Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China by Decheng Li, Yunhe Wang, Shuai Guo, Ziyang Ren, Binbin Su, Lichuan Zhang, Zuliyaer Talifu, Xiaoying Zheng

“…While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts. Methods: We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). …”
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Predictive Value of Frailty, Comorbidity, and Patient-Reported Measures for Hospitalization or Death in Older Outpatients: Quality of Life and Depression as Prognostic Red Flags by Dimitrios Anagnostou, Nikolaos Theodorakis, Sofia Kalantzi, Aikaterini Spyridaki, Christos Chitas, Vassilis Milionis, Zoi Kollia, Michalitsa Christodoulou, Ioanna Nella, Aggeliki Spathara, Efi Gourzoulidou, Sofia Athinaiou, Gesthimani Triantafylli, Georgia Vamvakou, Maria Nikolaou

“…The primary outcome was a composite of hospitalization or all-cause mortality. …”
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Comparison of sedentary time, number of steps and sit-to-stand-transitions of desk-based workers in different office environments including working from home: analysis of quantitat... by Martha Sauter, Eva Backé, Carina Pfab, Michaela Prigge, Claudia Brendler, Falk Liebers, Peter von Löwis, Andrea Pfeiffer, Falko Papenfuss, Janice Hegewald

“…Time-use data were also examined using compositional data analysis. Mixed model regression was performed to estimate means and 95% confidence intervals (CI). …”
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Long-term exposure to outdoor fine particulate and physical activity with mortality and cardiovascular events: an analysis of the Prospective Urban Rural Epidemiology (PURE)-China... by Jun Hao, Zhiguang Liu, Bo Hu, Duolao Wang, Sumathy Rangarajan, Yang Wang, Chuangshi Wang, Lap Ah Tse, Weida Liu, Sidong Li, Minghai Yan, Qiujing Cai, Salim Yusuf, Wei Li

“…Cox frailty models and restricted cubic splines were used to assess associations. …”
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Delivery of care in high mortality hospital settings: a direct observational study examining 1848 h of neonatal nursing in KenyaResearch in context by Abdulazeez Imam, Michuki Maina, Jalemba Aluvaala, Vincent Kagonya, Onesmus Onyango, Fredrick Were, Sebastian Fuller, Kenneth Karumba, Mike English, David Gathara, Peter Mwangi, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Loise Mwangi, Penina Musyoka, Zainab Kioni

“…The relationship between nursing workload and nursing care provision was assessed using multilevel models. Findings: Across 8 hospitals spanning 1848 h of observation of 597 sick newborns, the median nursing time available for each newborn ranged from 19.2 to 72.0 min on a 12-h shift. …”
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Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial by Qin Sun, Rui Zhang, Junyi Zhang, Jianfeng Xie, Yingzi Huang, Yi Yang, Haibo Qiu, Ling Liu, Hui Chen, the Chi-ARDS Net (Chinese ARDS Research Network)

“…A Cox proportional hazards regression model was employed to elucidate the associations, and the daily duration of APP was treated as time dependent. …”
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Regreening Practices and Effectiveness Evaluation for Rocky Slope Drawdown Zones in Pumped Storage Power Station Reservoirs by YANG Zhi-chao, MA Xiao-xiao, CHANG Shi-ju, TANG Yu-shuang, ZHAO Rui-yi, WAN Dan, ZHANG Qian-zhu

“…Vegetation measures should adopt a tree-shrub-herb configuration model tailored to the degree of submersion stress and the desired landscape effect. ①Permanently exposed zone. …”
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Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study by Rosa Oh, Seohyun Kim, Sang Ho Park, Myunghwa Jang, So Hyun Cho, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim

“…The risk of CVD across the TyG index quartiles was compared using the Cox proportional hazards model. Results The cut-off points for the TyG quartiles were 8.46, 9.03, and 9.60. …”
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Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-... by Paris J Baptiste, Angel Y S Wong, Anna Schultze, Catherine M Clase, Clémence Leyrat, Elizabeth Williamson, Emma Powell, Johannes F E Mann, Marianne Cunnington, Koon Teo, Shrikant I Bangdiwala, Peggy Gao, Kevin Wing, Laurie Tomlinson

“…We assessed outcomes using an inverse-probability-weighted Cox proportional hazards model for ARB versus ACEi with heterogeneity by ethnicity assessed on the relative and absolute scale. …”
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Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis by Wentao Chen, Guihua Zhang, Qiao Lei, Huixia Lu

“…The advanced lung cancer inflammation index (ALI) is a composite indicator consisting of several parameters used to assess inflammation and nutritional status. …”
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NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes by Michael Chang, Mohamed Sherief, Maria Ioannou, Viveka Chinnasamy, Lucy Chen, Michael Frost, Michelle Mattson-Hoss, Herb Sarnoff, David O. Kamson, Matthias Holdhoff, Debraj Mukherjee, Chetan Bettegowda, Jordina Rincon-Torroella, Victoria Croog, Peng Huang, Fausto J. Rodriguez, Calixto-Hope G. Lucas, Karisa C. Schreck

“…Here, we seek to perform a composite analysis for NF1 loss accounting for genomic alterations and protein expression via immunohistochemistry. …”
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The advanced lung cancer inflammation index has an L-shaped association with prognosis in American adults with metabolic dysfunction-associated fatty liver disease: a cohort study by Yuexia Lu, Shuaipeng Yuan, Huazhao Xu, Jiqi Ouyang, Jinsheng Dong, Xin Jiang, Xiao Shao, Runshun Zhang

“…Our study aims to find the relationship between advanced lung cancer inflammation index (ALI) levels and the prognosis of patients with MAFLD and to determine the predictive value of ALI in this context.MethodsMultivariate-adjusted Cox regression models were used to analyze the association between ALI and all-cause, cardiovascular, cancer, and diabetes-related mortalities in patients with MAFLD. …”
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MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation by Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore

“…Methods and results In this longitudinal prospective study, 162 patients with advanced heart failure (AHF) were enrolled; all patients included in the study were receiving the maximum tolerated medical therapy according to guidelines. …”
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Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice by Xuemeng Mu, Xinyi Du, Huitian Han, Fei Liu, Zhifa Zheng, Jing Hao, Lijin Liu, Su Liu, Ze Wei, Changfa Huang, Annan Liang, Wei Zou, Lina Zhao, Zhihong Wu, Jia Zhang

“…This study explores the potential of LNPs as an effective delivery system to treat osteoporosis. <b>Methods</b>: LNPs were prepared using microfluidic techniques with varying lipid compositions, and characterized in terms of size, zeta potential, and entrapment efficiency (EE%). …”
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Autoantibodies to Erythropoietin Receptor and Clinical Outcomes in Patients With Type 2 Diabetes and CKD: A Post Hoc Analysis of CREDENCE Trial by Akihiko Koshino, Brendon L. Neuen, Megumi Oshima, Tadashi Toyama, Akinori Hara, Clare Arnott, Bruce Neal, Meg Jardine, Sunil V. Badve, Kenneth W. Mahaffey, Carol Pollock, Michael K. Hansen, Takashi Wada, Hiddo J.L. Heerspink

“…Multivariable Cox-regression models estimated associations between anti-EPOR antibodies and outcomes. …”
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Perceived technology usefulness for caregiving among unpaid caregivers: a National Cross-Sectional Study by Matthew Lee Smith, Matthew Lee Smith, Shinduk Lee, Malinee Neelamegam, Deborah Vollmer Dahlke, Deborah Vollmer Dahlke, Deborah Vollmer Dahlke, Jodi L. Southerland, Zachary G. Baker, Kris Pui Kwan Ma, Darina V. Petrovsky, Zahra Rahemi, Justine S. Sefcik, Juanita-Dawne R. Bacsu, Chung Lin Kew, Chung Lin Kew, Marcia G. Ory, Marcia G. Ory

“…The primary dependent variable was the Perceived Technology Usefulness for Caregiving (PTUC) Scale, which is a composite score of six items ranging from 0 to 100. …”
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Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Results Diverse cellular compositions were observed in the tumor microenvironment (TME) during GGN– and PSN–LUAD invasion and metastasis. …”
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Metabolic Status and Atrioventricular Block Risk: The Role of Physical Activity by Ho-Gi Chung, Pil-Sung Yang, Eunsun Jang, Daeun Joung, Daehoon Kim, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung

“…We used the multivariable Cox proportional model to assess the associations between metabolic status and primary outcome (composite of second-degree AVB or third-degree AVB) or secondary outcomes (each component in the primary outcome and AVB-related pacemaker implantation). …”
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Contribution of hypertension and other risk factors to survival and mortality in the Russian population by Yu. A. Balanova, S. A. Shalnova, V. A. Kutsenko, A. E. Imaeva, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, S. A. Maksimov, N. S. Karamnova, E. B. Yarovaya, N. V. Kulakova, O. N. Kalachikova, T. M. Chernykh, O. A. Belova, G. V. Artamonova, E. V. Indukaeva, Yu. I. Grinshtein, R. A. Libis, D. V. Duplyakov, O. P. Rotar, I. A. Trubacheva, V. N. Serebryakova, A. Yu. Efanov, A. O. Konradi, S. A. Boytsov, O. M. Drapkina

“…HTN increases the risk of a composite endpoint for both men and women (p&lt;0,001). …”
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Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma by Ke Ma, Jie Xu, Jie Xu, Congyue Wang, Congyue Wang, Xu Cao, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Yanhua Liu, Chong Chen, Chong Chen, Xiaoli Mai, Xiaoli Mai

“…The robustness of the model was assessed using the concordance index (C-index), Kaplan-Meier survival analyses, receiver operating characteristic (ROC) curves, and both univariate and multivariate Cox regression analyses. …”
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