Non-linear association between dietary fiber intake and cognitive function mediated by vitamin E: a cross-sectional study in older adults by Qianyi He, Lucy An, Yue Yue, Can Cui, Chongjian Wang, Hong Xu, Yunfei Guo, Xinyu Zhao

“…Mediation analysis quantified the mediating role of vitamin E in the dietary fiber-cognitive function association, with effects assessed via the non-parametric percentile bootstrap method. Subgroup-specific sensitivity analyses demonstrated consistent findings.ResultsA J-shaped relationship between cognitive function and dietary fiber intake was identified using a two-piece-wise linear regression model. …”
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Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction evaluated by new angiography-derived index of microvascular resistance by Benoit Caullery, Laurent Riou, Stephanie Marliere, Estelle Vautrin, Nicolas Piliero, Olivier Ormerzzano, Helene Bouvaist, Gerald Vanzetto, Gilles Barone-Rochette

“…Background: Several methods for measuring IMR derived from angiography have been developed. …”
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Comparison of homologous and heterologous vaccination strategies for combating disease caused by Burkholderia pseudomallei by Sergei S. Biryukov, Christopher K. Cote, Christopher P. Klimko, Jennifer L. Dankmeyer, Nathaniel O. Rill, Melissa Hunter, Michael L. Davies, Zander M. Hedrick, Jennifer L. Shoe, Lindsey K. Schmidt, Caitlyn E. Orne, Ju Qiu, Susan L. Welkos, Mary N. Burtnick, Mary N. Burtnick, Paul J. Brett, Paul J. Brett, David DeShazer

“…Our laboratories have focused on the development of vaccines composed of live attenuated strains and defined subunit antigens.MethodsIn the current study, we evaluated homologous and heterologous combinations of candidate subunits and live vaccines in a murine aerosol model of melioidosis to determine the effects of vaccine composition and delivery scheme on protection in conjunction with immune responses and bacterial clearance.ResultsBoth strategies provided significant protection against lethal aerosol challenges, and the accumulated data support that a heterologous vaccination strategy employing capsular polysaccharide conjugate and Hcp1 subunits and a live but highly safe capsular polysaccharide-producing surrogate strain of B. thailandensis is an effective and potentially agile prophylactic strategy.…”
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Pathogenicity and host-interacting mechanisms of enterogenic Enterobacter cancerogenus in silkworm by Meng Luo, Linhui Lai, Zailin Wu, Zailin Wu, Zailin Wu, Xiaoli Ren, Xiaoli Ren, Xiaoli Ren, Jiacheng Zhao, Jiacheng Zhao, Jiacheng Zhao, Hongmei Liu, Hongmei Liu, Hongmei Liu, Yaohang Long, Yaohang Long, Yaohang Long

“…However, the molecular mechanisms underlying the pathogenicity of E. cancerogenus in insect hosts remain largely unexplored.MethodsIn this study, the Bombyx mori model was employed to investigate the pathogenicity of E. cancerogenus strain ECL7, a bacterium pathogenic to silkworms, through whole-genome sequencing, 16S rDNA sequencing, and transcriptome analysis.ResultsThe results revealed that ECL7 harbors virulence genes associated with biofilm formation, adhesion, type III secretion system (T3SS), type VI secretion system (T6SS), and other factors, which collectively lead to damage to the peritrophic matrix (PM) and intestinal epithelial cells of the silkworm midgut following infection, and reduced silkworm larval survival rates and inhibited their growth and development. …”
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Calculating slope gradient variations in the submarine landforms by R and Python statistical libraries by Polina Lemenkova

“…The results show differences in the gradient slope between various segments of the Mariana Trench located in four tectonic plates: Mariana, Caroline, Pacific and Philippine Sea, performed by statistical data modelling. Programming codes and snippets are presented for repeatability of the methods in similar research tasks.…”
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Niche partitioning and trait tradeoff strategies enable plants to coexist under interspecific competition in restored wetlands by Shenglin Yang, Shenglin Yang, Zhen Yuan, Bibi Ye, Feng Zhu, Feng Zhu, Xiaoxian Tang, Rui Gao, Zhaosheng Chu, Zhaosheng Chu, Xiaowei Liu

“…However, specific strategies of plants remained to be verified to guide community configuration and biodiversity maintenance in ecological restoration.MethodsThe variation of plants composition and niche breath were utilized to examine the temporal and spatial niche partition strategies, respectively. …”
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An Explainable Artificial Intelligence Text Classifier for Suicidality Prediction in Youth Crisis Text Line Users: Development and Validation Study by Julia Thomas, Antonia Lucht, Jacob Segler, Richard Wundrack, Marcel Miché, Roselind Lieb, Lars Kuchinke, Gunther Meinlschmidt

“…The model predicted suicidal ideation (SI) and advanced suicidal engagement (ASE), as indicated by composite Columbia-Suicide Severity Rating Scale scores. …”
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Tunable electrical properties of lignin: morphology-dependent ionic conduction in Kraft and organosolv-derived materials by Rosarita D’Orsi, Sebastiano De Stefano, Ofelia Durante, Marianna Ambrico, Domenico Aceto, Paolo Francesco Ambrico, Nadia Martucciello, Filippo Giubileo, Sandra Rivas, Alessandra Operamolla, Antonio Di Bartolomeo

“…Morphology-dependent adsorption of air molecules primarily enhances ionic conduction, and the good fit to the Arrhenius model suggests that charge transport occurs via carrier hopping across localized energy barriers. …”
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Petrogenetic evidences in geodynamics and placement of Nordoz intrusive masses in Alborz-Azerbaijan structural zone by Shahryar Mahmoudi, Shiva Lavi, Shohreh Hassanpour, Amir Ali Tabakh Shabani, Mehran Yegane Far

“…The magmatic complex in question is distributed throughout northwestern Iran, Armenia, and eastern Turkey in the northern and eastern parts around the Arabian Plate. Materials and methods In order to facilitate petrologic studies, 11 samples exhibiting the least degree of alteration were selected and sent to the Zarazma company for chemical analysis of rare elements by ICP-MS and major oxides by XRF method. …”
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Spatial transcriptomics and multi-omics reveal relapse and resistance mechanisms of EndMT-derived CAFs mediated by TNC and FLNC in glioblastoma by Li Ji, Die Xia, Yu Zhou, Yaling Hu, Zhenkun Yang, Ying Yin, Jingjing Wang, Bo Zhang, Lingli Gong, Koukou Li, Jian Zou, Mei Wang

“…Nevertheless, the role and source of CAFs in recurrent and chemotherapy-resistant GBMs still remain ambiguous. Methods Spatial transcriptome (ST) sequencing was conducted on the tissue microarray encompassing primary and recurrent glioma samples in order to characterize the cellular composition. …”
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Assessing the impact of an intensive dietitian-led telehealth intervention focusing on nutritional adequacy, symptom control and optional supplemental jejunal feeding, on quality o... by Emma McShane, Kate Furness, Lauren Hanna, Kate Connell, Terrence Haines, Catherine E. Huggins, John Zalcberg, Sharon Carey, Charles H.C. Pilgrim, Joanne Lundy, Andrew Metz, David Kissane, Michael Franco, John Coutsouvelis, Diederick W. De Boo, J Simon Bell, Mahesh Iddawela, Theresa Dodson, Ignatius Pereira, Nina Imad, Jill Kirkpatrick, Cherie Dear, Daniel Croagh

“…The consistent dietetic approach with the use of telehealth consultations to reduce malnutrition and aid symptom management challenges the current model of care. Trial registration 31st January 2024, Australian and New Zealand Clinical Trial Registry (Trial ID/No. …”
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulationResearch in context by Xuguang Li, Nobuaki Shiraki, Takami Watanabe, Rikako Fukui, Kyohei Furukawa, Yusuke Kato, Yuri Nakahara, Shoen Kume, Akashi Taguchi, Youichiro Wada, Dwina Juliana Warman, Kenji Saito, Haruyo Nakajima-Adachi, Satoshi Hachimura, Hisanori Kato, Huijuan Jia

“…However, the impact of a maternal methionine-deficiency (MD) diet on offspring during the critical stage of embryonic pancreatic differentiation remains unclear. Methods: We used an in vitro human induced pluripotent stem cell (hiPSC) differentiation model and in vivo mouse and rat models to assess the impact of short-term maternal MD during pancreatic development. …”
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Factors affecting hematological parameters in Creole goats on the Southern Coast of Peru by Jhony Soca, Emmanuel Alexander Sessarego, Pamela Sarmiento, María José Cevallos-Cardenas, Juan Canchino-Gutierrez, Jose Teran, Jose Antonio Ruiz, Juancarlos Cruz-Luis, Danny Julio Cruz

“…Robust linear regression models with MM-estimation were applied, with model selection based on Akaike information criterion, Bayesian information criterion, and root mean square error. …”
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Protocol for a randomised controlled trial of a weight maintenance intervention to promote fat loss in pregnant individuals with obesity by Suzanne Phelan, Leanne M Redman, Aaron B Caughey, Daniel S Hsia, John W Apolzan, Robbie A Beyl, Abby D Altazan, Madison S Dickey, Emerson Simeon, Emily W Flanagan, Hannah E Cabre, Joshua R Sparks, Maryam Kebbe, Amy M Valent, Elaine Yin, Sarah K Keadle

“…The primary outcomes of the trial (Healthy Mamas/Mamis Saludables) are weight, fat mass (via three-compartment model) and cardiometabolic disease risk factors (ie, blood pressure, lipids, glucose, insulin) from baseline (~13 weeks gestation) to ~35 weeks gestation and at 2 weeks postpartum. …”
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Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol for a randomized controlled double-blinded clinical trial by F. Azizi, A. Amouzegar, H. Abdi, M. Tohidi, S. Masoumi, D. Khalili, Y. Mehrabi, A. Zadehvakili, M. Hedayati, A. A. Momenan, L. Mehran

“…Before and after the intervention, body weight, heart rate, blood pressure, ECG, quality of life (by ThyPRO-39 and SF-12), resting energy expenditure, and body composition will be evaluated. Also, serum TSH, total T3, total T4, free T4, free T3, total cholesterol, LDL, HDL, triglycerides, fasting blood sugar (FBS), insulin, HbA1C, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), sex hormone-binding globulin (SHBG), enolase, lactate dehydrogenase (LDH), creatin kinase (CK), ferritin, and metabolomics will be assessed at baseline and compared with their corresponding values at 24 and 48 weeks. …”
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Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics by Tao Jiang, Peipei Du, Dongxia Liu, Hetao Chen, Yujin Ma, Bin Hu, Jingna Li, Hongwei Jiang, Xuejiao Li

“…This research aimed to elucidate the impact of ATM on glucolipid metabolism in a type 2 diabetes mellitus (T2DM) model db/db mice and what kind of role the gut microbiota played, and explored the underlying mechanisms involved.MethodsC57BL/KsJ-db/db mice were treated with 80 and 160 mg/kg of ATM for 8 weeks, with metformin as a positive control.ResultsATM treatment (160 mg/kg) observably ameliorated insulin resistance (IR), hyperglycemia, hyperlipemia and pathological injury in the liver and pancreas. …”
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Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity by Valentina Salvi, Carolina Gaudenzi, Barbara Mariotti, Gaia Giongrandi, Silvia Alacqua, Veronica Gianello, Tiziana Schioppa, Laura Tiberio, Angela Ceribelli, Carlo Selmi, Paolo Bergese, Stefano Calza, Annalisa Del Prete, Silvano Sozzani, Flavia Bazzoni, Daniela Bosisio

“…Methods To mimic the onset of psoriasis, keratinocytes were treated with a cocktail of psoriatic cytokines or UV-irradiated. …”
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Modified Huanjingjian Prevents Chemotherapy-Induced Alopecia by Inhibiting Genomic DNA Methylation of the Wnt Signaling Pathway in Mice by Liu X, Du T, Xi R, Cheng L, Wang Y, Lu H, Guo D, Zhu J, Liu T, Li F

“…And our main aim was to explore the efficacy and the mechanism of MHJJ in mice.Methods: UPLC-QE-Orbitrap-MS characterized MHJJ’s chemical composition. …”
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ARCHITECTONICS OF THE SILENCE IN VERCORS’ NOVEL “THE SILENCE OF THE SEA” by Tatyana A. Pakhareva

“…The combination of the structural-semiotic, contextual, and holistic methods during the story analysis allowed us to come to the conclusion that compositionally the “silence of the sea”, which corresponds to the “surface/depth” structure, is implemented in Vercors’ story in a similar way to L. …”
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DHLCA Alleviates Diabetic Kidney Disease via TGR5/FXR Activation and Gut Microbiota Remodeling by Zhou H, Mu X, Hu H, Zhao S, Hu N, Yang M, Jiang J

“…This study aimed to investigate the role of BA metabolism in the progression of DKD.Methods: Plasma BA profiles were measured in healthy controls (HC), patients with type 2 diabetes mellitus (T2DM), and patients with DKD using ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). …”
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