GLP-1R Agonists and Their Therapeutic Potential in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases, a Systematic Review of the Literature by Lena Thin, Wei Ling Teh

“…<b>Background/Objectives:</b> GLP-1 receptor agonists (GLP-1RAs) have revolutionized weight loss and shown anti-inflammatory actions in several experimental models of colitis. There has been a wealth of recent data suggesting that GLP-1RA treatment may modify disease outcomes in inflammatory bowel disease (IBD). …”
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Exploring the association between life’s essential 8 and gallstone disease in the US adult population: a population-based study utilizing NHANES data from 2017-2018 by Yi Xiao, Wenting Zhao, Qiuchan Zhao, Kangfeng Pang, Qiaoping Gao, Xiaoqu Yang, Huadi Chen, Hao Xu

“…This study aims to examine the association between LE8 scores and gallstone prevalence in a U.S. adult population. Methods A cross-sectional analysis was conducted on 2836 adults. …”
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Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related De... by Jeremy R. Williams, Theodore M. DeConne, Ryan Pewowaruk, Claudia Korcarz, Jordan Tanley, Cynthia Carlsson, Susan R. Heckbert, Mohamad Habes, Ilya Nasrallah, Samuel N. Lockhart, José A. Luchsinger, Jingzhong Ding, Kathleen M. Hayden, Timothy M. Hughes, Adam D. Gepner

“…Multivariable linear fixed and mixed effects regression models related standardized pulse wave velocity components to neuroimaging and cognitive decline parameters, respectively. …”
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Treatment of Mild-to-moderate Progressive Hemifacial Atrophy by Acellular Dermal Matrix Combined With Preoperative Digital Evaluation by Xinhao Cheng, MS, Haijiang Dong, MD, PhD, Chengxiang Yan, MS, Zhibin Li, MS, Baihui Xie, MS, Yu Li, MD, PhD, Huilong Liu, MS, Yijun Zhang, Ximei Wang, MD, PhD

“…Preoperative 3-dimensional facial scans were digitally analyzed, and corresponding 3-dimensional-printed models were generated to assess soft-tissue deficiencies. …”
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RNA mis‐splicing in children with congenital myotonic dystrophy is associated with physical function by Julia M. Hartman, Kobe Ikegami, Marina Provenzano, Kameron Bates, Amanda Butler, Aileen S. Jones, Kiera N. Berggren, Jeanne Dekdebrun, Marnee J. McKay, Jennifer N. Baldwin, Kayla M. D. Cornett, Joshua Burns, Michael Kiefer, Nicholas E. Johnson, Melissa A. Hale, the DMCRN Consortium

“…The strength of these correlations and the development of predictive models will assist in designing efficacious clinical trials for individuals with DM1, particularly CDM.…”
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The temporal onset of associations of cortical proteins with cognitive resilience vary during late life by Andrea R. Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aron S. Buchman

“…Cognition was assessed using a composite derived from 19 tests. We first used linear mixed-effects models to identify cortical proteins associated with cognitive resilience. …”
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Clinical and demographic factors modify the association between plasma phosphorylated tau‐181 and cognition by Corey J. Bolton, Marilyn Steinbach, Omair A. Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L. Jefferson, Timothy J. Hohman, Henrik Zetterberg, Katherine A. Gifford, for the Alzheimer's Disease Neuroimaging Initiative

“…Linear regression models related plasma p‐tau181 to neuropsychological composite and SCD scores with follow‐up models examining plasma p‐tau181 interactions with cognitive diagnosis, apolipoprotein E (APOE) ε4 carrier status, age, and sex on cognitive outcomes. …”
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Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone by Ning Sun, Xu Zhao, Xu Zhao, Fangyuan Liu, Fangyuan Liu, Ge Song, Mengmeng Zhang, Fuqiang Song

“…This study aims to investigate the effects of these practices on soil bacterial communities in the Northeast China Black Soil Region.MethodsWe utilized high-throughput sequencing to compare soil bacterial community characteristics between undisturbed grasslands (CK) and reclaimed croplands (F). …”
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Association between relative fat mass and cognitive function among US older men: NHANES 2011–2014 by Linlin Liu, Anshi Wu, Shengnan Yang

“…The objective of this study was to examine the correlation between cognitive performance and RFM in older American males. Methods A total of 1,321 individuals were selected from the National Health and Nutrition Examination Survey (NHANES) that was carried out between the years 2011 and 2014. …”
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Treatment response of patients with tuberculosis and HIV co-infection: a retrospective analysis of secondary data from Shanghai, China, 2010–2020 by Chenyu Dong, Renfang Zhang, Shenyang Li, Jun Chen, Yunhe Liu, Xiaoqiong Xia, Gang Liu, Yinzhong Shen, Lei Liu, Liyan Zeng

“…The best area under the receiver operating characteristic curve of the test set under three modeling methods is 0.560–0.763. Rate of lymphocyte percentage recovering to normal is significantly higher in the TB treatment-effective group than in the treatment-ineffective group (aOR: 1.83, 95% CI: 1.09–3.10, p  = 0.022). …”
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Application of metagenomics next-generation sequencing of pathogen in patients with pneumonia-induced sepsis by XU Feixiang, YU Feng, WANG Ruilan, SONG Zhenju, TONG Chaoyang, ZHU Changqing

“…Objective·To explore the diagnostic, therapeutic, and prognostic value of metagenomics next-generation sequencing (mNGS) in patients with pneumonia-induced sepsis.Methods·This study consisted of a multicenter, prospective, non-randomized controlled trial and a diagnostic test. …”
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Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a pr... by Christian Junghanss, Daniel Palmer, Larissa Henze, Uwe Walter, Hugo Murua Escobar, Robert Jaster, Rüdiger Köhling, Falko Lange, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer, Mohamed Hamed, Israel Barrantes, Steffen Möller, Axel Kowald, Nicole Heussen, Georg Fuellen

“…In some of the explorative analyses, we shall include insights from systems biology modelling as well as insights from preclinical animal models. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…Analyses will be performed via repeated measures linear mixed models and generalised linear mixed models of baseline, 6-month and 12-month time points, adjusted for baseline values and covariates selected a priori. …”
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Features of Distance Learning in Higher Education Institutions in The Context of The Covid-19 Pandemic by Oksana N. Goncharova, Milera Yu. Halilova

“…The data were processed in the IBM SPSS Statistics 23.0 program using descriptive statistics methods. The following methods were used in the work: analysis of methodological, pedagogical, psychological, scientific, technical and methodological literature on the research problem; private methods - classification, systematization, comparison, analysis and generalization of pedagogical experience, modeling of the content of education. 60.9% of women and 39.1% of men took part in the survey, among them the majority of full-time students (96.2%), less – extramural studies (2.7%) and composite study mode (1.1%). …”
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Socioeconomic factors and test preparation strategies are related to success on the USMLE Step 2 clinical knowledge (CK) exam: a single-institution study by Hila Ghersin, Michelle C. Gulfo, Bailey A. Frohlich, Scott M. Wilson, Ashley A. Berlot, Janice S. Zhang, Rohan Kankaria, Ashley Radparvar, Juan Lin, Michelle A. Blackmore, Amanda C. Raff

“…In this study, we investigated predictors of Step 2 CK success across two years at one institution. Methods A survey regarding Step 2 CK exam preparation and demographic factors was administered to two student cohorts at a New York medical school in 2022 and 2023. …”
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Sex Differences in the Association Between Lipoprotein(a) and Cardiovascular Outcomes: The MGB Lp(a) Registry by Gurleen Kaur, Adam N. Berman, David W. Biery, Stephanie A. Besser, Wanda Y. Wu, Brittany Weber, Michael C. Honigberg, Khurram Nasir, Martha Gulati, Marcelo F. Di Carli, Leslee J. Shaw, Deepak L. Bhatt, Ron Blankstein

“…Cox proportional hazard modeling was used to assess the association of lipoprotein(a) with the primary outcome. …”
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Structure and mineralization potential of the southwestern part of Sokoto Basin in Nigeria by U. Z. Magawata, U. Z. Magawata, N. K. Olasunkanmi, G. B. Egbeyale, A. Saleh

“…Depth models highlighted complex basement topography with favorable zones for subsurface mineralization. …”
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Production of prototype lab-scale oak barrel analogues using additive manufacturing by Hugh Holds, Kerry Wilkinson, David Jeffery, Frances Jack, Sue Bastian

“…Cost-effective methods that provide a semi-permeable environment for oxygen transfer and modelling of barrel maturation environments while maintaining a more realistic surface to volume ratio would therefore be valuable for researchers. …”
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Predicted quality benefits of achievable performance benchmarks of chronic heart failure care in China: results from a nationwide observational study by Xi Li, Chao Wang, Jingkun Li, Yupeng Wang, Xiaoqiang Bao, Meina Liu, Qiuju Zhang, Chang Yin, Xudong Ma

“…Objectives This study aimed to set a data-driven achievable performance benchmark, explore the process–outcome association and speculate about the net gain in quality improvement with benchmarking.Design Observational study.Setting Patient survey conducted at 466 secondary and tertiary hospitals across 31 provinces, autonomous regions and municipalities in China.Participants 183 334 patients diagnosed with chronic heart failure (CHF) who were treated at 466 Chinese hospitals from January 2011 through May 2017.Primary independent variables Hospital process composite performance (HPCP).Secondary independent variables Patient-level and hospital-level characteristics.Primary outcome measure Patients getting better or recovered after treatment, in-hospital mortality, length of hospital stay (LOS) and medical cost.Methods HPCP was calculated using denominator-based weights. …”
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A blood‐based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial by Gene L. Bowman, Hiroko H. Dodge, Sophie Guyonnet, Nina Zhou, Juliana Donohue, Aline Bichsel, Jeroen Schmitt, Claudie Hooper, Tamas Bartfai, Sandrine Andrieu, Bruno Vellas, MAPT/DSA Study Group, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Sandrine Andrieu, Christelle Cantet, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre‐Jean Ousset, Françoise Lala

“…The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed‐effects models. …”
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