Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal AdenocarcinomaSummary by Theresa Baumeister, Andrea Proaño-Vasco, Amira Metwaly, Karin Kleigrewe, Alexander Kuznetsov, Linus R. Schömig, Martin Borgmann, Mohammed Khiat, Akanksha Anand, Julia Strangmann, Katrin Böttcher, Dirk Haller, Andreas Dunkel, Veronika Somoza, Sinah Reiter, Chen Meng, Robert Thimme, Roland M. Schmid, Deepa T. Patil, Elke Burgermeister, Yiming Huang, Yiwei Sun, Harris H. Wang, Timothy C. Wang, Julian A. Abrams, Michael Quante

“…Here, we assess the effect of diet on the microbiota-BA axis and evaluate the role of FXR in disease progression. Methods: L2-IL1B mice (mouse model of BE and GEAC) under different diets, and L2-IL1B-FXR KO-mice were characterized. …”
Get full text

Binary pore structure and fractal characteristics of tight sandstone： A case study of Chang 7 Member of Triassic Yanchang Formation in Ordos Basin by WU Xiaobin, DU Zhiwen, QIANG Xiaolong, LEI Tian, JIANG Tingting, WANG Wei, ZHU Yushuang

“…Bound pores are mainly composed of intergranular pores， and the pore model is the envelope surface of clay accumulation. …”
Get full text

Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study by Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen, Nicolas Martinez-Majander, Eija Könönen, Teemu Niiranen, Leo Lahti, Juha Sinisalo, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju

“…However, its exact link to the oral microbiota remains unclear.Methods In a case-control study involving 120 participants, comprising 60 cases and 60 controls (mean age (SD) 36.6 (7.6) years; 50% males), nested within a prospective multicentre cohort study, we examined the oral microbiome composition of gingivitis patients and their controls using shotgun metagenomic sequencing of saliva samples. …”
Get full text

METAB‐HTX: prospective, longitudinal cohort study evaluating cardiac and systemic metabolism after heart transplantation by Amin Polzin, Daniel Scheiber, Fabian Voss, Jean Haurand, Elric Zweck, Daniel Oehler, Oliver Maier, Mareike Cramer, Maximilian Spieker, Constanze Moos, Ursala Tokhi, David Naguib, Philipp Mourikis, Marcel Benkhoff, Robert Wagner, Michael Roden, Heinz‐Peter Schultheiss, Sascha Dietrich, Hug Aubin, Udo Boeken, Artur Lichtenberg, Malte Kelm

“…Metabolic alterations will be investigated by (i) glucometabolic phenotyping including serial oral glucose tolerance tests, homeostasis model assessment, T2D endotyping, and muscle biopsies in selected cases; (ii) lipid disorders will be evaluated by classical lipid measurements in combination with evaluation of HDL function, plasma membrane lipid composition, fluidity analyses of circulating cells and MRI/MRS for adipose tissue distribution, and ectopic fat analysis. …”
Get full text

Mechanisms of Chromium Removal from Water and Soil Using Bioleached Nano Zero-Valent Iron-Mediated Biochar via Co-Pyrolysis by Zhiyi Liu, Shuhong Zhou, Yubing Cai, Xuehai Zhang, Muhammad Shaaban, Qi-an Peng, Yajun Cai

“…In aqueous conditions, the removal capacity of Cr(VI) by nZVI@BC increased by 72.01% and 66.92% compared to biochar (BC) and biochar–bioleachate composite (BBC), respectively. Under optimal conditions, nZVI@BC eliminated 90.11% of 20 mg/L Cr(VI), with experimental data fitting the Freundlich and pseudo-second-order kinetic models. …”
Get full text

Systematic review and network meta-analysis of retinal imaging biomarkers in neurodegenerative diseases: Correlation with brain changes by Farzaneh Nikparast, Zohreh Ganji, Hoda Zare, Nooshin Akbari-Sharak

“…This Systematic and network meta-analysis (NMA) aims to identify retinal-brain biomarkers across the spectrum of NDs. Methods: We conducted an NMA using random-effects models to assess retinal layer thickness changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). …”
Get full text

Papain Affects the Percentage and Morphology of Microglia in Hippocampal Neuron–Glial Cultures by Ivan A. Tumozov, Valentina N. Mal’tseva, Sergei A. Maiorov, Artem M. Kosenkov, Sergei G. Gaidin

“…</b> Microglia, accounting for 5–15% of total brain cells, represent an essential population of glial cells in the cultures used for modeling neuroinflammation in vitro. However, microglia proliferation is poor in neuron–glial cultures. …”
Get full text

Novel body component score predicts long‐term survival in patients with stage I–III colorectal cancer following radical resection by Takashi Aida, Teppei Kamada, Taigo Hata, Junji Takahashi, Eisaku Ito, Kenei Furukawa, Masashi Yoshida, Hironori Ohdaira, Toru Ikegami, Yutaka Suzuki

“…Methods This retrospective study included 300 patients with CRC who underwent curative colorectal resection in 2010–2019. …”
Get full text

MCT4: a key player influencing gastric cancer metastasis and participating in the regulation of the metastatic immune microenvironment by Tao Jiang, Jingcheng Zhang, Sicheng Zhao, Mingsi Zhang, Yunhai Wei, Xiaojuan Liu, Shuo Zhang, Wei Fan, Yueying Liu, Yuanlin Lv, Guangji Zhang

“…The role of MCT4 in the occurrence and development of gastric cancer has not been clarified. Methods In this study, we comprehensively utilized single-cell sequencing and external transcriptome sequencing databases to deeply analyze the mechanism of the impact of MCT4 on gastric cancer and its microenvironment. …”
Get full text

The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency by Jiawen Ma, Chaofan Zhu, Lifang Xie, Shuaiqi An, Zaiyang Zhang, Keying Wang, Yizhou Zhang

“…This study aimed to elucidate the molecular mechanism by which NTZF treats POI via proBDNF/mBDNF modulation. Methods POI rat models were established using cyclophosphamide (CTX). …”
Get full text

Experimental insights into the formation and characterization of iodine oxide aerosols by Mariam, Mariam, Manish Joshi, Amruta Nakhwa, Pallavi Khandare, Samanta Soumen, Arshad Khan, B. K. Sapra, B. K. Sapra

“…Therefore, this study was designed to generate and characterize iodine oxides in a laboratory scale setup.MethodsExperiments were conducted at room temperature and ambient relative humidity using an I2 concentration of ∼1 ppm and an O3 concentration of ∼30 ppm inside a controlled chamber. …”
Get full text

Obesity and Systemic Inflammation Disrupt the Compensatory Role of Physical Activity in Chronic Pain Conditions by Taynah Galassi, Kevin Pacheco-Barrios, Anna C. Gianlorenco, Felipe Fregni

“…Weighted logistic regression models were used to test the adjusted associations and effect modifications. …”
Get full text

Value-based healthcare in Latin America: a survey of 70 healthcare provider organisations from Argentina, Brazil, Chile, Colombia and Mexico by Pedro Ramos, Marcia Makdisse, Daniel Malheiro, Marcelo Katz, Luisa Novoa, Miguel Cendoroglo Neto, Jose Henrique Germann Ferreira, Sidney Klajner

“…Although the value equation had been cited by 24% of participants, its composition differed in most case from the original Equation. …”
Get full text

Diuretic effects of hydromethanolic extract of Rumex nepalensis Spreng. leaves and its solvent fractions in mice by Fasika Argaw Tafesse, Tafere Mulaw Belete, Assefa Belay Asrie

“…Purpose of the study: This study aimed to evaluate the diuretic activity of R. nepalensis leaf extract and solvent fractions using standardized experimental models. Methods: The leaves of the plant were dried under shade, crushed to a coarse powder, and subjected to cold maceration with 80% methanol and concentrated. …”
Get full text

Association of Intratumoral Microbiota with Prognosis in Patients with Lacrimal Gland Tumor by Jianping Hu, Yidi Yang, Yiyi Feng, Yu Yu, Xin Song, Renbing Jia

“…<b>Methods</b>: High-throughput 16S rDNA sequencing was performed on tumor DNA extracted from 89 paraffin-embedded tissues from patients with lacrimal gland tumors. …”
Get full text

Specialist Savvy Versus Generalist Grit: Elucidating the Trade‐Offs in Adaptive Dietary Ecomorphology Amongst African Green and Bush Snakes by Hanlie M. Engelbrecht, Kimberley E. J. Chapelle, Graham J. Alexander

“…There is limited knowledge of how small variations in prey type composition may influence feeding morphology among closely related species sharing similar ecological niches. …”
Get full text

County Incarceration Rate and Stroke Death: A Cross‐Sectional Study of the Influence of Physical Environment, Health Care Access, and Community Mental Distress by Anders Larrabee Sonderlund, Emily A. Wang, Natasha J. Williams, Carol R. Horowitz, Antoinette Schoenthaler, Louisa W. Holaday

“…We examine the link between county imprisonment rates and stroke death, testing pathways and identifying racial disparities. Methods In a cross‐sectional design, we regressed stroke death onto imprisonment rates, adjusting for poverty, racial composition, education, unemployment, insurance, and violent crime. …”
Get full text

Relationships between sleep duration, physical activity and body mass index in young New Zealanders: An isotemporal substitution analysis. by Borja Del Pozo-Cruz, Nicholas Gant, Jesús Del Pozo-Cruz, Ralph Maddison

“…Multiple linear regression models were used to examine the independent associations of SB, Sleep time, LPA, and MVPA on BMI. …”
Get full text

ANTHROPOGENIC APPELLATIVE DERIVED ORONYMS OF HISTORICAL UMAN REGION by Oksana B. Kolesnyk, Svitlana P. Karychkovska

“…Given that such objects were renamed, oronyms usually had several variants, and even within the same document, different models of the name of a particular object were recorded. …”
Get full text

Dried blood spot technique for dietary fat assessment in a human nutritional intervention focused on oily fish intake by Laura Garcia-Urtiaga, Ainara Cano, Mercedes Caro, Jaione Pagaldai, Javier Amezaga, Itziar Tueros, Sara Arranz

“…Differences among groups were tested by Student´s t test or by Wilcoxon test, and changes across visits were analysed via linear mixed models. Results The results revealed three main patterns of the DBS profile, which could be explained by the participants’ dietary habits. …”
Get full text