Analysis of the venom components of necrotic tissue exudates from Naja atra venom-infected Guangxi Bama miniature pigs by XIAO Manqi, GUAN Zhezhe, HU Shaocong, LI Yalan, ZHANG Ziyan, JIANG Ningjing, ZHANG Xuerong, LIAO Ming

“…Objective To investigate the components of snake venom and the dynamic changes in protein expression in the exudates of necrotic tissues affected by the Naja atra venom in Guangxi Bama miniature pigs. Methods Guangxi Bama miniature pigs were injected with Naja atra venom to establish a local tissue necrosis model due to snakebite poisoning. …”
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Value of a BRAFV600E and lymphocyte subset-based nomogram for discriminating benign lesions from papillary thyroid carcinoma in C-TIRADS 3 and higher nodules by Wenran Zhang, Simei Zeng, Jiaqing Dou, Chenfan Yu

“…This study established and validated a nomogram model to quantitatively predict the malignant risk of papillary thyroid carcinoma in thyroid nodules classified as C-TIRADS category 3 or higher, providing a reference for precise diagnosis and treatment of these moderately or highly suspicious nodules.MethodsThis retrospective study analyzed 210 patients with thyroid nodules (C-TIRADS ≥3), stratified by fine-needle aspiration biopsy (FNAB) results into benign and PTC groups. …”
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Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway by Minxing Zheng, Jiahui Qi, Xuanjing Wang, Tingting Fu, Ziqi Chang, Tong Zhao, Yaqin Sun, Jiayin Lu, Yi Yan, Haidong Wang

“…Methods: A cold stress model was established by subjecting mice to a 4 °C environment for 4 hours daily. …”
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CALCULATION STUDIES OF SPATIAL DISTRIBUTION OF THE ABSORBED DOSE RATE FOR VARIOUS SEEDS by N. A. Nerozin, A. P. Pyshko, V. V. Shapovalov

“…Sources of production IPPE are similar to the model 6711 of the company Nicomed Amersham, dosimetric characteristics of which are standardized in accordance with the TG43 AAPM formalism.Materials and methods. …”
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Identification of Risk Group for Root Caries and Analysis of Associated Factors in Older Adults Using Unsupervised Machine Learning Clustering by Jiang L, Huang S, Reissmann DR, Schmalz G, Li J

“…The confusion matrix and alluvial diagram were used to visualize the predictive accuracy and composition of the clustering results. Binary logistic regression models further analyzed the associated factors, while ROC (receiver operating characteristic) curves and the random forest model visualized the predictive performance and the most important associated factors.Results: Two clusters were identified: cluster 1, with low root caries risk (21.5% with and 78.5% without root caries), and cluster 2, with high root caries risk (83.7% with and 16.3% without root caries). …”
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Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling by Lulu Tang, Wei Dong, Danqing Liu, Chenling Zhao, Jie Chen, Yuya Wen, Jingyu Zeng, Ting Dong, Wenming Yang, Wenming Yang

“…Additionally, to detect alterations in the intestinal bacterial composition and metabolites, faecal samples were examined using non-targeted metabolomics and 16S rRNA sequencing.ResultsThe administration of GDL demonstrated anti-fibrotic effects on the liver, decreased serum inflammatory markers, ameliorated liver histopathology, and restored ileal permeability in the model group, as compared to the control group. …”
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Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice by Hui Li, Leeann Aguilar Meza, Shailesh K. Shahi, Zuohui Zhang, Wen Wen, Di Hu, Hong Lin, Ashutosh K. Mangalam, Jia Luo

“…We hypothesized that binge-like alcohol exposure induces gut dysbiosis, which in turn drives systemic inflammation and carcinogenic processes.MethodsWe utilized MMTV-Wnt1 transgenic mice, a well-established model for mammary tumor development, along with wild-type FVB mice. …”
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Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Abstract Background Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. Mdx mouse model of DMD exhibits impaired muscle performance, oxidative stress, and dysfunctional autophagy. …”
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Study on microscopic pore structures and mechanical properties by Shihu ZHAO, Yong LI, Yali LIU, Yanbin WANG, Zengqin LIU, Gang CHEN, Xinjun CHEN

“…Using atomic force microscopy (AFM), a combined characterization technique was established for microscopic pore structure and mechanical properties based on image segmentation and Derjaguin-Muller-Toporov (DMT) mechanical model. This method clarified the microscopic pore structure and mechanical properties of coal samples and revealed the influence of material composition, pore structure, and thermal evolution level on their microscopic mechanical properties. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Background: This study investigated the phytochemical composition and potential medicinal properties of arecanut grown in various regions of Karnataka. …”
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NT2-derived astrocyte–neuron co-culture reflects physiological relevance and offers research validity by Sylwia Kedracka-Krok, Ewelina Fic, Zuzanna Cepil, Piotr Rybczyński, Agata Szlaga, Radosław Cacała, Sławomir Lasota, Anna Blasiak, Marta Dziedzicka-Wasylewska

“…Ntera-2 cells and NT2 cells are used interchangeably in this publication. Methods Using an advanced proteomic approach, we assessed the protein composition and abundance of neuron and astrocyte co-cultures and discovered that the astrocytic protein profile in co-culture with neurons was more representative compared with that in pure astrocyte cultures. …”
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Chitosan/Sodium Tripolyphosphate/Sodium Alginate/miRNA-34c-5p Antagomir Scaffolds Promote the Functionality of Rabbit Cranial Parietal Repair by Lin C, Bai X, Zhang L

“…Subsequently, the in vivo efficacy of miR-34c-5p Agomir/Antagomir in regulating bone repair was evaluated in the rabbit cranial bone defect model, with micro-CT scanning and histological analysis conducted at 4, 8, and 12 weeks.Results: CTS scaffolds with a composition ratio of 1:0.2:0.1 were successfully synthesized, exhibiting a mean particle size of 360.1 nm. …”
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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device by Yang Jiao, Xin Wang, Aizhen Yu, Li Wu, Hongping Li

“…The present study is designed to investigate the impacts of this innovative device, utilizing a multi-omics profiling approach, on beagle dogs as a surrogate model.MethodsThis study involved seven-day-old male newborn beagle puppies, carefully selected and matched in terms of body weights. …”
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Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile by Wei Chen, Lin Xu, Long Wang, Yu-nan Shan, Yan Li, Jin-shui Zhu

“…However, its molecular mechanisms remain unclear.PurposeThis study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted metabolomics, and network pharmacology analysis.MethodsThe chemical composition of QRHSD was analyzed using quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). …”
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The role of bioimpedance status in the diagnosis of presarcopenia in elderly and elderly patients with type 2 diabetes mellitus by Ruslan N. Obyedkov, Evgeny I. Dedov, Irina G. Pshennikova

“…Determination of skeletal muscle mass (SMM) for the diagnosis of sarcopenia using bioimpedance analysis of body composition (BIAST) is a well-recognised method. However, as data are accumulating, alternative possibilities for its diagnosis are occurring, particularly the determination of phase angle (PA) and other BIAST parameters. …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…However, the specific mechanisms by which GQD exerts its effects remain poorly understood, limiting its application in UC treatment.Purpose: In this study, we utilized a dextran sodium sulfate-induced colitis model in mice to evaluate the efficacy of GQD and to elucidate its underlying mechanisms.Methods: Network pharmacology was employed to explore the potential targets and signaling pathways of GQD, which were subsequently validated using Western blot. …”
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A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice by R. Clay Bunn, Reuben Adatorwovor, Philip D. Ray, Alexander R. Keeble, Christopher S. Fry, Sasidhar Uppuganti, Jeffry S. Nyman, John L. Fowlkes, Evangelia Kalaitzoglou

“…At study end, body composition and in vivo contractile muscle function were assessed, systemic myostatin and glycated hemoglobin were quantified, gastrocnemii were weighed and analyzed for fiber type composition, and femur microarchitecture and biomechanical properties were analyzed.ResultsGlycated hemoglobin was significantly higher in diabetic mice compared to non-diabetic mice and diabetic mice treated with insulin. …”
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Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis by Hongming Wei, Lu Zhan, Xinhuang Lv, Yan Lin, Jie Zheng, Wenwen Yang, Jiaming Liu, Jing Sun, Songfang Chen

“…Recent studies have highlighted the important role of gut microbiota in both hyperuricemia and AIS, but there is little available data on the relationship between gut microbiota and the pathogenesis of AIS with hyperuricemia (HAS). Methods Here we profiled the gut microbiota composition in 63 HAS patients and 269 non-HAS patients through 16s rRNA sequencing. …”
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Predicting viral proteins that evade the innate immune system: a machine learning-based immunoinformatics tool by Jorge F. Beltrán, Lisandra Herrera Belén, Alejandro J. Yáñez, Luis Jimenez

“…We evaluated a comprehensive range of machine learning models, including ensemble methods, neural networks, and support vector machines. …”
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Short-term Wind Power Forecasting Based on BWO‒VMD and TCN‒BiGRU by LU Jing, ZHANG Yanru, WANG Rui

“…Given the instability and high volatility of wind power generation, this study proposes a short-term wind power prediction method based on BWO‒VMD and TCN‒BiGRU to improve the accuracy of wind power prediction and better support the energy transition under the “dual carbon” strategy.MethodsA short-term wind power generation prediction model based on the beluga whale optimization (BWO) algorithm, variational mode de-composition (VMD), temporal convolutional network (TCN), and bidirectional gated recurrent unit (BiGRU) was carefully proposed to improve the prediction accuracy of wind power generation, particularly considering its inherent instability and high volatility. …”
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