Integrating MaxEnt with chemometrics to evaluate the impact of environmental variables on the coumarin content and the distribution of Angelica dahurica by Zhengkun Gan, Jun Ma, Xinyu Liu, Jiaxin Luo, Junke Li, Lili Pu, Guihua Jiang, Guihua Jiang, Yan Lian

“…With climate change potentially affecting both species distribution and secondary metabolite accumulation, there is a pressing need to integrate ecological and chemical data to guide future cultivation and resource utilization strategies.MethodsThis study combined the Maximum Entropy (MaxEnt) ecological modeling approach with chemometric analysis to (i) predict the suitable habitat distribution of A. dahurica under current and future climate scenarios and (ii) evaluate the correlation between environmental variables and coumarin accumulation.Results(1) The key environmental variables influencing the distribution of A. dahurica were identified as BIO_13 (precipitation of the wettest month), BIO_11 (mean temperature of the coldest quarter), and elevation (DEM). (2) Presently, the highly suitable regions for A. dahurica cultivation are mainly in Sichuan, Henan, and Hebei provinces. (3) Under future climate scenarios, the highly suitable habitats are expected to expand and shift geographically, especially toward Henan and Jiaozuo, with parts of Hubei, Shaanxi, and Shandong transitioning into highly suitable zones. (4) Chemometric analyses revealed that A. dahurica samples from highly suitable areas contained significantly higher total coumarin content than those from medium-suitability regions. (5) A strong correlation was observed between key environmental factors (especially BIO_11 and DEM) and the relative content of five major coumarin components.(6) Spatial mapping of chemical composition indicated distinct regional differences in coumarin distribution, suggesting the potential for geoherbalism-based classification.DiscussionThe integration of ecological modeling with chemical analysis provides a powerful framework for understanding the impact of environmental variables on both the distribution and chemical quality of A. dahurica. …”
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Metformin-Enhanced Secretome from Periodontal Ligament Stem Cells Promotes Functional Recovery in an Inflamed Periodontal Model: In Vitro Study by Han Na Suh, Ju Young Ji, Jung Sun Heo

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Modeling of Hydrogeochemical Processes of Carbon Dioxide Interaction with Formation Water and Rock Minerals During Enhanced Oil Recovery and Underground storage by D. S. Klimov, I. M. Indrupskiy, Ch. A. Garifullina, I. I. Ibragimov, A. A. Lutfullin, B. F. Zakiev, F. M. Akhmetzyanov

“…A step-by-step method for modeling interactions in the “formation water – CO2 – rock” system using the PHREEQC hydrogeochemical simulator provides good reproducing accuracy for the results of laboratory experiments and analysis of their correspondence to the processes occurring under different conditions. …”
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Dynamics of physico-chemical forms of radionuclides in the bottom sediments of cooling pond of the ChNPP after their drying: 1. Model experiment by V. P. Protsak, О. О. Odintsov, Y. V. Khomutinin, M. A. Jurba, N. M. Prokopchuk, V. O. Kashparov

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Determination Modal parameters a Turning machining system by Юрій Петраков, Олександр Охріменко, О. Пасічник, А. Петришин

“…A dynamic model of the machining system of a lathe has been developed as a composition of the main units using the receptance coupling method, which made it possible to calculate the rigidity of the entire system, reduced to the tip of the cutter, as a function of the longitudinal coordinate when machining a workpiece installed in a chuck and in a chuck and rear center. …”
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Visualization OPLS class models of GC-MS-based metabolomics data for identifying agarwood essential oil extracted by hydro-distillation by Si-Zhu Qian, Yong-Mei Jiang, Qiao-Ling Yan, De-Huai Wu, Wen-Xian Zhang, Jen-Ping Chung

“…Supervised OPLS-DA was better than that of PLS-DA, providing a reference for the quality evaluation of AEOs. This method emphasizes providing more information and obtaining additional information when combined with appropriate multivariate modeling and effective visualization of specific labeled metabolites for identification.…”
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Spatial and temporal model for WQI prediction based on back-propagation neural network, application on EL MERK region (Algerian southeast) by Saber Kouadri, Samir Kateb, Rachid Zegait

“…The WQI was always posed in a homogeneous group with TH and mineralization, which indicate that TH and mineralisation are main factors in controlling water quality. ANN method is used to create a model to predict WQI using mineralisation, TH, NO3− and NO2− as inputs. …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…In addition, the cytotoxicity, antigen-specific T cell activation, cytokines, protective ability, and therapeutic ability of the nanovaccine were assessed in a mouse tumor model. Further, the immune cell composition was evaluated in tumors.Results: The Mg/Al LDH-5-OP-RU/mRNA nanovaccine was efficiently delivered into lung-draining mediastinal lymph nodes (MLNs), and it activated dendritic cells (DCs) and mucosa-associated invariant T (MAIT) cells after intranasal administration. …”
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An acoustic-optic confocal probe based photoacoustic and ultrasonic tracheal endoscopy for characterizing phantom and model of chronic obstructive pulmonary disease by Xiaowei Chen, Xue Wen, Bingyan Fang, Zhixiong Lei, Jiarui Chen, Lvming Zeng, Kedi Xiong, Weizhan Luo, Lan Zhang, Hongbo Fu, Shiyue Li, Jian Zhang

“…Integrated photoacoustic endoscopy and endoscopic ultrasound (PAE/EUS) are recognized as an effective method for detecting intestinal and intravascular diseases. …”
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Synthesis and swelling behavior of highly adsorbent hydrogel for the removal of brilliant green from an aqueous solution: Thermodynamic, kinetic, and isotherm models by Aseel M. Aljeboree, Ayad F. Alkaim, Shaymaa Abed Hussein, Mohammed Abed Jawad, Ishraq Hasan, Shahad Abdulhadi Khuder

“…Thus, after 1h of equilibrium time, it was used to obtain saturation of the adsorbate surface. Freundlich isotherm models and pseudo-second order kinetic models were found to be best in fitting the isotherm and kinetics data. …”
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An approach to forecasting damage due to unfavorable circumstances associated with indistinguishability of source data by V. F. Zolotukhin, A. V. Matershev, L. A. Podkolzina

“…The tasks are to consider this kind of uncertainty which includes indistinguishability of the true system condition and the real value of its quantitative characteristics; to formulate a combinatorial problem for the case when a rather dangerous composite feature is determined by the joint manifestation of two or more simple features.Materials and Methods. …”
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Electrochemical characteristics of the La0.9Sr0.1Sс0.4Mn0.6O3 – δ cathode contacting the La0.9Sr0.1SсO3 – δ proton-conducting electrolyte by Bervitskaya, Olga S., Ichetovkina, Victoria A., Bobro, Mark S., Stroeva, Anna Y., Kuzmin, Anton Valerievich

“…In this work, the material La0.9Sr0.1Sс0.4Mn0.6O3 – δ was synthesized using the citrate-nitrate method. The electrochemical characteristics of the material were studied using impedance spectroscopy on symmetric cells and compared with the model Pt cathode contacting the proton-conducting electrolyte. …”
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Geochemical-process extraction and interpretation using matrix factorization: a framework for verifying effectiveness through forward modeling and inversion analysis by Tatsu Kuwatani, Shotaro Akaho, Shotaro Akaho, Kengo Nakamura, Takeshi Komai

“…By constructing a forward model that simulates geochemical weathering, we generated synthetic datasets replicating real-world geochemical compositions, incorporating both the elemental leaching during fluid-rock interactions and the compositional heterogeneity of the original rocks. …”
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Stiffness analysis and structural optimization design of an air spring for ships by Yuqiang Cheng, Hua Gao, Jianguo Ma, Changgeng Shuai

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Experimental and Numerical Investigations of Punching Shear Strengthening of Slab-Circular Column Connection Incorporating UHPC and Galvanized Threaded Steel Bolts by Ahmed Hamoda, Khaled Sennah, Mizan Ahmed, Aref A. Abadel, Mohamed Emara

“…Further enhancements were observed by adding a second steel reinforcement mesh to the UHP-bonded layer. A numerical model was developed using the finite-element (FEM) method to predict the structural behavior of tested slabs. …”
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Wet granulation method in the technology of 6,8-dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-F]xanthine tablets, which increases the detoxifying function of the liver by A. I. Petrakov, V. V. Sheikin, S. V. Krivoshchekov, A. M. Guryev, M. V. Belousov

“…The crushing strength and disintegration of the tablets analyzed.Aim. Development of a composition for wet granulation of 6,8-dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-F]xanthine to obtain granules with optimal technological parameters to obtain high-quality tablets that pass tests according to the State Pharmacopoeia of the Russian Federation.Materials and methods. …”
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Response Surface Methodology Optimization of Wear Rate Parameters in Metallic Alloys by Blessing Ngozi Goodluck Aliemeke, Lucky Charles, Peace Omoregie, Abdulrazak Momodu, Christopher Jerry, Emmanuel Akpan

“…The wear rate, a critical factor affecting the durability and performance of metallic components, served as the response parameter, while track diameter, sliding speed, and mass difference were considered as independent variables. The Central Composite Design (CCD) experimental method systematically explored the response surface and optimizes the wear rate. …”
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Exploring the therapeutic potential of Quercus ilex acorn extract in papillomavirus-induced lesions by Ana I. Faustino-Rocha, Maria João Pires, Maria João Neuparth, Helena Vala, Cármen Vasconcelos-Nóbrega, Irene Gouvinhas, Ana Novo Barros, Maria Inês Dias, Lillian Barros, Margarida M. S. M. Bastos, Lio Gonçalves, Luís Félix, Carlos Venâncio, Rui Medeiros, Rui Miguel Gil da Costa, Paula A. Oliveira

“…Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. …”
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Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies by Veena Manja, Arnav Agarwal, Thomas Agoritsas, Farid Foroutan, Reem A Mustafa, Per Olav Vandvik, Daniel G Rayner, Darsh Shah, Si-Cheng Dai, David Gou, Jason Z X Chen

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Assessing sport commitment: the development and preliminary validation of recreational sport commitment questionnaire by Arthur Ling, Eng Wah Teo, Ngien Siong Chin

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