Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals by I. N. Tyurenkov, D. A. Bakulin, A. V. Smirnov, M. R. Ekova, A. I. Bisinbekova, G. L. Snigur, Yu. I. Velikorodnaya, E. I. Morkovin, D. V. Verkholyak, O. S. Vasilyeva

“…The aim of the work was to evaluate the GABA neuroprotective properties and its structural analogues in old animals after seven months of hyperglycemia.Materials and methods. Diabetes mellitus was modeled in white outbred male rats (12 months old) by the administration of a streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg) combination. …”
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Risk factors for disease progression and clinical outcomes in patients with COVID-19 in Taiwan: a nationwide population-based cohort study by Raymond N. Kuo, Wanchi Chen, Wen-Yi Shau

“…Multivariable logistic regression models were used to calculate odd ratios and 95% confidence intervals (CIs) for each outcome, adjusting for age, sex, region, risk factors, and vaccination status. …”
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Continuation vs Withdrawal of Beta-Blockers and Outcomes After Myocardial Infarction With Preserved Left Ventricular Function by Michael H. Chiu, MD, MSc, Yuan Dong, MSc, Nowell Fine, MD, SM, Finlay A. McAlister, MD, MSc, Tolulope Sajobi, MSc, PhD, Danielle A. Southern, MSc, Erik Youngson, MMath, Sean van Diepen, MD, MSc, Matthew T. James, MD, PhD, Stephen B. Wilton, MD, MSc

“…Secondary outcomes were each of the components of the composite. Cox proportional hazard models were used to evaluate the association between early BB discontinuation and outcomes. …”
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Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of oste... by Angela M. Mickle, Jared J. Tanner, Udell Holmes, III, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert, Siegfried Schmidt, Roland Staud, Jeffrey C. Edberg, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberly T. Sibille

“…We investigate group differences based on dispositional traits and poverty status, specific to (1) pain intensity and functional limitations and (2) biological measures, a clinical composite and brain age. Methods:. Adults aged 45 to 85 years with knee pain associated with chronic musculoskeletal pain provided information on demographics, socioeconomic and psychosocial factors, pain, and physical function. …”
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Late‐midlife lifestyle and brain and cognitive changes in individuals on the AD versus non‐AD continuum by Julie E. Oomens, Karly A. Cody, Lianlian Du, Erin M. Jonaitis, Rachel L. Studer, Nathaniel A. Chin, Sebastian Köhler, Pieter Jelle Visser, Stephanie J. B. Vos, Rebecca E. Langhough, Willemijn J. Jansen, Sterling C. Johnson

“…METHODS We used linear mixed models to examine whether the LIfestyle for BRAin Health (LIBRA) index was associated with changes in tau, white matter hyperintensity, neurodegeneration, and cognition and whether changes were similar in amyloid positive (A+; > 17 Centiloids) and negative participants. …”
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Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. by Ju-Sheng Zheng, Tao Huang, Jing Yang, Yuan-Qing Fu, Duo Li

“…Two authors independently extracted the data. Random-effects models were used to pool the summary relative risk (RR). …”
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Educational Attainment and the Effect of Intensive Blood Pressure Reduction: A Post Hoc Analysis of the SPRINT Study by Joshua Garfein, Akira Sekikawa, Andrew Mrkva, Djhenne Dalmacy, Jarett D. Berry, Yordanos M. Tiruneh, Jared W. Magnani

“…We examined the effect of intensive SBP lowering across educational strata in relation to both SBP achieved and the composite cardiovascular SPRINT end point using multivariable proportional hazards models. …”
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Translation, cross-cultural adaptation, and validation of the Chinese version of the injury-psychological readiness to return to sport scale by Siqi Liu, Yunxi Zhang, Young-Eun Noh, Tong Zhou

“…To evaluate the reliability of the I-PRRS-Ch, test-retest reliability was employed using the intraclass correlation coefficient (ICC 3,1). Composite reliability and convergent validity were assessed using partial least squares structural equation modeling (PLS-SEM). …”
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Prognostic Implications of Guideline-Directed Medical Therapy for Heart Failure in Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis by Vasileios Anastasiou, Andreas S. Papazoglou, Stylianos Daios, Dimitrios V. Moysidis, Eirinaios Tsiartas, Matthaios Didagelos, Kyriakos Dimitriadis, Theodoros Karamitsos, George Giannakoulas, Konstantinos Tsioufis, Antonios Ziakas, Vasileios Kamperidis

“…The use of RASi and BB was associated with a significantly lower risk of all-cause mortality (HR 0.52 [0.39–0.68]; <i>p</i> < 0.00001, I² = 62% and HR 0.62 [0.49–0.77]; <i>p</i> < 0.0001, I² = 44%, respectively) and the composite outcome (HR 0.54 [0.44–0.67]; <i>p</i> < 0.00001, I² = 33% and HR 0.62 [0.52–0.75], <i>p</i> < 0.00001, I² = 35%, respectively) in unadjusted models. …”
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Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease by Lanlan Li, XuZai Deng, Shuge Wang, Tao Huang

“…An independent cohort of 36 pediatric stool samples assessed by 16S rRNA sequencing validated top ML results.ResultsTraditional abundance-based methods showed compositional shifts but identified few consistently significant taxa. …”
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Research and Analysis of Carbon Fiber-Reinforced Polymer Prepreg Detection Based on Electromagnetic Coil Sensors by Sichang Zhang, Shouqi Cao, Meiling Wang

“…In response to the challenges posed by the complexity and potential hazards of traditional chemical methods for detecting the surface density of carbon fiber prepreg materials, this paper explores the use of eddy current testing principles. …”
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Parametric optimization of Archimedes screw turbine by response surface methodology and artificial neural networks by Vipin Uniyal, Ashish Karn, Varun Pratap Singh

“…Utilising response surface methodology (RSM) through a central composite design (CCD) and artificial neural networks (ANN), the research explores the predictive accuracy of these methods for optimal power generation. …”
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Evaluation of stress distribution in an endodontically treated tooth restored with four different post systems and two different crowns- A finite element analysis by Rajvi Nahar, Sunil Kumar Mishra, Ramesh Chowdhary

“…Aim and objectives: The study evaluated the stress distribution in an endodontically treated tooth with four different post systems and restored with two different prosthetic crown materials using finite element analysis (FEA). Material and methods: A total of eight 3D FEA models of maxillary central incisor were created and divided into two groups; group porcelain fused to metal (PFM) crown (n = 4) and group PEEK crown (n = 4). …”
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Generative Design and Additive Manufacturing Techniques on the Optimization of Multi-MW Offshore Direct-Drive Wind Turbine Electrical Generators by Daniel Gonzalez-Delgado, Pablo Jaen-Sola, Erkan Oterkus

“…New advances in structural optimization techniques and manufacturing methods, such as generative design (GD) and additive manufacturing (AM), are revolutionizing the capabilities to generate high-efficiency and lightweight models in comparison with conventional processes. …”
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Association of depressive and anxiety symptoms with adverse events in chronic kidney disease patients without dialysis:a prospective observational study by LING He, WANG Xiao-qin, HAN Si-ping, ZHAN Li-rui, CHEN Li, ZHANG Na

“…Cox proportional hazards models were used to calculate hazard ratio’s（ HRs） with a composite event of death and initiation of dialysis as outcome. …”
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64 Effect modification of familial longevity on the association between kidney dysfunction, cardiovascular disease, and mortality by Laith Alzyood, Tina Goa, Einstein Sanish Sathyan, Einstein Sandra Aleksic, Einstein Sofiya Milman, Einstein Michal Melamed, Wei Chen Einstein

“…Goals include assessing the impact of familial longevity on 1) CVD prevalence, 2) CVD incidence, and 3) mortality among individuals with CKD. Methods/Study Population: An observational, longitudinal study. …”
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Aging is associated with slower renal progression in patients with chronic kidney disease by Chia-Tse Yeh, Chun-Yu Lin, Ting-Yun Lin, Ching-Hsiu Peng, Yi-Chun Wang, Szu-Chun Hung

“…Notably, elderly did not predict a higher risk for the composite outcome (HR: 0.94; 95% CI: 0.67, 1.32; P = 0.723). …”
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Inhomogeneous Dust Biases Photometric Redshifts and Stellar Masses for LSST by ChangHoon Hahn, Peter Melchior

“…Spectral energy distribution (SED) modeling is one of the main methods to estimate galaxy properties, such as photometric redshifts, z , and stellar masses, M _* , for extragalactic imaging surveys. …”
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DIGITAL MEDIATION TOOLS IN RESOLVING SOCIAL CONFLICTS WITHIN THE PUBLIC ADMINISTRATION SYSTEM by Roman Stadniichuk, Olga Garafonova, Oleksandr Kornaha

“…The study concludes that, although digital mediation cannot replace traditional methods entirely, it is a vital addition to modern governance, particularly in times of crisis. …”
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The Capability of Amphibole in Tracing the Physicochemical Processes of Magma Mixing by Mingjian Li, Yunchuan Zeng, Massimo Tiepolo, Jifeng Xu, Enrico Cannaò, Francesca Forni, Feng Huang

“…Our study highlights that amphibole may be a more sensitive tracer of magma mixing relative to other commonly used methods.…”
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