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Comparative Analysis of Neurogenesis and Cerebral Angiogenesis in the Hippocampal Neurogenic Niche in Animals with Two Experimental Models of Alzheimer’s Disease
Published 2025-06-01“…The study aimed to assess neurogenesis and remodeling of the microvasculature in the subgranular zone (SGZ) of the hippocampal dentate gyrus in mice with two AD models. Materials and methods. The study employed two in vivo Alzheimer’s disease models: 1) animals with intrahippocampal administration of amyloid-β protein fragment Aβ25–35; 2) 5xFAD transgenic mice. …”
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2362
A deep learning-based detection model and illumination-adaptive behavioral analysis for soldier crabs in the intertidal zone
Published 2025-12-01“…Their behavioral rhythms respond sensitively to environmental fluctuations, especially variations in sediment composition and illumination. However, due to their small size and tidal-driven activity patterns, conventional behavior detection methods suffer from low efficiency and considerable observer bias, particularly under dark conditions where detection errors and omissions are prevalent. …”
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2363
Optimization of Protein Extraction from Sunflower Meal Using Taguchi Design and Regression Modeling for Human Nutrition Applications
Published 2025-07-01“…A first-order regression model was developed and validated (R<sup>2</sup> = 0.86, <i>p</i> < 0.05), identifying optimal conditions at pH 10.0, 30 °C, and 60 g per 500 mL of distilled water. …”
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2364
Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model
Published 2025-04-01“…Methods SHIME® model was used to investigate microbial and metabolic changes in the gut microbiota of UC patient induced by FMT application. …”
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2365
Deep-learning-based canopy height model generation from sub-meter resolution panchromatic satellite imagery
Published 2025-01-01“…We show that phenology and species composition play important roles in model transferability; when trained using imagery from a single conifer forest in autumn, the model performs well on autumn imagery from a second conifer forest several hundred kilometers distant with no re-training. …”
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2366
Spatio-temporal evolution of habitat quality and its influencing factors in karst areas based on the InVEST model.
Published 2025-01-01“…This article uses the InVEST model and the GeoDetector method to analyze the changes in landscape patterns, spatiotemporal evolution of habitat quality, and their driving factors in karst areas. …”
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A Bayesian hierarchical model with spatially varying dispersion for reference-free cell type deconvolution in spatial transcriptomics
Published 2025-04-01“…A major challenge in spatial transcriptomics (ST) is resolving cellular composition, especially in technologies lacking single-cell resolution. …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease
Published 2025-03-01“…Methods: EuEO composition was determined by GC–MS. …”
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2370
Effects of different vegetation restoration models on soil nutrients in the water level fluctuation zone of a large reservoir
Published 2024-12-01“…Assessing the influence of diverse vegetation restoration strategies on soil nutrient content in the WLFZ is essential for optimizing restoration models. To evaluate the effects of different restoration approaches on soil nutrients in the WLFZ of Heilongtan Reservoir, the integrated levels of soil nutrients in similar topographical environments but with varying vegetation restoration strategies were quantitatively assessed using the entropy weight method. …”
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2371
Passenger Flow Simulation Model for Urban Rail Transit Stations Based on Multipotential Fields in Three-Dimensional Space
Published 2025-01-01“…The effectiveness of the proposed model and method is verified via simulation of Changsha Metro Shumuling Station, and it is found that the proportion of escalators selected as interlayer facilities is significantly higher than that for stairs. …”
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Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury
Published 2024-12-01“…Abstract Background Organoids, as near-physiological 3D culture systems, offer new opportunities to study the pathogenesis of various organs in mimicking the cellular complexity and functionality of human organs. Method Here we used a quite simple and very practicable method to successfully generate induced pluripotent stem cell (iPSC)-derived human lung organoids (LuOrg) in a matrix-free manner as an alternative to the widely used preclinical mouse models in order to investigate normal lung damage in detail and as close as possible to the patient. …”
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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model.
Published 2018-01-01“…Here, we sought to compare originator and non-originator copies of insulin glargine for innate immune activity and mechanisms leading to differences in these response profiles in an in vitro model of human immunity.<h4>Methods</h4>An endothelial/dendritic cell-based innate immune model was used to study antigen-presenting cell activation, cytokine secretion, and insulin receptor signalling pathways induced by originator and non-originator insulin glargine products. …”
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2374
Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery
Published 2025-08-01“…The performance of including urine neutrophil gelatinase–associated lipocalin into the nomogram was compared with the model constructed for cRAI alone. Results Of 476 patients, 129 (27%) experienced the composite outcome, and 191 (40%) were cRAI positive. …”
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2375
On the Nonlinear Forced Vibration of the Magnetostrictive Laminated Beam in a Complex Environment
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Based on Fast Non-Singular Dynamic Terminal Sliding Mode Control for Four-Wheel Independently Driven Electric Vehicle Direct Yaw Moment Control
Published 2025-01-01“…Initially, 7-degree-of-freedom (7-DOF) and 2-degree-of-freedom (2-DOF) vehicle dynamic models are established, and a composite stability analysis method is developed by integrating yaw rate limit boundaries with dynamic adaptive dual-line boundaries to formulate stability criteria under extreme conditions. …”
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Synthesis and Photocatalytic Properties of Nitrogen Modified Titanium Dioxide
Published 2019-01-01“…The crystallite size of as-prepared composite powders was in the range 12-35 nm. The aim of this work was to investigate the efficiency of N-doped TiO2 as a photocatalyst in degradation of model organic pollutants - dyes Reactive Black 5 (RB5) and Malachite Green (MG), under ultraviolet (UV) and visible (Vis) irradiation. 0ur results indicated that synthesized N-TiO2 nanocomposites slightly improved the photocatalytic activity under UV irradiation, compared to the pure titanium dioxide (TiO2), and had no effect under Vis light illumination.…”
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Optimization of extrusion parameters for low-cost alumina–kaolin ceramic membranes via CCD
Published 2025-05-01“…This study investigates the effectiveness of central composite design (CCD)-based response surface methodology (RSM) in optimizing the extrusion method-based fabrication conditions of low-cost alumina-kaolin ceramic membranes. …”
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