Extraction Optimization of Tinospora cordifolia and Assessment of the Anticancer Activity of Its Alkaloid Palmatine by Huma Ali, Savita Dixit

“…To optimize the conditions for the extraction of alkaloid palmatine from Tinospora cordifolia by using response surface methodology (RSM) and study its anticancerous property against 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Methods. The effect of three independent variables, namely, extraction temperature, time, and cycles was investigated by using central composite design. …”
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An acoustic microscope for microflaw inspection and subsurface imaging by J. Litniewski

“…This paper describes a laboratory model of an acoustic microscope designed for imaging material interior using the B-scan representation mode. …”
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Prognostication in emergency room patients: comparing ultrasensitive and contemporary quantification of cardiac troponin levels below the 99th percentile by Anna Carrasquer, Anna Carrasquer, Anna Carrasquer, Germán Cediel, Germán Cediel, Germán Cediel, Alma Gómez-Sanz, Alma Gómez-Sanz, Óscar M. Peiró, Óscar M. Peiró, Óscar M. Peiró, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Alfredo Bardaji, Alfredo Bardaji, Alfredo Bardaji, Jose Luis Ferreiro, Jose Luis Ferreiro, Jose Luis Ferreiro

“…However, there were no statistically significant difference between the two predictive models that included the aforementioned troponin assays.ConclusionsDetectable levels of cardiac troponin using a contemporary analytical method or those near the 99th percentile using an ultra-sensitive analytical method improve the predictive efficacy for cardiovascular events, with no differences between the two methods…”
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Four-dimensional printing of acrylonitrile butadiene styrene – thermoplastic polyurethane shape memory polymers with excellent material and interfacial adhesion performance by Kianoosh Soltanmohammadi, Mohammad Aberoumand, Davood Rahmatabadi, Elyas Soleyman, Sogol Ghasemi, Ismaeil Ghasemi, Majid Baniassadi, Karen Abrinia, Mahdi Bodaghi, Mostafa Baghani

“…The fused deposition modeling (FDM) method is used for the four-dimensional printing of layered structures whose base materials show no SME. …”
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Personalized decision making for coronary artery disease treatment using offline reinforcement learning by Peyman Ghasemi, Matthew Greenberg, Danielle A. Southern, Bing Li, James A. White, Joon Lee

“…Our findings indicate that RL-guided therapy decisions outperformed physician-based decision making, with RL policies achieving up to 32% improvement in expected rewards based on composite major cardiovascular events outcomes. Additionally, we introduced methods to ensure that RL CAD treatment policies remain compatible with locally achievable clinical practice models, presenting an interpretable RL policy with a limited number of states. …”
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A Feasibility Study of Debonding Detection in Multi-Layered Marine Thin-Wall Structures Using a Non-Destructive Vibration-Based Approach by Yona Dawit, Zima Beata, Krata Przemysław

“…This study analyses different debonding defect scenarios on a multi-layered material composed of carbon fibre-reinforced polymer as a composite coating applied to structural steel, with the aim of applying it to marine structures. …”
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Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis by Thomas Rudolf Schneider, Ansgar Felbecker, Ansgar Felbecker, Ben von Mitzlaff, Ben von Mitzlaff, Gregor Weissofner, Gregor Weissofner, Sarah Meier, Sarah Meier, Patrick Eggenberger, Patrick Eggenberger, Patrick Eggenberger, Simon Annaheim

“…BackgroundMotor function is a sensitive indicator of cognitive aging but the unique contributions of different motor domains are unclear when assessed together.MethodsWe evaluated 98 community-dwelling older adults (median age: 74). …”
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ZEB1 transcription factor promotes immune escape in melanoma by Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel

“…We thus wondered whether ZEB1 signaling in melanoma cells may promote immune evasion and resistance to immunotherapy.Methods We evaluated the putative correlation between ZEB1 expression in melanoma cells and the composition of the immune infiltrate in a cohort of 60 human melanoma samples by combining transcriptomic (RNA-sequencing) and seven-color spatial multi-immunofluorescence analyses. …”
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Development and validation of the physical fitness test anxiety scale for college students by Shanshan Yin, Fang Tang, Pincao Gao

“…The model fit was good (χ2/df = 2.29, RMSEA = 0.051, IFI, CFI, TLI, GFI, AGFI >0.90). …”
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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate by Chenquan Lin, Chenquan Lin, Chenquan Lin, Rui Ma, Rui Ma, Rui Ma, Xiao Zeng, Xiao Zeng, Xiao Zeng, Bikui Zhang, Bikui Zhang, Bikui Zhang, Ting Cao, Ting Cao, Ting Cao, Shimeng Jiao, Shimeng Jiao, Shimeng Jiao, Hui Chen, Hui Chen, Hui Chen, Yifang He, Yifang He, Yifang He, Mouze Liu, Mouze Liu, Mouze Liu, Hualin Cai, Hualin Cai, Hualin Cai

“…Additionally, individual variations including genetic underpinnings attributable to disparities in therapeutic effects and clinical toxicity remain to be elucidated.MethodsA total of 374 patients receiving initial HD-MTX treatment were selected for this study, which aimed to establish a predictive model using binary logistic regression and a visual nomogram for DILI risk assessment. …”
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Understanding the attitudes towards climate change in the context of trust in selected countries of Central and Eastern Europe by Zsuzsanna Deák, Gintarė Vaznonienė, Agnieszka Wojewódzka-Wiewiórska

“…European Social Survey (ESS) Round 10 data were used, and a multivariable binary logistic regression method was applied. This paper considers three different dimensions of climate change, concern, personal norms, and attribution, as well as a composite indicator reflecting climate attitudes (skeptic or proponent). …”
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Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Findings were validated using external multi-omics datasets, tissue microarray cohort, spatial RNA in situ sequencing, CCA patient-derived organoids (PDOs), and mouse models. Results iCCAs and eCCAs exhibited distinct tumor ecosystems, with notable differences in cellular composition, diversity, and abundance across various cell types. …”
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Examining the impact of early life adversity on adolescent sleep health: Findings from the ABCD study by Ethan T. Hunt, Keith Brazendale, Augusto César Ferreira De Moraes, Marcus Vinicius Nascimento-Ferreira, Christopher D. Pfledderer, Sarah Sampaio Izabel, Erin E. Dooley, Baojiang Chen, Alejandra Fernandez, Micah E. Johnson, Hugh Garavan, Alexandra S. Potter, Sarajane L. Dube, Nicholas Allgaier, Deanna M. Hoelscher, Susan F. Tapert

“…Methods: Social jetlag and weekly sleep loss were assessed using the Munich Chronotype Questionnaire at 2-year and 3-year follow-ups. …”
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Synthesis and investigation of optical properties and enhancement photocatalytic activity of TiO2–SnO2 semiconductor for degradation of organic compounds by Wagih Sadik, Abdelghaffar M. El-Demerdash, Adel William Nashed, Amr Ahmed Mostafa, Elsayed Lamie

“…Abstract Industrial wastewater treatment using UV irradiation in combination with oxidants or catalysts (TiO2) has attracted attention as a promising substitute for conventional methods. Studying the preparation and characterization of TiO2–SnO2 nanocomposites with different ratios, as well as their use in the enhanced photocatalytic degradation of acid red 37 dye in aqueous solution under UV irradiation as a model pollutant, are the goals of the research. …”
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Association between red blood cell distribution width-to-albumin ratio and all-cause mortality in intracerebral hemorrhage by Jia Xu, Guangdong Wang, Xinran Chen, Xinyi Xu, Yun Wang, Li Wang, Yaxin Zhang

“…We aim to examine how RAR relates to mortality risk among individuals with ICH.MethodsWe performed a retrospective cohort analysis using the Medical Information Mart for Intensive Care-IV database. …”
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Cumulative behavioral and metabolic determinants of health are associated with higher inflammation-related indices: insights from a cross-sectional study (NHANES 2005–2018) by Anzhi Wang, Youping Zeng, Xiaoyan Gao, Xunge Lin, Shenshen Du, Ping Wang, Yun Pan

“…ObjectiveThis study innovatively investigates the cumulative associations between behavioral determinants of health (BDoH), metabolic determinants of health (MDoH), and systemic inflammation biomarkers in U.S. adults, using a novel cross-sectional framework to quantify their synergistic effects.MethodsUtilizing cross-sectional data from 18,500 participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018 cycle), we developed a composite exposure model integrating BDoH (smoking status, physical activity, dietary quality) and MDoH (obesity metrics, hypertension, diabetes) through standardized questionnaires and clinical measurements. …”
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Correlation of changes in inflammatory and collagen biomarkers with durable guselkumab efficacy through 2 years in participants with active psoriatic arthritis: results from a phas... by Stefan Siebert, Georg Schett, Siba P. Raychaudhuri, Monica Guma, Warner Chen, Sheng Gao, Soumya D. Chakravarty, Frederic Lavie, Proton Rahman

“…Guselkumab-randomized participants with available serum biomarker data (randomly selected to reflect demographic and disease characteristics of the DISCOVER-2 population) comprised inflammatory ( N  = 100) and collagen ( N  = 178) biomarker cohorts. Methods: Pharmacodynamic effects of guselkumab through 2 years on inflammatory and collagen biomarker levels (general linear model) and associations between biomarkers and improvements in composite measures of joint, skin, and overall disease activity (Spearman linear regression) through 2 years were assessed. …”
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Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Health Information Technology Usability Evaluation Scale in China: Instrument Validation Study by Rongrong Guo, Ziling Zheng, Fangyu Yang, Ying Wu

“…Confirmatory factor analysis confirmed a 4D structure with acceptable construct validity, as indicated by model fit indices. Both the Health-ITUES-R and Health-ITUES-P showed satisfactory convergent validity (average variance extracted [AVE] value>0.5, composite reliability value>0.7), except for a slightly lower AVE value (0.478) for the second dimension of the Health-ITUES-R. …”
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Stratifying risk outcomes among adult COVID-19 inpatients with high flow oxygen: The R4 score by G.M. Aguirre-García, D. Ramonfaur, G. Torre-Amione, M.T. Ramírez-Elizondo, R. Lara-Medrano, J.F. Moreno-Hoyos, E.S. Velázquez-Ávila, C.A. Diaz-Garza, V.M. Sanchez-Nava, F. Castilleja-Leal, G.M. Rhoades, M.F. Martínez-Reséndez

“…This study aims to provide a simple risk stratification system to predict invasive mechanical ventilation (IMV) or death among COVID-19 inpatients on HFO.Methods Among 529 adult inpatients with COVID-19 pneumonia, we selected unadjusted clinical risk factors for developing the composite endpoint of IMV or death. …”
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Calculation of the Effective Dielectric Constant and Capacitance of Slit and Plane-Parallel Capacitors with High Temperature Stability Characteristics Based on a Multilayer Ferroel... by I. G. Mironenko, S. S. Sokolov, M. E. Shevchenko, V. S. Severikov, Kong Che Fam, A. I. Protchenko, N. N. Sharova, A. P. Burovikhin, A. A. Ivanov

“…Creation of computational models of planar slit structures containing multilayer films with thickness-variable stoichiometric compositions of ferroelectric materials. …”
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