods. The research subject was the original substance Y, for which several dosage forms were made: gel, alcohol and oil compositions. …”
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