Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associate... by Marc A Benninga, Melvin B Heyman, Anthony Otley, Tim de Meij, Wouter J de Jonge, Charlotte M Verburgt, Katherine A Dunn, Sofia Verstraete, Withney Sunseri, Francisco Sylvester, Andre Comeau, Morgan Langille, Johan E Van Limbergen

“…We will additionally explore changes in faecal microbiome taxonomic composition between groups.Ethics and dissemination This study was approved by METC-AMC and CCMO (Netherlands) and IWK Health Centre (Canada). …”
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Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis by Guangyun Luo, Guangyun Luo, Xiangyi Kong, Fang Wang, Zhiming Wang, Zhuo Zhang, Huan Cui, Yiwen Zhang, Wen Huang, Xuesong Yang, Jianzhou Ye, Jianzhou Ye

“…However, current treatments have shown limited efficacy in improving the symptoms of both conditions simultaneously.ObjectiveThis study aimed to investigate the therapeutic efficacy of Fufang Longdan Mixture (FLM) in treating MS-P comorbidity, elucidate its mechanism through the miR-29a-5p/IGF-1R axis and evaluate treatment responses between APOE−/− and C57BL/6 mice.MethodsUPLC-Q-exactive-MS/MS analysis was used to characterise FLM’s chemical composition. …”
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Meta‐analysis of cardiac magnetic resonance in prognosticating left ventricular function in peripartum cardiomyopathy by Hawani Sasmaya Prameswari, William Kamarullah, Raymond Pranata, Iwan Cahyo Santosa Putra, Alberta Claudia Undarsa, Mohammad Iqbal, Triwedya Indra Dewi, Nuraini Yasmin Kusumawardhani, Mohammad Rizki Akbar, Astri Astuti

“…Comparisons between groups with the presence of LGE, myocardial oedema, and recovered against non‐recovered patients were pooled. A random‐effects model was employed to calculate the effect size. …”
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“Agent – Environment” Evolution Mechanism of Greenbelt from the Perspective of Complex Adaptive System: A Case Study of Beijing’s Greenbelts by Song LIU, Peiyu SHEN, Dizi LIU, Zhaocheng BAI

“…This research takes Beijing’s greenbelts (the first greenbelt and the second greenbelt) as an example to, according to the “bottom-up” research paradigm of complex adaptive system theory (CAS), depict the adaptation process of multiple agents to promote the evolution of the greenbelt system, and explore the evolution mechanism of greenbelt, so as to seek targeted solutions to optimize greenbelt planning and promote the implementation of greenbelt policies.MethodsBased on the theory of complex adaptive system, the characteristics of the greenbelt system are analyzed from the perspectives of basic characteristics, structural composition and adaptive mechanism. …”
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Amelioration of Metabolic Syndrome by Co-Administration of <i>Lactobacillus johnsonii</i> CRL1231 and Wheat Bran in Mice via Gut Microbiota and Metabolites Modulation by Matias Russo, Antonela Marquez, Estefanía Andrada, Sebastián Torres, Arlette Santacruz, Roxana Medina, Paola Gauffin-Cano

“…Methods: Mice were divided into three groups and fed for 14 weeks as follows: the Control group (standard diet), the MS group (HFD+WB), and the MS+Lj group (HFD+WB and <i>Lj</i> CRL1231-dose 10⁸ cells/day). …”
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Association between the early or late onset of gestational diabetes mellitus with neonatal adverse outcomes: a retrospective cohort study by Fabiana Vieira Duarte de Souza Reis, Carlos Izaias Sartorão Filho, Luis Sobrevia, Caroline Baldini Prudencio, Bruna Bologna, Luana Favaro Iamundo, Adriely Magyori, Luiz Takano, Raissa Escandiussi Avramidis, Rafael Guilen de Oliveira, Marilza Vieira Cunha Rudge, Angélica Mércia Pascon Barbosa, Diamater Study Group

“…We aimed to investigate the association between early-onset GDM and adverse outcomes in newborns and neonates, comparing it with the late-onset GDM model. Methods It was a retrospective cohort study conducted at the Perinatal Diabetes Research Center in Assis/SP, affiliated with the Botucatu Medical School-UNESP in Brazil. …”
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A Polysorbate-Based Lipid Nanoparticle Vaccine Formulation Induces In Vivo Immune Response Against SARS-CoV-2 by Aishwarya Saraswat, Alireza Nomani, Lin-Kin Yong, Jimmy Chun-Tien Kuo, Heather Brown, Muralikrishna Narayanareddygari, Avery Peace, Rizan Fazily, Timothy Blake, Christopher D. Petro, Bindhu Rayaprolu, Johanna Hansen, Amardeep Singh Bhalla, Mohammed Shameem

“…By leveraging PS-80’s unique structural properties, this study aimed to develop an mRNA-LNP platform with improved extrahepatic delivery and robust freeze/thaw tolerance. <b>Methods</b>: We employed a stepwise optimization to establish both the lipid composition and formulation buffer to yield a stable, high-performing PS-80-based SARS-CoV-2 mRNA-LNP (SC2-PS80 LNP). …”
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Active learning for advanced biodegradable film design by Yi Gao, Chengcheng Liu, Yang Zhao, Peng Zhao, Feihui Chen, Qinghai Li, Yanguo Zhang, Bin Yang, Hui Zhou

“…Through six iterations with 186 data points for three-target optimization and seven iterations with 166 data points for two-target modeling, a data-driven platform was established to accurately predict CMC film properties based on composition and autonomously identify optimal formulations for specific performance targets. …”
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Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus by Fredirick L. Mashili, Kaushik Ramaiya, Janet Lutale, Marina Njelekela, Filbert Francis, Juleen Zierath, Anna Krook

“…Based on statistical models, measures of adiposity explained up to 59% of the variability in FGF-21 levels in the circulation. …”
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A GIS-based multiscale mapping framework to assess and visualize complex and polygenetic geomorphic systems – A novel ‘Geomorphic Entities’ approach by Manuel La Licata, Alberto Bosino, Mattia De Amicis, Andrea Terret, Michael Maerker

“…It complements traditional mapping methods by structuring complex geomorphological data for use in integrated modelling procedures.…”
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Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function by Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Hwee Ying Lim, Liao Wupeng, Liao Wupeng, Sheau Yng Lim, Sheau Yng Lim, Sheng Jie Natalie Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Chung Hwee Thiam, Shu Wen Tan, Shu Wen Tan, Joan Lau Joo Eng, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Veronique Angeli, Veronique Angeli

“…However, the cellular mechanisms driving collagen remodeling and the functional implications of this process in the pathophysiology of pulmonary diseases remain poorly understood.MethodsTo address this question, we employed Lyve1wt/cre; Csf1rflox/flox mice with specific depletion of Lyve-1+ macrophages and assessed the content, types and organization of collagen in lung compartments at steady state and after chronic exposure to cigarette smoke (CS).ResultsUsing this mouse model, we found that the absence of this subpopulation of tissue resident macrophage led to the deposition of type I collagen fibers around the alveoli and bronchi at steady state. …”
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Vaccinium myrtillus L. ameliorates diabetic nephropathy via modulating metabolites and gut microbiota in rats by Xinxin Cao, Xinxin Cao, Xinxin Cao, Xinxin Cao, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Wenxiu Liu, Wenxiu Liu, Wenxiu Liu, Wenxiu Liu, Yufang Wang, Zhen Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Zhengqi Dong, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Ruikun He, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…The aim of this study was to investigate the effect and mechanism of Vaccinium myrtillus L. extract (VCE) on diabetic nephropathy in vivo and in vitro.MethodsStreptozocin (STZ) combined with high fat induced DN model was established in rats. …”
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Limits for <i>Coregonus migratorius</i> (Georgi, 1775) catches and likely ecological effects by P. N. Anoshko, M. M. Makarov, V. I. Zorkaltsev, N. N. Denikina, E. V. Dzyuba

“…The results of changes in the modelling of the number and age composition of fish with different protection strategies indicate that maintaining a low level of replenishment stock the limits would not increase commercial stocks of C. migratorius. …”
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The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress by Michaela A. O'Hare, Patricia C. Swart, Stefanie Malan-Müller, Leigh L. van den Heuvel, Erine Bröcker, Soraya Seedat, Sian M.J. Hemmings

“…Methods: Participants completed validated, online self-report questionnaires to evaluate symptoms of state anxiety, trait anxiety, depression, and PTSD. …”
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Isomorphism and its approximation in Islamic art decorations by Thalfaa Ali Mahdi Altimimi, Amin Abdel Zahra Yassin

“…The conclusions, including: that the ability and experience of the decorator have the most prominent role in choosing the optimal and appropriate methods of the appearance of the decorations, and they may be The adaptability and flexibility that characterize Islamic art decorations play a role in the ease of formation and combination, as these components demonstrate the artist’s ingenuity and skill in designing complex and interwoven shapes, which gives the artwork a high artistic value. …”
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Characterization of the salivary microbiome of adults with inflammatory bowel disease by Vanessa DeClercq, Robyn J. Wright, Johan van Limbergen, Morgan G. I. Langille

“…This study aimed to evaluate the oral microbiome of adults with IBD and of matched controls.Methods Saliva samples and data were obtained from a Canadian population cohort (n = 320). …”
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E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…In vivo, an inflammatory bowel disease (IBD) model was exploited to evaluate the carcinogenic potential of CNF1. …”
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Electrocaloric Effect in Multilayer Ferroelectric Structures by Alexander S. Starkov, Alexander S. Anokhin, Andrey V. Es'kov, Alexander A. Semenov, Andrey L. Kholkin

“…Development of a mathematical model quantifying the ferroelectric polarization, static dielectric constant, as well as pyroelectric and electrocaloric properties of multilayered ferroelectric film structures.Materials and methods. …”
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Managers' Ability and Debt Structure: Evidence from Iran's Financial Reporting Environment by Aqil al hasoon, Seyed Abbas Hashemi, Narges Hamidian

“…A multivariate regression model based on panel data analysis was employed to test the hypotheses. …”
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Sedimentary environment analysis of the Asmari Formation (Upper Rupelian) based on microfossils in Bandar Abbas Hinterland, south Iran by Jahanbakhsh Daneshian, Mahboobeh Sadat Tabatabaei, Alireza Tahmasbi

“…Based on this, the sedimentary model for the Asmari Formation in the study area was attributed to a carbonate ramp, which can be divided into three sub-environments: inner, middle and outer ramp.Keywords: Asmari Formation, Rupelian, depositional environments, Bandar Abbas Hinterland  IntroductionThe carbonates of the Asmari Formation are the main petroleum reservoir rock in the Zagros Basin. …”
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