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4481
The effects of a semen cuscutae flavonoids-based antidepressant treatment on microbiome and metabolome in mice
Published 2025-05-01“…Given that the gut microbiota has been proven to play a significant role in the etiology of depression and serves as a promising target for its treatment in humans, this study aims to elucidate the antidepressant effects of SCFs and to investigate how they modulate microbial and metabolic pathways to alleviate depressive symptoms.Materials and methodsChronic unpredictable mild stress (CUMS)-induced mice were used as a depression model. …”
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4482
Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy
Published 2025-04-01“…In both in vitro and in vivo NAFLD models, GA-MSe@AR demonstrated more pronounced lipid-lowering and antioxidant properties than AR and GA-MSe. …”
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4483
Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism
Published 2025-01-01“…This research aims to restore intestinal microbiota to a healthy state through the oral administration of Bifidobacterium in the early stages with the goal of delaying the onset and progression of RA.MethodsCollagen-induced arthritis (CIA) rat model was constructed to assess the development of RA using arthritis clinical scores, paw thickness, pathological analysis of knee joint. …”
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4484
Ameliorative Effect of Lacticaseibacillus paracasei Combined with Aerobic Exercise on Obesity in Mice
Published 2025-06-01“…Objective: To investigate the effect of Lacticaseibacillus paracasei N1115 combined with aerobic exercise on improving glucose and lipid metabolism, inflammatory response, learning and memory capacity, intestinal morphology and intestinal flora diversity in obese mice. Methods: C57BL/6 mice were used to establish an obese mouse model by feeding them a high-fat diet. …”
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4485
New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach
Published 2025-02-01“…Recent research indicates that gut microbiota might be pivotal in RA development through the “gut-joint axis,” presenting novel therapeutic possibilities.PurposeThis study seeks to explore the therapeutic potential of the traditional Chinese medicine (TCM) compound new bitongling (NBTL) for RA, with an emphasis on its capacity to regulate gut microbiota and suppress angiogenesis via the vascular endothelial growth factor (VEGF) signaling pathway.MethodsWe utilized a collagen-induced arthritis (CIA) rat model to assess the impact of NBTL. …”
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4486
Conversion relationships and three-dimensional storage and utilization modes of four water resources in an open-pit mining area
Published 2025-07-01“…Using methods such as field survey and sampling, borehole monitoring, laboratory hydrochemical tests, and numerical simulation, this study primarily determined the quantitative composition, hydrogeochemical characteristics, and mutual conversion relationships of meteoric water, surface water, groundwater, and mine water (collectively referred to as the four water resources). …”
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4487
Thermal and Dynamo Evolution of the Lunar Core Based on the Transport Properties of Fe‐S‐P Alloys
Published 2024-07-01“…These values were incorporated into thermal and dynamo models to investigate the evolution of the lunar core. …”
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4488
Software-Based Transformation of White Light Endoscopy Images to Hyperspectral Images for Improved Gastrointestinal Disease Detection
Published 2025-06-01“…Conventional diagnostic methods employing white light imaging (WLI) in wireless capsule endoscopy (WCE) provide limited spectrum information, therefore influencing classification performance. …”
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4489
RCS and stealth performance analyses of marine low-altitude helicopter
Published 2025-06-01“…The study of radar target characteristics and stealth performance of low altitude helicopters at sea can provide a basis for path planning. a random rough sea surface model is established in this paper. Based on the high frequency approximation method, the radar target characteristics of helicopters flying at low altitude on the sea are analyzed. …”
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4490
Gut microbiota and gut-derived metabolites are altered and associated with dietary intake in women with polycystic ovary syndrome
Published 2024-11-01“…Results Gut microbiota diversity, composition, and metabolic pathways differed between the PCOS and control groups. …”
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4491
Plasma Fatty Acid Profiling and Mathematical Estimation of the Omega-3 Index: Toward Diagnostic Tools in Atherosclerosis and Statin Therapy Monitoring
Published 2025-06-01“…A mathematical model was developed to predict the erythrocyte omega-3 index from plasma. …”
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4492
Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study
Published 2025-06-01“…Conclusions In this pig model of nonreperfused MI treated with beta‐blocker, early initiation of empagliflozin reduced inflammation, improved nitric oxide bioavailability, increased protective liver lipids, and modified scar composition without affecting cardiac function or VT risk. …”
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4493
Working Mechanism of Pile Group with Different Pile Spacing in Dense Sand
Published 2019-01-01“…To realize the pile-soil load transmission mechanism in detail, the failure pattern of pile groups installed in dense sand considering different pile spacing was investigated by means of laboratory experimental model test and three-dimensional discrete element method. …”
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4494
Underwater sound absorption characteristics of the acoustic metamaterials with multiple coupling substructure
Published 2025-06-01“…Based on underwater acoustic calculation model for the functional gradient acoustic structure established by grade finite element method (G-FEM), the underwater sound absorption characteristics of the AMs-MCS are studied, and the influence of each substructure on the acoustic performance of the AMs-MCS is explored. …”
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4495
Development and optimization of levofloxacin in-situ emulgel to manage ocular bacterial infections
Published 2025-02-01“…The current study intended to formulate an eye in-situ gel containing model antibacterial Levofloxacin. Several in-situ emulgels with different gelling agents were prepared by the fusion method followed by stirring with a magnetic stirrer. …”
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4496
Distributed Knowledge Base System
Published 2019-07-01“…The goal of the work was the models of the distributed knowledge based systems and methods for structuring the system. …”
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4497
Eccentric Compression Performance of Core-Steel Tube with T-Shaped Steel Reinforced Concrete Column
Published 2024-01-01“…This paper introduces a novel steel–concrete composite column referred to as the core-steel tube with T-shaped steel reinforced concrete (CSTRC) column, which is composed of a core steel tube with T-shaped steel embedded in a reinforced concrete column. …”
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4498
Small Antenna Based on MEMS and Metamaterial Properties for Reconfigurable Applications
Published 2013-01-01“…The antenna is designed using coplanar waveguide (CPW) technology, presenting lower dielectric losses and higher signal integrity. The design method for this MEMS-MTM antenna, herein presented, is based on a composite right/left hand (CRLH) transmission Line (TL) using a mixed approach; considering the circuit model and full-wave simulations. …”
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4499
Pd nanowire coatings of laser-treated polyethylene naphthalate: Preparation, characterization and biological response
Published 2018-12-01“…Then, the antibacterial and cytotoxic effects were evaluated by (i) drop plate method using E. coli (G–) and S. epidermidis (G+ bacteria), and (ii) WST-1 cytotoxicity assay with three model cell lines (L929, NIH 3T3, RAW 264.7), respectively. …”
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4500
Mechanical Performance of Novel Split Precast Cap Beams
Published 2025-06-01“…The findings provide both theoretical and practical foundations for optimizing and promoting this efficient construction method in bridge engineering applications.…”
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