Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…This study aims to investigate the effect of PD-L1 knockout on gut microbiota in an experimental autoimmune uveitis (EAU) model.MethodsEAU was induced via immunization with interphotoreceptor retinoid-binding protein peptide 651-670 (IRBP651-670) in either wild type (WT) or PD-L1 knockout (KO) C57BL/6J female mice. …”
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Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia by Rongrong Zhou, Rongrong Zhou, Tingting Liu, You Qin, Jing Xie, Shuihan Zhang, Yi Xie, Jia Lao, Wei He, Hongliang Zeng, Xueyang Tang, Xuefei Tian, Xuefei Tian, Yuhui Qin, Yuhui Qin

“…This research endeavored to assess the medicinal efficacy of PCPs in alleviating muscle atrophy and fat lipolysis and explore the potential mechanisms.Methods: A cancer cachexia model was induced by male C57BL/6 mice bearing Lewis lung tumor cells and chemotherapy. …”
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Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden S... by Ekaterina Stepanova, Victoria Matyushenko, Daria Mezhenskaya, Ekaterina Bazhenova, Tatiana Kotomina, Alexandra Rak, Svetlana Donina, Anna Chistiakova, Arina Kostromitina, Vlada Novitskaya, Polina Prokopenko, Kristina Rodionova, Konstantin Sivak, Kirill Kryshen, Valery Makarov, Larisa Rudenko, Irina Isakova-Sivak

“…The trivalent LAIV/CoV-2 composition was compared to the classical 3×LAIV in the golden Syrian hamster model. …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…However, whether timely controlled delivery of ESL1 antigens in vivo, as in natural infections, could enhance its therapeutic potential for MS is still unknown.Methods: To test this, we encapsulated ESL1 antigens into biodegradable poly (lactide-co-glycolic) acid (PLGA) nanofibers by emulsion electrospinning as a delivery system and assessed their release dynamics in vitro, and in an animal MS model, experimental autoimmune encephalomyelitis (EAE), induced 7 days after PLGA/ESL1 subcutaneous implantation. …”
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Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway by Na Yang, Meiduo Huayu, Shanshan Su, Bin Hou, Zhanting Yang, Xingmei Nan, Zhanqiang Li, Zhanqiang Li

“…Although its active fraction (ACRT) shows therapeutic potential for HAPH, the main pharmacodynamic substances remain unclear due to its complex composition.AimsThis study aimed to identify bioactive equivalent combinatorial components (BECCs) of ACRT that alleviate pulmonary vascular remodeling in HAPH rats and explore the underlying pharmacological mechanisms.MethodsSeventy adult Sprague–Dawley rats were divided into control, hypoxia, hypoxia + ACRT (150 mg/kg), hypoxia + BECCs (25, 50, and 100 mg/kg), and hypoxia + sildenafil (30 mg/kg) groups. …”
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Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study by Yuqin Zhang, Min Zhang, Meili Cai, Xiaowen Shao, Diliqingna Dilimulati, Jiayi Lu, Cuiling Zhu, Haibing Chen, Changbin Li, Shen Qu, Manna Zhang

“…The present study aimed to investigate the relationship between bedtime, androgen-associated traits, and dual-energy X-ray absorptiometry (DEXA)-based lean mass (LM) in polycystic ovary syndrome (PCOS). Methods This cross-sectional study recruited 899 reproductive-aged women with PCOS from the PCOS subspecialty clinic at Shanghai Tenth People’s Hospital, and finally, 636 women were included in the study. …”
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Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…We hypothesized that dysbiosis disrupts immune tolerance and promotes PTB, and that butyrate (short-chain fatty acid produced by specific gut bacteria) may counteract this effect by enhancing regulatory T cell (Treg)-mediated immune regulation. Methods We established a dysbiosis-induced PTB mouse model using vancomycin treatment combined with subclinical immune activation via anti-CD3ε antibody. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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New framework for the development of clinical guidelines in Russia by D. V. Blinov, E. S. Akarachkova, A. S. Orlova, E. V. Kryukov, D. I. Korabelnikov

“…Aim - based on the existing regulations and recent documents from the regulatory bodies, determine the methodology for the development of clinical guidelines (CG) that meet the requirements of the legislation in the Russian Federation.Materials and methods. We analyzed a number of regulatory and subordinate acts confirming the concept and status of the CG, in particular, the Federal Law № 323-ФЗ “On the principles of health care for citizens of the Russian Federation”, Federal Law № 489-ФЗ “On the amendments to article 40 of the Federal Law “On compulsory medical insurance in the Russian Federation” and the Federal Law “On the principles of health care for citizens of the Russian Federation” concerning clinical guidelines, Order № 102н of the Ministry of Health of the Russian Federation dated 28 Feb 2019 “Regulations on the scientific and practical council of the Ministry of Health of Russia” and Order № 103н of the Ministry of Health of the Russian Federation of 28 Feb 2019 “On Approval of the procedure and terms for the development of clinical guidelines and their revision, the model format of clinical guidelines and requirements to their structure, contents and scientific validity of the information included in the clinical guidelines”. …”
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Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer by Tetsuya Isaka, Takuya Nagashima, Kota Washimi, Haruhiro Saito, Hiroto Narimatsu, Shunsuke Shigefuku, Chiaki Kanno, Ryotaro Matsuyama, Naoko Shigeta, Yui Sueishi, Hiroyuki Ito

“…ABSTRACT Background The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early‐stage lung cancer remains unclear. …”
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The mechanism of SAP overexpression in alleviating periodontitis in mice by HUANG Yinyin, LIANG Dongliang, ZOU Yaokun, HAN Jingru, GE Qing, LIU Xueyan, GUO Yadong, HUANG Xinli, YANG Lan

“…Oral microorganism composition was analyzed using 16S ribosomal RNA (16S rRNA) gene sequencing. …”
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Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier by Yi Gao, Yi Gao, Lan Deng, Lan Deng, Yuanyuan Chen, Yuanyuan Chen, Peiyou Qin, Yuanyuan Zhao, Xiaoyan Zhao, Wei Liu, Dan Wang, Shuang Zhao

“…This study investigated the therapeutic potential of Pleurotus citrinopileatus polysaccharide (PCP-g), a novel galactoglucan, against sucralfate-induced constipation murine model, focusing on intestinal motility, fecal parameters, aquaporin signaling, and gut microbiota modulation.MethodsPCP-g was purified from P. citrinopileatus and its physicochemical properties were characterized. …”
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Chemical and isotopic signatures of hot springs from east-central Sonora State, Mexico: a new prospection survey of promissory low-to-medium temperature geothermal systems by Erika Almirudis, Edgar R. Santoyo-Gutiérrez, Mirna Guevara, Francisco Paz-Moreno, Enrique Portugal

“…The collected samples were analysed by chemical and isotopic methods for determining their chemical (major and trace elements) and isotopic (18O/16O and D/H) compositions. …”
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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation by Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

“…However, it remains unknown whether and how FPHA affects the immune microenvironment of the bone defects. Methods FPHA was synthesized and its composition and structural properties were confirmed. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Their structure and composition characterization were performed using TEM, NTA and UHPLC-QTOFMS. …”
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Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing by Yueling Peng, Yaling Zhang, Yaling Zhang, Rui Wang, Xinyu Wang, Xingwei Liu, Hui Liao, Rongshan Li

“…Inonotus obliquus (Chaga), a traditional medicinal mushroom, has shown promising effects in chronic kidney disease (CKD), yet its cellular and molecular mechanisms remain largely unexplored.MethodsWe analysed the chemical composition of Chaga using UPLC-MS and predicted its biological targets using PubChem and Swiss Target Prediction. …”
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Petrogenesis of Intrusive body in Northeast of Joveinan, North of Isfahan, Urumieh- Dokhtar magmatic zone by Shahzad Sherafat, Majid Zeidi, Mahnaz Khodami

“…This study aims to understand the nature, tectonic setting, origin, and various processes involved in the magmatic evolution of the Northeast Joveinan intrusive rocks. Material and Methods After field studies and the sampling of outcrops, 52 microscopic thin sections were prepared and studied using an Olympus polarizing microscope model BX-2. …”
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Short-Wave Infrared (SWIR) Imaging for Robust Material Classification: Overcoming Limitations of Visible Spectrum Data by Hanbin Song, Sanghyeop Yeo, Youngwan Jin, Incheol Park, Hyeongjin Ju, Yagiz Nalcakan, Shiho Kim

“…Traditional vision systems, relying on visible spectrum imaging, struggle to distinguish between objects with similar appearances but different material compositions. Our method leverages SWIR’s distinct reflectance characteristics, particularly for materials containing moisture, and demonstrates a significant improvement in accuracy. …”
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Efficiently charting the space of mixed vacancy-ordered perovskites by machine-learning encoded atomic-site information by Fan Zhang, Li Fu, Weiwei Gao, Peihong Zhang, Jijun Zhao

“…Mixing these materials creates a vast compositional space for tunable properties but complicates efficient screening of target candidates. …”
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Robust Continuous Sliding-Mode-Based Assistive Torque Control for Series Elastic Actuator-Driven Hip Exoskeleton by Rui Wang, Xiaoou Lin, Changwei Yin, Zhongtao Liu, Yang Zhang, Wenping Liu, Fuxin Du

“…On this basis, to enhance the torque tracking performance of the hip joint exoskeleton, in this study, a robust composite control strategy is proposed, which can maintain accuracy in the presence of unknown external disturbances and model parameter inaccuracies. …”
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